LOCUS       NM_017945               4366 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens solute carrier family 35 member A5 (SLC35A5),
            transcript variant 1, mRNA.
ACCESSION   NM_017945
VERSION     NM_017945.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4366)
  AUTHORS   Benz,C., Ali,M., Krystkowiak,I., Simonetti,L., Sayadi,A.,
            Mihalic,F., Kliche,J., Andersson,E., Jemth,P., Davey,N.E. and
            Ivarsson,Y.
  TITLE     Proteome-scale mapping of binding sites in the unstructured regions
            of the human proteome
  JOURNAL   Mol Syst Biol 18 (1), e10584 (2022)
   PUBMED   35044719
REFERENCE   2  (bases 1 to 4366)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 4366)
  AUTHORS   Sosicka,P., Bazan,B., Maszczak-Seneczko,D., Shauchuk,Y., Olczak,T.
            and Olczak,M.
  TITLE     SLC35A5 Protein-A Golgi Complex Member with Putative Nucleotide
            Sugar Transport Activity
  JOURNAL   Int J Mol Sci 20 (2), 276 (2019)
   PUBMED   30641943
  REMARK    GeneRIF: Study provide evidence suggesting that SLC35A5 might be
            the first mammalian nucleotide sugar transport (NST) engaged in the
            transport of three different UDP-sugars. It contains several
            diacidic motifs within its cytosolically exposed C-terminus, some
            of which might be capable of UDP-sugar binding. SLC35A5 protein
            might be a Golgi-resident multi-protein complex member engaged in
            NST.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4366)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   5  (bases 1 to 4366)
  AUTHORS   Hadley,B., Maggioni,A., Ashikov,A., Day,C.J., Haselhorst,T. and
            Tiralongo,J.
  TITLE     Structure and function of nucleotide sugar transporters: Current
            progress
  JOURNAL   Comput Struct Biotechnol J 10 (16), 23-32 (2014)
   PUBMED   25210595
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4366)
  AUTHORS   Hoglund,P.J., Nordstrom,K.J., Schioth,H.B. and Fredriksson,R.
  TITLE     The solute carrier families have a remarkably long evolutionary
            history with the majority of the human families present before
            divergence of Bilaterian species
  JOURNAL   Mol Biol Evol 28 (4), 1531-1541 (2011)
   PUBMED   21186191
REFERENCE   7  (bases 1 to 4366)
  AUTHORS   He,L., Vasiliou,K. and Nebert,D.W.
  TITLE     Analysis and update of the human solute carrier (SLC) gene
            superfamily
  JOURNAL   Hum Genomics 3 (2), 195-206 (2009)
   PUBMED   19164095
REFERENCE   8  (bases 1 to 4366)
  AUTHORS   Ishida,N. and Kawakita,M.
  TITLE     Molecular physiology and pathology of the nucleotide sugar
            transporter family (SLC35)
  JOURNAL   Pflugers Arch 447 (5), 768-775 (2004)
   PUBMED   12759756
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC092692.6 and AC048334.21.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_017945.4.
            
            Summary: This gene encodes a transmembrane protein which belongs to
            subfamily 35A of the solute carrier superfamily. The encoded
            protein is a nucleoside-sugar transporter. Alternative splicing
            results in multiple transcript variants. [provided by RefSeq, Feb
            2017].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1). Variants 1-4 encode the same isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660809.245423.1,
                                           SRR1660805.41190.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000492406.6/ ENSP00000417654.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-229               AC092692.6         57731-57959
            230-378             AC092692.6         59071-59219
            379-477             AC048334.21        209561-209659       c
            478-608             AC048334.21        208160-208290       c
            609-676             AC048334.21        204874-204941       c
            677-1457            AC048334.21        197504-198284       c
            1458-4366           AC048334.21        193251-196159       c
FEATURES             Location/Qualifiers
     source          1..4366
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q13.2"
     gene            1..4366
                     /gene="SLC35A5"
                     /note="solute carrier family 35 member A5"
                     /db_xref="GeneID:55032"
                     /db_xref="HGNC:HGNC:20792"
                     /db_xref="MIM:620298"
     exon            1..229
                     /gene="SLC35A5"
                     /inference="alignment:Splign:2.1.0"
     exon            230..378
                     /gene="SLC35A5"
                     /inference="alignment:Splign:2.1.0"
     CDS             249..1523
                     /gene="SLC35A5"
                     /note="isoform 1 is encoded by transcript variant 1;
                     probable UDP-sugar transporter protein SLC35A5"
                     /codon_start=1
                     /product="UDP-sugar transporter protein SLC35A5 isoform 1"
                     /protein_id="NP_060415.1"
                     /db_xref="CCDS:CCDS2967.1"
                     /db_xref="GeneID:55032"
                     /db_xref="HGNC:HGNC:20792"
                     /db_xref="MIM:620298"
                     /translation="MEKQCCSHPVICSLSTMYTFLLGAIFIALSSSRILLVKYSANEE
                     NKYDYLPTTVNVCSELVKLVFCVLVSFCVIKKDHQSRNLKYASWKEFSDFMKWSIPAF
                     LYFLDNLIVFYVLSYLQPAMAVIFSNFSIITTALLFRIVLKRRLNWIQWASLLTLFLS
                     IVALTAGTKTLQHNLAGRGFHHDAFFSPSNSCLLFRSECPRKDNCTAKEWTFPEAKWN
                     TTARVFSHIRLGMGHVLIIVQCFISSMANIYNEKILKEGNQLTESIFIQNSKLYFFGI
                     LFNGLTLGLQRSNRDQIKNCGFFYGHSAFSVALIFVTAFQGLSVAFILKFLDNMFHVL
                     MAQVTTVIITTVSVLVFDFRPSLEFFLEAPSVLLSIFIYNASKPQVPEYAPRQERIRD
                     LSGNLWERSSGDGEELERLTKPKSDESDEDTF"
     exon            379..477
                     /gene="SLC35A5"
                     /inference="alignment:Splign:2.1.0"
     exon            478..608
                     /gene="SLC35A5"
                     /inference="alignment:Splign:2.1.0"
     exon            609..676
                     /gene="SLC35A5"
                     /inference="alignment:Splign:2.1.0"
     exon            677..1457
                     /gene="SLC35A5"
                     /inference="alignment:Splign:2.1.0"
     exon            1458..4366
                     /gene="SLC35A5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2922..2927
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC35A5"
                     /note="hexamer: ATTAAA"
     polyA_site      2943
                     /gene="SLC35A5"
                     /note="major polyA site"
     regulatory      3492..3497
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC35A5"
                     /note="hexamer: AATAAA"
     polyA_site      3512
                     /gene="SLC35A5"
     regulatory      4343..4348
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC35A5"
                     /note="hexamer: AATAAA"
     polyA_site      4366
                     /gene="SLC35A5"
ORIGIN      
        1 actgaacgtg cctgcgcaat gggtgtcggg tccgcttttt cccaatccgg acgtaatcgt
       61 ggtttttgtt ctgcaatagg cggcttagag ggaggggctt tttcgcctat acctactgta
      121 gcttctccac gtatggaccc taaaggctac tgctgctact acggggctag acagttactg
      181 tctcagctct aggatgtgcg ttcttccact agaagctctt ctgagggagg taattaaaaa
      241 acagtggaat ggaaaaacag tgctgtagtc atcctgtaat atgctccttg tcaacaatgt
      301 atacattcct gctaggtgcc atattcattg ctttaagctc aagtcgcatc ttactagtga
      361 agtattctgc caatgaagaa aacaagtatg attatcttcc aactactgtg aatgtgtgct
      421 cagaactggt gaagctagtt ttctgtgtgc ttgtgtcatt ctgtgttata aagaaagatc
      481 atcaaagtag aaatttgaaa tatgcttcct ggaaggaatt ctctgatttc atgaagtggt
      541 ccattcctgc ctttctttat ttcctggata acttgattgt cttctatgtc ctgtcctatc
      601 ttcaaccagc catggctgtt atcttctcaa attttagcat tataacaaca gctcttctat
      661 tcaggatagt gctgaagagg cgtctaaact ggatccagtg ggcttccctc ctgactttat
      721 ttttgtctat tgtggccttg actgccggga ctaaaacttt acagcacaac ttggcaggac
      781 gtggatttca tcacgatgcc tttttcagcc cttccaattc ctgccttctt ttcagaagtg
      841 agtgtcccag aaaagacaat tgtacagcaa aggaatggac ttttcctgaa gctaaatgga
      901 acaccacagc cagagttttc agtcacatcc gtcttggcat gggccatgtt cttattatag
      961 tccagtgttt tatttcttca atggctaata tctataatga aaagatactg aaggaaggga
     1021 accagctcac tgaaagcatc ttcatacaga acagcaaact ctatttcttt ggcattctgt
     1081 ttaatgggct gactctgggc cttcagagga gtaaccgtga tcagattaag aactgtggat
     1141 ttttttatgg ccacagtgca ttttcagtag cccttatttt tgtaactgca ttccagggcc
     1201 tttcagtggc tttcattctg aagttcctgg ataacatgtt ccatgtcttg atggcccagg
     1261 ttaccactgt cattatcaca acagtgtctg tcctggtctt tgacttcagg ccctccctgg
     1321 aatttttctt ggaagcccca tcagtccttc tctctatatt tatttataat gccagcaagc
     1381 ctcaagttcc ggaatacgca cctaggcaag aaaggatccg agatctaagt ggcaatcttt
     1441 gggagcgttc cagtggggat ggagaagaac tagaaagact taccaaaccc aagagtgatg
     1501 agtcagatga agatactttc taactggtac ccacatagtt tgcagctctc ttgaacctta
     1561 ttttcacatt ttcagtgttt gtaatattta tcttttcact ttgataaacc agaaatgttt
     1621 ctaaatccta atattctttg catatatcta gctactccct aaatggttcc atccaaggct
     1681 tagagtaccc aaaggctaag aaattctaaa gaactgatac aggagtaaca atatgaagaa
     1741 ttcattaata tctcagtact tgataaatca gaaagttata tgtgcagatt attttccttg
     1801 gccttcaagc ttccaaaaaa cttgtaataa tcatgttagc tatagcttgt atatacacat
     1861 agagatcaat ttgccaaata ttcacaatca tgtagttcta gtttacatgc caaagtcttc
     1921 cctttttaac attataaaag ctaggttgtc tcttgaattt tgaggcccta gagatagtca
     1981 ttttgcaagt aaagagcaac gggacccttt ctaaaaacgt tggttgaagg acctaaatac
     2041 ctggccatac catagatttg ggatgatgta gtctgtgcta aatattttgc tgaagaagca
     2101 gtttctcaga cacaacatct cagaatttta atttttagaa attcatggga aattggattt
     2161 ttgtaataat cttttgatgt tttaaacatt ggttccctag tcaccatagt taccacttgt
     2221 attttaagtc atttaaacaa gccacggtgg ggcttttttc tcctcagttt gaggagaaaa
     2281 atcttgatgt cattactcct gaattattac attttggaga ataagagggc attttatttt
     2341 attagttact aattcaagct gtgactattg tatatctttc caagagttga aatgctggct
     2401 tcagaatcat accagattgt cagtgaagct gatgcctagg aacttttaaa gggatccttt
     2461 caaaaggatc acttagcaaa cacatgttga cttttaactg atgtatgaat attaatactc
     2521 taaaaataga aagaccagta atatataagt cactttacag tgctacttca cacttaaaag
     2581 tgcatggtat ttttcatggt attttgcatg cagccagtta actctcgtag atagagaagt
     2641 caggtgatag atgatattaa aaattagcaa acaaaagtga cttgctcagg gtcatgcagc
     2701 tgggtgatga tagaagagtg ggctttaact ggcaggcctg tatgtttaca gactaccata
     2761 ctgtaaatat gagctttatg gtgtcattct cagaaactta cacatttctg ctctcctttc
     2821 tcctaagttt catgcagatg aatataaggt aatatactat tatataattc atttgtgata
     2881 tccacaataa tatgactggc aagaattggt ggaaatttgt aattaaaata attattaaac
     2941 ctatgtcttg tgttgccact ctgtcattta gggtgggatg tagagtactt ttaatcttaa
     3001 aaaatagagt gagacaaaaa cctacacaac ttttaaaact ttctctttaa gtagatcttt
     3061 acttctaaca ataacaaagg cattttcatc agttatgtga aatacgaaga ttatatctat
     3121 tatggcgatt tattttaaag gtaagggaaa tgaggtacag caggaccttt ctaggaaatg
     3181 tggcatacaa aacattttta tctcataaaa cataaaaatt acaaaaatat tcttacaaag
     3241 gtatcacata cagaatacat taaatagcag atttcagtag tgcatggaga ttgattttct
     3301 tatttacgat tacttttttt cctcaccttc ctctttggaa agcatttttt gcacaaagtt
     3361 aagtttactt atgttaactt gccacttaat gagagaggaa gagaaagagt gagagcacaa
     3421 gatcatgtgc tggaactaaa aatgttctat tcaacccagc aatccctcta ctgggtacct
     3481 acccaaagga aaataaatcg ttttatcaaa aagacacttg cagtggtatg tttatcacag
     3541 cagtattcac agtaacaaaa tcatggactc aacctaagtg tccatcagtg gtgcctggaa
     3601 taagaaaatg tggtacatat acaccatgga atactttgca gccataaaaa ataatgaaac
     3661 catgtgcttt aaagccacat ggatgcagct ggaagccatt atcctaactg aaataattca
     3721 gaaacagaaa atcaaatacc acatgttctc acttataagt gggagctaaa cagtgggtac
     3781 atgtggacac aggattccaa agtgagaagg gtggtgtatt agtccattct catgctgcta
     3841 caaagaaata cccgagactg ggtaatctat aaagaaaagg ggtttaaatg actcgcagtt
     3901 ctgcatggct ggggaggagg cctcaggaaa ctcacaagca tggctgaagg cgaaacagaa
     3961 gcaagcacct tcttcacaag gcagcaggag agagagtgcc aacaggggaa atggcagatg
     4021 cttataaaac catcagatct catgagaact tactatcatg agaacagcat gggggaaact
     4081 gcccccatga ttcaattacc cccacctggt tccttcctca acacctgggg attatgggga
     4141 ttacaattca agatgagatt tgggcgggga cagaaagcct aatcatatca gatgggaagg
     4201 acatgagggt tgacaaaata tgtattgggt acaatgttca ctgtttgagt gatgggtcca
     4261 ctagaagccc aaacttcacc attatgcaat gtaccatata tacgcaatgt aacaaacctg
     4321 tacatgtacc ccttcaatct gaaataaaag ttgttttttt ttttaa
//
