LOCUS       NM_080670               2666 bp    mRNA    linear   PRI 06-DEC-2024
DEFINITION  Homo sapiens solute carrier family 35 member A4 (SLC35A4), mRNA.
ACCESSION   NM_080670
VERSION     NM_080670.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2666)
  AUTHORS   Rocha,A.L., Pai,V., Perkins,G., Chang,T., Ma,J., De Souza,E.V.,
            Chu,Q., Vaughan,J.M., Diedrich,J.K., Ellisman,M.H. and
            Saghatelian,A.
  TITLE     An Inner Mitochondrial Membrane Microprotein from the SLC35A4
            Upstream ORF Regulates Cellular Metabolism
  JOURNAL   J Mol Biol 436 (10), 168559 (2024)
   PUBMED   38580077
REFERENCE   2  (bases 1 to 2666)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   3  (bases 1 to 2666)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 2666)
  AUTHORS   Sosicka,P., Maszczak-Seneczko,D., Bazan,B., Shauchuk,Y.,
            Kaczmarek,B. and Olczak,M.
  TITLE     An insight into the orphan nucleotide sugar transporter SLC35A4
  JOURNAL   Biochim Biophys Acta Mol Cell Res 1864 (5), 825-838 (2017)
   PUBMED   28167211
  REMARK    GeneRIF: A modulatory role for SLC35A4 in intracellular trafficking
            of SLC35A2/SLC35A3 complexes.
REFERENCE   5  (bases 1 to 2666)
  AUTHORS   Andreev,D.E., O'Connor,P.B., Fahey,C., Kenny,E.M., Terenin,I.M.,
            Dmitriev,S.E., Cormican,P., Morris,D.W., Shatsky,I.N. and
            Baranov,P.V.
  TITLE     Translation of 5' leaders is pervasive in genes resistant to eIF2
            repression
  JOURNAL   Elife 4, e03971 (2015)
   PUBMED   25621764
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2666)
  AUTHORS   Yamada,A., Kawano,K., Koga,M., Takamori,S., Nakagawa,M. and Itoh,K.
  TITLE     Gene and peptide analyses of newly defined lung cancer antigens
            recognized by HLA-A2402-restricted tumor-specific cytotoxic T
            lymphocytes
  JOURNAL   Cancer Res 63 (11), 2829-2835 (2003)
   PUBMED   12782588
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC011399.6 and AC116353.2.
            
            On Oct 23, 2020 this sequence version replaced NM_080670.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC009906.2, AL833972.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000323146.8/ ENSP00000327133.3
            RefSeq Select criteria :: based on single protein-coding transcript
            regulatory uORF        :: PMID: 25621764
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-31                AC011399.6         1033-1063           c
            32-49               AC011399.6         1-18                c
            50-130              AC116353.2         21602-21682
            131-2666            AC116353.2         22276-24811
FEATURES             Location/Qualifiers
     source          1..2666
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q31.3"
     gene            1..2666
                     /gene="SLC35A4"
                     /note="solute carrier family 35 member A4"
                     /db_xref="GeneID:113829"
                     /db_xref="HGNC:HGNC:20753"
                     /db_xref="MIM:620297"
     exon            1..31
                     /gene="SLC35A4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      17..328
                     /regulatory_class="uORF"
                     /gene="SLC35A4"
                     /experiment="DESCRIPTION:regulatory uORF[PMID:25621764]"
                     /note="this uORF encodes a 102 aa protein which contains a
                     DUF4535 domain"
     exon            32..130
                     /gene="SLC35A4"
                     /inference="alignment:Splign:2.1.0"
     exon            131..2666
                     /gene="SLC35A4"
                     /inference="alignment:Splign:2.1.0"
     CDS             736..1710
                     /gene="SLC35A4"
                     /note="solute carrier family 35 (UDP-galactose
                     transporter), member A4; tumor rejection antigen;
                     SLC35A4-MP; SLC35A4 microprotein"
                     /codon_start=1
                     /product="probable UDP-sugar transporter protein SLC35A4"
                     /protein_id="NP_542401.1"
                     /db_xref="CCDS:CCDS4231.1"
                     /db_xref="GeneID:113829"
                     /db_xref="HGNC:HGNC:20753"
                     /db_xref="MIM:620297"
                     /translation="MSVEDGGMPGLGRPRQARWTLMLLLSTAMYGAHAPLLALCHVDG
                     RVPFRPSSAVLLTELTKLLLCAFSLLVGWQAWPQGPPPWRQAAPFALSALLYGANNNL
                     VIYLQRYMDPSTYQVLSNLKIGSTAVLYCLCLRHRLSVRQGLALLLLMAAGACYAAGG
                     LQVPGNTLPSPPPAAAASPMPLHITPLGLLLLILYCLISGLSSVYTELLMKRQRLPLA
                     LQNLFLYTFGVLLNLGLHAGGGSGPGLLEGFSGWAALVVLSQALNGLLMSAVMKHGSS
                     ITRLFVVSCSLVVNAVLSAVLLRLQLTAAFFLATLLIGLAMRLYYGSR"
     regulatory      2622..2627
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC35A4"
                     /note="hexamer: AATAAA"
     polyA_site      2666
                     /gene="SLC35A4"
                     /note="major polyA site"
ORIGIN      
        1 aagttcggcg gggaagatgg cggatgacaa ggattctctg cctaagctta aggacctggc
       61 atttctcaag aaccagctgg aaagcctgca gcggcgtgta gaagacgaag tcaacagtgg
      121 agtgggccag gatggctcgc tgttgtcctc cccgttcctc aagggattcc tggctggcta
      181 tgtggtggcc aaactgaggg catcagcagt attgggcttt gctgtgggca cctgcactgg
      241 catctatgcg gctcaggcat atgctgtgcc caacgtggag aagacattaa gggactattt
      301 gcagttgcta cgcaaggggc ccgactagct ctaggtgcca tggaagaggc aggatgagca
      361 gctcagcctt caggtggaga cactttatct ggattcccca gctgtcatcc atttgctatc
      421 tccaactttc ctgccacctt catccttgcc tcccttcctg cagattgtgg acagtagttc
      481 ctcagcctgc accctggatt ccttcttccc cttcctagct ccatgggact cgccccaaga
      541 ctgtggcttc aaggaccacc agccccttac tcttcaagcc ctgactgtgg agttggtaga
      601 tgcctctgat cctcagtatt ctctctggca atgttccacg gcttctcctt cctgggagct
      661 ggctccataa cttgattttc cccaaacgtg ttgcaatccc tgctgcccct tagccaccca
      721 gggtcttgtg tgggtatgag tgtagaggat gggggtatgc caggcctggg ccgtcccagg
      781 caggcccgct ggaccctgat gctactccta tccactgcca tgtacggtgc ccatgcccca
      841 ttgctggcac tgtgccatgt ggacggccga gtgcccttcc ggccctcctc agccgtgctg
      901 ctgactgagc tgaccaagct actgttatgc gccttctccc ttctggtagg ctggcaagca
      961 tggccccagg ggcccccacc ctggcgccag gctgctccct tcgcactatc agccctgctc
     1021 tatggcgcta acaacaacct ggtgatctat cttcagcgtt acatggaccc cagcacctac
     1081 caggtgctga gtaatctcaa gattggaagc acagctgtgc tctactgcct ctgcctccgg
     1141 caccgcctct ctgtgcgtca ggggttagcg ctgctgctgc tgatggctgc gggagcctgc
     1201 tatgcagcag ggggccttca agttcccggg aacacccttc ccagtccccc tccagcagct
     1261 gctgccagcc ccatgcccct gcatatcact ccgctaggcc tgctgctcct cattctgtac
     1321 tgcctcatct caggcttgtc gtcagtgtac acagagctgc tcatgaagcg acagcggctg
     1381 cccctggcac ttcagaacct cttcctctac acttttggtg tgcttctgaa tctaggtctg
     1441 catgctggcg gcggctctgg cccaggcctc ctggaaggtt tctcaggatg ggcagcactc
     1501 gtggtgctga gccaggcact aaatggactg ctcatgtctg ctgtcatgaa gcatggcagc
     1561 agcatcacac gcctctttgt ggtgtcctgc tcgctggtgg tcaacgccgt gctctcagca
     1621 gtcctgctac ggctgcagct cacagccgcc ttcttcctgg ccacattgct cattggcctg
     1681 gccatgcgcc tgtactatgg cagccgctag tccctgacaa cttccaccct gattccggac
     1741 cctgtagatt gggcgccacc accagatccc cctcccaggc cttcctccct ctcccatcag
     1801 cagccctgta acaagtgcct tgtgagaaaa gctggagaag tgagggcagc caggttattc
     1861 tctggaggtt ggtggatgaa ggggtacccc taggagatgt gaagtgtggg tttggttaag
     1921 gaaatgctta ccatccccca cccccaacca agttcttcca gactaaagaa ttaaggtaac
     1981 atcaatacct aggcctgaga aataacccca tccttgttgg gcagctccct gctttgtcct
     2041 gcatgaacag agttgatgaa agtggggtgt gggcaacaag tggctttcct tgcctacttt
     2101 agtcacccag cagagccact ggagctggct agtccagccc agccatggtg catgactctt
     2161 ccataaggga tcctcaccct tccactttca tgcaagaagg cccagttgcc acagattata
     2221 caaccattac ccaaaccact ctgacagtct cctccagttc cagcaatgcc tagagacatg
     2281 ctccctgccc tctccacagt gctgctcccc acacctagcc tttgttctgg aaaccccaga
     2341 gagggctggg cttgactcat ctcagggaat gtagcccctg ggccctggct taagccgaca
     2401 ctcctgacct ctctgttcac cctgagggct gtcttgaagc ccgctaccca ctctgaggct
     2461 cctaggaggt accatgcttc ccactctggg gcctgcccct gcctagcagt ctcccagctc
     2521 ccaacagcct ggggaagctc tgcacagagt gacctgagac caggtacagg aaacctgtag
     2581 ctcaatcagt gtctctttaa ctgcataagc aataagatct taataaagtc ttctaggctg
     2641 tagggtggtt cctacaacca cagcca
//
