LOCUS       NM_006424               4115 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens solute carrier family 34 member 2 (SLC34A2),
            transcript variant 1, mRNA.
ACCESSION   NM_006424
VERSION     NM_006424.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4115)
  AUTHORS   Xu,Y., Duan,S., Ye,W., Zheng,Z., Zhang,J., Gao,Y. and Ye,S.
  TITLE     SLC34A2 promotes cell proliferation by activating STX17-mediated
            autophagy in esophageal squamous cell carcinoma
  JOURNAL   Thorac Cancer 15 (17), 1369-1384 (2024)
   PUBMED   38720472
  REMARK    GeneRIF: SLC34A2 promotes cell proliferation by activating
            STX17-mediated autophagy in esophageal squamous cell carcinoma.
REFERENCE   2  (bases 1 to 4115)
  AUTHORS   Jonsson,A.L.M., Hilberg,O., Simonsen,U., Christensen,J.H. and
            Bendstrup,E.
  TITLE     New insights in the genetic variant spectrum of SLC34A2 in
            pulmonary alveolar microlithiasis; a systematic review
  JOURNAL   Orphanet J Rare Dis 18 (1), 130 (2023)
   PUBMED   37259144
  REMARK    GeneRIF: New insights in the genetic variant spectrum of SLC34A2 in
            pulmonary alveolar microlithiasis; a systematic review.
            Review article
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4115)
  AUTHORS   Jonsson,A.L.M., Hernando,N., Knopfel,T., Mogensen,S., Bendstrup,E.,
            Hilberg,O., Christensen,J.H., Simonsen,U. and Wagner,C.A.
  TITLE     Impaired phosphate transport in SLC34A2 variants in patients with
            pulmonary alveolar microlithiasis
  JOURNAL   Hum Genomics 16 (1), 13 (2022)
   PUBMED   35443721
  REMARK    GeneRIF: Impaired phosphate transport in SLC34A2 variants in
            patients with pulmonary alveolar microlithiasis.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4115)
  AUTHORS   Vlasenkova,R., Nurgalieva,A., Akberova,N., Bogdanov,M. and
            Kiyamova,R.
  TITLE     Characterization of SLC34A2 as a Potential Prognostic Marker of
            Oncological Diseases
  JOURNAL   Biomolecules 11 (12), 1878 (2021)
   PUBMED   34944522
  REMARK    GeneRIF: Characterization of SLC34A2 as a Potential Prognostic
            Marker of Oncological Diseases.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4115)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 4115)
  AUTHORS   Xu,H., Inouye,M., Missey,T., Collins,J.F. and Ghishan,F.K.
  TITLE     Functional characterization of the human intestinal NaPi-IIb
            cotransporter in hamster fibroblasts and Xenopus oocytes
  JOURNAL   Biochim Biophys Acta 1567 (1-2), 97-105 (2002)
   PUBMED   12488042
REFERENCE   7  (bases 1 to 4115)
  AUTHORS   Segawa,H., Kaneko,I., Takahashi,A., Kuwahata,M., Ito,M., Ohkido,I.,
            Tatsumi,S. and Miyamoto,K.
  TITLE     Growth-related renal type II Na/Pi cotransporter
  JOURNAL   J Biol Chem 277 (22), 19665-19672 (2002)
   PUBMED   11880379
REFERENCE   8  (bases 1 to 4115)
  AUTHORS   Xu,H., Collins,J.F., Bai,L., Kiela,P.R. and Ghishan,F.K.
  TITLE     Regulation of the human sodium-phosphate cotransporter NaP(i)-IIb
            gene promoter by epidermal growth factor
  JOURNAL   Am J Physiol Cell Physiol 280 (3), C628-C636 (2001)
   PUBMED   11171583
REFERENCE   9  (bases 1 to 4115)
  AUTHORS   Xu,H., Bai,L., Collins,J.F. and Ghishan,F.K.
  TITLE     Molecular cloning, functional characterization, tissue
            distribution, and chromosomal localization of a human, small
            intestinal sodium-phosphate (Na+-Pi) transporter (SLC34A2)
  JOURNAL   Genomics 62 (2), 281-284 (1999)
   PUBMED   10610722
REFERENCE   10 (bases 1 to 4115)
  AUTHORS   Feild,J.A., Zhang,L., Brun,K.A., Brooks,D.P. and Edwards,R.M.
  TITLE     Cloning and functional characterization of a sodium-dependent
            phosphate transporter expressed in human lung and small intestine
  JOURNAL   Biochem Biophys Res Commun 258 (3), 578-582 (1999)
   PUBMED   10329428
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC092436.5.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_006424.2.
            
            Summary: The protein encoded by this gene is a pH-sensitive
            sodium-dependent phosphate transporter. Phosphate uptake is
            increased at lower pH. Defects in this gene are a cause of
            pulmonary alveolar microlithiasis. Three transcript variants
            encoding two different isoforms have been found for this gene.
            [provided by RefSeq, May 2010].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF111856.1, DRR138524.1150931.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA1968832
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000382051.8/ ENSP00000371483.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-40                AC092436.5         63466-63505
            41-155              AC092436.5         70113-70227
            156-293             AC092436.5         70320-70457
            294-422             AC092436.5         71817-71945
            423-566             AC092436.5         73743-73886
            567-678             AC092436.5         75495-75606
            679-874             AC092436.5         77262-77457
            875-970             AC092436.5         78353-78448
            971-1091            AC092436.5         79216-79336
            1092-1259           AC092436.5         80702-80869
            1260-1376           AC092436.5         81911-82027
            1377-1501           AC092436.5         82120-82244
            1502-4115           AC092436.5         83750-86363
FEATURES             Location/Qualifiers
     source          1..4115
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4p15.2"
     gene            1..4115
                     /gene="SLC34A2"
                     /gene_synonym="NAPI-3B; NAPI-IIb; NaPi2b; NPTIIb; PULAM"
                     /note="solute carrier family 34 member 2"
                     /db_xref="GeneID:10568"
                     /db_xref="HGNC:HGNC:11020"
                     /db_xref="MIM:604217"
     exon            1..40
                     /gene="SLC34A2"
                     /gene_synonym="NAPI-3B; NAPI-IIb; NaPi2b; NPTIIb; PULAM"
                     /inference="alignment:Splign:2.1.0"
     exon            41..155
                     /gene="SLC34A2"
                     /gene_synonym="NAPI-3B; NAPI-IIb; NaPi2b; NPTIIb; PULAM"
                     /inference="alignment:Splign:2.1.0"
     CDS             44..2116
                     /gene="SLC34A2"
                     /gene_synonym="NAPI-3B; NAPI-IIb; NaPi2b; NPTIIb; PULAM"
                     /note="isoform a is encoded by transcript variant 1; type
                     II sodium-dependent phosphate transporter 3b;
                     sodium-dependent phosphate transport protein 2B;
                     sodium/phosphate cotransporter 2B; solute carrier family
                     34 (sodium phosphate), member 2; solute carrier family 34
                     (type II sodium/phosphate cotransporter), member 2"
                     /codon_start=1
                     /product="sodium-dependent phosphate transport protein 2B
                     isoform a"
                     /protein_id="NP_006415.3"
                     /db_xref="CCDS:CCDS3435.1"
                     /db_xref="GeneID:10568"
                     /db_xref="HGNC:HGNC:11020"
                     /db_xref="MIM:604217"
                     /translation="MAPWPELGDAQPNPDKYLEGAAGQQPTAPDKSKETNKTDNTEAP
                     VTKIELLPSYSTATLIDEPTEVDDPWNLPTLQDSGIKWSERDTKGKILCFFQGIGRLI
                     LLLGFLYFFVCSLDILSSAFQLVGGKMAGQFFSNSSIMSNPLLGLVIGVLVTVLVQSS
                     STSTSIVVSMVSSSLLTVRAAIPIIMGANIGTSITNTIVALMQVGDRSEFRRAFAGAT
                     VHDFFNWLSVLVLLPVEVATHYLEIITQLIVESFHFKNGEDAPDLLKVITKPFTKLIV
                     QLDKKVISQIAMNDEKAKNKSLVKIWCKTFTNKTQINVTVPSTANCTSPSLCWTDGIQ
                     NWTMKNVTYKENIAKCQHIFVNFHLPDLAVGTILLILSLLVLCGCLIMIVKILGSVLK
                     GQVATVIKKTINTDFPFPFAWLTGYLAILVGAGMTFIVQSSSVFTSALTPLIGIGVIT
                     IERAYPLTLGSNIGTTTTAILAALASPGNALRSSLQIALCHFFFNISGILLWYPIPFT
                     RLPIRMAKGLGNISAKYRWFAVFYLIIFFFLIPLTVFGLSLAGWRVLVGVGVPVVFII
                     ILVLCLRLLQSRCPRVLPKKLQNWNFLPLWMRSLKPWDAVVSKFTGCFQMRCCCCCRV
                     CCRACCLLCDCPKCCRCSKCCEDLEEAQEGQDVPVKAPETFDNITISREAQGEVPASD
                     SKTECTAL"
     exon            156..293
                     /gene="SLC34A2"
                     /gene_synonym="NAPI-3B; NAPI-IIb; NaPi2b; NPTIIb; PULAM"
                     /inference="alignment:Splign:2.1.0"
     exon            294..422
                     /gene="SLC34A2"
                     /gene_synonym="NAPI-3B; NAPI-IIb; NaPi2b; NPTIIb; PULAM"
                     /inference="alignment:Splign:2.1.0"
     exon            423..566
                     /gene="SLC34A2"
                     /gene_synonym="NAPI-3B; NAPI-IIb; NaPi2b; NPTIIb; PULAM"
                     /inference="alignment:Splign:2.1.0"
     exon            567..678
                     /gene="SLC34A2"
                     /gene_synonym="NAPI-3B; NAPI-IIb; NaPi2b; NPTIIb; PULAM"
                     /inference="alignment:Splign:2.1.0"
     exon            679..874
                     /gene="SLC34A2"
                     /gene_synonym="NAPI-3B; NAPI-IIb; NaPi2b; NPTIIb; PULAM"
                     /inference="alignment:Splign:2.1.0"
     exon            875..970
                     /gene="SLC34A2"
                     /gene_synonym="NAPI-3B; NAPI-IIb; NaPi2b; NPTIIb; PULAM"
                     /inference="alignment:Splign:2.1.0"
     exon            971..1091
                     /gene="SLC34A2"
                     /gene_synonym="NAPI-3B; NAPI-IIb; NaPi2b; NPTIIb; PULAM"
                     /inference="alignment:Splign:2.1.0"
     exon            1092..1259
                     /gene="SLC34A2"
                     /gene_synonym="NAPI-3B; NAPI-IIb; NaPi2b; NPTIIb; PULAM"
                     /inference="alignment:Splign:2.1.0"
     exon            1260..1376
                     /gene="SLC34A2"
                     /gene_synonym="NAPI-3B; NAPI-IIb; NaPi2b; NPTIIb; PULAM"
                     /inference="alignment:Splign:2.1.0"
     exon            1377..1501
                     /gene="SLC34A2"
                     /gene_synonym="NAPI-3B; NAPI-IIb; NaPi2b; NPTIIb; PULAM"
                     /inference="alignment:Splign:2.1.0"
     exon            1502..4115
                     /gene="SLC34A2"
                     /gene_synonym="NAPI-3B; NAPI-IIb; NaPi2b; NPTIIb; PULAM"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4094..4099
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC34A2"
                     /gene_synonym="NAPI-3B; NAPI-IIb; NaPi2b; NPTIIb; PULAM"
                     /note="hexamer: AATAAA"
     polyA_site      4115
                     /gene="SLC34A2"
                     /gene_synonym="NAPI-3B; NAPI-IIb; NaPi2b; NPTIIb; PULAM"
                     /note="major polyA site"
ORIGIN      
        1 ggccgccgcc tccagcccag cacctgcgga gggagcgctg accatggctc cctggcctga
       61 attgggagat gcccagccca accccgataa gtacctcgaa ggggccgcag gtcagcagcc
      121 cactgcccct gataaaagca aagagaccaa caaaacagat aacactgagg cacctgtaac
      181 caagattgaa cttctgccgt cctactccac ggctacactg atagatgagc ccactgaggt
      241 ggatgacccc tggaacctac ccactcttca ggactcgggg atcaagtggt cagagagaga
      301 caccaaaggg aagattctct gtttcttcca agggattggg agattgattt tacttctcgg
      361 atttctctac tttttcgtgt gctccctgga tattcttagt agcgccttcc agctggttgg
      421 aggaaaaatg gcaggacagt tcttcagcaa cagctctatt atgtccaacc ctttgttggg
      481 gctggtgatc ggggtgctgg tgaccgtctt ggtgcagagc tccagcacct caacgtccat
      541 cgttgtcagc atggtgtcct cttcattgct cactgttcgg gctgccatcc ccattatcat
      601 gggggccaac attggaacgt caatcaccaa cactattgtt gcgctcatgc aggtgggaga
      661 tcggagtgag ttcagaagag cttttgcagg agccactgtc catgacttct tcaactggct
      721 gtccgtgttg gtgctcttgc ccgtggaggt ggccacccat tacctcgaga tcataaccca
      781 gcttatagtg gagagcttcc acttcaagaa tggagaagat gccccagatc ttctgaaagt
      841 catcactaag cccttcacaa agctcattgt ccagctggat aaaaaagtta tcagccaaat
      901 tgcaatgaac gatgaaaaag cgaaaaacaa gagtcttgtc aagatttggt gcaaaacttt
      961 taccaacaag acccagatta acgtcactgt tccctcgact gctaactgca cctccccttc
     1021 cctctgttgg acggatggca tccaaaactg gaccatgaag aatgtgacct acaaggagaa
     1081 catcgccaaa tgccagcata tctttgtgaa tttccacctc ccggatcttg ctgtgggcac
     1141 catcttgctc atactctccc tgctggtcct ctgtggttgc ctgatcatga ttgtcaagat
     1201 cctgggctct gtgctcaagg ggcaggtcgc cactgtcatc aagaagacca tcaacactga
     1261 tttccccttt ccctttgcat ggttgactgg ctacctggcc atcctcgtcg gggcaggcat
     1321 gaccttcatc gtacagagca gctctgtgtt cacgtcggcc ttgacccccc tgattggaat
     1381 cggcgtgata accattgaga gggcttatcc actcacgctg ggctccaaca tcggcaccac
     1441 caccaccgcc atcctggccg ccttagccag ccctggcaat gcattgagga gttcactcca
     1501 gatcgccctg tgccactttt tcttcaacat ctccggcatc ttgctgtggt acccgatccc
     1561 gttcactcgc ctgcccatcc gcatggccaa ggggctgggc aacatctctg ccaagtatcg
     1621 ctggttcgcc gtcttctacc tgatcatctt cttcttcctg atcccgctga cggtgtttgg
     1681 cctctcgctg gccggctggc gggtgctggt tggtgtcggg gttcccgtcg tcttcatcat
     1741 catcctggta ctgtgcctcc gactcctgca gtctcgctgc ccacgcgtcc tgccgaagaa
     1801 actccagaac tggaacttcc tgccgctgtg gatgcgctcg ctgaagccct gggatgccgt
     1861 cgtctccaag ttcaccggct gcttccagat gcgctgctgc tgctgctgcc gcgtgtgctg
     1921 ccgcgcgtgc tgcttgctgt gtgactgccc caagtgctgc cgctgcagca agtgctgcga
     1981 ggacttggag gaggcgcagg aggggcagga tgtccctgtc aaggctcctg agacctttga
     2041 taacataacc attagcagag aggctcaggg tgaggtccct gcctcggact caaagaccga
     2101 atgcacggcc ttgtagggga cgccccagat tgtcagggat ggggggatgg tccttgagtt
     2161 ttgcatgctc tcctccctcc cacttctgca ccctttcacc acctcgagga gatttgctcc
     2221 ccattagcga atgaaattga tgcagtccta cctaactcga ttccctttgg cttggtggta
     2281 ggcctgcagg gcacttttat tccaacccct ggtcactcag taatctttta ctccaggaag
     2341 gcacaggatg gtacctaaag agaattagag aatgaacctg gcgggacgga tgtctaatcc
     2401 tgcgcctagc tgggttggtc agtagaacct attttcagac tcaaaaacca tcttcagaaa
     2461 gaaaaggccc agggaaggaa tgtatgagag gctctcccag atgaggaagt gtactctcta
     2521 tgactatcaa gctcaggcct ctcccttttt ttaaaccaaa gtctggcaac caagagcagc
     2581 agctccatgg cctccttgcc ccagatcagc ctgggtcagg ggacatagtg tcattgtttg
     2641 gaaactgcag accacaaggt gtgggtctat cccacttcct agtgctcccc acattcccca
     2701 tcagggcttc ctcacgtgga caggtgtgct agtccaggca gttcacttgc agtttccttg
     2761 tcctcatgct tcggggatgg gagccacgcc tgaactagag ttcaggctgg atacatgtgc
     2821 tcacctgctg ctcttgtctt cctaagagac agagagtggg gcagatggag gagaagaaag
     2881 tgaggaatga gtagcatagc attctgccaa aagggcccca gattcttaat ttagcaaact
     2941 aagaagccca attcaaaagc attgtggcta aagtctaacg ctcctctctt ggtcagataa
     3001 caaaagccct ccctgttgga tcttttgaaa taaaacgtgc aagttatcca ggctcgtagc
     3061 ctgcatgctg ccaccttgaa tcccagggag tatctgcacc tggaatagct ctccacccct
     3121 ctctgcctcc ttactttctg tgcaagatga cttcctgggt taacttcctt ctttccatcc
     3181 acccacccac tggaatctct ttccaaacat ttttccattt tcccacagat gggctttgat
     3241 tagctgtcct ctctccatgc ctgcaaagct ccagattttt ggggaaagct gtacccaact
     3301 ggactgccca gtgaactggg atcattaagt acagtcgagc acacgtgtgt gcatgggtca
     3361 aaggggtgtg ttccttctca tcctagatgc cttctctgtg ccttccacag cctcctgcct
     3421 gattacacca ctgcccccgc cccaccctca gccatcccaa ttcttcctgg ccagtgcgct
     3481 ccagccttat ctaggaaagg aggagtgggt gtagccgtgc agcaagattg gggcctcccc
     3541 catcccagct tctccaccat cccagcaagt caggatatca gacagtcctc ccctgaccct
     3601 cccccttgta gatatcaatt cccaaacaga gccaaatact ctatatctat agtcacagcc
     3661 ctgtacagca tttttcataa gttatatagt aaatggtctg catgatttgt gcttctagtg
     3721 ctctcatttg gaaatgaggc aggcttcttc tatgaaatgt aaagaaagaa accactttgt
     3781 atattttgta ataccacctc tgtggccatg cctgccccgc ccactctgta tatatgtaag
     3841 ttaaacccgg gcaggggctg tggccgtctt tgtactctgg tgatttttaa aaattgaatc
     3901 tttgtacttg cattgattgt ataataattt tgagaccagg tctcgctgtg ttgctcaggc
     3961 tggtctcaaa ctcctgagat caagcaatcc gcccacctca gcctcccaaa gtgctgagat
     4021 cacaggcgtg agccaccacc aggcctgatt gtaatttttt tttttttttt tttactggtt
     4081 atgggaaggg agaaataaaa tcatcaaacc caaaa
//
