LOCUS       NM_004733               9266 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens solute carrier family 33 member 1 (SLC33A1),
            transcript variant 1, mRNA.
ACCESSION   NM_004733
VERSION     NM_004733.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 9266)
  AUTHORS   Chevalier,B., Baatallah,N., Najm,M., Castanier,S., Jung,V.,
            Pranke,I., Golec,A., Stoven,V., Marullo,S., Antigny,F.,
            Guerrera,I.C., Sermet-Gaudelus,I., Edelman,A. and Hinzpeter,A.
  TITLE     Differential CFTR-Interactome Proximity Labeling Procedures
            Identify Enrichment in Multiple SLC Transporters
  JOURNAL   Int J Mol Sci 23 (16), 8937 (2022)
   PUBMED   36012204
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 9266)
  AUTHORS   Lim,S.H., Snider,J., Birimberg-Schwartz,L., Ip,W., Serralha,J.C.,
            Botelho,H.M., Lopes-Pacheco,M., Pinto,M.C., Moutaoufik,M.T.,
            Zilocchi,M., Laselva,O., Esmaeili,M., Kotlyar,M., Lyakisheva,A.,
            Tang,P., Lopez Vazquez,L., Akula,I., Aboualizadeh,F., Wong,V.,
            Grozavu,I., Opacak-Bernardi,T., Yao,Z., Mendoza,M., Babu,M.,
            Jurisica,I., Gonska,T., Bear,C.E., Amaral,M.D. and Stagljar,I.
  TITLE     CFTR interactome mapping using the mammalian membrane two-hybrid
            high-throughput screening system
  JOURNAL   Mol Syst Biol 18 (2), e10629 (2022)
   PUBMED   35156780
REFERENCE   3  (bases 1 to 9266)
  AUTHORS   Dieterich,I.A., Cui,Y., Braun,M.M., Lawton,A.J., Robinson,N.H.,
            Peotter,J.L., Yu,Q., Casler,J.C., Glick,B.S., Audhya,A., Denu,J.M.,
            Li,L. and Puglielli,L.
  TITLE     Acetyl-CoA flux from the cytosol to the ER regulates engagement and
            quality of the secretory pathway
  JOURNAL   Sci Rep 11 (1), 2013 (2021)
   PUBMED   33479349
  REMARK    GeneRIF: Acetyl-CoA flux from the cytosol to the ER regulates
            engagement and quality of the secretory pathway.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 9266)
  AUTHORS   Romero,R., Sanchez-Rivera,F.J., Westcott,P.M.K., Mercer,K.L.,
            Bhutkar,A., Muir,A., Gonzalez Robles,T.J., Lamboy Rodriguez,S.,
            Liao,L.Z., Ng,S.R., Li,L., Colon,C.I., Naranjo,S., Beytagh,M.C.,
            Lewis,C.A., Hsu,P.P., Bronson,R.T., Vander Heiden,M.G. and Jacks,T.
  TITLE     Keap1 mutation renders lung adenocarcinomas dependent on Slc33a1
  JOURNAL   Nat Cancer 1 (6), 589-602 (2020)
   PUBMED   34414377
  REMARK    GeneRIF: Keap1 mutation renders lung adenocarcinomas dependent on
            Slc33a1.
            Erratum:[Nat Cancer. 2020 Sep;1(9):935. doi:
            10.1038/s43018-020-00118-z.. PMID: 35121957]
REFERENCE   5  (bases 1 to 9266)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   6  (bases 1 to 9266)
  AUTHORS   Lin,P., Li,J., Liu,Q., Mao,F., Li,J., Qiu,R., Hu,H., Song,Y.,
            Yang,Y., Gao,G., Yan,C., Yang,W., Shao,C. and Gong,Y.
  TITLE     A missense mutation in SLC33A1, which encodes the acetyl-CoA
            transporter, causes autosomal-dominant spastic paraplegia (SPG42)
  JOURNAL   Am J Hum Genet 83 (6), 752-759 (2008)
   PUBMED   19061983
  REMARK    GeneRIF: A missense mutation in SLC33A1 causes autosomal-dominant
            spastic paraplegia.
REFERENCE   7  (bases 1 to 9266)
  AUTHORS   Hirabayashi,Y., Kanamori,A., Nomura,K.H. and Nomura,K.
  TITLE     The acetyl-CoA transporter family SLC33
  JOURNAL   Pflugers Arch 447 (5), 760-762 (2004)
   PUBMED   12739170
  REMARK    Review article
REFERENCE   8  (bases 1 to 9266)
  AUTHORS   Kanamori,A., Nakayama,J., Fukuda,M.N., Stallcup,W.B., Sasaki,K.,
            Fukuda,M. and Hirabayashi,Y.
  TITLE     Expression cloning and characterization of a cDNA encoding a novel
            membrane protein required for the formation of O-acetylated
            ganglioside: a putative acetyl-CoA transporter
  JOURNAL   Proc Natl Acad Sci U S A 94 (7), 2897-2902 (1997)
   PUBMED   9096318
REFERENCE   9  (bases 1 to 9266)
  AUTHORS   Bindu,P.S., Chiplunkar,S., Vandana,V.P., Nagappa,M., Govindaraj,P.
            and Taly,A.
  TITLE     Huppke-Brendel Syndrome
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   31194315
REFERENCE   10 (bases 1 to 9266)
  AUTHORS   Hedera,P.
  TITLE     Hereditary Spastic Paraplegia Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301682
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC104472.14 and D88152.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_004733.3.
            
            Summary: The protein encoded by this gene is required for the
            formation of O-acetylated (Ac) gangliosides. The encoded protein is
            predicted to contain 6 to 10 transmembrane domains, and a leucine
            zipper motif in transmembrane domain III. Defects in this gene have
            been reported to cause spastic paraplegia autosomal dominant type
            42 (SPG42) in one Chinese family, but not in similar patients of
            European descent. Two transcript variants encoding the same protein
            have been found for this gene. [provided by RefSeq, Jul 2010].
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Variants 1 and 2 both encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660803.127590.1,
                                           SRR1660805.19821.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000643144.2/ ENSP00000496241.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-88                AC104472.14        35073-35160
            89-2708             D88152.1           46-2665
            2709-9266           AC104472.14        61919-68476
FEATURES             Location/Qualifiers
     source          1..9266
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q25.31"
     gene            1..9266
                     /gene="SLC33A1"
                     /gene_synonym="ACATN; AT-1; AT1; CCHLND; HPBDS; SPG42"
                     /note="solute carrier family 33 member 1"
                     /db_xref="GeneID:9197"
                     /db_xref="HGNC:HGNC:95"
                     /db_xref="MIM:603690"
     exon            1..1205
                     /gene="SLC33A1"
                     /gene_synonym="ACATN; AT-1; AT1; CCHLND; HPBDS; SPG42"
                     /inference="alignment:Splign:2.1.0"
     CDS             431..2080
                     /gene="SLC33A1"
                     /gene_synonym="ACATN; AT-1; AT1; CCHLND; HPBDS; SPG42"
                     /note="isoform 1 is encoded by transcript variant 1;
                     acetyl-coenzyme A transporter 1; solute carrier family 33
                     (acetyl-CoA transporter), member 1"
                     /codon_start=1
                     /product="acetyl-coenzyme A transporter 1 isoform 1"
                     /protein_id="NP_004724.1"
                     /db_xref="CCDS:CCDS3173.1"
                     /db_xref="GeneID:9197"
                     /db_xref="HGNC:HGNC:95"
                     /db_xref="MIM:603690"
                     /translation="MSPTISHKDSSRQRRPGNFSHSLDMKSGPLPPGGWDDSHLDSAG
                     REGDREALLGDTGTGDFLKAPQSFRAELSSILLLLFLYVLQGIPLGLAGSIPLILQSK
                     NVSYTDQAFFSFVFWPFSLKLLWAPLVDAVYVKNFGRRKSWLVPTQYILGLFMIYLST
                     QVDRLLGNTDDRTPDVIALTVAFFLFEFLAATQDIAVDGWALTMLSRENVGYASTCNS
                     VGQTAGYFLGNVLFLALESADFCNKYLRFQPQPRGIVTLSDFLFFWGTVFLITTTLVA
                     LLKKENEVSVVKEETQGITDTYKLLFAIIKMPAVLTFCLLILTAKIGFSAADAVTGLK
                     LVEEGVPKEHLALLAVPMVPLQIILPLIISKYTAGPQPLNTFYKAMPYRLLLGLEYAL
                     LVWWTPKVEHQGGFPIYYYIVVLLSYALHQVTVYSMYVSIMAFNAKVSDPLIGGTYMT
                     LLNTVSNLGGNWPSTVALWLVDPLTVKECVGASNQNCRTPDAVELCKKLGGSCVTALD
                     GYYVESIICVFIGFGWWFFLGPKFKKLQDEGSSSWKCKRNN"
     exon            1206..1393
                     /gene="SLC33A1"
                     /gene_synonym="ACATN; AT-1; AT1; CCHLND; HPBDS; SPG42"
                     /inference="alignment:Splign:2.1.0"
     exon            1394..1578
                     /gene="SLC33A1"
                     /gene_synonym="ACATN; AT-1; AT1; CCHLND; HPBDS; SPG42"
                     /inference="alignment:Splign:2.1.0"
     exon            1579..1696
                     /gene="SLC33A1"
                     /gene_synonym="ACATN; AT-1; AT1; CCHLND; HPBDS; SPG42"
                     /inference="alignment:Splign:2.1.0"
     exon            1697..1912
                     /gene="SLC33A1"
                     /gene_synonym="ACATN; AT-1; AT1; CCHLND; HPBDS; SPG42"
                     /inference="alignment:Splign:2.1.0"
     exon            1913..9266
                     /gene="SLC33A1"
                     /gene_synonym="ACATN; AT-1; AT1; CCHLND; HPBDS; SPG42"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3746..3751
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC33A1"
                     /gene_synonym="ACATN; AT-1; AT1; CCHLND; HPBDS; SPG42"
                     /note="hexamer: AAGAAA"
     polyA_site      3770
                     /gene="SLC33A1"
                     /gene_synonym="ACATN; AT-1; AT1; CCHLND; HPBDS; SPG42"
                     /note="major polyA site"
     regulatory      9249..9254
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC33A1"
                     /gene_synonym="ACATN; AT-1; AT1; CCHLND; HPBDS; SPG42"
                     /note="hexamer: AATAAA"
     polyA_site      9266
                     /gene="SLC33A1"
                     /gene_synonym="ACATN; AT-1; AT1; CCHLND; HPBDS; SPG42"
ORIGIN      
        1 atgctttttc tggagtcctg tagagaaagt gctctctgcc gcattgatag cagcgagagc
       61 tggaggtgtt gggtcgggag accagccgtt cgatcccgcc gcaggtagga gctggtttcc
      121 atcctggcac cacggcacac acctccagcc tcgagcccgg cgctgctgcc cgggggtctc
      181 cttcaggctc tttgacgccg ttccaggggg cacctatcca ggcatcctct gggcctctag
      241 ccagaggact ggctcccggc ttcagcactc cgggctgcag taagaagtgc ccttatcgct
      301 ctgagccctg ccaccatccc gtgaaccacc gaaaccctgg tccagcgcga cagccttgga
      361 cctgggactg gacggatcca aaacgctcag cctcggcccc ccacagacgg ggctctgcat
      421 cgtctctgat atgtcaccca ccatctccca caaggacagc agccggcaac ggcggccagg
      481 gaatttcagt cactctctgg atatgaagag cggtcccctg ccgccaggcg gttgggatga
      541 cagtcatttg gactcagcgg gccgggaagg ggacagagaa gctcttctgg gggataccgg
      601 cactggcgac ttcttaaaag ccccacagag cttccgggcc gaactaagca gcattttgct
      661 actactcttt ctttacgtgc ttcagggtat tcccctgggc ttggcgggaa gcatcccact
      721 cattttgcaa agcaaaaatg ttagctatac agaccaagct ttcttcagtt ttgtcttttg
      781 gcccttcagt ctcaaattac tctgggcccc gttggttgat gcggtctacg ttaagaactt
      841 cggtcgtcgc aaatcttggc ttgtcccgac acagtatata ctaggactct tcatgatcta
      901 tttatccact caggtggacc gtttgcttgg gaataccgat gacagaacac ccgacgtgat
      961 tgctctcact gtggcgttct ttttgtttga attcttggcc gccactcagg acattgccgt
     1021 cgatggttgg gcgttaacta tgttatccag ggaaaatgtg ggttatgctt ctacttgcaa
     1081 ttcggtgggc caaacagcgg gttacttttt gggcaatgtt ttgtttttgg cccttgaatc
     1141 tgccgacttt tgtaacaaat atttgcggtt tcagcctcaa cccagaggaa tcgttactct
     1201 ttcagatttc ctttttttct ggggaactgt atttttaata acaacaacat tggttgccct
     1261 tctgaaaaaa gaaaacgaag tatcagtagt aaaagaagaa acacaaggga tcacagatac
     1321 ttacaagctg ctttttgcaa ttataaaaat gccagcagtt ctgacatttt gccttctgat
     1381 tctaactgca aagattggtt tttcagcagc agatgctgta acaggactga aattggtaga
     1441 agagggagta cccaaagaac atttagcctt attggcagtt ccaatggttc ctttgcagat
     1501 aatactgcct ctgattatca gcaaatacac tgcaggtccc cagccattaa acacatttta
     1561 caaagccatg ccctacagat tattgcttgg gttagaatat gccctactgg tttggtggac
     1621 tcctaaagta gaacatcaag ggggattccc tatatattac tatatcgtag tcctgctgag
     1681 ttatgcttta catcaggtta cagtgtacag catgtatgtt tctataatgg ctttcaatgc
     1741 aaaggttagt gatccactta ttggaggaac atacatgacc cttttaaata ccgtgtccaa
     1801 tctgggagga aactggcctt ctacagtagc tctttggctt gtagatcccc tcacagtaaa
     1861 agagtgtgta ggagcatcaa accagaattg tcgaacacct gatgctgttg agctttgcaa
     1921 aaaactgggt ggctcatgtg ttacagccct ggatggttat tatgtggagt ccattatttg
     1981 tgttttcatt ggatttggtt ggtggttctt tcttggtcca aaatttaaaa agttacagga
     2041 tgaaggatca tcttcgtgga aatgcaaaag gaacaattaa tatatatgct actggacatt
     2101 ctagcaaggt aattgtagtt tagttttaat tcggagagca atgataatca gtgcacagga
     2161 gtataaaata ttattttaaa cagcgaaatt aataatataa aatgccaaat ggttgaaaaa
     2221 atagaaacct ttctgtatat ttgatcatat tttttttttg ccttgtcaat gtatttaaag
     2281 tttacttaag gtcaggaaat tctaaaacaa cttttctggc cttgttattt gatgtatatc
     2341 ttttaaattt actgaccaaa gcatgtttta agctgcaatg cagtagtcac gggtggtaac
     2401 catgtagtca ggtattgtta ttagtaccta tcactgctga gctgtattta aaattttggt
     2461 acaatatata aaatggagaa gagcttgata ttcaggtact aaccacaact agtctgacat
     2521 tgttggcagt taaaatctta ttttgaattg taaattagtt aaattttatg tggaatttgc
     2581 tgagaaaaga atatagacta ctgaaatgtc attttagtta tttttcttat gaccacattg
     2641 tacaaatgaa tctgtgttaa aaagactatt ttaaatgtat ttcctgcttt tgtaagcatt
     2701 aaagatttat aagaaaatta ttcaaactat tttttataaa atgaaagtta tgatttttaa
     2761 acttattgat tcctcttgcc cctaccccct ctttttggaa gatattttga ttccttataa
     2821 acttttaccc taagcttata tatgttttct gtcacaagtg cttcctggca cacagacagc
     2881 caatggaggg gatcaaattc agtgttgtat gtatgtttat ggcaacattt tgaaaataaa
     2941 aattaaatgt ttttcttcaa gtagtttttt tttaattgct gagagaaaaa aacagtaaag
     3001 ctttctgatt aagtaaaatt taaatgggca gtaccataat ttaaaaaact aatactttaa
     3061 agagagagac aaagatattt tgtgcctttg acaaattaaa tctaatagtg gaaaaatgtt
     3121 tcttaattaa gcactttact agtgaaaaag atctcacaat ttatgccaaa tcaggtactg
     3181 tattttcatg tattaacaca taaccttttg tttgaatact atagttttca gtggacagtt
     3241 gctattccaa gaaaattaag cttttgagta ctttagcaat tcccagcgta ttacatacac
     3301 ccagtgataa ggttctttgc atgttttgtg ttatgtatta ctctgactct ttagagatta
     3361 tataaatcct ccaaaagtta gacgaaacaa gatagtacat tatgagtctt aattttatca
     3421 ttgtggaaaa atgtgtacta actcctgatt ttgttaattt tataacatag gttgaatttt
     3481 agagtggggt ttttataagt aatggaggat aaaatgggtg ggagaaaatg gcacacagca
     3541 cctgaagaaa gatggggcag tgacctctag aactcatgca ttgccattgg aaagcctgtg
     3601 ttgggcatcg atgtcagatc ctgaagaatc acctggaaaa aatcccatcc tagaggcaag
     3661 gaggctacac caaaccatac actacagtac tttgtcacat ggttgtccat tatcatgtat
     3721 tagagtctaa atgattactt gaataaagaa aaaaaaccac ttaactctta catatgaaat
     3781 gtgttttgat ttttaatttt tggattaaga aactcagatt gccataataa ccttttattt
     3841 cttcccgtgt atattattac aaattatata tactttcaaa catagttttt ttttttttta
     3901 attgagacag agtctcactt tgtcacccag gctggagtac agtggtgcaa tctcggctca
     3961 ctgcaacctc tgcctcctgg gttcaagtga ttctcctgcc ccagtcctct gagtagctgg
     4021 gactacaggc gcacaccacc acacccggct aatttttgta tttttagtag agatggggtt
     4081 tcaccatgtt ggccaggctg gtcttgaact cctgacctca agtgatccac ccgcctcggc
     4141 ctcccaaagt gctgggatta caggcatgag ccactgcgcc cagccttcaa acatagtttt
     4201 aatgtcagta catctttaat gacttgaagt tttaaaacat tttaagcctt taaggtgaaa
     4261 gccatttaat taatttgctc tagaaataag cacaaaaaat tatagttaat ttgaatacat
     4321 gtatgtaatg catgtcaaaa taacttgtta atagctatgt gcaactgtgt tgcatacatt
     4381 gatcactaat ggcatttaaa aatgatctgc ctaaatctga ggatctgttt attataaatc
     4441 agtagtacta aaatatacca ccctgttttt atgttgtggg tgtttttctt gattgattga
     4501 tcctgataaa ttaaacagta ccttcaagta tggactttta actcctccag ttaatgcatc
     4561 atatgtttac tggctaatat tagattgaac atttttctct ctatgtcagt atctccatat
     4621 gcacattggt tgccgcatat atacatctga gtttgaaaag ttcttctgag attacctaaa
     4681 agtaacacca cagattcctt ccattgtaaa tactttattt tattttatta ttatttttta
     4741 gagacatggt ctcacttttg cccaagctgg agtacagtga tgcaatcata gctcactgca
     4801 gcctcaaatt cctaggctca agggatcttc cttaggctgg atgctgtggc tcacacctgt
     4861 aatcacaaca ctttaggagg ccaaggcagg aggatcactt gaggtcaaga gttcaagacc
     4921 aacctggtca atataataag aacctgtctt tatgacttct tttttttttt taattatcca
     4981 ggcatggtgg tacacaccag tagtcccagc tacttgggaa gcttaggcgg gagggttact
     5041 tgaacccagg aggtcaaggc ttcagtaagc agtgattgtg gtactacatt cctgtctggg
     5101 tgacagagtg agaccctgtc tcaacaacaa aaaaggatct ttccacctca gcctctctgg
     5161 tagctaggac tacaggcaca cagcactatg cccagctaat aaaaaataat aattttttat
     5221 agaggtgggg tccgctatat tttccaggct agtcccaatc tcatagcttc aagcagtcgt
     5281 ccagccttga cctctcaaaa tgctgggatt acaggtgtaa gccaccgtgc cctgcccatg
     5341 ataaatattt taattttgcc tgataagtca taaaaagttt attcaacacc ttaaatagat
     5401 ttctcaattt tttaaaaata ttaaaccttt gaaatcgaaa gtaatttttg gatttcaccc
     5461 ctttattgca aggtttttga tgtctgtggg aaaaacccct gaattgcttg tgaaactctg
     5521 gatatgtaat tttttttctt tttctgaaca gagtaaaatc ttggatgggc catgatccaa
     5581 aaatcatggt tttgaaagta gaccgtacta taagccataa tcacaaatct gaggtaatag
     5641 ttgtgaaagt gtttaaaaca tcctgaaaac aatgttgaaa aaaaaaatct atgataaaaa
     5701 ctataaaatc tctgcatatg ttatactgta ttgaacttga aactttgaag gaattagagt
     5761 agataagaca ttaatggtag aagagaaacc acaggggtga attatatcct acaaaagaga
     5821 aatcttcatg atttaacctt ttttttctga gtgactttta ttttgcctta ttaacagaaa
     5881 cctgagaaag tatgttgctt tgtattaaat ggttgagacc attatttgat ataaaagctg
     5941 aaaatttaat ttttgtattt tggagaattc tgtggttcca agtaattgaa agaatgacta
     6001 aagctgtatg tcatagaccc tgctaaaatg aaataacttg ttgggaacat tccatgcaga
     6061 tttccaaaat gtattttacc ttattattag agaaagaaaa taaactttta aaataatctg
     6121 ataactagca ttcatatatt taataagtat tttggttaca gaagggaagg tgatactgta
     6181 cattgtaact gctgagactt ttttttaacc aatgtctttg gtagatagcg aggcacaatt
     6241 attttctctt agggaggatt ttgaatacct attgcaggct gggcatggtg gctcacgcct
     6301 gtaatcccaa ccctttggga ggccgaggtg ggtggatcac ttgaggtcag gagtttgaga
     6361 ccagcctggc caacatggtg aaacgccgtc tctactaaaa atacaaaaat tagccaggca
     6421 tagggtggca cacgactgta atcccagcta ctagggaggc tgaggcagga gaattgcttg
     6481 agcccgggag gcggagcttg cagtgagttg agattgcgcc actacacttc agcctgggcg
     6541 acagagcgag actccgtttc aaaaacaaac aaacaaaaac aaaacaaaaa cacctactgc
     6601 agaccatgtt ctttttactt tattttattt tattattttt ttgagatgga gtctggctct
     6661 gttgcccaag ctgctcactg caacctccgc ctcccgggtt caagcgattc tcctgcctca
     6721 gccttccaag tagctgggac tacagatgtg cactactacg cccagcttat ttttgtattt
     6781 ttggtcgaga tggggttttg ccatgttggc caggctgatc tcaaactcct gaccttaggt
     6841 gatcttcccg ccttggcctc ctaaagtgct gggattacag gcgtgagcca ccgctgctgg
     6901 ctctttttac tttagattgt atctgcctga tttgacaatg ccaaattttt tatgtaatca
     6961 ccatttggtt tgggactgag agctctttca ttttctacca gtcaaaccac tattagagtc
     7021 ttcatgttac ttccccaatt tgctagcaag gtagaatcag catggatagc ttattttcct
     7081 tattggaatt ctgttttgga agaggcaggt cttatagcag ggcagactaa ttaatgtgct
     7141 gaactcattc cctcctgctt aagtgaataa aaacttttat ttgactatgg attataaaga
     7201 ttgcctttaa ggagccttgt ttattttggg gaaggagaat ggatattttg taggagaaaa
     7261 agactttata tagtaaatga aaagtctatg ggctgggtgt agtggctcat acctttaatc
     7321 ccaacacttt gggatgccaa ggtaggagta ttgcttgagc tcaggagatc gagaccaggg
     7381 agactgcatc tctattttta attaaaaagg aaagaaaaag aaagaaagtt ctatgactaa
     7441 tcacctttac tctaaaaaaa ttttgcccaa atgtgtaatg aaagagatca tatttaaata
     7501 tcagcaatat taatttgcat agctcataag aagtcttgac tcatttagaa aaaggttgct
     7561 acagtttaat agttttttat tgtcaatata gacaatataa ctttataaca attttatgtg
     7621 aagaataatg attaaatggc atgactgaaa tgcacaaggt acaggtacaa tccttaggga
     7681 gttatcttaa atttcttttt tttttttttt ttgagatgga gtcttgctct gtcgcccagg
     7741 ctggagtgca gtggcatgac tccctgcacc ctctgcctgc tgggttcaag tgattctcct
     7801 tcctcagcct ctccattagc tgggattaca ggtgccttcc accacacctg gctaattttt
     7861 ttgtatagta tagacggggt ttcaccatgt tggtcaggct ggtctcaaac tcctgacctc
     7921 gtgatctgcc tgcctcggcc tcccaaagtg ctgggattgc aggtgtgagc cactgcacct
     7981 ggcgggaatt atcttaaatt tctaaaattg aataccccag tcagctacaa ttaatcaatc
     8041 actaatgtaa atattaaagc ctattcttat tttccttgaa atgatcttaa atgttggaaa
     8101 agtttaattt tgtagtcaga gttagtgaaa ttgaaatttt tttatcacct gcccctataa
     8161 aattagagaa atataagatt ggaaaaaaat ttgatattta agaaagtggc atatttgaac
     8221 caggtgtgtt ggcttacacc tgtagtccca ttagtttggg aggcttaggc aggagaatca
     8281 cttgaggtca ggagtttgag accagcctgg ccaacatggt gaaaccctgt ctctactgca
     8341 aatacagaaa ttagccgggc atggtggtgg gcacctgtaa tcccagctac ttgggaggct
     8401 gaggcaggag aatcggttga acctgagaga gggatgttgc agtgagccga gattgtgcta
     8461 ctattctcca gcctgggcaa tagagtgaga ctcagtctca attaaaaaaa aaaaaaaaaa
     8521 atgcggccgg gtccagtggc tcacgtctgt aatcccagca ctttgggagg ccaaggcagg
     8581 cagatcactt gaggtcagga gttgaagacc ggcctgaccc acatggagaa accccatctc
     8641 tactaaaaat acaaaattag ccgggtgtgg tggcccaggt ctgtaatccc atctactcgg
     8701 gaggctgagg caggagaatc gcttgaaccc gggaggcagg ggttgcggtg agccgagatc
     8761 gcaccatcgc actccagcct gggtgcaaga gcgaaactct gtctcaaaaa aaaaaaggaa
     8821 gtggcatatt tggtaaattg ataaattacc actgtcaaat tatattggtg agtctatatc
     8881 tattgttgtc cccagatgtt gcctttgcaa gaattagtgt aaaattggaa aaaatactca
     8941 atgttgaaag ctgtcattgt tgagatcttt atgaaattat tgtgcccatg tccaagtttg
     9001 aattagagat acacagcaca caatcatttc tgttaccact tttggaatat ctagcattag
     9061 ccttgatagt tttgtgtggt gtgttttgag tatatctgaa ctgttagtta tatttggtta
     9121 atttattaaa agatgtgtgt taaaccttaa tatttatgca gtgtttaagt atttggaata
     9181 tatttgaaat aaattatcca gtgttttaga taaatggtta tttaattgct taaagtgatt
     9241 ctctaaaaaa taaaacatta atgaaa
//
