LOCUS       NM_001860               1723 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens solute carrier family 31 member 2 (SLC31A2), mRNA.
ACCESSION   NM_001860
VERSION     NM_001860.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1723)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 1723)
  AUTHORS   Li,T., Peng,J., Zeng,F., Zhang,K., Liu,J., Li,X., Ouyang,Q.,
            Wang,G., Wang,L., Liu,Z. and Liu,Y.
  TITLE     Association between polymorphisms in CTR1, CTR2, ATP7A, and ATP7B
            and platinum resistance in epithelial ovarian cancer
  JOURNAL   Int J Clin Pharmacol Ther 55 (10), 774-780 (2017)
   PUBMED   28737129
  REMARK    GeneRIF: 11 single-nucleotide polymorphisms (SNPs) in CTR1, CTR2,
            ATP7A, and ATP7B were genotyped in these patients.
REFERENCE   3  (bases 1 to 1723)
  AUTHORS   Logeman,B.L., Wood,L.K., Lee,J. and Thiele,D.J.
  TITLE     Gene duplication and neo-functionalization in the evolutionary and
            functional divergence of the metazoan copper transporters Ctr1 and
            Ctr2
  JOURNAL   J Biol Chem 292 (27), 11531-11546 (2017)
   PUBMED   28507097
  REMARK    GeneRIF: Gene duplication and neo-functionalization in the
            evolutionary and functional divergence of the metazoan copper
            transporters Ctr1 and Ctr2
REFERENCE   4  (bases 1 to 1723)
  AUTHORS   Xia,Y., Liu,L., Long,Q., Bai,Q., Wang,J., Xu,J. and Guo,J.
  TITLE     Decreased expression of CTR2 predicts poor prognosis of patients
            with clear cell renal cell carcinoma
  JOURNAL   Urol Oncol 34 (1), 5 (2016)
   PUBMED   26411550
  REMARK    GeneRIF: Decreased expression of CTR2 is associated with clear cell
            renal cell carcinoma.
REFERENCE   5  (bases 1 to 1723)
  AUTHORS   Tsai,C.Y., Liebig,J.K., Tsigelny,I.F. and Howell,S.B.
  TITLE     The copper transporter 1 (CTR1) is required to maintain the
            stability of copper transporter 2 (CTR2)
  JOURNAL   Metallomics 7 (11), 1477-1487 (2015)
   PUBMED   26205368
  REMARK    GeneRIF: Studied the interaction of CTR1 and CTR2 in fully
            malignant HEK293T and OVCAR8 human ovarian cancer cells using a
            CRISPR-Cas9 knock out system.
REFERENCE   6  (bases 1 to 1723)
  AUTHORS   Yoshida,H., Teramae,M., Yamauchi,M., Fukuda,T., Yasui,T., Sumi,T.,
            Honda,K. and Ishiko,O.
  TITLE     Association of copper transporter expression with platinum
            resistance in epithelial ovarian cancer
  JOURNAL   Anticancer Res 33 (4), 1409-1414 (2013)
   PUBMED   23564780
  REMARK    GeneRIF: Increased CTR2 expression is associated with platinum
            resistance in epithelial ovarian cancer.
REFERENCE   7  (bases 1 to 1723)
  AUTHORS   Blair,B.G., Larson,C.A., Safaei,R. and Howell,S.B.
  TITLE     Copper transporter 2 regulates the cellular accumulation and
            cytotoxicity of Cisplatin and Carboplatin
  JOURNAL   Clin Cancer Res 15 (13), 4312-4321 (2009)
   PUBMED   19509135
  REMARK    GeneRIF: CTR2 functions by limiting drug accumulation, and its
            expression correlates with the sensitivity of human ovarian
            carcinoma cell lines to cisplatin.
REFERENCE   8  (bases 1 to 1723)
  AUTHORS   Bertinato,J., Swist,E., Plouffe,L.J., Brooks,S.P. and L'abbe,M.R.
  TITLE     Ctr2 is partially localized to the plasma membrane and stimulates
            copper uptake in COS-7 cells
  JOURNAL   Biochem J 409 (3), 731-740 (2008)
   PUBMED   17944601
  REMARK    GeneRIF: Ctr2 promotes copper uptake at the plasma membrane and
            plays a role in regulating copper levels in COS-7 cells
REFERENCE   9  (bases 1 to 1723)
  AUTHORS   van den Berghe,P.V., Folmer,D.E., Malingre,H.E., van Beurden,E.,
            Klomp,A.E., van de Sluis,B., Merkx,M., Berger,R. and Klomp,L.W.
  TITLE     Human copper transporter 2 is localized in late endosomes and
            lysosomes and facilitates cellular copper uptake
  JOURNAL   Biochem J 407 (1), 49-59 (2007)
   PUBMED   17617060
  REMARK    GeneRIF: hCTR2 is as an oligomeric membrane protein localized in
            lysosomes, which stimulates copper delivery to the cytosol of human
            cells at relatively high copper concentrations.
REFERENCE   10 (bases 1 to 1723)
  AUTHORS   Zhou,B. and Gitschier,J.
  TITLE     hCTR1: a human gene for copper uptake identified by complementation
            in yeast
  JOURNAL   Proc Natl Acad Sci U S A 94 (14), 7481-7486 (1997)
   PUBMED   9207117
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BP341248.1, U83461.1, AL449105.22 and CN480022.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001860.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK057903.1, SRR1660807.166777.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000259392.8/ ENSP00000259392.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-63                BP341248.1         50-112
            64-337              U83461.1           59-332
            338-1398            AL449105.22        99245-100305
            1399-1723           CN480022.1         20-344              c
FEATURES             Location/Qualifiers
     source          1..1723
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q32"
     gene            1..1723
                     /gene="SLC31A2"
                     /gene_synonym="COPT2; CTR2; hCTR2"
                     /note="solute carrier family 31 member 2"
                     /db_xref="GeneID:1318"
                     /db_xref="HGNC:HGNC:11017"
                     /db_xref="MIM:603088"
     exon            1..74
                     /gene="SLC31A2"
                     /gene_synonym="COPT2; CTR2; hCTR2"
                     /inference="alignment:Splign:2.1.0"
     CDS             69..500
                     /gene="SLC31A2"
                     /gene_synonym="COPT2; CTR2; hCTR2"
                     /note="copper transporter 2; probable low affinity copper
                     uptake protein 2; solute carrier family 31 (copper
                     transporters), member 2; solute carrier family 31 (copper
                     transporter), member 2"
                     /codon_start=1
                     /product="protein SLC31A2"
                     /protein_id="NP_001851.1"
                     /db_xref="CCDS:CCDS6788.1"
                     /db_xref="GeneID:1318"
                     /db_xref="HGNC:HGNC:11017"
                     /db_xref="MIM:603088"
                     /translation="MAMHFIFSDTAVLLFDFWSVHSPAGMALSVLVLLLLAVLYEGIK
                     VGKAKLLNQVLVNLPTSISQQTIAETDGDSAGSDSFPVGRTHHRWYLCHFGQSLIHVI
                     QVVIGYFIMLAVMSYNTWIFLGVVLGSAVGYYLAYPLLSTA"
     exon            75..141
                     /gene="SLC31A2"
                     /gene_synonym="COPT2; CTR2; hCTR2"
                     /inference="alignment:Splign:2.1.0"
     exon            142..331
                     /gene="SLC31A2"
                     /gene_synonym="COPT2; CTR2; hCTR2"
                     /inference="alignment:Splign:2.1.0"
     exon            332..1723
                     /gene="SLC31A2"
                     /gene_synonym="COPT2; CTR2; hCTR2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1689..1694
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC31A2"
                     /gene_synonym="COPT2; CTR2; hCTR2"
                     /note="hexamer: AATACA"
     regulatory      1703..1708
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC31A2"
                     /gene_synonym="COPT2; CTR2; hCTR2"
                     /note="hexamer: AATATA"
     polyA_site      1708
                     /gene="SLC31A2"
                     /gene_synonym="COPT2; CTR2; hCTR2"
                     /note="major polyA site"
     polyA_site      1723
                     /gene="SLC31A2"
                     /gene_synonym="COPT2; CTR2; hCTR2"
                     /note="major polyA site"
ORIGIN      
        1 gaactgactc ggagcgagga gacccgagcg agcagacgcg gccctggcgc ccgccctgcg
       61 cactcaccat ggcgatgcat ttcatcttct cagatacagc ggtgcttctg tttgatttct
      121 ggagtgtcca cagtcctgct ggcatggccc tttcggtgtt ggtgctcctg cttctggctg
      181 tactgtatga aggcatcaag gttggcaaag ccaagctgct caaccaggta ctggtgaacc
      241 tgccaacctc catcagccag cagaccatcg cagagacaga cggggactct gcaggctcag
      301 attcattccc tgttggcaga acccaccaca ggtggtattt gtgtcacttt ggccagtctc
      361 taatccatgt catccaggtg gtcatcggct acttcatcat gctggccgta atgtcctaca
      421 acacctggat tttccttggt gtggtcttgg gctctgctgt gggctactac ctagcttacc
      481 cacttctcag cacagcttag ctggtgagga acgtgcaggc actgaggctg gagggacatg
      541 gagccccctc ttccagacac tatacttcca actgcccttt cttctgatgg ctattcctcc
      601 accttattcc cagcccctgg aaactttgag ctgaagccag cacttgctcc ctggagttcg
      661 gaagccattg cagcaacctt ccttctcagc cagcctacgt agggcccagg catggtcttg
      721 tgtcttaaga cagctgctgt gaccaaaggg agaatggaga taacaggggt ggcagggtta
      781 ctgagcccat gacaatgctt ctctgtgact caaaccagga atttccaaag atttcaagcc
      841 agggagaagg gttcttggtg atgcagggca tggaacctgg acaccctcag ctctcctgct
      901 ttgtgcctta tctacaggag catcgcccat tggacttcct gacctcttct gtctttgagg
      961 gacagagacc aagctagatc ctttttctca cctttctgcc tttggaacac atgaagatca
     1021 tctcgtctat ggatcatgtt gacaaactaa gtttttttta tttttcccat tgaactccta
     1081 gttggcaatt ttgcacattc atacaaaaaa atttttaatg aaatgatttc attgattcat
     1141 gatggatggc agaaactgct gagacctatt tccctttctt ggggagagaa taagtgacag
     1201 ctgattaaag gcagagacac aggactgctt tcaggctcct ggtttattct ctgatagact
     1261 gagctccttc caccagaagg cactgcctgc aggaagaaga tgatctgatg gccgtgggtg
     1321 tctgggaagc tcttcgtggc ctcaatgccc tcctttatcc tcatctttct tctatgcaga
     1381 acaaaaagct gcatctaata atgttcaata cttaatattc tctatttatt acttactgct
     1441 tactcgtaat gatctagtgg ggaaacatga ttcattcact taaaatactg attaagccat
     1501 gggcaggtac tgactgaaga tgcaatccaa ccaaagccat tacatttttt gagttagatg
     1561 ggactctctg gatagttgaa cctcttcact ttataaaaaa ggaaagagag aaaatcactg
     1621 ctgtatacta aatacctcac agattagatg aaaagatggt tgtaagcttt gggaattaaa
     1681 aacaaacaaa tacattttag taaatatata tttttaaata gtc
//
