LOCUS       NM_001859               4762 bp    mRNA    linear   PRI 15-OCT-2024
DEFINITION  Homo sapiens solute carrier family 31 member 1 (SLC31A1), mRNA.
ACCESSION   NM_001859
VERSION     NM_001859.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4762)
  AUTHORS   Wang,J., Ren,J., Tu,X., Yuan,H., Ye,Z., Wang,X., Cui,J., Wang,J.,
            Tang,Y., Han,P. and Bai,Y.
  TITLE     ARNTL2 facilitates bladder cancer progression through potentiating
            ENO1-mediated glycolysis in a SLC31A1-independent and -dependent
            manner
  JOURNAL   Life Sci 355, 122974 (2024)
   PUBMED   39147318
  REMARK    GeneRIF: ARNTL2 facilitates bladder cancer progression through
            potentiating ENO1-mediated glycolysis in a SLC31A1-independent and
            -dependent manner.
REFERENCE   2  (bases 1 to 4762)
  AUTHORS   Lin,Y.Z., Liu,W.H., Wu,Y.P., Cai,H., Zheng,Q.S., Wei,Y., Xu,N. and
            Xue,X.Y.
  TITLE     Revealing the potential of solute carrier family 31 (copper
            transporters), member 1: Insights into its role in bladder cancer
            progression and therapeutic implications
  JOURNAL   Int J Immunopathol Pharmacol 38, 3946320241240706 (2024)
   PUBMED   38712735
  REMARK    GeneRIF: Revealing the potential of solute carrier family 31
            (copper transporters), member 1: Insights into its role in bladder
            cancer progression and therapeutic implications.
REFERENCE   3  (bases 1 to 4762)
  AUTHORS   Wu,J.H., Cheng,T.C., Zhu,B., Gao,H.Y., Zheng,L. and Chen,W.X.
  TITLE     Identification of cuproptosis-related gene SLC31A1 and upstream
            LncRNA-miRNA regulatory axis in breast cancer
  JOURNAL   Sci Rep 13 (1), 18390 (2023)
   PUBMED   37884650
  REMARK    GeneRIF: Identification of cuproptosis-related gene SLC31A1 and
            upstream LncRNA-miRNA regulatory axis in breast cancer.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4762)
  AUTHORS   Qi,Y., Yao,Q., Li,X., Li,X., Zhang,W. and Qu,P.
  TITLE     Cuproptosis-related gene SLC31A1: prognosis values and potential
            biological functions in cancer
  JOURNAL   Sci Rep 13 (1), 17790 (2023)
   PUBMED   37853210
  REMARK    GeneRIF: Cuproptosis-related gene SLC31A1: prognosis values and
            potential biological functions in cancer.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4762)
  AUTHORS   Wang,J., Li,S., Guo,Y., Zhao,C., Chen,Y., Ning,W., Yang,J. and
            Zhang,H.
  TITLE     Cuproptosis-related gene SLC31A1 expression correlates with the
            prognosis and tumor immune microenvironment in glioma
  JOURNAL   Funct Integr Genomics 23 (3), 279 (2023)
   PUBMED   37610668
  REMARK    GeneRIF: Cuproptosis-related gene SLC31A1 expression correlates
            with the prognosis and tumor immune microenvironment in glioma.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4762)
  AUTHORS   Puig,S., Lee,J., Lau,M. and Thiele,D.J.
  TITLE     Biochemical and genetic analyses of yeast and human high affinity
            copper transporters suggest a conserved mechanism for copper uptake
  JOURNAL   J Biol Chem 277 (29), 26021-26030 (2002)
   PUBMED   11983704
  REMARK    GeneRIF: fundamentally conserved mechanism for high affinity copper
            uptake through the Ctr proteins in yeast and humans
REFERENCE   7  (bases 1 to 4762)
  AUTHORS   Klomp,A.E., Tops,B.B., Van Denberg,I.E., Berger,R. and Klomp,L.W.
  TITLE     Biochemical characterization and subcellular localization of human
            copper transporter 1 (hCTR1)
  JOURNAL   Biochem J 364 (Pt 2), 497-505 (2002)
   PUBMED   12023893
  REMARK    GeneRIF: biochemical characterization and subcellular localization
REFERENCE   8  (bases 1 to 4762)
  AUTHORS   Lee,J., Pena,M.M., Nose,Y. and Thiele,D.J.
  TITLE     Biochemical characterization of the human copper transporter Ctr1
  JOURNAL   J Biol Chem 277 (6), 4380-4387 (2002)
   PUBMED   11734551
REFERENCE   9  (bases 1 to 4762)
  AUTHORS   Moller,L.B., Petersen,C., Lund,C. and Horn,N.
  TITLE     Characterization of the hCTR1 gene: genomic organization,
            functional expression, and identification of a highly homologous
            processed gene
  JOURNAL   Gene 257 (1), 13-22 (2000)
   PUBMED   11054564
REFERENCE   10 (bases 1 to 4762)
  AUTHORS   Zhou,B. and Gitschier,J.
  TITLE     hCTR1: a human gene for copper uptake identified by complementation
            in yeast
  JOURNAL   Proc Natl Acad Sci U S A 94 (14), 7481-7486 (1997)
   PUBMED   9207117
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL449305.4, AL831843.1 and
            BC013611.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001859.3.
            
            Summary: The protein encoded by this gene is a high-affinity copper
            transporter found in the cell membrane. The encoded protein
            functions as a homotrimer to effect the uptake of dietary copper.
            [provided by RefSeq, Aug 2011].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AL831843.1, SRR1803615.266015.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000374212.5/ ENSP00000363329.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-44                AL449305.4         52870-52913
            45-133              AL831843.1         1-89
            134-882             BC013611.1         79-827
            883-4598            AL449305.4         91939-95654
            4599-4762           AL831843.1         4553-4716
FEATURES             Location/Qualifiers
     source          1..4762
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q32"
     gene            1..4762
                     /gene="SLC31A1"
                     /gene_synonym="COPT1; CTR1; NSCT"
                     /note="solute carrier family 31 member 1"
                     /db_xref="GeneID:1317"
                     /db_xref="HGNC:HGNC:11016"
                     /db_xref="MIM:603085"
     exon            1..135
                     /gene="SLC31A1"
                     /gene_synonym="COPT1; CTR1; NSCT"
                     /inference="alignment:Splign:2.1.0"
     exon            136..299
                     /gene="SLC31A1"
                     /gene_synonym="COPT1; CTR1; NSCT"
                     /inference="alignment:Splign:2.1.0"
     CDS             171..743
                     /gene="SLC31A1"
                     /gene_synonym="COPT1; CTR1; NSCT"
                     /note="copper transport 1 homolog; copper transporter 1;
                     solute carrier family 31 (copper transporters), member 1;
                     solute carrier family 31 (copper transporter), member 1"
                     /codon_start=1
                     /product="high affinity copper uptake protein 1"
                     /protein_id="NP_001850.1"
                     /db_xref="CCDS:CCDS6789.1"
                     /db_xref="GeneID:1317"
                     /db_xref="HGNC:HGNC:11016"
                     /db_xref="MIM:603085"
                     /translation="MDHSHHMGMSYMDSNSTMQPSHHHPTTSASHSHGGGDSSMMMMP
                     MTFYFGFKNVELLFSGLVINTAGEMAGAFVAVFLLAMFYEGLKIARESLLRKSQVSIR
                     YNSMPVPGPNGTILMETHKTVGQQMLSFPHLLQTVLHIIQVVISYFLMLIFMTYNGYL
                     CIAVAAGAGTGYFLFSWKKAVVVDITEHCH"
     exon            300..372
                     /gene="SLC31A1"
                     /gene_synonym="COPT1; CTR1; NSCT"
                     /inference="alignment:Splign:2.1.0"
     exon            373..541
                     /gene="SLC31A1"
                     /gene_synonym="COPT1; CTR1; NSCT"
                     /inference="alignment:Splign:2.1.0"
     exon            542..4762
                     /gene="SLC31A1"
                     /gene_synonym="COPT1; CTR1; NSCT"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1798..1803
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC31A1"
                     /gene_synonym="COPT1; CTR1; NSCT"
                     /note="hexamer: AATAAA"
     polyA_site      1818
                     /gene="SLC31A1"
                     /gene_synonym="COPT1; CTR1; NSCT"
                     /note="major polyA site"
     regulatory      4736..4741
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC31A1"
                     /gene_synonym="COPT1; CTR1; NSCT"
                     /note="hexamer: AATAAA"
     polyA_site      4762
                     /gene="SLC31A1"
                     /gene_synonym="COPT1; CTR1; NSCT"
                     /note="major polyA site"
ORIGIN      
        1 aaatcctcgg cctcggtggc ggtggtggac acgtcgagcc gggtagaagt ggaggggccg
       61 ttcgaagagt cgtgaggggg tgacgggtta agattcggag agagaggtgc tagtggctgg
      121 acttgacctg gaaagaatct tctgctgact ctcaactttt cctggaaaaa atggatcatt
      181 cccaccatat ggggatgagc tatatggact ccaacagtac catgcaacct tctcaccatc
      241 acccaaccac ttcagcctca cactcccatg gtggaggaga cagcagcatg atgatgatgc
      301 ctatgacctt ctactttggc tttaagaatg tggaactact gttttccggt ttggtgatca
      361 atacagctgg agaaatggct ggagcttttg tggcagtgtt tttactagca atgttctatg
      421 aaggactcaa gatagcccga gagagcctgc tgcgtaagtc acaagtcagc attcgctaca
      481 attccatgcc tgtcccagga ccaaatggaa ccatccttat ggagacacac aaaactgttg
      541 ggcaacagat gctgagcttt cctcacctcc tgcaaacagt gctgcacatc atccaggtgg
      601 tcataagcta cttcctcatg ctcatcttca tgacctacaa cgggtacctc tgcattgcag
      661 tagcagcagg ggccggtaca ggatacttcc tcttcagctg gaagaaggca gtggtagtgg
      721 atatcacaga gcattgccat tgacatcaaa ctctatggcg tggccttatc gattgcagtg
      781 ggaagttgtt gaagacttga agacgtgatt cctgctccaa tcatcccttc ttgctcctct
      841 ttgtgcacgt acacacacac acacacacac acacacacac acccctgctc aacagaggtt
      901 tagtttacag tctctgaact aaagtagtaa cctcccaaat tgttttttct aataagctga
      961 gattcccatt tctcttaagg agaagccacc catgagatgt cttttccttc tccatcatct
     1021 tagagccaag ttatatgttc ttgtctaatc catgtagctt tttgttcaat gacttgatca
     1081 tctgcttcct ttttgaattt ttaacagata gtaagtaaat ttggtggttt tttcccctgg
     1141 gtcagtgatg gaaaggggtt aacttcagcc aggattgatg gcagctgagg gaaattcttg
     1201 cccaactaaa cccagaactc aaacttaaca ttagaaaata aggtccaggg ccggacacag
     1261 tggcccatgc ctgtaatccc agcactttgg ggggccaagg caggctggat cacctgagga
     1321 caggagttcg agaccagtct ggccaacatg gggaaacccc gtctctacta aaaatacaaa
     1381 aattagccgg gcatggtggt gggcgcctgt aatcccagct actcagaagg ctgaggcagg
     1441 agaatcactt gaacctagga ggcggaggtt gcagtgagcc aagatggcgc cattgcactc
     1501 cagcctgggt gacaagagtg aaactccatc tcaaaaaaaa agaaaagaag gtccagcttt
     1561 tggattcaat gagtgggaaa tacattgtgc ctttctctag atgtgatacg ttataccaaa
     1621 atctttgtag tgtgcagagc ggtggtttga gactaaatac aggcttagaa cttgcagagt
     1681 gtgtattctt ggatggctga tgcatcgact tgcattccca cttaacactt tgattagcat
     1741 gaacttgcca atcaaaaaat gacaatcaat ttgagaaaat agaaatagat atttttaaat
     1801 aaaaccattc acagtttact ttgtcttgat accttggttt gtcccagctg aagtgaagca
     1861 agagagtttg aattaatttt tccattataa tgttttcgca tgtctgcctc taaaactgtg
     1921 attttcaagc tttagcgtgc atcagaatca cctgtagggc ttgttaaaac actaattgct
     1981 gggcctcaac ccaaaagccc ccaaagtggc acttctgagt tcctgctgat gttacaaggg
     2041 accacacttt tgagaatctg tgctttaagc taaggaaata ttgcctggtg ggttggctgc
     2101 ctggtattgg gcatggaaat ttgaattgct gattggtaga tggtgtgtct ggacttaact
     2161 cacgtagtaa atactgctga tcaataccta atcattccac atttattgag ctccacctgt
     2221 gtgtatgtgt acccaagcac acatgtgtga agggctatag ccaaagtatt tttactagcc
     2281 tgtatgaaat cactagtcct tatttttaaa ggtctatggt ttcttggaag tagtttgatt
     2341 gttgagagag acctttgatc tgcagtgtaa atctaccagt catgggccag aagggcaaaa
     2401 gcccagcttt ctctttggaa agactcaggc tgtggtttgt tgatggccag gttttcctca
     2461 ggctccaaca actgtgctta taccaagcag atcctcatcc tccatataat catctttgtt
     2521 attcgtgggg gtttaattac attacaagtg gccaaaaccc ctgttctcag tgaagaacca
     2581 cattggattt gtattctgtt cagttgtagt ctacactgca gtcttattcc tggttcaaac
     2641 tacctcttta aattgatttg tcttgtgctg gtctgttaaa tcctgccctc cttggtgcta
     2701 gatccagttg tgcctcaggg cagaggaaac aaaacacagc tatcctgttg gcctgtgttg
     2761 tggttttgaa gtttgtactt tctctgtggg tgccagttaa atattggaga gcaaggaatg
     2821 tggacttgta tggctttgaa ccaagagagg gttatgagcc tactggattg aggttaaaat
     2881 ccaagaacca acatttagag ctttgtgctt ttctctcatt ccatcacttt gtaatgatga
     2941 tacttaacat gagcagggtg aatgacaggt actgacgaag tccaacacaa aggtataata
     3001 cagcctgttg tctaaagcca aggagtcata aaaccatgag aaataaatag gaatcaatag
     3061 ttagtagtga cattggtgct ctctagaaat ctcagcatga gctgctatag aataccctcc
     3121 cagcaacaaa acctaatcag taaggccagc tagacccaat ggctcatgcc tgtaatccca
     3181 acactttggg aggccaaggt gggaggatgg cttgtgtcca gaagttcgag accagcctgg
     3241 acaacatagt gagatcctat ctctataaaa aatcaaaaat tagccaggca tggtggtgca
     3301 tacctatagt cctggctatt tgggaggctg aggcaggagg attgctttag ccctggaggt
     3361 cgaggctgca gtaagccatg attgcgccac tgcactcagc ccgggtgaca aagcaagacc
     3421 ctgtctcaga aaaaaagaaa attcaaggcc agttaagaca aaatgctatg actttgaaat
     3481 tcacagaaag aaataacagt ttagattagg tcttcaggta ttcaggatag agataatctc
     3541 ctgaaaaacc tgaatttcag agattcttag actggctgcc aaaggatgaa gctagtgaag
     3601 gagaaaaagc ttaaattcca tcttgagctc ttggattgtg ataatacaat gatttcatta
     3661 acttttcatt tctgtatacc tgttcatttg gaatttaatg cttgacttct ttgttcattt
     3721 tggatctaaa cttctctttt cttccttccc cattcacatc tattagaaga ctgcatcacc
     3781 atttctttgg cccccttact ctgttgtcct ttcccttttc tttcagtttt tttaatcgca
     3841 tgtctagtat attaagtctc catagccctc ctgatgcagt agacagtgct atgctgtgga
     3901 tataatacca accagaaatt ggcatttata aacctgttaa gagactttaa gcatgcttca
     3961 agaggcagtt gacccactgg aatttctata aggctggtac ccttcccaga gttacagaat
     4021 cttaggtgcc gtctctagtc tgtgagggag gaactcccag catccccatt gcccacaaat
     4081 ggaatcctca ctgtatccac taggagatta gaaattaagg tttcttcact acttctatgg
     4141 tagggttgtc tgaaattccc tttcaggctg tgggtactgg tcttgggttc tagtcataag
     4201 gggttcctta taaggagcag gcggagggga gtacactttc atgtgattta attttgatcc
     4261 tgccctctcc agctgctcct tcaaaagata catcaaaaga tagaaactct gggctgggca
     4321 cagtggctca cacactttgg gaggccaagc gggggtgcag atcacctgag gtcaggagtt
     4381 tgagaccagc ctggccaatg tggtgaaacc ccatctctac taaaaataca aaaattagct
     4441 gggcgtggtg gtgcatgcct gtaatcccag ctactcggga ggctgaggca ggagaatcgc
     4501 ttgaacccag gaggcggagg ttgcagtgag ccaagatggc gccattgcac tccagcctgg
     4561 gcgacaagag caaaactccg tctcaaaaaa aaaaaaaaga tacaaagtct gcatttgata
     4621 taatgcctta attactgggt ctacaattaa tgttgactgt tttagattgt aagctcctgg
     4681 agagcagtat tgctgtagta ggaatgtttt aacagtgtca tatgaaaaag aacaaaataa
     4741 atattttgat tttgtgattc ta
//
