LOCUS       NM_133496               8204 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens solute carrier family 30 member 7 (SLC30A7),
            transcript variant 1, mRNA.
ACCESSION   NM_133496
VERSION     NM_133496.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8204)
  AUTHORS   Yu,W., Gui,S., Xie,J., Peng,L., Xiao,J., Luo,H., Tao,Z. and
            Cheng,Z.
  TITLE     Investigation of cuproptosis regulator-mediated modification
            patterns and SLC30A7 function in GBM
  JOURNAL   Aging (Albany NY) 16 (4), 3554-3582 (2024)
   PUBMED   38393693
  REMARK    GeneRIF: Investigation of cuproptosis regulator-mediated
            modification patterns and SLC30A7 function in GBM.
REFERENCE   2  (bases 1 to 8204)
  AUTHORS   Huang,L., Yang,Z., Kirschke,C.P., Prouteau,C., Copin,M.C.,
            Bonneau,D., Pellier,I., Coutant,R., Miot,C. and Ziegler,A.
  TITLE     Identification of novel compound heterozygous variants in the
            SLC30A7 (ZNT7) gene in two French brothers with stunted growth,
            testicular hypoplasia and bone marrow failure
  JOURNAL   Hum Mol Genet 32 (12), 2016-2031 (2023)
   PUBMED   36821639
  REMARK    GeneRIF: Identification of novel compound heterozygous variants in
            the SLC30A7 (ZNT7) gene in two French brothers with stunted growth,
            testicular hypoplasia and bone marrow failure.
REFERENCE   3  (bases 1 to 8204)
  AUTHORS   Penon-Portmann,M., Eldomery,M.K., Potocki,L., Marafi,D.,
            Posey,J.E., Coban-Akdemir,Z., Harel,T., Grochowski,C.M., Loucks,H.,
            Devine,W.P., Van Ziffle,J., Doherty,D., Lupski,J.R. and Shieh,J.T.
  TITLE     De novo heterozygous variants in SLC30A7 are a candidate cause for
            Joubert syndrome
  JOURNAL   Am J Med Genet A 188 (8), 2360-2366 (2022)
   PUBMED   35751429
  REMARK    GeneRIF: De novo heterozygous variants in SLC30A7 are a candidate
            cause for Joubert syndrome.
REFERENCE   4  (bases 1 to 8204)
  AUTHORS   Li,W., Yang,S., Chen,G. and He,S.
  TITLE     MiR-200c-3p regulates pyroptosis by targeting SLC30A7 in diabetic
            retinopathy
  JOURNAL   Hum Exp Toxicol 41, 9603271221099589 (2022)
   PUBMED   35607288
  REMARK    GeneRIF: MiR-200c-3p regulates pyroptosis by targeting SLC30A7 in
            diabetic retinopathy.
REFERENCE   5  (bases 1 to 8204)
  AUTHORS   Wei,T., Ji,X., Gao,Y., Zhu,X. and Xiao,G.
  TITLE     ZnT7 RNAi favors RafGOFscrib-/--induced tumor growth and invasion
            in Drosophila through JNK signaling pathway
  JOURNAL   Oncogene 40 (12), 2217-2229 (2021)
   PUBMED   33649534
  REMARK    GeneRIF: ZnT7 RNAi favors Raf(GOF)scrib(-/-)-induced tumor growth
            and invasion in Drosophila through JNK signaling pathway.
REFERENCE   6  (bases 1 to 8204)
  AUTHORS   Suzuki,T., Ishihara,K., Migaki,H., Matsuura,W., Kohda,A.,
            Okumura,K., Nagao,M., Yamaguchi-Iwai,Y. and Kambe,T.
  TITLE     Zinc transporters, ZnT5 and ZnT7, are required for the activation
            of alkaline phosphatases, zinc-requiring enzymes that are
            glycosylphosphatidylinositol-anchored to the cytoplasmic membrane
  JOURNAL   J Biol Chem 280 (1), 637-643 (2005)
   PUBMED   15525635
REFERENCE   7  (bases 1 to 8204)
  AUTHORS   Devergnas,S., Chimienti,F., Naud,N., Pennequin,A., Coquerel,Y.,
            Chantegrel,J., Favier,A. and Seve,M.
  TITLE     Differential regulation of zinc efflux transporters ZnT-1, ZnT-5
            and ZnT-7 gene expression by zinc levels: a real-time RT-PCR study
  JOURNAL   Biochem Pharmacol 68 (4), 699-709 (2004)
   PUBMED   15276077
REFERENCE   8  (bases 1 to 8204)
  AUTHORS   Seve,M., Chimienti,F., Devergnas,S. and Favier,A.
  TITLE     In silico identification and expression of SLC30 family genes: an
            expressed sequence tag data mining strategy for the
            characterization of zinc transporters' tissue expression
  JOURNAL   BMC Genomics 5 (1), 32 (2004)
   PUBMED   15154973
  REMARK    Publication Status: Online-Only
REFERENCE   9  (bases 1 to 8204)
  AUTHORS   Kirschke,C.P. and Huang,L.
  TITLE     ZnT7, a novel mammalian zinc transporter, accumulates zinc in the
            Golgi apparatus
  JOURNAL   J Biol Chem 278 (6), 4096-4102 (2003)
   PUBMED   12446736
REFERENCE   10 (bases 1 to 8204)
  AUTHORS   Simpson,J.C., Wellenreuther,R., Poustka,A., Pepperkok,R. and
            Wiemann,S.
  TITLE     Systematic subcellular localization of novel proteins identified by
            large-scale cDNA sequencing
  JOURNAL   EMBO Rep 1 (3), 287-292 (2000)
   PUBMED   11256614
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA997188.1, BC064692.1, AL732465.6 and BX648884.1.
            
            On Nov 22, 2018 this sequence version replaced NM_133496.4.
            
            Summary: Zinc functions as a cofactor for numerous enzymes, nuclear
            factors, and hormones and as an intra- and intercellular signal
            ion. Members of the zinc transporter (ZNT)/SLC30 subfamily of the
            cation diffusion facilitator family, such as SLC30A7, permit
            cellular efflux of zinc (Seve et al., 2004 [PubMed
            15154973]).[supplied by OMIM, Mar 2008].
            
            Transcript Variant: This variant (1) is the longer transcript.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803614.17968.1, BC064692.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000357650.9/ ENSP00000350278.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-32                DA997188.1         13-44
            33-1288             BC064692.1         1-1256
            1289-7123           AL732465.6         7876-13710
            7124-8202           BX648884.1         4295-5373
            8203-8204           AL732465.6         14790-14791
FEATURES             Location/Qualifiers
     source          1..8204
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p21.2"
     gene            1..8204
                     /gene="SLC30A7"
                     /gene_synonym="ZHS; ZnT-7; ZNT7; ZnTL2"
                     /note="solute carrier family 30 member 7"
                     /db_xref="GeneID:148867"
                     /db_xref="HGNC:HGNC:19306"
                     /db_xref="MIM:611149"
     exon            1..253
                     /gene="SLC30A7"
                     /gene_synonym="ZHS; ZnT-7; ZNT7; ZnTL2"
                     /inference="alignment:Splign:2.1.0"
     CDS             174..1304
                     /gene="SLC30A7"
                     /gene_synonym="ZHS; ZnT-7; ZNT7; ZnTL2"
                     /note="zinc transporter like 2; zinc transporter ZnT-7;
                     znt-like transporter 2; solute carrier family 30 (zinc
                     transporter), member 7"
                     /codon_start=1
                     /product="zinc transporter 7"
                     /protein_id="NP_598003.2"
                     /db_xref="CCDS:CCDS776.1"
                     /db_xref="GeneID:148867"
                     /db_xref="HGNC:HGNC:19306"
                     /db_xref="MIM:611149"
                     /translation="MLPLSIKDDEYKPPKFNLFGKISGWFRSILSDKTSRNLFFFLCL
                     NLSFAFVELLYGIWSNCLGLISDSFHMFFDSTAILAGLAASVISKWRDNDAFSYGYVR
                     AEVLAGFVNGLFLIFTAFFIFSEGVERALAPPDVHHERLLLVSILGFVVNLIGIFVFK
                     HGGHGHSHGSGHGHSHSLFNGALDQAHGHVDHCHSHEVKHGAAHSHDHAHGHGHFHSH
                     DGPSLKETTGPSRQILQGVFLHILADTLGSIGVIASAIMMQNFGLMIADPICSILIAI
                     LIVVSVIPLLRESVGILMQRTPPLLENSLPQCYQRVQQLQGVYSLQEQHFWTLCSDVY
                     VGTLKLIVAPDADARWILSQTHNIFTQAGVRQLYVQIDFAAM"
     exon            254..355
                     /gene="SLC30A7"
                     /gene_synonym="ZHS; ZnT-7; ZNT7; ZnTL2"
                     /inference="alignment:Splign:2.1.0"
     exon            356..469
                     /gene="SLC30A7"
                     /gene_synonym="ZHS; ZnT-7; ZNT7; ZnTL2"
                     /inference="alignment:Splign:2.1.0"
     exon            470..557
                     /gene="SLC30A7"
                     /gene_synonym="ZHS; ZnT-7; ZNT7; ZnTL2"
                     /inference="alignment:Splign:2.1.0"
     exon            558..684
                     /gene="SLC30A7"
                     /gene_synonym="ZHS; ZnT-7; ZNT7; ZnTL2"
                     /inference="alignment:Splign:2.1.0"
     exon            685..828
                     /gene="SLC30A7"
                     /gene_synonym="ZHS; ZnT-7; ZNT7; ZnTL2"
                     /inference="alignment:Splign:2.1.0"
     exon            829..879
                     /gene="SLC30A7"
                     /gene_synonym="ZHS; ZnT-7; ZNT7; ZnTL2"
                     /inference="alignment:Splign:2.1.0"
     exon            880..1015
                     /gene="SLC30A7"
                     /gene_synonym="ZHS; ZnT-7; ZNT7; ZnTL2"
                     /inference="alignment:Splign:2.1.0"
     exon            1016..1106
                     /gene="SLC30A7"
                     /gene_synonym="ZHS; ZnT-7; ZNT7; ZnTL2"
                     /inference="alignment:Splign:2.1.0"
     exon            1107..1256
                     /gene="SLC30A7"
                     /gene_synonym="ZHS; ZnT-7; ZNT7; ZnTL2"
                     /inference="alignment:Splign:2.1.0"
     exon            1257..8204
                     /gene="SLC30A7"
                     /gene_synonym="ZHS; ZnT-7; ZNT7; ZnTL2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2920..2925
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC30A7"
                     /gene_synonym="ZHS; ZnT-7; ZNT7; ZnTL2"
                     /note="hexamer: AATAAA"
     polyA_site      2958
                     /gene="SLC30A7"
                     /gene_synonym="ZHS; ZnT-7; ZNT7; ZnTL2"
                     /note="major polyA site"
     regulatory      5141..5146
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC30A7"
                     /gene_synonym="ZHS; ZnT-7; ZNT7; ZnTL2"
                     /note="hexamer: AATAAA"
     polyA_site      5161
                     /gene="SLC30A7"
                     /gene_synonym="ZHS; ZnT-7; ZNT7; ZnTL2"
                     /note="major polyA site"
     regulatory      6890..6895
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC30A7"
                     /gene_synonym="ZHS; ZnT-7; ZNT7; ZnTL2"
                     /note="hexamer: AATAAA"
     polyA_site      6915
                     /gene="SLC30A7"
                     /gene_synonym="ZHS; ZnT-7; ZNT7; ZnTL2"
     regulatory      8178..8183
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC30A7"
                     /gene_synonym="ZHS; ZnT-7; ZNT7; ZnTL2"
                     /note="hexamer: AATAAA"
     polyA_site      8204
                     /gene="SLC30A7"
                     /gene_synonym="ZHS; ZnT-7; ZNT7; ZnTL2"
                     /note="major polyA site"
ORIGIN      
        1 ggaagtaagc gaattcccgg gtgtgtgtct gtgtctgtct gtgtctcgca gcggcgcgcg
       61 gccccggaca agcgctgggg attcccgttt gaggcgtcac tactgtcact gccatcaccc
      121 cacggagcca cttctagagg ggagtagacc cggcccttcg ccgggcagag aagatgttgc
      181 ccctgtccat caaagacgat gaatacaaac cacccaagtt caatttgttc ggcaagatct
      241 cgggctggtt taggtctata ctgtccgaca agacttcccg gaacctgttt ttcttcctgt
      301 gcctgaacct ctctttcgct tttgtggaac tactctacgg catctggagc aactgcttag
      361 gcttgatttc cgactctttt cacatgtttt tcgatagcac tgccattttg gctggactgg
      421 cagcttctgt tatttcaaaa tggagagata atgatgcttt ctcctatggg tatgttagag
      481 cggaagttct ggctggcttt gtcaatggcc tatttttgat cttcactgct ttttttattt
      541 tctcagaagg agttgagaga gcattagccc ctccagatgt ccaccatgag agactgcttc
      601 ttgtttccat tcttgggttt gtggtaaacc taataggaat atttgttttc aaacatggag
      661 gtcatggaca ttctcatggc tctggccacg gacacagtca ttccctcttt aatggtgctc
      721 tagatcaggc acatggccat gtcgatcatt gccatagcca tgaagtgaaa catggtgctg
      781 cacatagcca tgatcatgct catggacatg gacactttca ttctcatgat ggcccgtcct
      841 taaaagaaac aacaggaccc agcagacaga ttttacaagg tgtattttta catatcctag
      901 cagatacact tggaagtatt ggtgtaattg cttctgccat catgatgcaa aattttggtc
      961 tgatgatagc agatcctatc tgttcaattc ttatagccat tcttatagtt gtaagtgtta
     1021 ttcctctttt aagagaatct gttggaatat taatgcagag aactcctccc ctattagaaa
     1081 atagtctgcc tcagtgctat cagagggtac agcagttgca aggagtttac agtttacagg
     1141 aacagcactt ctggacttta tgttctgacg tttatgttgg gaccttgaaa ttaatagtag
     1201 cacctgatgc tgatgctagg tggattttaa gccaaacaca taatattttt actcaggctg
     1261 gagtgagaca gctctacgta cagattgact ttgcagccat gtagtgaatg gaaagaaatt
     1321 atgcaccttt tatggaccaa atttttctgg tactgtacga tccaaaacat tgtacccagc
     1381 tttttaaaag agagaaatta tcactacaac tcccgagcac taagtagacg gggtagagtc
     1441 agccgttcat gctttgtggg gagttcacag ctaagggatc agatttaaga ggatatctcc
     1501 tggacttttg gtcttttctt ttgtgctctt tcctccaaat ctttttgact tctgaggttt
     1561 ttagcttagg atgttaattt gtccttttgt ctttcttttt ttgtttttgt tttctgtttg
     1621 tttgttttca tgttgaatgc ccacaccacc atcctctcat cccagccagt aagaatttca
     1681 gttgtgggcc tccagtcttc tggaatgtct tcactgcagc tgctggaaat cactgctttc
     1741 attcccacaa aaccagtatt actttttttt aaaaaaagaa agaaattgga aatctgtgct
     1801 atacgtaatg tcataattgt tgacgttctt cagtataatc atgtttgtta aattgtttgt
     1861 accttgcaaa cttatgaacc aaaccatatt gggttttcaa agtgcctttg tatccaaaaa
     1921 tgtatttgcc agcatagaaa tgtaccatca agagtcatgt atgttttatt tttgttttta
     1981 ttttttattt tttgagatgg agtctcgctc tgtagccagg ctggagtgca gtggcataat
     2041 ctcagctcac tgcaacctct gcttcccggg ttcaagctat tctcctgcct cagccttctg
     2101 agtagctgcg actatgggcg tgtgccacca tgcccagcta atttttgcat ttttagtaga
     2161 gatggggttt caccatgttg gccaggatgg tcttgatctc ttgacctcgt gatccgtcca
     2221 cctcagcctc ccaaagtgct gggattacag gtgtgagcca ccacgcccgg ctatgttttt
     2281 tttttttttt tttttttttt ttaacaatgg atattctgta aaatatcctg tacaaaacaa
     2341 gactattgcc agtaatgtat acaaattgtc tttttgtgta cttccagcat aggtttggat
     2401 atatgaacat ttttctttta ttgttttatc ttcacagaaa ataaaaggtg ttaatttgct
     2461 ttttaaaaca aatttaatta tcacatttta aattactttg tggactgtgt tttcaaaact
     2521 ttgcaaattc atctgttaca cagaaaattt tgacttaaaa catctgctga attccaaatt
     2581 tctgtaatag ctactgtatc tgtgataaac tttcctatat ctttccttgc catttctatg
     2641 gattttataa tgaaagaaaa aggcattgga gactgaaggc agaaatggtt gtgacagtgc
     2701 tgtttggctt tttcattctt caaatgccaa gtcatccact ttgttttcct gtttaggctt
     2761 tgcacaaata caattgcttt caggaatcct aaagcagcat tttattgagt ttgaattatt
     2821 aaaggtacag aggaaatgtg gtgatgtaga acttttccta acacaggtat ctaggaagta
     2881 agtgctgagt tgattttcta ggttcttacg tatttgaaaa ataaaattgc aattcgagat
     2941 aagtgcttga gcactctact taagtattct ctgtgtttta tgaagagaaa atgatctgat
     3001 tttcccttat acttcatttt acaatacata ttccctttta acttaaaaaa attgtaaatg
     3061 tgggagaaaa aaccctgcag gatggaaaca attattaaga atgtagatca ataagtactt
     3121 tttagtgatg tggcagaaat ccctgttgat tctaagtttt agagtgtctt ttcccctatt
     3181 tctgacctac aactataaac tactctctat taggagaact agaccacttt cttcattctt
     3241 ttctaaactg ctgcagattg ccgtgaactc tatcaatagt ctcttttccg caggcaaagt
     3301 ggcattttct aaacatgttt gcttactgcc aggtggtttg aaatctatga tttactgcag
     3361 tagtatgtgc ttaaaacaac tgttgaggtc ttttaagcag gaaagttcaa aaggaagtgt
     3421 cctgataatg gtactggttt ttctacaaat ataagtagtc attagaagtt tgcaaccacc
     3481 accaagtctg agagaactct gggatattct gtgggttttg gcatattaga tagagaaaat
     3541 gacagatcta gatgaaggga gcttttggat gtgtgccttt aaaaactgat tatgtataaa
     3601 tactgatatt tcacatacgg agatatttga agacccaagt ctgcctttca cagagccctc
     3661 cattccaagt ttagtttttg tcaaaatatg aatcatttta tttgactgta ctatcagtac
     3721 acaaatgcat gagtatgttt atacagtgtt agactgatgt gaatttgcat ttgttacatt
     3781 acattgccag cgcatatcat ttagcaagtt ggcattaaca tttatgcttt aattaaatgc
     3841 cagtatacct atgtgtgcag cagtaaaaaa ttagtgagaa aaagcaactt tttgtcactc
     3901 ttaggaaata ttttgtctta ttagtgttct tggcacatgt atattactaa agtagataat
     3961 tccaatgaga aatactacca gattattgtt ataaaattaa tttacaatgt ccctgatatt
     4021 gagctaactc ttaaaaaaac caaacaaaac tcgtatctga gtgtaacttt gccaatattt
     4081 taaaagccaa aatattctct ggacaacaaa tttgtattgc tcagggacag tttaccttgc
     4141 ctggtaaacc ttcccaaaca gaaatatagc tatactatct ttggttttgt ttttttgttt
     4201 tttttgtttg tttgtattag atggaatttc actcttgtcg cccaggctgg agtgtagtgg
     4261 cgcagtctca gctcactgca acctccacct cccgggttca agtgattctc ctgtctcagc
     4321 tccctgagta actggaatta caggtgcacg ccaccacgcc cggctaattt ttgtgttttt
     4381 agcagagaca gggtttcacc acgttggcca gggtggtctt ggactcctga cctcaggtca
     4441 tcctcctgcc tcggcctccc aaagtgctga gactacaggt gtgagccacc gtgctcagcc
     4501 actagctttg gttttttaaa catagattat attcctcaag atgaagggct taacatatcc
     4561 acagcttcct cagtttgcta actccccatg catctttgtg aaggacagta tctagtttat
     4621 ctgtaggtca gtgttccttg tgctgtcatt tcccttatat ctggaatttg tcagcattcc
     4681 tgaaaaccta cacgtgtata tcagtaacca aaatgctatg ccttttttgc acctttgtac
     4741 agcagccaaa tcatgaactc aaaatgtatt tgatcacagt tctataatgt ttttacctac
     4801 ctattatgga ataatcagtt tttacagaga ttattaatat ggtagaaccc tgttatgtaa
     4861 ttccaaaact taagaaccat atttacattg cttaacacag aattttacat ctaagcaagg
     4921 actggcttta gaagcagtgt agttctacct ctcattttac agatgagaaa accgaagccc
     4981 agaaaaactc tcatttgctc aaagtcacag agaaaattag tggcaaagcc aaaaagattc
     5041 agatcttctg actcgaagtt gagagttctt tatactctat tatgctgcct ctccagtgta
     5101 atatttgcct ttctgtaaat gggattaaat atgatttgta aataaaggac atctgacctc
     5161 cttttttggt acattaaggc actttataaa tggactttta ttgtctcatt tttcgtatat
     5221 aattatttcc atcatattct ttatggaaga tgcaattaat tttaactttt ttactcttat
     5281 aaaaccagtt cctgacattt taaaaaacaa tatctgtaaa atggatcctt ttatgagtga
     5341 atttttctgc taattgccca aggctaaatc caatttaagg attgcttagt ttctttattt
     5401 tgtttatggt ctctgaactg gtattttttt ataaaccagg ctaattcaca ggtcatacca
     5461 tttcattctt gtcgtgttgg cttccagtca ctggaaaagc ttttgcattt taaagatttt
     5521 tagagccatg caaaactggg cattaaatgt tgcataaagc aaatctttta agtaaggtaa
     5581 aatgttgaag tcttaaccag aattcctaca actaattact aaaactgcta tttctaactc
     5641 ttcatgaaag cattaccttt ggaaagttaa actttttttt tcctttcatc accgtctttg
     5701 aaacaaatta ttttccaatt cataagaact ttggtaaaaa aaaaaataaa aggaaattat
     5761 atgtttttct ttggacattc attggaaggc ttgttgaaga catgatcccc cagaagcctt
     5821 agtgacccag atctcaacca gagactcaag atagcctcaa atacagtgaa agattatgta
     5881 tccaaaaaaa aaaaaaaaaa aaaaagaaaa ggagcaggga aggacagttc tagttaaagc
     5941 caaatggatg tgagtctgac aagggtgtct ttgatttata tttcctaact gcaaattaca
     6001 cagaaagtga gaatggggaa taacttttat taagtattta tgtgccaggc ggttagtgtg
     6061 gccttcatgt tattacattt aatcctcaaa tttctacaaa ggaataattt tgcatgattt
     6121 tatgattgac ggagcatttt caaatctcct ctaattctca taacatctct gtgaggaagg
     6181 aatttttatc cttattttac agatgaggaa gctgtttgga gataatttaa gtgacttgcc
     6241 tggggaatct agccagtagt agagtactga ttaatcaggt gctgacatct gctctgcttt
     6301 gtgtatgtaa ttcagcagtg cttcaaagat ccaagaagct gtagcagatc tcaatacact
     6361 ctcctataaa attagtgaat aatcaccatg acaaaattgg tatggcggaa cagtcattat
     6421 acattattta gactcattcc ttcttccagt gcccttatga ttatttccta cctttaccat
     6481 tgatcttaaa ctgtgcaggc taaaaagagg aaccagaact cccttaagca cttttaagac
     6541 tatttaaaaa ataaagtttt gttggcattg aagagtaagc tgcttaaggg actgaatgaa
     6601 aagatagtac cctttgtggc tgtatgaaga gagaaactga atttctatcc aagagacctt
     6661 aatttagttt attagggaat tatcttcccc aaaagtacaa gtaattttgc actgcaggag
     6721 aaggataagt agatttgatt tacatcacat tttatacaca cctttcaaaa ggaagaaatc
     6781 tgtttcataa atagtagtaa tctatgctta aacttaacat ttaatgttga cttcttacaa
     6841 cagccttgaa aattatttgt aattttgatc atgatgttgg aaagcttgta ataaagaata
     6901 tctttctctt ctgcatcctt ttatcctcaa acttagcatg gattcacatg ctgagtaaat
     6961 gtttggttaa ctagtgaaca ttttagatag ttgtgtcaaa aataagggtt agggataggt
     7021 aaaaccagta atttactgtt ttttacagaa gacatctcag catttctttg gcatttttgc
     7081 acaaataaat gactatatat tcaccttggc catttttttt tttaagtagc cctatgagct
     7141 gctcattctt tttcatatac agtggaagta tacagatgtt atccatttta caaattgttg
     7201 gatcggaatt tgacagaatt gggactgtgg aacctgggtc acttgaattt tctatatttt
     7261 gtatggccaa atcaggaacc agacagtctc catagtctcc tttgttttta tggaaaattg
     7321 ccatattcac atatttcatt tatcctaatg tattgtcatc caaaatgaaa gaggtctttc
     7381 ttgaaggtgc tttaaagaca tcactacatg tattcaatta ctgatttaaa tattcccaga
     7441 attatttttt acctttctct ttttcctctc aaacacaaaa ttttagtagt acctccctct
     7501 atttcttcac tgatttttca tctgttttca ttgttatttc cactatagaa cttctacttt
     7561 atactagcgg ggaaaatttt tttatttaga attttaatat ttgaattttg tttatgtatc
     7621 acatactgtg ctacagttag cctcaatgaa gattctattt tgaactagac atcctgtcaa
     7681 tagtttgtca agtaacttca ttgcttcctt tgatagcaat tcagtgaaat tttttcccaa
     7741 gtgatatttt cccccaactt ttgtgagttt gataaatagg atgagtcttt tatattggaa
     7801 atactgtgaa tggaaaattg ccaaatccct tcttagtata ttttaagcac cctacaacac
     7861 tttacctccc tgcctttagt ggtatttaaa catatggcca agttagtatt tgggtttgat
     7921 tcctttggtg aagattaagg catcaaaaca tttcttaaaa tgtttgagta caaggctaag
     7981 ttataatgtc aactttcaaa gactatgttg tgattcggtt tgaatatgct gaagtgagca
     8041 attatgattt gcccaagtgc aatacaacaa atctataatg tatatttcac attttctact
     8101 tgaacacatt catgtatata ttttgttaaa cttcatatgt atttaaaaag aatcatgaac
     8161 tgtatcaaaa ttctttcaat aaaatttcta tttaaaaatc tcta
//
