LOCUS       NM_017964               5089 bp    mRNA    linear   PRI 08-OCT-2024
DEFINITION  Homo sapiens solute carrier family 30 member 6 (SLC30A6),
            transcript variant 2, mRNA.
ACCESSION   NM_017964
VERSION     NM_017964.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5089)
  AUTHORS   Song,C.C., Liu,T., Hogstrand,C., Zhong,C.C., Zheng,H., Sun,L.H. and
            Luo,Z.
  TITLE     SENP1 mediates zinc-induced ZnT6 deSUMOylation at Lys-409 involved
            in the regulation of zinc metabolism in Golgi apparatus
  JOURNAL   Cell Mol Life Sci 81 (1), 422 (2024)
   PUBMED   39367979
  REMARK    GeneRIF: SENP1 mediates zinc-induced ZnT6 deSUMOylation at Lys-409
            involved in the regulation of zinc metabolism in Golgi apparatus.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5089)
  AUTHORS   Aktay,I., Billur,D., Tuncay,E. and Turan,B.
  TITLE     An Overexpression of SLC30A6 Gene Contributes to Cardiomyocyte
            Dysfunction via Affecting Mitochondria and Inducing Activations in
            K-Acetylation and Epigenetic Proteins
  JOURNAL   Biochem Genet 62 (4), 3198-3214 (2024)
   PUBMED   38091184
  REMARK    GeneRIF: An Overexpression of SLC30A6 Gene Contributes to
            Cardiomyocyte Dysfunction via Affecting Mitochondria and Inducing
            Activations in K-Acetylation and Epigenetic Proteins.
REFERENCE   3  (bases 1 to 5089)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   4  (bases 1 to 5089)
  AUTHORS   Zhu,B., Huo,R., Zhi,Q., Zhan,M., Chen,X. and Hua,Z.C.
  TITLE     Increased expression of zinc transporter ZIP4, ZIP11, ZnT1, and
            ZnT6 predicts poor prognosis in pancreatic cancer
  JOURNAL   J Trace Elem Med Biol 65, 126734 (2021)
   PUBMED   33631610
  REMARK    GeneRIF: Increased expression of zinc transporter ZIP4, ZIP11,
            ZnT1, and ZnT6 predicts poor prognosis in pancreatic cancer.
REFERENCE   5  (bases 1 to 5089)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 5089)
  AUTHORS   Falcon-Perez,J.M. and Dell'Angelica,E.C.
  TITLE     Zinc transporter 2 (SLC30A2) can suppress the vesicular zinc defect
            of adaptor protein 3-depleted fibroblasts by promoting zinc
            accumulation in lysosomes
  JOURNAL   Exp Cell Res 313 (7), 1473-1483 (2007)
   PUBMED   17349999
REFERENCE   7  (bases 1 to 5089)
  AUTHORS   Smith,J.L., Xiong,S., Markesbery,W.R. and Lovell,M.A.
  TITLE     Altered expression of zinc transporters-4 and -6 in mild cognitive
            impairment, early and late Alzheimer's disease brain
  JOURNAL   Neuroscience 140 (3), 879-888 (2006)
   PUBMED   16580781
  REMARK    GeneRIF: Our results show that Zn transporter-4 and Zn
            transporter-6 are significantly (P<0.05) increased in
            hippocampus/parahippocampal gyrus of early Alzheimer's disease and
            Alzheimer's disease subjects.
REFERENCE   8  (bases 1 to 5089)
  AUTHORS   Suzuki,T., Ishihara,K., Migaki,H., Ishihara,K., Nagao,M.,
            Yamaguchi-Iwai,Y. and Kambe,T.
  TITLE     Two different zinc transport complexes of cation diffusion
            facilitator proteins localized in the secretory pathway operate to
            activate alkaline phosphatases in vertebrate cells
  JOURNAL   J Biol Chem 280 (35), 30956-30962 (2005)
   PUBMED   15994300
REFERENCE   9  (bases 1 to 5089)
  AUTHORS   Seve,M., Chimienti,F., Devergnas,S. and Favier,A.
  TITLE     In silico identification and expression of SLC30 family genes: an
            expressed sequence tag data mining strategy for the
            characterization of zinc transporters' tissue expression
  JOURNAL   BMC Genomics 5 (1), 32 (2004)
   PUBMED   15154973
  REMARK    Publication Status: Online-Only
REFERENCE   10 (bases 1 to 5089)
  AUTHORS   Huang,L., Kirschke,C.P. and Gitschier,J.
  TITLE     Functional characterization of a novel mammalian zinc transporter,
            ZnT6
  JOURNAL   J Biol Chem 277 (29), 26389-26395 (2002)
   PUBMED   11997387
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK055663.1, BC032525.1,
            BG527678.1 and AA594503.1.
            
            On Nov 22, 2018 this sequence version replaced NM_017964.4.
            
            Summary: This gene encodes a member of a family of proteins that
            function as zinc transporters. This protein can regulate
            subcellular levels of zinc in the Golgi and vesicles. Expression of
            this gene is altered in the Alzheimer's disease brain plaques.
            [provided by RefSeq, Aug 2016].
            
            Transcript Variant: This variant (2) lacks an alternate in-frame
            exon compared to variant 1. The resulting protein (isoform 2) is
            shorter than isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK055663.1, SRR1803611.92922.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000282587.9/ ENSP00000282587.5
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2253              AK055663.1         1-2253
            2254-3485           BC032525.1         1627-2858
            3486-4182           BG527678.1         21-717
            4183-4798           BC032525.1         3555-4170
            4799-5089           AA594503.1         6-296               c
FEATURES             Location/Qualifiers
     source          1..5089
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p22.3"
     gene            1..5089
                     /gene="SLC30A6"
                     /gene_synonym="MST103; MSTP103; ZNT6"
                     /note="solute carrier family 30 member 6"
                     /db_xref="GeneID:55676"
                     /db_xref="HGNC:HGNC:19305"
                     /db_xref="MIM:611148"
     exon            1..40
                     /gene="SLC30A6"
                     /gene_synonym="MST103; MSTP103; ZNT6"
                     /inference="alignment:Splign:2.1.0"
     CDS             38..1423
                     /gene="SLC30A6"
                     /gene_synonym="MST103; MSTP103; ZNT6"
                     /note="isoform 2 is encoded by transcript variant 2; zinc
                     transporter 6; solute carrier family 30 (zinc
                     transporter), member 6"
                     /codon_start=1
                     /product="zinc transporter 6 isoform 2"
                     /protein_id="NP_060434.2"
                     /db_xref="CCDS:CCDS1780.1"
                     /db_xref="GeneID:55676"
                     /db_xref="HGNC:HGNC:19305"
                     /db_xref="MIM:611148"
                     /translation="MGTIHLFRKPQRSFFGKLLREFRLVAADRRSWKILLFGVINLIC
                     TGFLLMWCSSTNSIALTAYTYLTIFDLFSLMTCLISYWVTLRKPSPVYSFGFERLEVL
                     AVFASTVLAQLGALFILKESAERFLEQPEIHTGRLLVGTFVALCFNLFTMLSIRNKPF
                     AYVSEAASTSWLQEHVADLSRSLCGIIPGLSSIFLPRMNPFVLIDLAGAFALCITYML
                     IEINNYFAVDTASAIAIALMTFGTMYPMSVYSGKVLLQTTPPHVIGQLDKLIREVSTL
                     DGVLEVRNEHFWTLGFGSLAGSVHVRIRRDANEQMVLAHVTNRLYTLVSTLTVQIFKD
                     DWIRPALLSGPVAANVLNFSDHHVIPMPLLKGTDDLNPVTSTPAKPSSPPPEFSFNTP
                     GKNVNPVILLNTQTRPYGFGLNHGHTPYSSMLNQGLGVPGIGATQGLRTGFTNIPSRY
                     GTNNRIGQPRP"
     exon            41..127
                     /gene="SLC30A6"
                     /gene_synonym="MST103; MSTP103; ZNT6"
                     /inference="alignment:Splign:2.1.0"
     exon            128..212
                     /gene="SLC30A6"
                     /gene_synonym="MST103; MSTP103; ZNT6"
                     /inference="alignment:Splign:2.1.0"
     exon            213..255
                     /gene="SLC30A6"
                     /gene_synonym="MST103; MSTP103; ZNT6"
                     /inference="alignment:Splign:2.1.0"
     exon            256..321
                     /gene="SLC30A6"
                     /gene_synonym="MST103; MSTP103; ZNT6"
                     /inference="alignment:Splign:2.1.0"
     exon            322..402
                     /gene="SLC30A6"
                     /gene_synonym="MST103; MSTP103; ZNT6"
                     /inference="alignment:Splign:2.1.0"
     exon            403..438
                     /gene="SLC30A6"
                     /gene_synonym="MST103; MSTP103; ZNT6"
                     /inference="alignment:Splign:2.1.0"
     exon            439..533
                     /gene="SLC30A6"
                     /gene_synonym="MST103; MSTP103; ZNT6"
                     /inference="alignment:Splign:2.1.0"
     exon            534..582
                     /gene="SLC30A6"
                     /gene_synonym="MST103; MSTP103; ZNT6"
                     /inference="alignment:Splign:2.1.0"
     exon            583..702
                     /gene="SLC30A6"
                     /gene_synonym="MST103; MSTP103; ZNT6"
                     /inference="alignment:Splign:2.1.0"
     exon            703..805
                     /gene="SLC30A6"
                     /gene_synonym="MST103; MSTP103; ZNT6"
                     /inference="alignment:Splign:2.1.0"
     exon            806..853
                     /gene="SLC30A6"
                     /gene_synonym="MST103; MSTP103; ZNT6"
                     /inference="alignment:Splign:2.1.0"
     exon            854..922
                     /gene="SLC30A6"
                     /gene_synonym="MST103; MSTP103; ZNT6"
                     /inference="alignment:Splign:2.1.0"
     exon            923..5089
                     /gene="SLC30A6"
                     /gene_synonym="MST103; MSTP103; ZNT6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4786..4791
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC30A6"
                     /gene_synonym="MST103; MSTP103; ZNT6"
                     /note="hexamer: ATTAAA"
     polyA_site      4796
                     /gene="SLC30A6"
                     /gene_synonym="MST103; MSTP103; ZNT6"
                     /note="major polyA site"
     regulatory      5066..5071
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC30A6"
                     /gene_synonym="MST103; MSTP103; ZNT6"
                     /note="hexamer: ATTAAA"
     polyA_site      5089
                     /gene="SLC30A6"
                     /gene_synonym="MST103; MSTP103; ZNT6"
ORIGIN      
        1 agaacggctt ccggcgggag ctgtgcagct ccttatcatg gggacaattc atctctttcg
       61 aaaaccacaa agatcctttt ttggcaagtt gttacgggaa tttagacttg tagcagctga
      121 ccgaaggtcc tggaagatac tgctctttgg tgtaataaac ttgatatgta ctggcttcct
      181 gcttatgtgg tgcagttcta ctaatagtat agctttaact gcctatactt acctgaccat
      241 ttttgatctt tttagtttaa tgacatgttt aataagttac tgggtaacat tgaggaaacc
      301 tagccctgtc tattcatttg ggtttgaaag attagaagtc ctggctgtat ttgcctccac
      361 agtcttggca cagttgggag ctctctttat attaaaagaa agtgcagaac gctttttgga
      421 acagcccgag atacacacgg gaagattatt agttggtact tttgtggctc tttgtttcaa
      481 cctgttcacg atgctttcta ttcggaataa accttttgct tatgtctcag aagctgctag
      541 tacgagctgg cttcaagagc atgttgcaga tcttagtcga agcttgtgtg gaattattcc
      601 gggacttagc agtatcttcc ttccccgaat gaatccattt gttttgattg atcttgctgg
      661 agcatttgct ctttgtatta catatatgct cattgaaatt aataattatt ttgccgtaga
      721 cactgcctct gctatagcta ttgccttgat gacatttggc actatgtatc ccatgagtgt
      781 gtacagtggg aaagtcttac tccagacaac accaccccat gttattggtc agttggacaa
      841 actcatcaga gaggtatcta ccttagatgg agttttagaa gtccgaaatg aacatttttg
      901 gaccctaggt tttggctcat tggctggatc agtgcatgta agaattcgac gagatgccaa
      961 tgaacaaatg gttcttgctc atgtgaccaa caggctgtac actctagtgt ctactctaac
     1021 tgttcaaatt ttcaaggatg actggattag gcctgcctta ttgtctgggc ctgttgcagc
     1081 caatgtccta aacttttcag atcatcacgt aatcccaatg cctcttttaa agggtactga
     1141 tgatttgaac ccagttacat caactccagc taaacctagt agtccacctc cagaattttc
     1201 atttaacact cctgggaaaa atgtgaaccc agttattctt ctaaacacac aaacaaggcc
     1261 ttatggtttt ggtctcaatc atggacacac accttacagc agcatgctta atcaaggact
     1321 tggagttcca ggaattggag caactcaagg attgaggact ggttttacaa atataccaag
     1381 tagatatgga actaataata gaattggaca accaagacca tgatagactc taacttattt
     1441 ttataaggaa tattgactcc ttggcttcca atttatttag taatccaact ttgcattgac
     1501 tgtttaatca tttactctaa atgttagata atagtagtct tgttcacatt tcatgaaacc
     1561 tatgaaacta tatttttgta aaatgtattt gtgacagtga aatcctcgta aatgttaaag
     1621 gctttaaata ggcttccttt agaaaatgtg tttctttaaa tttggatttt ggtatctttg
     1681 gttttgtagt tgactgcagt gtgatgtgac cttaccttta taagagccac ttgatggagt
     1741 agatctgtca cattactaag atacgatatt tctttttttt tccgagacgg agtcttgctc
     1801 tgccactgtg cccggccaat acattattat taacttaagg ctgtacttta ttaaggcttc
     1861 cttagttttt gttttgtttt gttttttgag atggagtctc actctgtcgc ccaggctgga
     1921 atgcagtggc atgatctcag ctcactgcaa cctctgcctc ctgagttcaa atgattctcc
     1981 tgcctcagcc tcccgagtag ctgggattac aggcacctgc caccacgccc agctaatttt
     2041 tgtattttta gtaaagacgg gggatttcac catgttggcc aggctggtct tgaactcctg
     2101 acctcatgat ccacccacct tagcctccca aagtgctggg attaggtgtg agccaccgca
     2161 cctggccgat attttcttta atgaaattta taaatatgct tcttgaataa tacacatttt
     2221 gggaaaggga aaaatgtctg ttcaaaaagt aaaagtctct tttatagctt ttccaaactt
     2281 aattgctaaa tttttctttg aggttctcct gaattatgtc ttacaaacta aaagcaaaaa
     2341 tttttagcag aaattttgga atacattcta tctagcacaa tttgaatttt taattatcaa
     2401 gatttttgtt aaagtttctc tcctttaaaa attttagtac atttgtaaat agtccatggt
     2461 tctcagtgtt ttattttgat taagtgacta cccaactttt ggtgatatgc agtgaaagaa
     2521 tcccaatttt ctatgttaca tttaatcaaa tactgacata atgaatttat ctttcctgac
     2581 acattttcat tcattggctt tttaatttct tattttatta acaaaatata tcagatatat
     2641 taccaaaaca catggagttc catacataat atggaatttg atgtcttttc aagttgcaca
     2701 aagaatttga gcatatataa ttttaccaaa gcataatgga ccttagatta tagaatacag
     2761 cattgttagg tctgcagtgg gcagtttctt tttgttttgc tttgtcaaaa atgggaaatt
     2821 gttaactgtg atgaaatgtg agaattacat agattatgtt attttttagt tgttttccaa
     2881 atgcagagtt taaggacttt ctaacatggc tagtattact tccaaaaagt ataacaagca
     2941 gcagtcacac atgacctagg agggtttttt attgttttat tttattatgc attccataac
     3001 agttttaaaa tgggattttg agaatggact taactttcct ggaatccaat gctcctggag
     3061 atttatgact ttcccagcca tcagccagct atctagagaa gatttttgtt tttcttttgc
     3121 aacagtttct tcagtcaact cattcacttt caaataggag cagcactttg aaatcctttt
     3181 tcttcactgt ggattaaaaa catccaagaa gccatctctg tcaagcagaa ttgtcatctg
     3241 tggtaataag tgaccatgtc ctaaatacct ttttcttagt gaggagttgg tcattgtctt
     3301 tggcatctgc aacccctgtt caggcatgtg acctgctaaa gaaatacagc ctacactacc
     3361 ttgactactg gggaaaatga tacttcgtaa aatgtaataa ggcaacctgt tccttggcct
     3421 ttatcttatg ttttccaact attactgtat ctgttattgg tctactatta caggatgatt
     3481 cttcttcctc cattgatctc aactaaatat gaattagggt catgcatgaa atctgaactg
     3541 ccgtgtcctg agttatggtt aagaggtatg tgctgccacc ccatgcatgt cttccccatc
     3601 cccataggat tttaaagtgt tcaggtacca aacacagttc tgtgtgaggt tttatgccta
     3661 cttcctcaac accaattcag aggcaacacc tgtgcatctg tcccaccaaa ggtgctttaa
     3721 tacctacctt cactatttga gaaaggacac tcacagttgc ctgtgggtta tgaaagaatt
     3781 ggccctacgt cctgcatgta agatgttaca ggggacattg ggccaggcat tattatatag
     3841 agaagtctta tttgccaagc tctgactaac ttctggatat gaaaataagg aacttgccca
     3901 gcataggcct ataggcagca gccttactag taaatcttgc cacagaatca cttgaagcta
     3961 gacagagaaa gaagttcaat ttaaatattt gtcccattgt ttgtgattag gatgtaagct
     4021 ttgtggaatg taattaaccc tgctttacga agtcaccata ttataatagg aaaaacactg
     4081 cctaggaggc aagagatctg aattccagtt ctgatgctgc cactgtgtaa ggaagtagtt
     4141 ttataaccca tgggcaaatc atctgagctt tctcatctgt aaagttaggg agaggaatta
     4201 attagttgat ctgtaaaata atcagcttca aaacgttatg gctaaatctg tagaatgtat
     4261 gcccaattgc taaacggatg ttgtgcccag aattttatct agtgactacc tcaacataca
     4321 ggccaagcgt tacctacacc aacacccaag ccattaattt gaggtgccat gagaataggt
     4381 gaaccacagc ctaacaccat ttaggttttt gtgttttttt caggcttgcc tctacttaaa
     4441 tatatttaga tgagagagtt ctcttagact tctttctttg taaggaaggg ttatttgggg
     4501 aagtgttgga aaaaagatta gggcagggta cccttagttt atatagggta caaaagaatg
     4561 ggaaacatct tccctttctt ctttaatctc tgaagtcatg tttggaatta catataatgt
     4621 agcaggtact ggagaggacc tgaatttcaa gcttctgatt tagctgtttg taaacttcca
     4681 agttttgctt gactaaagaa tgctgatctt ttttgggagt ctgatctcct tctaatatca
     4741 gaaagtgctt tttatattcc agattgcttg aattaaactg tttggattaa agaacatata
     4801 tggagtttcc tctctggttt taaataatct ttctttattc agtagctatt aataatttat
     4861 ctcatattca gcgaatattt attgagaata ttgttgagaa tctcttacat gccaggcact
     4921 atactaagtt aatatgcatt cagtatacca gttggtgtga cccagaccaa aggtaacaca
     4981 aagatgaatg agaattcctt caaggcgccg ataatcctag taggagagct aagacacaaa
     5041 actgttgcat gtttttaatc atcaaattaa acttctttcc acgtcctta
//
