LOCUS       NM_022902               3992 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens solute carrier family 30 member 5 (SLC30A5),
            transcript variant 1, mRNA.
ACCESSION   NM_022902
VERSION     NM_022902.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3992)
  AUTHORS   Wagatsuma,T., Shimotsuma,K., Sogo,A., Sato,R., Kubo,N., Ueda,S.,
            Uchida,Y., Kinoshita,M. and Kambe,T.
  TITLE     Zinc transport via ZNT5-6 and ZNT7 is critical for cell surface
            glycosylphosphatidylinositol-anchored protein expression
  JOURNAL   J Biol Chem 298 (6), 102011 (2022)
   PUBMED   35525268
REFERENCE   2  (bases 1 to 3992)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   3  (bases 1 to 3992)
  AUTHORS   Lieberwirth,J.K., Joset,P., Heinze,A., Hentschel,J., Stein,A.,
            Iannaccone,A., Steindl,K., Kuechler,A. and Abou Jamra,R.
  TITLE     Bi-allelic loss of function variants in SLC30A5 as cause of
            perinatal lethal cardiomyopathy
  JOURNAL   Eur J Hum Genet 29 (5), 808-815 (2021)
   PUBMED   33547425
  REMARK    GeneRIF: Bi-allelic loss of function variants in SLC30A5 as cause
            of perinatal lethal cardiomyopathy.
            Erratum:[Eur J Hum Genet. 2021 May;29(5):887. doi:
            10.1038/s41431-021-00843-8.. PMID: 33750920]
REFERENCE   4  (bases 1 to 3992)
  AUTHORS   Rafalo-Ulinska,A., Piotrowska,J., Kryczyk,A., Opoka,W.,
            Sowa-Kucma,M., Misztak,P., Rajkowska,G., Stockmeier,C.A., Datka,W.,
            Nowak,G. and Szewczyk,B.
  TITLE     Zinc transporters protein level in postmortem brain of depressed
            subjects and suicide victims
  JOURNAL   J Psychiatr Res 83, 220-229 (2016)
   PUBMED   27661418
  REMARK    GeneRIF: There was a significant increase in protein levels of ZnT5
            in the prefrontal cortex in Major depression disorder, relative to
            control subjects.
REFERENCE   5  (bases 1 to 3992)
  AUTHORS   Falcon-Perez,J.M. and Dell'Angelica,E.C.
  TITLE     Zinc transporter 2 (SLC30A2) can suppress the vesicular zinc defect
            of adaptor protein 3-depleted fibroblasts by promoting zinc
            accumulation in lysosomes
  JOURNAL   Exp Cell Res 313 (7), 1473-1483 (2007)
   PUBMED   17349999
REFERENCE   6  (bases 1 to 3992)
  AUTHORS   Suzuki,T., Ishihara,K., Migaki,H., Ishihara,K., Nagao,M.,
            Yamaguchi-Iwai,Y. and Kambe,T.
  TITLE     Two different zinc transport complexes of cation diffusion
            facilitator proteins localized in the secretory pathway operate to
            activate alkaline phosphatases in vertebrate cells
  JOURNAL   J Biol Chem 280 (35), 30956-30962 (2005)
   PUBMED   15994300
REFERENCE   7  (bases 1 to 3992)
  AUTHORS   Suzuki,T., Ishihara,K., Migaki,H., Matsuura,W., Kohda,A.,
            Okumura,K., Nagao,M., Yamaguchi-Iwai,Y. and Kambe,T.
  TITLE     Zinc transporters, ZnT5 and ZnT7, are required for the activation
            of alkaline phosphatases, zinc-requiring enzymes that are
            glycosylphosphatidylinositol-anchored to the cytoplasmic membrane
  JOURNAL   J Biol Chem 280 (1), 637-643 (2005)
   PUBMED   15525635
REFERENCE   8  (bases 1 to 3992)
  AUTHORS   Devergnas,S., Chimienti,F., Naud,N., Pennequin,A., Coquerel,Y.,
            Chantegrel,J., Favier,A. and Seve,M.
  TITLE     Differential regulation of zinc efflux transporters ZnT-1, ZnT-5
            and ZnT-7 gene expression by zinc levels: a real-time RT-PCR study
  JOURNAL   Biochem Pharmacol 68 (4), 699-709 (2004)
   PUBMED   15276077
REFERENCE   9  (bases 1 to 3992)
  AUTHORS   Cragg,R.A., Christie,G.R., Phillips,S.R., Russi,R.M., Kury,S.,
            Mathers,J.C., Taylor,P.M. and Ford,D.
  TITLE     A novel zinc-regulated human zinc transporter, hZTL1, is localized
            to the enterocyte apical membrane
  JOURNAL   J Biol Chem 277 (25), 22789-22797 (2002)
   PUBMED   11937503
  REMARK    GeneRIF: A novel zinc-regulated human zinc transporter, hZTL1, is
            localized to the enterocyte apical membrane
REFERENCE   10 (bases 1 to 3992)
  AUTHORS   Kambe,T., Narita,H., Yamaguchi-Iwai,Y., Hirose,J., Amano,T.,
            Sugiura,N., Sasaki,R., Mori,K., Iwanaga,T. and Nagao,M.
  TITLE     Cloning and characterization of a novel mammalian zinc transporter,
            zinc transporter 5, abundantly expressed in pancreatic beta cells
  JOURNAL   J Biol Chem 277 (21), 19049-19055 (2002)
   PUBMED   11904301
  REMARK    GeneRIF: cloning and characterization of ZnT-5 which is expressed
            in pancreatic beta cells
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB090660.1, BX537394.1 and
            AL833716.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_022902.4.
            
            Summary: This gene encodes a member of the SLC30A/ZnT family of
            zinc transporter proteins. ZnT proteins mediate both cellular zinc
            efflux and zinc sequestration into membrane-bound organelles. The
            encoded protein plays a role in the early secretory pathway as a
            heterodimer with zinc transporter 6, and may also regulate zinc
            sequestration into secretory granules of pancreatic beta cells.
            Alternatively spliced transcript variants encoding multiple
            isoforms have been observed for this gene, and a pseudogene of this
            gene is located on the long arm of chromosome 19. [provided by
            RefSeq, Oct 2011].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BX537394.1, SRR1803611.36309.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000396591.8/ ENSP00000379836.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-242               DB090660.1         66-307
            243-3297            BX537394.1         1-3055
            3298-3992           AL833716.1         1988-2682
FEATURES             Location/Qualifiers
     source          1..3992
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q13.1-q13.2"
     gene            1..3992
                     /gene="SLC30A5"
                     /gene_synonym="ZnT-5; ZNT5; ZNTL1; ZTL1"
                     /note="solute carrier family 30 member 5"
                     /db_xref="GeneID:64924"
                     /db_xref="HGNC:HGNC:19089"
                     /db_xref="MIM:607819"
     exon            1..325
                     /gene="SLC30A5"
                     /gene_synonym="ZnT-5; ZNT5; ZNTL1; ZTL1"
                     /inference="alignment:Splign:2.1.0"
     CDS             243..2540
                     /gene="SLC30A5"
                     /gene_synonym="ZnT-5; ZNT5; ZNTL1; ZTL1"
                     /note="isoform 1 is encoded by transcript variant 1; zinc
                     transporter ZTL1; znT-like transporter 1; solute carrier
                     family 30 (zinc transporter), member 5; proton-coupled
                     zinc antiporter SLC30A5"
                     /codon_start=1
                     /product="proton-coupled zinc antiporter SLC30A5 isoform
                     1"
                     /protein_id="NP_075053.2"
                     /db_xref="CCDS:CCDS3996.1"
                     /db_xref="GeneID:64924"
                     /db_xref="HGNC:HGNC:19089"
                     /db_xref="MIM:607819"
                     /translation="MEEKYGGDVLAGPGGGGGLGPVDVPSARLTKYIVLLCFTKFLKA
                     VGLFESYDLLKAVHIVQFIFILKLGTAFFMVLFQKPFSSGKTITKHQWIKIFKHAVAG
                     CIISLLWFFGLTLCGPLRTLLLFEHSDIVVISLLSVLFTSSGGGPAKTRGAAFFIIAV
                     ICLLLFDNDDLMAKMAEHPEGHHDSALTHMLYTAIAFLGVADHKGGVLLLVLALCCKV
                     GFHTASRKLSVDVGGAKRLQALSHLVSVLLLCPWVIVLSVTTESKVESWFSLIMPFAT
                     VIFFVMILDFYVDSICSVKMEVSKCARYGSFPIFISALLFGNFWTHPITDQLRAMNKA
                     AHQESTEHVLSGGVVVSAIFFILSANILSSPSKRGQKGTLIGYSPEGTPLYNFMGDAF
                     QHSSQSIPRFIKESLKQILEESDSRQIFYFLCLNLLFTFVELFYGVLTNSLGLISDGF
                     HMLFDCSALVMGLFAALMSRWKATRIFSYGYGRIEILSGFINGLFLIVIAFFVFMESV
                     ARLIDPPELDTHMLTPVSVGGLIVNLIGICAFSHAHSHAHGASQGSCHSSDHSHSHHM
                     HGHSDHGHGHSHGSAGGGMNANMRGVFLHVLADTLGSIGVIVSTVLIEQFGWFIADPL
                     CSLFIAILIFLSVVPLIKDACQVLLLRLPPEYEKELHIALEKIQKIEGLISYRDPHFW
                     RHSASIVAGTIHIQVTSDVLEQRIVQQVTGILKDAGVNNLTIQVEKEAYFQHMSGLST
                     GFHDVLAMTKQMESMKYCKDGTYIM"
     exon            326..448
                     /gene="SLC30A5"
                     /gene_synonym="ZnT-5; ZNT5; ZNTL1; ZTL1"
                     /inference="alignment:Splign:2.1.0"
     exon            449..515
                     /gene="SLC30A5"
                     /gene_synonym="ZnT-5; ZNT5; ZNTL1; ZTL1"
                     /inference="alignment:Splign:2.1.0"
     exon            516..601
                     /gene="SLC30A5"
                     /gene_synonym="ZnT-5; ZNT5; ZNTL1; ZTL1"
                     /inference="alignment:Splign:2.1.0"
     exon            602..689
                     /gene="SLC30A5"
                     /gene_synonym="ZnT-5; ZNT5; ZNTL1; ZTL1"
                     /inference="alignment:Splign:2.1.0"
     exon            690..777
                     /gene="SLC30A5"
                     /gene_synonym="ZnT-5; ZNT5; ZNTL1; ZTL1"
                     /inference="alignment:Splign:2.1.0"
     exon            778..854
                     /gene="SLC30A5"
                     /gene_synonym="ZnT-5; ZNT5; ZNTL1; ZTL1"
                     /inference="alignment:Splign:2.1.0"
     exon            855..1025
                     /gene="SLC30A5"
                     /gene_synonym="ZnT-5; ZNT5; ZNTL1; ZTL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1026..1314
                     /gene="SLC30A5"
                     /gene_synonym="ZnT-5; ZNT5; ZNTL1; ZTL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1315..1523
                     /gene="SLC30A5"
                     /gene_synonym="ZnT-5; ZNT5; ZNTL1; ZTL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1524..1681
                     /gene="SLC30A5"
                     /gene_synonym="ZnT-5; ZNT5; ZNTL1; ZTL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1682..1811
                     /gene="SLC30A5"
                     /gene_synonym="ZnT-5; ZNT5; ZNTL1; ZTL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1812..2013
                     /gene="SLC30A5"
                     /gene_synonym="ZnT-5; ZNT5; ZNTL1; ZTL1"
                     /inference="alignment:Splign:2.1.0"
     exon            2014..2240
                     /gene="SLC30A5"
                     /gene_synonym="ZnT-5; ZNT5; ZNTL1; ZTL1"
                     /inference="alignment:Splign:2.1.0"
     exon            2241..2369
                     /gene="SLC30A5"
                     /gene_synonym="ZnT-5; ZNT5; ZNTL1; ZTL1"
                     /inference="alignment:Splign:2.1.0"
     exon            2370..3992
                     /gene="SLC30A5"
                     /gene_synonym="ZnT-5; ZNT5; ZNTL1; ZTL1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3165..3170
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC30A5"
                     /gene_synonym="ZnT-5; ZNT5; ZNTL1; ZTL1"
                     /note="hexamer: AATAAA"
     polyA_site      3189
                     /gene="SLC30A5"
                     /gene_synonym="ZnT-5; ZNT5; ZNTL1; ZTL1"
                     /note="major polyA site"
     regulatory      3967..3972
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC30A5"
                     /gene_synonym="ZnT-5; ZNT5; ZNTL1; ZTL1"
                     /note="hexamer: ATTAAA"
     polyA_site      3992
                     /gene="SLC30A5"
                     /gene_synonym="ZnT-5; ZNT5; ZNTL1; ZTL1"
                     /note="major polyA site"
ORIGIN      
        1 gtccctaccg ccgctgcttc ccgggaacct ggcgccgccg gaactgatcg cggcctagtc
       61 ccgacgcgtg tgtgctagtg agccggagcc ggcgacggcg gcagtggcgg cccggcctgc
      121 aggagcccga cggggtctct gccatggggg agtgacgcgc ctgcacccgc tgttccgcgg
      181 cagcggcgag acatgaggag accccgcgac aggggcagcg gcggcggctc gtgagccccg
      241 ggatggagga gaaatacggc ggggacgtgc tggccggccc cggcggcggc ggcggccttg
      301 ggccggtgga cgtacccagc gctcgattaa caaaatatat tgtgttacta tgtttcacta
      361 aatttttgaa ggctgtggga cttttcgaat catatgatct cctaaaagct gttcacattg
      421 ttcagttcat ttttatatta aaacttggga ctgcattttt tatggttttg tttcaaaagc
      481 cattttcttc tgggaaaact attaccaaac accagtggat caaaatattt aaacatgcag
      541 ttgctgggtg tattatttca ctcttgtggt tttttggcct cactctttgt ggaccactaa
      601 ggactttgct gctatttgag cacagtgata ttgttgtcat ttcactactc agtgttttgt
      661 tcaccagttc tggaggagga ccagcaaaga caaggggagc tgcttttttc attattgctg
      721 tgatctgttt attgcttttt gacaatgatg atctcatggc taaaatggct gaacaccctg
      781 aaggacatca tgacagtgct ctaactcata tgctttacac agccattgcc ttcttaggtg
      841 tggcagatca caagggtgga gtattattgc tagtactggc tttgtgttgt aaagttggtt
      901 ttcatacagc ttccagaaag ctctctgtcg acgttggtgg agctaaacgt cttcaagctt
      961 tatctcatct tgtttctgtg cttctcttgt gcccatgggt cattgttctt tctgtgacaa
     1021 ctgagagtaa agtggagtct tggttttctc tcattatgcc ttttgcaacg gttatctttt
     1081 ttgtcatgat cctggatttc tacgtggatt ccatttgttc agtcaaaatg gaagtttcca
     1141 aatgtgctcg ttatggatcc tttcccattt ttattagtgc tctccttttt ggaaattttt
     1201 ggacacatcc aataacagac cagcttcggg ctatgaacaa agcagcacac caggagagca
     1261 ctgaacacgt cctgtctgga ggagtggtag tgagtgctat attcttcatt ttgtctgcca
     1321 atatcttatc atctccctct aagagaggac aaaaaggtac ccttattgga tattctcctg
     1381 aaggaacacc tctttataac ttcatgggtg atgcttttca gcatagctct caatcgatcc
     1441 ctaggtttat taaggaatca ctaaaacaaa ttcttgagga gagtgactct aggcagatct
     1501 tttacttctt gtgcttgaat ctgcttttta cctttgtgga attattctat ggcgtgctga
     1561 ccaatagtct gggcctgatc tcggatggat tccacatgct ttttgactgc tctgctttag
     1621 tcatgggact ttttgctgcc ctgatgagta ggtggaaagc cactcggatt ttctcctatg
     1681 ggtacggccg aatagaaatt ctgtctggat ttattaatgg actttttcta atagtaatag
     1741 cgttttttgt gtttatggag tcagtggcta gattgattga tcctccagaa ttagacactc
     1801 acatgttaac accagtctca gttggagggc tgatagtaaa ccttattggt atctgtgcct
     1861 ttagccatgc ccatagccat gcccatggag cttctcaagg aagctgtcac tcatctgatc
     1921 acagccattc acaccatatg catggacaca gtgaccatgg gcatggtcac agccacggat
     1981 ctgcgggtgg aggcatgaat gctaacatga ggggtgtatt tctacatgtt ttggcagata
     2041 cacttggcag cattggtgtg atcgtatcca cagttcttat agagcagttt ggatggttca
     2101 tcgctgaccc actctgttct ctttttattg ctatattaat atttctcagt gttgttccac
     2161 tgattaaaga tgcctgccag gttctactcc tgagattgcc accagaatat gaaaaagaac
     2221 tacatattgc tttagaaaag atacagaaaa ttgaaggatt aatatcatac cgagaccctc
     2281 atttttggcg tcattctgct agtattgtgg caggaacaat tcatatacag gtgacatctg
     2341 atgtgctaga acaaagaata gtacagcagg ttacaggaat acttaaagat gctggagtaa
     2401 acaatttaac aattcaagtg gaaaaggagg catactttca acatatgtct ggcctaagta
     2461 ctggatttca tgatgttctg gctatgacaa aacaaatgga atccatgaaa tactgcaaag
     2521 atggtactta catcatgtga gataactcaa gaattacccc tggagaataa acaatgaaga
     2581 ttaaatgact cagtatttgt aatattgcca gaaggataaa aattacacat taactgtaca
     2641 gaaacagagt tccctactac tggatcaagg aatctttctt gaaggaaatt taaatacaga
     2701 atgaaacatt aatggtaaaa gtggagtaat tatttaaatt atgtgtataa aaggaatcaa
     2761 attttgagta aacatgatgt attacatcat cttcaaaaat agatatgatg gattctagtg
     2821 aagaccaaaa ttacttctgt ttactttcta tcaggaagca tctccattgt aaatatgtat
     2881 ttacatgttt attacaaaga cccaaatgaa aaatttttag tccatttttt gcatagccta
     2941 aagataaaat aggaataaaa gttctatatt tatggatttt ctgtatataa aactggtttc
     3001 taattataac ttaagtccat taagtaaaat ctgtattgcc actttaaatg taaactaaat
     3061 tatttgggag aaacttcaac cactgatatg agataagcaa tgagaatagg gaagtgtata
     3121 acatcacagt ttttgatgta ttacaaaaat caaccactct ataaaataaa ttttttttac
     3181 ttttggtaat atttgcaaat gaataattaa tttattaggg taaagaactt atactaagtt
     3241 gtgtccatgt tattcattta cttaccatgt tcctttaaag tagaatattt cctttcttgt
     3301 tatatatttg acattccaag ctgcttatca agctggtatc caagcagtgg taagctttca
     3361 tcctttctta gctccataac gttgtgaaac agccagttaa gagaatcgta aataattgtc
     3421 aactcacagt tgaattctct gcctatgtag gtaacttttt tctaatttct ggaacatata
     3481 gatatataag aaatatcaaa gaataggtag ttatttcaaa gtttaataag taaaacttgt
     3541 tcataaacat ttgagcacca tgaaatcaaa ataccctata actactttct atagtcatat
     3601 ctaatttata tttttttcat ttccagttgt aactagatat gtagtaaagt ctgaaaagac
     3661 tttaccatag acaataacat gcagttttat cagcaccaaa gaatgttgtc caaaagaaac
     3721 tttttaatac ctgtctttct atttataaca tctgaatatt ttcattctta tattaagaat
     3781 tttgataagt agattgaatt tagtatgagt actattttct tatatatacc acaatggcaa
     3841 acatgtatta taaatcatat ttttgtctta ccaattttaa tatatgaggg gttttagaaa
     3901 tttgttgtaa gttattttta tattccttgt cttttgcata ttttttggcc aaaatcttca
     3961 atacatatta aaatttttga gtggtgggaa aa
//
