LOCUS       NM_013309               7110 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens solute carrier family 30 member 4 (SLC30A4),
            transcript variant 1, mRNA.
ACCESSION   NM_013309
VERSION     NM_013309.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7110)
  AUTHORS   Escobar,A., Styrpejko,D.J., Ali,S. and Cuajungco,M.P.
  TITLE     Transmembrane 163 (TMEM163) protein interacts with specific
            mammalian SLC30 zinc efflux transporter family members
  JOURNAL   Biochem Biophys Rep 32, 101362 (2022)
   PUBMED   36204728
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7110)
  AUTHORS   Lo,S.T., Parrott,D., Jordan,M.V.C., Joseph,D.B., Strand,D.,
            Lo,U.G., Lin,H., Darehshouri,A. and Sherry,A.D.
  TITLE     The Roles of ZnT1 and ZnT4 in Glucose-Stimulated Zinc Secretion in
            Prostate Epithelial Cells
  JOURNAL   Mol Imaging Biol 23 (2), 230-240 (2021)
   PUBMED   33140261
  REMARK    GeneRIF: The Roles of ZnT1 and ZnT4 in Glucose-Stimulated Zinc
            Secretion in Prostate Epithelial Cells.
REFERENCE   3  (bases 1 to 7110)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 7110)
  AUTHORS   Rafalo-Ulinska,A., Piotrowska,J., Kryczyk,A., Opoka,W.,
            Sowa-Kucma,M., Misztak,P., Rajkowska,G., Stockmeier,C.A., Datka,W.,
            Nowak,G. and Szewczyk,B.
  TITLE     Zinc transporters protein level in postmortem brain of depressed
            subjects and suicide victims
  JOURNAL   J Psychiatr Res 83, 220-229 (2016)
   PUBMED   27661418
  REMARK    GeneRIF: There was a significant increase in protein levels of ZnT4
            in the prefrontal cortex in Major depression disorder, relative to
            control subjects.
REFERENCE   5  (bases 1 to 7110)
  AUTHORS   Zhao,Y., Feresin,R.G., Falcon-Perez,J.M. and Salazar,G.
  TITLE     Differential Targeting of SLC30A10/ZnT10 Heterodimers to
            Endolysosomal Compartments Modulates EGF-Induced MEK/ERK1/2
            Activity
  JOURNAL   Traffic 17 (3), 267-288 (2016)
   PUBMED   26728129
REFERENCE   6  (bases 1 to 7110)
  AUTHORS   Nakano,A., Nakano,H., Hanada,K., Nomura,K. and Uitto,J.
  TITLE     ZNT4 gene is not responsible for acrodermatitis enteropathica in
            Japanese families
  JOURNAL   Hum Genet 110 (2), 201-202 (2002)
   PUBMED   11935329
  REMARK    GeneRIF: not responsible for acrodermatitis enteropathica in
            Japanese families
REFERENCE   7  (bases 1 to 7110)
  AUTHORS   Bleck,O., Ashton,G.H., Mallipeddi,R., South,A.P., Whittock,N.V.,
            McLean,W.H., Atherton,D.J. and McGrath,J.A.
  TITLE     Genomic localization, organization and amplification of the human
            zinc transporter protein gene, ZNT4, and exclusion as a candidate
            gene in different clinical variants of acrodermatitis enteropathica
  JOURNAL   Arch Dermatol Res 293 (8), 392-396 (2001)
   PUBMED   11686514
  REMARK    GeneRIF: Genomic localization, organization; exclusion in variants
            of acrodermatitis enteropathica.
REFERENCE   8  (bases 1 to 7110)
  AUTHORS   Kury,S., Devilder,M.C., Avet-Loiseau,H., Dreno,B. and Moisan,J.P.
  TITLE     Expression pattern, genomic structure and evaluation of the human
            SLC30A4 gene as a candidate for acrodermatitis enteropathica
  JOURNAL   Hum Genet 109 (2), 178-185 (2001)
   PUBMED   11511923
REFERENCE   9  (bases 1 to 7110)
  AUTHORS   Murgia,C., Vespignani,I., Cerase,J., Nobili,F. and Perozzi,G.
  TITLE     Cloning, expression, and vesicular localization of zinc transporter
            Dri 27/ZnT4 in intestinal tissue and cells
  JOURNAL   Am J Physiol 277 (6), G1231-G1239 (1999)
   PUBMED   10600821
REFERENCE   10 (bases 1 to 7110)
  AUTHORS   Huang,L. and Gitschier,J.
  TITLE     A novel gene involved in zinc transport is deficient in the lethal
            milk mouse
  JOURNAL   Nat Genet 17 (3), 292-297 (1997)
   PUBMED   9354792
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC026089.2, AC025580.8 and BC042520.1.
            
            On Nov 22, 2018 this sequence version replaced NM_013309.5.
            
            Summary: Zinc is the second most abundant trace metal in the human
            body. It is an essential element, serving both a structural role,
            as in the formation of zinc fingers in DNA-binding proteins, and a
            catalytic role in metalloenzymes, such as pancreatic
            carboxypeptidases (e.g., MIM 114852), alkaline phosphatases (e.g.,
            MIM 171760), various dehydrogenases, and superoxide dismutases
            (e.g., MIM 147450). SLC30A4, or ZNT4, belongs to the ZNT family of
            zinc transporters. ZNTs are involved in transporting zinc out of
            the cytoplasm and have similar structures, consisting of 6
            transmembrane domains and a histidine-rich cytoplasmic loop (Huang
            and Gitschier, 1997 [PubMed 9354792]).[supplied by OMIM, Mar 2008].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803611.67412.1,
                                           SRR1803615.211527.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000261867.5/ ENSP00000261867.3
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1636              BC026089.2         50-1685
            1637-5250           AC025580.8         147956-151569       c
            5251-7103           BC042520.1         1-1853
            7104-7110           AC025580.8         146096-146102       c
FEATURES             Location/Qualifiers
     source          1..7110
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q21.1"
     gene            1..7110
                     /gene="SLC30A4"
                     /gene_synonym="znT-4; ZNT4"
                     /note="solute carrier family 30 member 4"
                     /db_xref="GeneID:7782"
                     /db_xref="HGNC:HGNC:11015"
                     /db_xref="MIM:602095"
     exon            1..149
                     /gene="SLC30A4"
                     /gene_synonym="znT-4; ZNT4"
                     /inference="alignment:Splign:2.1.0"
     exon            150..654
                     /gene="SLC30A4"
                     /gene_synonym="znT-4; ZNT4"
                     /inference="alignment:Splign:2.1.0"
     CDS             264..1553
                     /gene="SLC30A4"
                     /gene_synonym="znT-4; ZNT4"
                     /note="isoform 1 is encoded by transcript variant 1; zinc
                     transporter 4; solute carrier family 30 (zinc
                     transporter), member 4; probable proton-coupled zinc
                     antiporter SLC30A4"
                     /codon_start=1
                     /product="probable proton-coupled zinc antiporter SLC30A4
                     isoform 1"
                     /protein_id="NP_037441.2"
                     /db_xref="CCDS:CCDS10125.1"
                     /db_xref="GeneID:7782"
                     /db_xref="HGNC:HGNC:11015"
                     /db_xref="MIM:602095"
                     /translation="MAGSGAWKRLKSMLRKDDAPLFLNDTSAFDFSDEAGDEGLSRFN
                     KLRVVVADDGSEAPERPVNGAHPTLQADDDSLLDQDLPLTNSQLSLKVDSCDNCSKQR
                     EILKQRKVKARLTIAAVLYLLFMIGELVGGYIANSLAIMTDALHMLTDLSAIILTLLA
                     LWLSSKSPTKRFTFGFHRLEVLSAMISVLLVYILMGFLLYEAVQRTIHMNYEINGDIM
                     LITAAVGVAVNVIMGFLLNQSGHRHSHSHSLPSNSPTRGSGCERNHGQDSLAVRAAFV
                     HALGDLVQSVGVLIAAYIIRFKPEYKIADPICTYVFSLLVAFTTFRIIWDTVVIILEG
                     VPSHLNVDYIKEALMKIEDVYSVEDLNIWSLTSGKSTAIVHIQLIPGSSSKWEEVQSK
                     ANHLLLNTFGMYRCTIQLQSYRQEVDRTCANCQSSSP"
     exon            655..801
                     /gene="SLC30A4"
                     /gene_synonym="znT-4; ZNT4"
                     /inference="alignment:Splign:2.1.0"
     exon            802..955
                     /gene="SLC30A4"
                     /gene_synonym="znT-4; ZNT4"
                     /inference="alignment:Splign:2.1.0"
     exon            956..1157
                     /gene="SLC30A4"
                     /gene_synonym="znT-4; ZNT4"
                     /inference="alignment:Splign:2.1.0"
     exon            1158..1263
                     /gene="SLC30A4"
                     /gene_synonym="znT-4; ZNT4"
                     /inference="alignment:Splign:2.1.0"
     exon            1264..1398
                     /gene="SLC30A4"
                     /gene_synonym="znT-4; ZNT4"
                     /inference="alignment:Splign:2.1.0"
     exon            1399..7110
                     /gene="SLC30A4"
                     /gene_synonym="znT-4; ZNT4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6951..6956
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC30A4"
                     /gene_synonym="znT-4; ZNT4"
                     /note="hexamer: AATAAA"
     polyA_site      6974
                     /gene="SLC30A4"
                     /gene_synonym="znT-4; ZNT4"
                     /note="major polyA site"
     regulatory      7085..7090
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC30A4"
                     /gene_synonym="znT-4; ZNT4"
                     /note="hexamer: AATAAA"
     polyA_site      7110
                     /gene="SLC30A4"
                     /gene_synonym="znT-4; ZNT4"
ORIGIN      
        1 agacctgggg agccggcctc cagcagcggg cgcggcgggc gcgagcacga ccccactctc
       61 ctgcggccgc gggtggagca gcgcgagccc gcctcgctga gccggccggg ggcggggaga
      121 tgagttgcgg ccccgcggca gcgccccagg atggggaggg acgcgcggca ctgccctcga
      181 gaactggcgc tccggtgaag taggcgccgc cggccgtccg cctcccccaa gccgttccgc
      241 accgcggccg ctcagcctct gccatggccg gctctggcgc gtggaagcgc ctcaaatcta
      301 tgctaaggaa ggatgatgcg ccgctgtttt taaatgacac cagcgccttt gacttctcgg
      361 atgaggcggg ggacgagggg ctttctcggt tcaacaaact tcgagttgtg gtggccgatg
      421 acggttccga agccccggaa aggcctgtta acggggcgca cccgaccctc caggccgacg
      481 atgattcctt actggaccaa gacttacctt tgaccaacag tcagctgagt ttgaaggtgg
      541 actcctgtga caactgcagc aaacagagag agatactgaa gcagagaaag gtgaaagcca
      601 ggttgaccat tgctgccgtt ctgtacttgc ttttcatgat tggagaactt gtaggtggat
      661 acattgcaaa tagcctagca atcatgacag atgcacttca tatgttaact gacctaagcg
      721 ccatcatact caccctgctt gctttgtggc tatcatcaaa atcaccaacc aaaagattca
      781 cctttggatt tcatcgctta gaggttttgt cagctatgat tagtgtgctg ttggtgtata
      841 tacttatggg attcctctta tatgaagctg tgcaaagaac tatccatatg aactatgaaa
      901 taaatggaga tataatgctc atcaccgcag ctgttggagt tgcagttaat gtaataatgg
      961 ggtttctgtt gaaccagtct ggtcaccgtc actcccattc ccactccctg ccttcaaatt
     1021 cccctaccag aggttctggg tgtgaacgta accatgggca ggatagcctg gcagtgagag
     1081 ctgcatttgt acatgctttg ggagatttgg tacagagtgt tggtgtgcta atagctgcat
     1141 acatcatacg attcaagcca gaatacaaga ttgctgaccc catctgtaca tacgtatttt
     1201 cattacttgt ggcttttaca acatttcgaa tcatatggga tacagtagtt ataatactag
     1261 aaggtgtgcc aagccatttg aatgtagact atatcaaaga agccttgatg aaaatagaag
     1321 atgtatattc agtcgaagat ttaaatatct ggtctctcac ttcaggaaaa tctactgcca
     1381 tagttcacat acagctaatt cctggaagtt catctaaatg ggaggaagta cagtccaaag
     1441 caaaccattt attattgaac acatttggca tgtatagatg tactattcag cttcagagtt
     1501 acaggcaaga agtggacaga acttgtgcaa attgtcagag ttctagtccc taattttatg
     1561 tattttggga actcctgcct tatttatcct gcagtcacag acttgagagc aataaatgca
     1621 aacctaaatg agaaaatgga atccctgaca gctgtgtccg tatcaagcat cagtctctca
     1681 aacagttgcc ccagcctgac agtgctagtc tctgtttaat ggtaaaagga gactttgcca
     1741 taattttcag atgaagatgt ttcccaaaca ctgtttacag aatgagatgt gactctacag
     1801 atacctcata gaagacaatc caagatcata cttcattaac ttgacagagt acgtgtctta
     1861 aaggaagcat caagaattca atatttgcat ttaaaaatac tttttaaggc cattttatat
     1921 taagccagtg ctggaaaact gaattttttt tattatgtat aataatctcg acacccagct
     1981 tctggaattg ctgctttctt tttacagaaa ttactaccca acagatttca ggaagtacta
     2041 gtagttatcc caaaagtgga ataagcatgt attcctaagt gtttcagaaa tgttttattt
     2101 cacacataag tcttaatgtt attgttatga ttatacttta taaacaacct tttccagatg
     2161 ctacagggtt ttgaatctca aagttaacat ttttcattat ttgtaatctt agaaccaaat
     2221 ctttatttat tgtggtcact gttattaaat gatttaggaa atactttcaa tattattctg
     2281 aatggctgaa gttagtctta aactcaaatt actatatgat gatttaaaac aaaataaaag
     2341 agcgaggatg ggggttggag tttcaggttt atgtcttccc gacatcactt ttatcattca
     2401 tgaaattgtc ttaaaaaagc aagagactgc aaaatgtaaa cagtaatctt ctgtcccttt
     2461 aagaactgcc aacaatttgt acaaaaaatg tggtacgttg gttcctgcct ccactccagg
     2521 tcatctgtgt gtttagcctt tcagggtaaa ctctagaggg ttcagtttat aattcccacc
     2581 tttcacatat agttcaacaa cattaatcca gagagaattt tatgttttat gatatgggtt
     2641 atgttttatt atatatttta tgttttatga tatgggttag ggattctcca tggactccag
     2701 aaaccctaaa atacaatttt gaggttttcc aataatacca tagcagaaat gtccaagggg
     2761 ttgggggaag atattacttt gagaaaacag aaatgtaaag gatttttgac cttatatatg
     2821 tgtgtggttt tgtttttgtt tttgttcttg agagagtctc actctgtcac ccaggctgga
     2881 gtgcagtggc gtgacctctg ctcactgtaa cctctgcctc ctgggttcaa gtgattcttc
     2941 tgcctcagcc tcccaactag ctgggactac aggtacacca cacccagctc atttttttgt
     3001 atttttagta gagacagggt tttgccacat tggcctgtct ggtcttgaac tcctgacctc
     3061 aggtgatccg cctgccttgg ccttccagag tgctgggatt acagcatgag ccaccatgcc
     3121 tggcctgtat gtgtgtgttt taaagcacta gatagggatg gacattaaat ctgtgttgca
     3181 gggaaactaa acagaggttt ccaaactgaa ggcaacctaa ttgtaaatgc ctgtgttaaa
     3241 gaggcagctt gactgttcat gtttcatttt gcaaccattg gttttgagat tatcttttat
     3301 gcacatttgg agtccctttt caacagtgac agtttcttac acgaagaatg gatatggtta
     3361 ttgggctcct ctaagaatca gagtagggta acaatgtacc aggcaaattg taagttgaaa
     3421 ttctagataa gcatgcagat gacttacaat ataaatgaag aataggaaac attttatctt
     3481 cttaccaagt accttactat aagtaaacct aagataagaa aacccagatt tacctataag
     3541 attgttggga gttaatggtg tcaataaaag gattgatggt ccctctaatg aaacccagta
     3601 gatgtttgtt gaattgaact gaaaatttat gtggccagac acagtggctc atgcctgtaa
     3661 tctcagcatt tggggaggca aaggtggaag tatccctcga ggccaagagt tcatgaccag
     3721 cctggtcttt tgtagagacc ctgtctctac aaaaatataa aaatcagcca ggcgtcgtgc
     3781 acacctgtag tatcagctac ttgtaaggct gtggcagaag tgctttagcc caggaggttg
     3841 aggctgcagt gagccatgtc cacaccattg cactgcagcc tgagtaacaa aatgagaccc
     3901 tatctcaaaa acaaaaagga aaagaaaata tacatgatgg gattcctatt gtgaagtcat
     3961 ttaaaataat gacttgaatt tctcagaaat ttcaggagca tataaactat ttaaatcaaa
     4021 atattcttac atatagaaac caagtaagaa taaatgagag atatttcagt ggacatctgg
     4081 acatatttat ggactttgag tatctagcaa gtagaaagga aaaaaatatt catcatactc
     4141 taatcatttt tttatatcta ttgagcttgt ttcttgtaaa cttttcttta tcttataaag
     4201 gcatatctcg cttttgtatc gacctgttcc ttaaaaaatg tatttgataa aacaggctaa
     4261 aattcatttg agtattgaaa agaattcttt tttttttttt aagatggtgt ctcactgtca
     4321 cccaggctgg agtgcagtgg cacagttggg ctcactgcag cctctgcctc ccaggctcaa
     4381 gtggtcctcc catctcagcc tcccaagtag ctggtaccac aggcatgcac caccacaccc
     4441 agctaatttt ttgtattttt ggtagacaca gtgtttcacc atgttgccca ggctggtctt
     4501 gaactcctga gctcaagtga tctgcccacc tcggcctccc aaagtgctgg gcttatgggc
     4561 atgaaccact gtgcccagcc aaaaagaatc cttttgtaaa atacagaaac actgcaaacc
     4621 tttgtaaatc tttttttttt tttttttttt ttttttttaa tgagatgggg tctccctatg
     4681 ttgcccaggc tggtcttgag ctcctgggct caagaaatcc ttccacctcg ggctcccaaa
     4741 gtgctgagat tacagggtgt gagctaccgc acccagccat gaaaacttct gtaaatctta
     4801 actatcgtgt tctgcttaaa gtgaggtaca cataaagttt cctgtgcttt gtttttgtag
     4861 gaaaaagtac atagtttgta tctttacctt acggagtcta tgagatttga gaatttgatt
     4921 tcactttttg taacttaacc cacagaaaag gacattaact tagcagatag gaccaaggac
     4981 tgaatgactt ctgacaaaaa gcgtttggtc tatccttcac ttgttgagct acaaccatgc
     5041 attacacttc tcagctgagc tctcaaagag ctctatgccc tgtgaaaagc agtggctgag
     5101 ttggatgaac acatagcatt attaattttg cactgggaaa acagattatg acaggaccac
     5161 agaccacaat ataaaaactt ggcagttctt tggtgtgata tattttaatt agtatttgca
     5221 aataatcaga gttacttgtg tacataaacg tgtgtttcac aactatggcc agatgcaacc
     5281 ttttggtctg tttcaggaaa agacctatta ttccactaac aattatgctg ccttagaaac
     5341 ataatgggag tgtaattgaa gaaagcatgt ctcagaaggt tttgatatgc agaactggaa
     5401 gctattgtaa ttcctacata catttccatt agctatgcct tatgtaatgt gagtgcagat
     5461 ttttacaact tagagttccc atcagtgttt ttttgccaca tcaccgggtt tcttatttta
     5521 ctgttttctt ttcaactttg ggtgctttat ttccattctc taaaactaag tttcttgctc
     5581 ttacgagact tagtgttcct tttgaaccca ggtgttccac ctgacagtgt ttgtctttca
     5641 tagactttcc agaatagaca tagtcaagat cagacacgtg agcttctctc tcattttaat
     5701 gtgaggaaaa tcatctttca gagacaaggc accgcttaga aatgtatgtc caggtatgaa
     5761 agaacctttt taaaatggct ggttgttcca gatccagatt tctctgcaca ctggacttcg
     5821 tagagtaagt gtggtagaca aagagactac actgcacaac caccagtgaa tatcattgct
     5881 aagaagactt tgggtcgtgt ttctcagcca ctctcacagc ttttgtagac ttatttgatt
     5941 ttgaaacaag cagttagcta aatctatttt ccttttatgc atatatgtta attggctcaa
     6001 cttaatatgg tgttcttaca gaatatgagc ccatttgaaa taaggtttta ggcaattttg
     6061 ctgttggctc tgatttgtat atagcaaatt taaagttaca gagtgtttcc tagatagaag
     6121 attagttcat ttggttcatt ttgtctttga agcaagccaa gctcatgagc cagttggtta
     6181 tttgtcataa atgaacaccc atcactatat gctatgttga ggggaggcaa gtctgatctt
     6241 cgaataattg ataaagttta atatctttgt agccaaaata caatttgcaa accctaactc
     6301 cagatgtgtc gtatgaatct tgacaaccag gtcttgagat ttgttttact gattgccaat
     6361 caggtatatt atttgtgatg ttcgtgggag catgcaaatt agaagacagt gttgtgggag
     6421 ttcctcagta ttgaattaca tgtgtgcact caggcctgcc agtcactgaa ttctgacttg
     6481 taaagggttt aacctgctgt tccaatcatt gaggaccaat ttgctttttg ataagattgg
     6541 aaaacattta tggagacttt cccagttaaa tctatgacag tgtccactta aatagtgcaa
     6601 tttagtatat tctcagataa ctgcaacaca aaattgaaat gtgccagtat gtcatctttc
     6661 tacctggaag atactgtata tttggaaagt ttatgcttct ctcaataaat acatgttatt
     6721 aaataagcca tatcacagtt taagaaattg tatatacttt atcatatgcc ctttcagaaa
     6781 ccaggtattt tgcatatgat tgattttaga aagattttga agctggggtt tgtccatgtt
     6841 aattaagatc aaagtatata tatatatata tatatgtgct gtatttgcaa ctttcacatt
     6901 gtaatttcct atacacttat taaagtattg ttttgccatg tggtttatta aataaaaatg
     6961 tacagtctct taaatatctg ctctttttat taagtaatat tagtaggcct aaaaacattg
     7021 ttcttaaaag aaaatctttt ataattataa tgtcatttta taatgccctc ttatatgttt
     7081 aagaaataaa actgaaaaaa atcttctgga
//
