LOCUS       NM_003459               2936 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens solute carrier family 30 member 3 (SLC30A3),
            transcript variant 1, mRNA.
ACCESSION   NM_003459
VERSION     NM_003459.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2936)
  AUTHORS   Escobar,A., Styrpejko,D.J., Ali,S. and Cuajungco,M.P.
  TITLE     Transmembrane 163 (TMEM163) protein interacts with specific
            mammalian SLC30 zinc efflux transporter family members
  JOURNAL   Biochem Biophys Rep 32, 101362 (2022)
   PUBMED   36204728
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2936)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 2936)
  AUTHORS   Zhang,L., Liu,Z., Dong,Y. and Kong,L.
  TITLE     Epigenetic targeting of SLC30A3 by HDAC1 is related to the
            malignant phenotype of glioblastoma
  JOURNAL   IUBMB Life 73 (5), 784-799 (2021)
   PUBMED   33715270
  REMARK    GeneRIF: Epigenetic targeting of SLC30A3 by HDAC1 is related to the
            malignant phenotype of glioblastoma.
REFERENCE   4  (bases 1 to 2936)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 2936)
  AUTHORS   Enache,D., Pereira,J.B., Jelic,V., Winblad,B., Nilsson,P.,
            Aarsland,D. and Bereczki,E.
  TITLE     Increased Cerebrospinal Fluid Concentration of ZnT3 Is Associated
            with Cognitive Impairment in Alzheimer's Disease
  JOURNAL   J Alzheimers Dis 77 (3), 1143-1155 (2020)
   PUBMED   32925049
  REMARK    GeneRIF: Increased Cerebrospinal Fluid Concentration of ZnT3 Is
            Associated with Cognitive Impairment in Alzheimer's Disease.
REFERENCE   6  (bases 1 to 2936)
  AUTHORS   Falcon-Perez,J.M. and Dell'Angelica,E.C.
  TITLE     Zinc transporter 2 (SLC30A2) can suppress the vesicular zinc defect
            of adaptor protein 3-depleted fibroblasts by promoting zinc
            accumulation in lysosomes
  JOURNAL   Exp Cell Res 313 (7), 1473-1483 (2007)
   PUBMED   17349999
REFERENCE   7  (bases 1 to 2936)
  AUTHORS   Seve,M., Chimienti,F., Devergnas,S. and Favier,A.
  TITLE     In silico identification and expression of SLC30 family genes: an
            expressed sequence tag data mining strategy for the
            characterization of zinc transporters' tissue expression
  JOURNAL   BMC Genomics 5 (1), 32 (2004)
   PUBMED   15154973
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 2936)
  AUTHORS   Salazar,G., Love,R., Werner,E., Doucette,M.M., Cheng,S., Levey,A.
            and Faundez,V.
  TITLE     The zinc transporter ZnT3 interacts with AP-3 and it is
            preferentially targeted to a distinct synaptic vesicle
            subpopulation
  JOURNAL   Mol Biol Cell 15 (2), 575-587 (2004)
   PUBMED   14657250
REFERENCE   9  (bases 1 to 2936)
  AUTHORS   Iguchi,K., Otsuka,T., Usui,S., Ishii,K., Onishi,T., Sugimura,Y. and
            Hirano,K.
  TITLE     Zinc and metallothionein levels and expression of zinc transporters
            in androgen-independent subline of LNCaP cells
  JOURNAL   J Androl 25 (1), 154-161 (2004)
   PUBMED   14662799
  REMARK    GeneRIF: AIDL cells exhibited a lower expression of zinc
            transporter 1 (ZnT1) and higher expression of ZnT3 than LNCaP
            cells.
REFERENCE   10 (bases 1 to 2936)
  AUTHORS   Palmiter,R.D., Cole,T.B., Quaife,C.J. and Findley,S.D.
  TITLE     ZnT-3, a putative transporter of zinc into synaptic vesicles
  JOURNAL   Proc Natl Acad Sci U S A 93 (25), 14934-14939 (1996)
   PUBMED   8962159
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC028358.2 and AC013413.6.
            
            On May 17, 2019 this sequence version replaced NM_003459.4.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660809.189726.1,
                                           SRR1803613.412219.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1968189 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000233535.9/ ENSP00000233535.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2048              BC028358.2         34-2081
            2049-2936           AC013413.6         36677-37564         c
FEATURES             Location/Qualifiers
     source          1..2936
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p23.3"
     gene            1..2936
                     /gene="SLC30A3"
                     /gene_synonym="ZNT3"
                     /note="solute carrier family 30 member 3"
                     /db_xref="GeneID:7781"
                     /db_xref="HGNC:HGNC:11014"
                     /db_xref="MIM:602878"
     exon            1..236
                     /gene="SLC30A3"
                     /gene_synonym="ZNT3"
                     /inference="alignment:Splign:2.1.0"
     CDS             142..1308
                     /gene="SLC30A3"
                     /gene_synonym="ZNT3"
                     /note="isoform a is encoded by transcript variant 1; zinc
                     transporter 3; zinc transporter ZnT-3; znT-3; solute
                     carrier family 30 (zinc transporter), member 3; probable
                     proton-coupled zinc antiporter SLC30A3"
                     /codon_start=1
                     /product="probable proton-coupled zinc antiporter SLC30A3
                     isoform a"
                     /protein_id="NP_003450.2"
                     /db_xref="CCDS:CCDS1743.1"
                     /db_xref="GeneID:7781"
                     /db_xref="HGNC:HGNC:11014"
                     /db_xref="MIM:602878"
                     /translation="MEPSPAAGGLETTRLVSPRDRGGAGGSLRLKSLFTEPSEPLPEE
                     SKPVEMPFHHCHRDPLPPPGLTPERLHARRQLYAACAVCFVFMAGEVVGGYLAHSLAI
                     MTDAAHLLADVGSMMGSLFSLWLSTRPATRTMTFGWHRSETLGALASVVSLWMVTGIL
                     LYLAFVRLLHSDYHIEGGAMLLTASIAVCANLLMAFVLHQAGPPHSHGSRGAEYAPLE
                     EGPEEPLPLGNTSVRAAFVHVLGDLLQSFGVLAASILIYFKPQYKAADPISTFLFSIC
                     ALGSTAPTLRDVLRILMEGTPRNVGFEPVRDTLLSVPGVRATHELHLWALTLTYHVAS
                     AHLAIDSTADPEAVLAEASSRLYSRFGFSSCTLQVEQYQPEMAQCLRCQEPPQA"
     exon            237..418
                     /gene="SLC30A3"
                     /gene_synonym="ZNT3"
                     /inference="alignment:Splign:2.1.0"
     exon            419..565
                     /gene="SLC30A3"
                     /gene_synonym="ZNT3"
                     /inference="alignment:Splign:2.1.0"
     exon            566..719
                     /gene="SLC30A3"
                     /gene_synonym="ZNT3"
                     /inference="alignment:Splign:2.1.0"
     exon            720..918
                     /gene="SLC30A3"
                     /gene_synonym="ZNT3"
                     /inference="alignment:Splign:2.1.0"
     exon            919..1024
                     /gene="SLC30A3"
                     /gene_synonym="ZNT3"
                     /inference="alignment:Splign:2.1.0"
     exon            1025..1159
                     /gene="SLC30A3"
                     /gene_synonym="ZNT3"
                     /inference="alignment:Splign:2.1.0"
     exon            1160..2936
                     /gene="SLC30A3"
                     /gene_synonym="ZNT3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2027..2032
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC30A3"
                     /gene_synonym="ZNT3"
                     /note="hexamer: AATAAA"
     polyA_site      2048
                     /gene="SLC30A3"
                     /gene_synonym="ZNT3"
                     /note="major polyA site"
ORIGIN      
        1 agtcgctgca gttcgctcca ctctggtggc cccgccgccc tgcggggatc ccgggggtcg
       61 gcgggctgct cggacttggc gcggggccgg cccggcctct ctcttcctcg gtggggccta
      121 gacggtcggg gcaccgggaa catggagccc tctccagccg ctgggggctt ggagaccact
      181 cgcctggtga gcccccggga ccgcggtggc gccggaggca gcctgcgttt gaagagtctc
      241 ttcacagagc cctcagagcc cctccctgag gagtccaaac ctgtggagat gcccttccac
      301 cactgccaca gggaccccct tccgccgccg ggccttaccc ctgagaggct gcatgcacgg
      361 aggcagctat atgctgcctg tgccgtttgc tttgtcttca tggctgggga ggtggtcggc
      421 gggtatctgg cacacagcct ggccatcatg accgatgcag cccacttgct ggcggatgtg
      481 ggcagcatga tgggcagcct cttctccctc tggctctcca cccgtccagc cacccgcacc
      541 atgacctttg gctggcaccg ttcagagact ctgggggctt tggcctctgt ggtctccctc
      601 tggatggtca ctggcatcct cctgtacctg gccttcgtcc gcctgctgca cagcgactac
      661 cacatcgagg ggggtgccat gctgctgacc gccagcatcg cagtctgtgc caacctgtta
      721 atggcctttg tgctgcacca ggctgggccc ccccacagcc acgggtctag gggagcagag
      781 tatgcaccgc tggaggaggg gcctgaagag cccctgcccc tggggaacac cagcgtccgg
      841 gcggcatttg tgcacgtgct gggggacctc ctgcagagct ttggggtact ggctgcctcc
      901 atcctcatct acttcaagcc tcaatacaag gcagccgacc ccatcagcac cttcctcttc
      961 tccatctgtg cccttggatc caccgctccc accctccgag acgttcttcg aatcctcatg
     1021 gaaggtaccc cccgcaatgt ggggttcgaa cctgtgcggg atacgctgtt gtcggtgcca
     1081 ggagtccggg caacccatga gctgcacctg tgggccctta cgctcactta ccatgttgcc
     1141 tctgcacacc tggccatcga ctccaccgct gaccctgaag ccgtcctggc tgaagcctca
     1201 tcccggctct actcccggtt tggattctcc agctgcaccc tgcaggtcga gcagtatcag
     1261 ccggagatgg cccagtgcct gcgctgccag gaaccccccc aagcctgagc catggccctg
     1321 ccctcacccc actgccaggc cgaggctcag ccccagactc tcagcatctg ctgccctgat
     1381 cacagagacg ggaccgagcc aggtccatac cccttcctct ctccctccta ccacctgcca
     1441 gtttccccag cctcagcccc agccccagcc ccagtgggca agaccaaagt gtggcgggga
     1501 gtggggtggg agtcagggga atagatgtga ctagttcagg ggcggggact cccaggcctc
     1561 agtgtggcag ggtgtgttga aggcctgtgg tgccatctcc ccatggttca tgtggagcca
     1621 cgaacatcct ttccctgcag tccatttgtc tgtgtggcag gctggctggc tgggggcatc
     1681 tgcctgtcta tgtgctgttg gtgtgcctat gcctggggga ggtcagtagg ggccccctcc
     1741 ccacatggcc ctcgctctgt ctatgcaggg gccccaaagc ccgcactttg tccgtgtgtc
     1801 ttagccctgt ggttttgtct gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt
     1861 tcttggtgct gtggcctgtg tgtctctgtg cctatgtggc tgtgctatgg tttctatgag
     1921 tctgctccat ccatgtgtct gtttgggggt ctatctctcc atccctctgt tggtgctgtg
     1981 cccttggcta tccctgaaag agggaggact ccgctgcagc tccaccaata aacttgtgtc
     2041 tcactgcatc tttcagcctg tgtgctgact cctcaggagg gggaagtcaa ataggtcact
     2101 tgagaacaac agaatccctc ctgtcccttc ccagcctctg gagtgacctc ccacagacct
     2161 cctgtccctt cccagcccct ccaccctcag atggagggta aaagccacca gtctctttac
     2221 tccccttccc ctggctcaca gcatgcctgg gtccttggct cagggacagt cccatgtgcc
     2281 ctgggcttgg ttgcaggaga atgctggaag gtaaggagcc aaggaatccc tgggagtcag
     2341 tcgttctcag aggtccctgc atgccagtgg gcctcaggct ggctggaggg aggctgggtc
     2401 cctttgaggg agaatggcta gaccatagca ctgatgtggg cttggttctc aggccatcta
     2461 aggtgtccag cggtagggac ccctcaaccc tgatagcagc caaccctgag tccaggttta
     2521 ggctgtgaac accaaggacc tcttttacac ctattccccc tttgtcttaa gaactgcata
     2581 ttttgacaca ttaagtctta aaatcaggct cattaaggga ttgttgattt tctctttaaa
     2641 aaaaatcaaa ctcaagctgg acatagtggc ctgtgcctgt aatctcagcc ctttggaggc
     2701 tgaggcagga ggattgtttg agcccaggag ttcaagacca gcctgggcaa cctagggaaa
     2761 cccctgtctc tacaaataat ttaaaaatta gctgggtgtg gtggtgcata cctgtagtcc
     2821 cagctattca ggaggctgag gcaggaggat tgcctgagcc caggaggtca aggcagcagt
     2881 cagccatgat catgccactg cacttcagcc tgggcaacag agcaagacct tgtctc
//
