LOCUS       NM_018713               6579 bp    mRNA    linear   PRI 12-FEB-2025
DEFINITION  Homo sapiens solute carrier family 30 member 10 (SLC30A10),
            transcript variant 1, mRNA.
ACCESSION   NM_018713
VERSION     NM_018713.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6579)
  AUTHORS   Verma,A.K., Naseeb,M.A., Basaqr,R.O., Albajri,E.A., Khan,M.I.,
            Dev,K. and Beg,M.M.A.
  TITLE     Cell-free SLC30A10 messenger ribonucleic acid (mRNA) expression and
            their association with vitamin-D level among non-small cell lung
            cancer (NSCLC) patients
  JOURNAL   J Cancer Res Ther 19 (Suppl 2), S764-S769 (2023)
   PUBMED   38384053
  REMARK    GeneRIF: Cell-free SLC30A10 messenger ribonucleic acid (mRNA)
            expression and their association with vitamin-D level among
            non-small cell lung cancer (NSCLC) patients.
REFERENCE   2  (bases 1 to 6579)
  AUTHORS   Gurol,K.C., Li,D., Broberg,K. and Mukhopadhyay,S.
  TITLE     Manganese efflux transporter SLC30A10 missense polymorphism T95I
            associated with liver injury retains manganese efflux activity
  JOURNAL   Am J Physiol Gastrointest Liver Physiol 324 (1), G78-G88 (2023)
   PUBMED   36414535
  REMARK    GeneRIF: Manganese efflux transporter SLC30A10 missense
            polymorphism T95I associated with liver injury retains manganese
            efflux activity.
REFERENCE   3  (bases 1 to 6579)
  AUTHORS   Seidelin,A.S., Nordestgaard,B.G., Tybjaerg-Hansen,A., Yaghootkar,H.
            and Stender,S.
  TITLE     A rare genetic variant in the manganese transporter SLC30A10 and
            elevated liver enzymes in the general population
  JOURNAL   Hepatol Int 16 (3), 702-711 (2022)
   PUBMED   35397106
  REMARK    GeneRIF: A rare genetic variant in the manganese transporter
            SLC30A10 and elevated liver enzymes in the general population.
REFERENCE   4  (bases 1 to 6579)
  AUTHORS   Tuschl,K., Clayton,P.T., Gospe,S.M. Jr., Gulab,S., Ibrahim,S.,
            Singhi,P., Aulakh,R., Ribeiro,R.T., Barsottini,O.G., Zaki,M.S., Del
            Rosario,M.L., Dyack,S., Price,V., Rideout,A., Gordon,K.,
            Wevers,R.A., Chong,W.K. and Mills,P.B.
  TITLE     Syndrome of hepatic cirrhosis, dystonia, polycythemia, and
            hypermanganesemia caused by mutations in SLC30A10, a manganese
            transporter in man
  JOURNAL   Am J Hum Genet 90 (3), 457-466 (2012)
   PUBMED   22341972
  REMARK    GeneRIF: This work has confirmed that SLC30A10 functions as a Mn
            transporter in humans that, when defective, causes Mn accumulation
            in liver and brain.
            Erratum:[Am J Hum Genet. 2016 Aug 4;99(2):521. doi:
            10.1016/j.ajhg.2016.07.015.. PMID: 27486784]
REFERENCE   5  (bases 1 to 6579)
  AUTHORS   Quadri,M., Federico,A., Zhao,T., Breedveld,G.J., Battisti,C.,
            Delnooz,C., Severijnen,L.A., Di Toro Mammarella,L., Mignarri,A.,
            Monti,L., Sanna,A., Lu,P., Punzo,F., Cossu,G., Willemsen,R.,
            Rasi,F., Oostra,B.A., van de Warrenburg,B.P. and Bonifati,V.
  TITLE     Mutations in SLC30A10 cause parkinsonism and dystonia with
            hypermanganesemia, polycythemia, and chronic liver disease
  JOURNAL   Am J Hum Genet 90 (3), 467-477 (2012)
   PUBMED   22341971
  REMARK    GeneRIF: SLC30A10 mutations cause a treatable recessive disease
            with pleomorphic phenotype, and provide compelling evidence that
            SLC30A10 plays a pivotal role in manganese transport.
REFERENCE   6  (bases 1 to 6579)
  AUTHORS   Patrushev,N., Seidel-Rogol,B. and Salazar,G.
  TITLE     Angiotensin II requires zinc and downregulation of the zinc
            transporters ZnT3 and ZnT10 to induce senescence of vascular smooth
            muscle cells
  JOURNAL   PLoS One 7 (3), e33211 (2012)
   PUBMED   22427991
REFERENCE   7  (bases 1 to 6579)
  AUTHORS   Wang,L., McDonnell,S.K., Hebbring,S.J., Cunningham,J.M., St
            Sauver,J., Cerhan,J.R., Isaya,G., Schaid,D.J. and Thibodeau,S.N.
  TITLE     Polymorphisms in mitochondrial genes and prostate cancer risk
  JOURNAL   Cancer Epidemiol Biomarkers Prev 17 (12), 3558-3566 (2008)
   PUBMED   19064571
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   8  (bases 1 to 6579)
  AUTHORS   Seve,M., Chimienti,F., Devergnas,S. and Favier,A.
  TITLE     In silico identification and expression of SLC30 family genes: an
            expressed sequence tag data mining strategy for the
            characterization of zinc transporters' tissue expression
  JOURNAL   BMC Genomics 5 (1), 32 (2004)
   PUBMED   15154973
  REMARK    GeneRIF: identified the full-length sequences of SLC30A10,
            extending the SLC30 family to ten members; used an expressed
            sequence tag (EST) data mining strategy to determine the pattern of
            ZnT genes expression in tissues
            Publication Status: Online-Only
REFERENCE   9  (bases 1 to 6579)
  AUTHORS   Tuschl,K., Clayton,P.T., Gospe,S.M. Jr. and Mills,P.B.
  TITLE     Hypermanganesemia with Dystonia 1
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   22934317
REFERENCE   10 (bases 1 to 6579)
  AUTHORS   Klein,C., Lohmann,K., Marras,C. and Munchau,A.
  TITLE     Hereditary Dystonia Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301334
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC093562.3.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 30, 2019 this sequence version replaced NM_018713.2.
            
            Summary: This gene is highly expressed in the liver and is
            inducible by manganese. Its protein product appears to be critical
            in maintaining manganese levels, and has higher specificity for
            manganese than zinc. Loss of function mutations appear to result in
            a pleomorphic phenotype, including dystonia and adult-onset
            parkinsonism. Alternatively spliced transcript variants have been
            observed for this gene. [provided by RefSeq, Mar 2012].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660807.240694.1,
                                           SRR1660805.253701.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000366926.4/ ENSP00000355893.4
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-757               AC093562.3         185930-186686       c
            758-835             AC093562.3         185157-185234       c
            836-1075            AC093562.3         176384-176623       c
            1076-6579           AC093562.3         168574-174077       c
FEATURES             Location/Qualifiers
     source          1..6579
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q41"
     gene            1..6579
                     /gene="SLC30A10"
                     /gene_synonym="HMDPC; HMNDYT1; ZnT-10; ZNT10; ZNT8; ZRC1"
                     /note="solute carrier family 30 member 10"
                     /db_xref="GeneID:55532"
                     /db_xref="HGNC:HGNC:25355"
                     /db_xref="MIM:611146"
     exon            1..757
                     /gene="SLC30A10"
                     /gene_synonym="HMDPC; HMNDYT1; ZnT-10; ZNT10; ZNT8; ZRC1"
                     /inference="alignment:Splign:2.1.0"
     CDS             118..1575
                     /gene="SLC30A10"
                     /gene_synonym="HMDPC; HMNDYT1; ZnT-10; ZNT10; ZNT8; ZRC1"
                     /note="isoform 1 is encoded by transcript variant 1; zinc
                     transporter 8; manganese transporter SLC30A10; zinc
                     resistance conferring homolog; calcium/manganese
                     antiporter SLC30A10"
                     /codon_start=1
                     /product="calcium/manganese antiporter SLC30A10 isoform 1"
                     /protein_id="NP_061183.2"
                     /db_xref="CCDS:CCDS31026.1"
                     /db_xref="GeneID:55532"
                     /db_xref="HGNC:HGNC:25355"
                     /db_xref="MIM:611146"
                     /translation="MGRYSGKTCRLLFMLVLTVAFFVAELVSGYLGNSIALLSDSFNM
                     LSDLISLCVGLSAGYIARRPTRGFSATYGYARAEVVGALSNAVFLTALCFTIFVEAVL
                     RLARPERIDDPELVLIVGVLGLLVNVVGLLIFQDCAAWFACCLRGRSRRLQQRQQLAE
                     GCVPGAFGGPQGAEDPRRAADPTAPGSDSAVTLRGTSVERKREKGATVFANVAGDSFN
                     TQNEPEDMMKKEKKSEALNIRGVLLHVMGDALGSVVVVITAIIFYVLPLKSEDPCNWQ
                     CYIDPSLTVLMVIIILSSAFPLIKETAAILLQMVPKGVNMEELMSKLSAVPGISSVHE
                     VHIWELVSGKIIATLHIKYPKDRGYQDASTKIREIFHHAGIHNVTIQFENVDLKEPLE
                     QKDLLLLCNSPCISKGCAKQLCCPPGALPLAHVNGCAEHNGGPSLDTYGSDGLSRRDA
                     REVAIEVSLDSCLSDHGQSLNKTQEDQCYVNRTHF"
     exon            758..835
                     /gene="SLC30A10"
                     /gene_synonym="HMDPC; HMNDYT1; ZnT-10; ZNT10; ZNT8; ZRC1"
                     /inference="alignment:Splign:2.1.0"
     exon            836..1075
                     /gene="SLC30A10"
                     /gene_synonym="HMDPC; HMNDYT1; ZnT-10; ZNT10; ZNT8; ZRC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1076..6579
                     /gene="SLC30A10"
                     /gene_synonym="HMDPC; HMNDYT1; ZnT-10; ZNT10; ZNT8; ZRC1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2719..2724
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC30A10"
                     /gene_synonym="HMDPC; HMNDYT1; ZnT-10; ZNT10; ZNT8; ZRC1"
                     /note="hexamer: AATAAA"
     polyA_site      2757
                     /gene="SLC30A10"
                     /gene_synonym="HMDPC; HMNDYT1; ZnT-10; ZNT10; ZNT8; ZRC1"
                     /note="major polyA site"
     regulatory      6558..6563
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC30A10"
                     /gene_synonym="HMDPC; HMNDYT1; ZnT-10; ZNT10; ZNT8; ZRC1"
                     /note="hexamer: AATAAA"
     polyA_site      6579
                     /gene="SLC30A10"
                     /gene_synonym="HMDPC; HMNDYT1; ZnT-10; ZNT10; ZNT8; ZRC1"
                     /note="major polyA site"
ORIGIN      
        1 aatctgggag gcgggtaccg ggcctcacgg atccgcgccg cgccccccac ctgtggctgc
       61 gcgcggggtg ggctgcgctc ccctgggcgg cgccgggcgc ccggggctgg tggcgagatg
      121 ggccgctact ctggcaagac gtgccggctg ctcttcatgc tggtgctcac cgtcgccttc
      181 ttcgtggcgg agctggtctc cggctacctg ggcaactcca tcgcgctgct ctccgactcc
      241 ttcaacatgc tctccgacct gatctcgctg tgcgtgggcc tgagcgccgg ctacatcgcc
      301 cggcgcccca cccggggctt cagcgccacc tacggctacg cccgcgccga ggtggtgggc
      361 gcgctgagca acgcggtctt cctcaccgcg ctctgcttca ccatcttcgt ggaggccgtg
      421 ctgcgcctgg cccggcccga gcgcatcgat gaccccgagc tggtgctcat cgtcggcgtc
      481 ctggggctgt tggtcaacgt ggtggggctg ctcatcttcc aggactgcgc cgcctggttc
      541 gcgtgctgcc tccggggacg cagtcgccgc ctgcagcagc ggcagcagct ggcggagggc
      601 tgtgtccccg gcgctttcgg ggggcctcag ggcgcggagg acccgcggcg cgcggcggac
      661 ccgacagccc caggctcgga ctcggccgta accctccggg ggacctcggt ggaaaggaag
      721 cgggagaagg gggcgaccgt gttcgcaaac gtagcaggtg attccttcaa cacccagaat
      781 gagccagaag acatgatgaa aaaagagaaa aagtctgaag ctctgaatat cagaggtgta
      841 cttttgcatg tgatgggaga tgccctgggg tccgtggttg tggtcatcac ggccatcata
      901 ttctatgtgc ttcccctgaa gagtgaggac ccgtgtaact ggcagtgtta cattgacccc
      961 agcctgactg tcctcatggt catcatcatt ttgtcatctg ccttcccgct tatcaaggag
     1021 accgctgcca ttctgctaca gatggtccca aaaggagtca acatggaaga gctgatgagt
     1081 aaactctctg ctgtgcctgg aattagcagt gtacatgaag tgcacatctg ggaacttgta
     1141 agtggaaaga ttattgccac cctgcacatc aagtatccta aggacagggg atatcaagat
     1201 gccagcacaa aaattcgaga aatcttccac catgcgggaa tccacaatgt gaccatccag
     1261 tttgaaaatg tggacttgaa ggaacccctg gagcagaagg acttactgtt gctctgcaac
     1321 tcaccctgca tctccaaggg ctgtgctaag cagctgtgtt gtccccccgg ggcactgcct
     1381 ctggctcacg tcaatggctg tgctgagcac aatggtgggc cctctctaga cacatacgga
     1441 agtgatggcc tcagtagaag agacgcaaga gaagtggcta ttgaagtgtc tttggatagc
     1501 tgtctgagtg accacggaca aagtcttaac aaaactcagg aggaccaatg ttatgtcaac
     1561 agaacgcatt tttaatctgg tactcacata atcagaccat atagacgagg cactttggaa
     1621 ccacaagctt ggctcacaaa aagagctttc tgggttgtag gcccagacta gacttgcagc
     1681 atgcatgctc tgtgttcact aggggttggc tgtttgggat tttagttaaa cgtgtctgtg
     1741 aatttttatg taactaactc ctttccattc ccctgggtgt ctcatgctgc tctttgactg
     1801 tttcagcttg aacatgcatt ttctaaagca aactgcacta gtgtatatat cagggacatt
     1861 aaagtctggg actggggctc aatagctgcg gatacagtgt tcaaagaagt tcttgtttct
     1921 aaactgatta gaacttctag ctaatgctca ggtgagatca tagcttaaat acattgaaaa
     1981 aactaaagta ccacaatagc tgtatttttc ccaatcccct taacgatcat aaaagaggca
     2041 agttaagtat ttctggcact gaagaaatat cttttttctt tgattcattt ttgaataaat
     2101 ataaaatgaa taactattaa ggtagaaaat attctcagaa cattctagag gaggtaaagg
     2161 ttagtaggag ggcgttggcc atctctacat tttgtgaggt gagagaaaac taatgtttac
     2221 tttctgctgt gaactgaact gcagctatag aatgtttcaa atgcttaaat atataataca
     2281 tttttttcca tggaagtgag ggaatatttc agtttcctga agtatgacac aaatactcat
     2341 atactgtctt ttagagtcag tatagttgga gctgttttca tttagtgctt tgataatgat
     2401 ttacttattt ttccaaattt cgtttgaatt ttctttcata tgattgcatt gatctatgca
     2461 gcatttacca gaaaagagta ttcctgggat agcagaatgc ataacactga gtgttaattc
     2521 ttgtgaaata aataagctag actgccttct ctttaattag acatatttta aagtatttat
     2581 tatagttgtc aactagtaac tcaatgaaaa agttgatgcc caagggagaa atgagaatta
     2641 gcttaattgc tgcctttaat gtgtttttga ggaacttaaa attttctttc atgtcgctga
     2701 tccatattac caagttcaaa taaaattttt ataatcggat tcagacccat aaccaaacta
     2761 tgttggtagt agagaagcat ctgtcatgtt tttaacacat tgctcagaca tcagtattta
     2821 aatcagaaca gtctcacagg tatgagaaaa tgggaagtgc ctcactagac aactagtatc
     2881 atctctggta gactgcaaga ttgtctgaaa ataaccatct cttagtgtgt aaagtcctgt
     2941 tcagaatctg cacagggttt ttcagaggtg ctgggttgat aatgaaggca gcatccacag
     3001 aacaaacatc atatttaaac aatgtatctt agtcctaaat ttgaaggcta aaataaataa
     3061 gcagctatga tccgtaggat aggaaattat tatttttttc tttttttgta gagacagggt
     3121 ctcgctatgt tgcccagctg gccttgaact cctagcctca agtgattctc tcgccttggc
     3181 ctcccaaagc actgggagaa cagtcatgag ccactgcacc tggccaggaa attctttatt
     3241 ccttgaaaat gtattatctg agtttaaatt ggctgtgaag taggtaaata gaaaaatgcc
     3301 taaaaatgtt tttatttcta ggagcttatt gggctaggtt atatgccctt tataagctca
     3361 aaggggttaa taagtaagaa tttctatttt tagtattaaa agtgtggcat gtactcacac
     3421 aaaacagtgc atcctcttaa gaaacttggc atggagatca gtgggccaga ttctcctaca
     3481 taaacattgg ttgaaattcc ttagagccaa aaaagaaatt tttctctgac ttccaaattt
     3541 gaaggtctaa tttgatttca catcattctg cctttattaa aagggaaaat tataatttca
     3601 cagtttttgt gcaactggct gaaggaatgg atattagttt gcacttaaac actgttcttt
     3661 aatctctaaa atatttttct gggtaagaaa aggcacttaa ttccactgta attaaaccta
     3721 acttcagaaa agtatcttga tagacagtta taccagatta tggcctggag tcaatatgaa
     3781 gtaatacctt tttaagacag tttggctgac tgcatttaat aatgtccaat catgctaagt
     3841 gcaataattt tgtattgggt tgagtggctt gcatttgcca cctgtggcac tgtgatgcct
     3901 gctgtatgct attttcactt gggtttcact ctctctttaa ttgtcctgcc ttttaattct
     3961 cccaaggaaa tacaagagtt ttctttttcc ctttaaatca gccctgcttg gtggcagtag
     4021 cagctgataa atagatttaa aacagcactg ttttccttta agattagaaa aacactggca
     4081 ctcagtttgg tgctcctgta tacttaggtt atttacagaa aatcccctcc tccccgcctt
     4141 tttttaaaga actgacataa tttttttttg gtttgtttgt ttgtttcttt gagacggagt
     4201 cttgctctgt cgcccaggct ggagtgcagt ggtgctatct cggctcactg caagctctgc
     4261 ctcctgggtt cacgccattc tcctgcctca gcctcccgag tagctgggat tacaggtgct
     4321 cgccaccatg cccggctaat tttttgtatt tttagtagag accgggtttc accatgttag
     4381 ccaggatggt ctcgatctcc tgaccttgtg atccacccac ctcggcctcc caaagtgctg
     4441 ggattacagg cgtaagccac tgcgcccggc cagaactgac ataattttta aagtctacgg
     4501 catattttgt gtgtcagctc agggaccagt tgtcctgtgt gctcacctgg ccttctacac
     4561 ggccctactg cacttctgtt tctacagaaa cagtcctttc cacattattt tagcattggc
     4621 cataggaaat actgtctgtt tcattttctg actctcaaca ttgtttttga aaatataatt
     4681 aatttttttc atgatattgg gccattatga atacccacag gctccattgt tgacagaaaa
     4741 taaaattact ctcttcttga taaaatgtca ataaagtagg gagacattat ttgaggaaga
     4801 attaagaata ttctccatat ttagttcttt tttttttttt tttttttttt tttgccattg
     4861 gtagagcaaa ttccagtggt ggtaaatcaa gaactctaaa gttcagtaga gacaggtgtt
     4921 ttgaatgtca aggaaatcac tgaggtagat ttgggattac aataagacag ctgccctgtg
     4981 aggtcataag agcttttgtg aggcttactc caggggttct cagtcttggc attactgaca
     5041 ttttgaattg gatgtgttct tgctcctgat gtgtgggttg tgtactgtag gatgtttagc
     5101 tgcacccctg accgctatgc ataaatgccg gtactgtccc ccgaagttgt gacaaccaat
     5161 gtctccagac attgccacat ataacctggg aaaaaaaatt gccccaagtt ctgagccact
     5221 gggtagaact aagggtagtt tagggacaat gttaatgaaa gcctctccaa agtcccatag
     5281 tctttttaat aattaattct gcagaatttg ctctttaaaa acatattttt aaaggcaaga
     5341 ccagcctatt cataaaaatt gcagttgttt ccacataaga actttggata tttaaagaaa
     5401 aatgtaattt gaaatgaaaa gcccttataa atccctttat actcatcagt cattataaca
     5461 gtaaatgaaa tgaagaaaaa gcatttggtc tcactcttct gtgctgatct ctttaactcc
     5521 tgaatatcct caatttgatg agcccactat ccaatgagac tggatagtta tcagcacaat
     5581 tgattcatgg ggttgagatg tttaaatctc cttcatattt aaaatgatcg attttaaact
     5641 tgatgatgtt aattcttctt agttcctggt aagcagctca tcttagtgct aatgacaagt
     5701 tcagatgtta aaaaaatctt tatcatttat ggctaatttt atcctttgcc aaatcatatc
     5761 tattttcttc aagagagcaa aatacatttc ctgattttaa agtattctat ttttaaatat
     5821 atcttcacat tcctgtagta aaagactgca aaaaaaaaaa aaaaaaaaaa aaaactgatg
     5881 tagaaaaaat gaagaaacat gacctgattt gaattttgag tttggatgaa tgatcgcgga
     5941 ctgcatgcct gctctataga agtcatgcac ctgataaagt gtcacgtatt tgtgcttctt
     6001 agtttattta cccttgagta gccacaggta gaaatgaggt tgtcaaacca ggaatttagt
     6061 ttctcaagtg gaaattgcat tgaaagataa tcctcaatgt aatctgcatg ttcttaccca
     6121 tctggagttt agataatgca gacgagtcat tttctggtgc ttctcttttc atgtgtttta
     6181 tttcgtacct ttttgtttac atggaacttt cttgaatgtt tgctagatga tcaactgtca
     6241 cctcttagta caaagccatg ccagacactg cacctactct gcactctaat gagaacaatc
     6301 cggaaaggat gattttcaag ggagagtgac ctcttcctgg agatctgagg ttatgttaca
     6361 gtattgtgga gttttgttgc ttaaaattct cctcctgtcc tcacaggcaa ttttgctaga
     6421 gttgcaatcc tcacatttga gagaactgtc aaaactctaa gacataaagt ttaaataact
     6481 cattaataat tgcatgtgaa tcccccagta atgtatgtac atgagcatac ctttcaaaga
     6541 tgttcaatgg tgctgtaaat aaaatttttt taaaaaata
//
