LOCUS       NM_021194               5893 bp    mRNA    linear   PRI 17-SEP-2024
DEFINITION  Homo sapiens solute carrier family 30 member 1 (SLC30A1), mRNA.
ACCESSION   NM_021194
VERSION     NM_021194.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5893)
  AUTHORS   Li,Y., Ma,J., Wang,R., Luo,Y., Zheng,S. and Wang,X.
  TITLE     Zinc transporter 1 functions in copper uptake and cuproptosis
  JOURNAL   Cell Metab 36 (9), 2118-2129 (2024)
   PUBMED   39111308
  REMARK    GeneRIF: Zinc transporter 1 functions in copper uptake and
            cuproptosis.
REFERENCE   2  (bases 1 to 5893)
  AUTHORS   Sun,C., He,B., Gao,Y., Wang,X., Liu,X. and Sun,L.
  TITLE     Structural insights into the calcium-coupled zinc export of human
            ZnT1
  JOURNAL   Sci Adv 10 (17), eadk5128 (2024)
   PUBMED   38669333
  REMARK    GeneRIF: Structural insights into the calcium-coupled zinc export
            of human ZnT1.
REFERENCE   3  (bases 1 to 5893)
  AUTHORS   Kakita,N., Katayama,K., Yasui,T., Satake,S., Aoi,K., Jo,H.,
            Kim,Y.K., Yamazaki,M., Hashimoto,A. and Kambe,T.
  TITLE     Zinc transporter 1 expression in hepatocellular carcinoma
            correlates with prognosis: A single-center retrospective study
  JOURNAL   J Trace Elem Med Biol 82, 127354 (2024)
   PUBMED   38103516
  REMARK    GeneRIF: Zinc transporter 1 expression in hepatocellular carcinoma
            correlates with prognosis: A single-center retrospective study.
REFERENCE   4  (bases 1 to 5893)
  AUTHORS   Rege,J., Bandulik,S., Nanba,K., Kosmann,C., Blinder,A.R., Plain,A.,
            Vats,P., Kumar-Sinha,C., Lerario,A.M., Else,T., Yamazaki,Y.,
            Satoh,F., Sasano,H., Giordano,T.J., Williams,T.A., Reincke,M.,
            Turcu,A.F., Udager,A.M., Warth,R. and Rainey,W.E.
  TITLE     Somatic SLC30A1 mutations altering zinc transporter ZnT1 cause
            aldosterone-producing adenomas and primary aldosteronism
  JOURNAL   Nat Genet 55 (10), 1623-1631 (2023)
   PUBMED   37709865
  REMARK    GeneRIF: Somatic SLC30A1 mutations altering zinc transporter ZnT1
            cause aldosterone-producing adenomas and primary aldosteronism.
REFERENCE   5  (bases 1 to 5893)
  AUTHORS   Escobar,A., Styrpejko,D.J., Ali,S. and Cuajungco,M.P.
  TITLE     Transmembrane 163 (TMEM163) protein interacts with specific
            mammalian SLC30 zinc efflux transporter family members
  JOURNAL   Biochem Biophys Rep 32, 101362 (2022)
   PUBMED   36204728
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5893)
  AUTHORS   Lovell,M.A., Smith,J.L., Xiong,S. and Markesbery,W.R.
  TITLE     Alterations in zinc transporter protein-1 (ZnT-1) in the brain of
            subjects with mild cognitive impairment, early, and late-stage
            Alzheimer's disease
  JOURNAL   Neurotox Res 7 (4), 265-271 (2005)
   PUBMED   16179263
  REMARK    GeneRIF: correlation analysis of ZnT-1 levels and senile plaque and
            neurofibrillary tangle counts of Alzheimer's disease showed a
            significant positive correlation
REFERENCE   7  (bases 1 to 5893)
  AUTHORS   Segal,D., Ohana,E., Besser,L., Hershfinkel,M., Moran,A. and
            Sekler,I.
  TITLE     A role for ZnT-1 in regulating cellular cation influx
  JOURNAL   Biochem Biophys Res Commun 323 (4), 1145-1150 (2004)
   PUBMED   15451416
  REMARK    GeneRIF: Our findings therefore indicate that ZnT-1 modulates the
            permeation of cations through LTCC, thereby, regulating cation
            homeostasis through this pathway.
REFERENCE   8  (bases 1 to 5893)
  AUTHORS   Devergnas,S., Chimienti,F., Naud,N., Pennequin,A., Coquerel,Y.,
            Chantegrel,J., Favier,A. and Seve,M.
  TITLE     Differential regulation of zinc efflux transporters ZnT-1, ZnT-5
            and ZnT-7 gene expression by zinc levels: a real-time RT-PCR study
  JOURNAL   Biochem Pharmacol 68 (4), 699-709 (2004)
   PUBMED   15276077
REFERENCE   9  (bases 1 to 5893)
  AUTHORS   Iguchi,K., Otsuka,T., Usui,S., Ishii,K., Onishi,T., Sugimura,Y. and
            Hirano,K.
  TITLE     Zinc and metallothionein levels and expression of zinc transporters
            in androgen-independent subline of LNCaP cells
  JOURNAL   J Androl 25 (1), 154-161 (2004)
   PUBMED   14662799
  REMARK    GeneRIF: AIDL cells exhibited a lower expression of zinc
            transporter 1 (ZnT1) and higher expression of ZnT3 than LNCaP
            cells.
REFERENCE   10 (bases 1 to 5893)
  AUTHORS   Takeda,J., Yano,H., Eng,S., Zeng,Y. and Bell,G.I.
  TITLE     A molecular inventory of human pancreatic islets: sequence analysis
            of 1000 cDNA clones
  JOURNAL   Hum Mol Genet 2 (11), 1793-1798 (1993)
   PUBMED   7506601
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC105275.3, AW183618.1, AI621266.1, AI467909.1, BE744293.1,
            AA853540.1, CB990012.1, BF057194.1 and CF529684.1.
            
            On Nov 22, 2018 this sequence version replaced NM_021194.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803612.57966.1,
                                           SRR1803615.67741.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000367001.5/ ENSP00000355968.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-404               AC105275.3         121852-122255       c
            405-700             AW183618.1         2-297
            701-722             AI621266.1         279-300
            723-885             AI467909.1         300-462
            886-1096            BE744293.1         31-241
            1097-1375           AA853540.1         23-301
            1376-1937           CB990012.1         184-745
            1938-2398           BF057194.1         23-483              c
            2399-2422           CF529684.1         17-40               c
            2423-5893           AC105275.3         114662-118132       c
FEATURES             Location/Qualifiers
     source          1..5893
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q32.3"
     gene            1..5893
                     /gene="SLC30A1"
                     /gene_synonym="ZNT1; ZRC1"
                     /note="solute carrier family 30 member 1"
                     /db_xref="GeneID:7779"
                     /db_xref="HGNC:HGNC:11012"
                     /db_xref="MIM:609521"
     exon            1..1171
                     /gene="SLC30A1"
                     /gene_synonym="ZNT1; ZRC1"
                     /inference="alignment:Splign:2.1.0"
     CDS             550..2073
                     /gene="SLC30A1"
                     /gene_synonym="ZNT1; ZRC1"
                     /note="zinc transporter 1; znT-1; solute carrier family 30
                     (zinc transporter), member 1; zinc resistance conferring
                     homolog"
                     /codon_start=1
                     /product="proton-coupled zinc antiporter SLC30A1"
                     /protein_id="NP_067017.2"
                     /db_xref="CCDS:CCDS1499.1"
                     /db_xref="GeneID:7779"
                     /db_xref="HGNC:HGNC:11012"
                     /db_xref="MIM:609521"
                     /translation="MGCWGRNRGRLLCMLALTFMFMVLEVVVSRVTSSLAMLSDSFHM
                     LSDVLALVVALVAERFARRTHATQKNTFGWIRAEVMGALVNAIFLTGLCFAILLEAIE
                     RFIEPHEMQQPLVVLGVGVAGLLVNVLGLCLFHHHSGFSQDSGHGHSHGGHGHGHGLP
                     KGPRVKSTRPGSSDINVAPGEQGPDQEETNTLVANTSNSNGLKLDPADPENPRSGDTV
                     EVQVNGNLVREPDHMELEEDRAGQLNMRGVFLHVLGDALGSVIVVVNALVFYFSWKGC
                     SEGDFCVNPCFPDPCKAFVEIINSTHASVYEAGPCWVLYLDPTLCVVMVCILLYTTYP
                     LLKESALILLQTVPKQIDIRNLIKELRNVEGVEEVHELHVWQLAGSRIIATAHIKCED
                     PTSYMEVAKTIKDVFHNHGIHATTIQPEFASVGSKSSVVPCELACRTQCALKQCCGTL
                     PQAPSGKDAEKTPAVSISCLELSNNLEKKPRRTKAENIPAVVIEIKNMPNKQPESSL"
     exon            1172..5893
                     /gene="SLC30A1"
                     /gene_synonym="ZNT1; ZRC1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2404..2409
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC30A1"
                     /gene_synonym="ZNT1; ZRC1"
                     /note="hexamer: AATAAA"
     polyA_site      2422
                     /gene="SLC30A1"
                     /gene_synonym="ZNT1; ZRC1"
                     /note="major polyA site"
     regulatory      5808..5813
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC30A1"
                     /gene_synonym="ZNT1; ZRC1"
                     /note="hexamer: TATAAA"
     polyA_site      5831
                     /gene="SLC30A1"
                     /gene_synonym="ZNT1; ZRC1"
     regulatory      5872..5877
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC30A1"
                     /gene_synonym="ZNT1; ZRC1"
                     /note="hexamer: AATAAA"
     polyA_site      5893
                     /gene="SLC30A1"
                     /gene_synonym="ZNT1; ZRC1"
ORIGIN      
        1 gaagaaggcg cccgagaccg ggccgagtgc agctgccgtg gccgccgcct ctctagctcc
       61 tcagccatcc gctcctcagt ccagccgccg cagaggagac cagcaagcag agccctcaga
      121 tgctcggagc tttctcggcg cgaagctgcc cgtcgccctc tcctgccgcc ctcgcccgcc
      181 gccctcctgc tcctgctccg gctgcggctc ttggtacccc ggctccggga gcccagctcc
      241 ccgccaccgc cgccgcctgg gtgtgggggc tgctgaggct gagccgggcc tcggcgccgg
      301 ctctgaggac ggacgcctga ggagctgcgc ggcgcggcgc cgccggctgg cggagaacgc
      361 ccacaggcgc ggggctcggc ggcttgaccc gggcttgtcc ccgtgcggcc gcgggggccc
      421 ctcagcggtt tcccgaacgg cccgactcgg gcgctcctcc gtgtcgcggt cgccgaccct
      481 ccgcgtcccg ccaacgccgc cgctgcacca gtctccgggc cgggctcggc gggccccgca
      541 gccgcagcca tggggtgttg gggtcggaac cggggccggc tgctgtgcat gctggcgctg
      601 accttcatgt tcatggtgct ggaggtggtg gtgagccggg tgacctcgtc gctggcgatg
      661 ctctccgact ccttccacat gctgtcggac gtgctggcgc tggtggtggc gctggtggcc
      721 gagcgcttcg cccggcggac ccacgccacc cagaagaaca cgttcggctg gatccgagcc
      781 gaggtaatgg gggctctggt gaacgccatc ttcctgactg gcctctgttt cgccatcctg
      841 ctggaggcca tcgagcgctt catcgagccg cacgagatgc agcagccgct ggtggtcctt
      901 ggggtcggcg tggccgggct gctggtcaac gtgctggggc tctgcctctt ccaccatcac
      961 agcggcttca gccaggactc cggccacggc cactcgcacg ggggtcacgg ccacggccac
     1021 ggcctcccca aggggcctcg cgttaagagc acccgccccg ggagcagcga catcaacgtg
     1081 gccccgggcg agcagggtcc cgaccaggag gagaccaaca ccctggtggc caataccagc
     1141 aactccaacg ggctgaaatt ggaccccgca gacccagaaa accccagaag tggtgataca
     1201 gtggaagtac aagtgaatgg aaatcttgtc agagaacctg accatatgga actggaagaa
     1261 gatagggctg gacaacttaa catgcgtgga gtttttctgc atgtccttgg agatgccttg
     1321 ggttcagtga ttgtagtagt aaatgcctta gtcttttact tttcttggaa aggttgttct
     1381 gaaggggatt tttgtgtgaa tccatgtttc cctgacccct gcaaagcatt tgtagaaata
     1441 attaatagta ctcatgcatc agtttatgag gctggtcctt gctgggtgct atatttagat
     1501 ccaactcttt gtgttgtaat ggtttgtata cttctttaca caacctatcc attacttaag
     1561 gaatctgctc ttattcttct acaaactgtt cctaaacaaa ttgatatcag aaatttgata
     1621 aaagaacttc gaaatgttga aggagttgag gaagttcatg aattacatgt ttggcaactt
     1681 gctggaagca gaatcattgc cactgctcac ataaaatgtg aagatccaac atcatacatg
     1741 gaggtggcta aaaccattaa agacgttttt cataatcacg gaattcacgc tactaccatt
     1801 cagcctgaat ttgctagtgt aggctctaaa tcaagtgtag ttccgtgtga acttgcctgc
     1861 agaacccagt gtgctttgaa gcaatgttgt gggacactac cacaagcccc ttctggaaag
     1921 gatgcagaaa agaccccagc agttagcatt tcttgtttag aacttagtaa caatctagag
     1981 aagaagccca ggaggactaa agctgaaaac atccctgctg ttgtgataga gattaaaaac
     2041 atgccaaaca aacaacctga atcatctttg tgagtcttga aaaagatgtg atatttgact
     2101 tttgctttaa actgcaagag gaaaaagact ccactgaaat tctaagtttg ccaagtagtg
     2161 taattgaagt ccttgtctgg tcacacagtt taattctatt tttgtaagaa cataatggga
     2221 ctgcataaca gagttctata ttacaatttt gtgattatta gtacagagta cagctatgct
     2281 gtgactgttt tggaaagcca gttttaacac tatgttacat ttttgtttaa agtaagttaa
     2341 accttatata acataatgac atttgatttc tggatttttc ccatgataaa aattaggggg
     2401 ataaataaaa ttgttactgg aatttctctg cttttctttt cccccagtgt tatactttat
     2461 tagaattata attgatagaa ctttaaaatc atcaacagtt tgtttccttt gacattttag
     2521 gtgatattgc cctttgagat cattacatag cataatggca gcatatttta agagtgactc
     2581 atggctatta gtaggaaata agatcagtta ctatcctgta ttctgtattg ctggctatta
     2641 aacagtaaga taattaacaa attgaactac agtttacaca caatggggca aatggggtag
     2701 taagagcaag gaagaaagtt taccaaacta aatatttagg ttattgtatg ataatattga
     2761 gactacattt ctaaattatt ttgagaattt caacttttta ttctaccaaa gttaatctga
     2821 aacttggaca tgttcaccag cattactttc tttgaaagat tggtataaaa acattgagct
     2881 gcaagtttat ttacaaaata tataagtatt tttaaggatg ttgacaccta ataattacat
     2941 gctaaacgca aacgattaat gtaatctttt aaaccgggcg tttgaaaaaa aattttcaag
     3001 gtcatttcat gataaccaat catgaatgga tttaaatgga gctttttgag cacaaccagc
     3061 aatgtttgtg ctttctaaga gtcactgact tgagaggaaa gaaaaccaga aggttaatgc
     3121 agtttggata ttaaattctt agcaaaatta ataattaaag caaaattaat taagattttg
     3181 taagtcatcc tgtcttcaca tactcagatc ttccaatagt ggcttatttt gcaagatgcc
     3241 acaatatcta cacagaaaat tgtggctatt tcattattgc tatagatttc aaatccaaca
     3301 caaatattta agggtgttta agttatattt ttcttgatag agggtatgct ttgtgacaaa
     3361 attagatttt tgtccttgaa aggattaata ttagcatcag ttatgtatag ctctattttt
     3421 ctagaaacaa ggtattctga ctacttttat agctgactac ttttgggatg gctacgtttt
     3481 gggatttaaa atagttcatt gtttaatggg ttgtaagagg aaaaagtgtt aggatttgac
     3541 agttactttt taaagggatg atcttttgtg gtgtgtgttt ttcctagtat aagcctattg
     3601 ctggcgatgg gcctatttaa gaacagctga ttttttccag tgaaaatatg gtaattttag
     3661 gaacacagtt tgtaagttca catttactat aatgggccaa aaccataacc tgccagtttg
     3721 caatacatct tgatctttta atattcttat ctgatattgt gtaattcaat tcctaaactg
     3781 atagttacct tgaattttgc gaaaaggttt gggtggtttt ttttaaacat gaaattgagg
     3841 gatctcatct gggcgaacaa gaagagaaag ctgtgaattg tactgtatca tgtacattcc
     3901 tgatttaata ctttacagaa cattttattc agatatcaat ttgttacata aacatttcag
     3961 caatgataca aagataactg ataaaatata ttacattcaa tgaggttttc tttacaaatg
     4021 ctctacttga ggtctgtgtc ttaaagatgg catgacacct aagtacaaga catcaactga
     4081 atgaggattt taaaaaatgg tatataagca taggacaagg gctatgtttg tttgtttttc
     4141 aaaagtgctt tgaagataac agcctttagg tttgagttat ttcacttttc ataattttta
     4201 agtagcttat atataatggt ggtaccatag gattttcttt tttcaaatga ctgtcggcag
     4261 aaacagtggg cactgactca ccttttgagt tttagcagag aattatttat ttctttacaa
     4321 tgcactttct aacccattgt agctatatta gcattatctt ttaaaaaaga catgcttttg
     4381 tatttaaata ttgtaggatt taagtgtctt tctcaaaata gcttattcct ttctgaaaga
     4441 aaatgaggga aatactctga attattagga gacttaaacc caatatttaa atatgctatt
     4501 ttataacact gcatcagttt taggagttgc atctctcctg ctggctcttt tatatttgag
     4561 caagatcagt gtagaatatg tgtttagaaa cttgtctgtt gtctcagttt agtgaaaagg
     4621 aggtgctgca tgtgcctgaa ttaaaaccaa gaaatttttc caagccaaat gcagccttag
     4681 tgatgagaga tttaattctc cattgtcacc ttttagcttt tatgattgct tagttttttc
     4741 tgaaggatgt ctgcattgta aaactatgga ctaaaaccta aaaaacagaa tcctcaaaaa
     4801 ctttgctgta tgtgttttaa cattttagag aacagtatgt tgaataacta aggtatgtaa
     4861 cttgaatagg aaaaatgtcc atcaaatgca ccttggaaaa tcacagtagg tagaaggctg
     4921 tgttaaccgt ttgtgtctta ttaacatcct taagttaatt ttgaattttt gacagttttg
     4981 agggaaaaga cctatggaac ctaatgtgaa gtatttcgta tgttaactgg tgttgagttg
     5041 aagattttta ctgtgtataa gcagatatca tttgaatgat aaaaatgtca ttaacctgct
     5101 gtcttaagat gttcacacaa atatggagag taattctaca atataaaaat atttatttta
     5161 atactgagtt tcagttaagt cataaacagt gttaaaactc ttgggaaggt gtaggggttt
     5221 tttgtttgtc atttttaaaa ttgaaactgt gtcatacagt gtttcacgtc tctgaaattg
     5281 ggattataat agcactattt tgatgtagct ctaccgatac tatgtggtaa tgctattttg
     5341 ttttactaac aagctctgga atatttagca gtcattttca ctggcacaag agccttttgt
     5401 atgttattca atttaaactt ttaaaccaaa aattttatgg tccagtgtct ttggcaaaaa
     5461 gatgctggag ggaatgtaac atacaattaa tatgtggtta tatatatata taaaaagaca
     5521 caaattgcca tgttatggtt ctgccttgaa acagcacaat gaagtgtatc agtatattct
     5581 gtgattatga aacttatatg ttgtgttgtt ttgtgtcttc tgttgcctgt cctttgggcc
     5641 agatgtgggc cagttaaatg cagttatcat ctcattaaat acagatgcag ataaaatatc
     5701 tttagtgctg caacatttta cctaactttt tgtatgtttt catgactgtg tgttattttc
     5761 caaagctgtt cctacctcac catgaggctt tatggattgt tatgtattat aaatgttcta
     5821 tatgagacag actactgtgt ttcttctcat ttattaaaag ttaagtagaa aaataaacta
     5881 attttaatat cta
//
