LOCUS       NM_207420               1944 bp    mRNA    linear   PRI 17-FEB-2024
DEFINITION  Homo sapiens solute carrier family 2 member 7 (SLC2A7), mRNA.
ACCESSION   NM_207420
VERSION     NM_207420.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1944)
  AUTHORS   Gauer,J.S., Tumova,S., Lippiat,J.D., Kerimi,A. and Williamson,G.
  TITLE     Differential patterns of inhibition of the sugar transporters
            GLUT2, GLUT5 and GLUT7 by flavonoids
  JOURNAL   Biochem Pharmacol 152, 11-20 (2018)
   PUBMED   29548810
REFERENCE   2  (bases 1 to 1944)
  AUTHORS   Ebert,K., Ludwig,M., Geillinger,K.E., Schoberth,G.C.,
            Essenwanger,J., Stolz,J., Daniel,H. and Witt,H.
  TITLE     Reassessment of GLUT7 and GLUT9 as Putative Fructose and Glucose
            Transporters
  JOURNAL   J Membr Biol 250 (2), 171-182 (2017)
   PUBMED   28083649
REFERENCE   3  (bases 1 to 1944)
  AUTHORS   Cheeseman,C.
  TITLE     GLUT7: a new intestinal facilitated hexose transporter
  JOURNAL   Am J Physiol Endocrinol Metab 295 (2), E238-E241 (2008)
   PUBMED   18477702
  REMARK    Review article
REFERENCE   4  (bases 1 to 1944)
  AUTHORS   Schurmann,A.
  TITLE     Insight into the 'odd' hexose transporters GLUT3, GLUT5, and GLUT7
  JOURNAL   Am J Physiol Endocrinol Metab 295 (2), E225-E226 (2008)
   PUBMED   18460594
REFERENCE   5  (bases 1 to 1944)
  AUTHORS   Manolescu,A., Salas-Burgos,A.M., Fischbarg,J. and Cheeseman,C.I.
  TITLE     Identification of a hydrophobic residue as a key determinant of
            fructose transport by the facilitative hexose transporter SLC2A7
            (GLUT7)
  JOURNAL   J Biol Chem 280 (52), 42978-42983 (2005)
   PUBMED   16186102
  REMARK    GeneRIF: a hydrophobic residue is a key determinant of fructose
            transport in SLC2A7
REFERENCE   6  (bases 1 to 1944)
  AUTHORS   Li,Q., Manolescu,A., Ritzel,M., Yao,S., Slugoski,M., Young,J.D.,
            Chen,X.Z. and Cheeseman,C.I.
  TITLE     Cloning and functional characterization of the human GLUT7 isoform
            SLC2A7 from the small intestine
  JOURNAL   Am J Physiol Gastrointest Liver Physiol 287 (1), G236-G242 (2004)
   PUBMED   15033637
  REMARK    GeneRIF: Unusual substrate specificity and close sequence identity
            with GLUT5. GLUT7 may represent intermediate between class II GLUTs
            and class I member GLUT2. Comparison may give key to structural
            determinants for recognition of fructose as a substrate.
REFERENCE   7  (bases 1 to 1944)
  AUTHORS   Joost,H.G. and Thorens,B.
  TITLE     The extended GLUT-family of sugar/polyol transport facilitators:
            nomenclature, sequence characteristics, and potential function of
            its novel members (review)
  JOURNAL   Mol Membr Biol 18 (4), 247-256 (2001)
   PUBMED   11780753
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL158048.35.
            
            On Sep 30, 2020 this sequence version replaced NM_207420.2.
            
            Summary: SLC2A7 belongs to a family of transporters that catalyze
            the uptake of sugars through facilitated diffusion (Li et al.,
            2004). This family of transporters shows conservation of 12
            transmembrane helices as well as functionally significant amino
            acid residues (Joost and Thorens, 2001 [PubMed 11780753]).[supplied
            by OMIM, Mar 2008].
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY571960.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2152474, SAMEA2153733
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000400906.2/ ENSP00000383698.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-129               AL158048.35        106698-106826
            130-228             AL158048.35        108047-108145
            229-389             AL158048.35        110043-110203
            390-514             AL158048.35        113788-113912
            515-667             AL158048.35        114746-114898
            668-793             AL158048.35        117879-118004
            794-981             AL158048.35        118253-118440
            982-1092            AL158048.35        119486-119596
            1093-1194           AL158048.35        122877-122978
            1195-1270           AL158048.35        125736-125811
            1271-1398           AL158048.35        128242-128369
            1399-1944           AL158048.35        129603-130148
FEATURES             Location/Qualifiers
     source          1..1944
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p36.23"
     gene            1..1944
                     /gene="SLC2A7"
                     /gene_synonym="GLUT-7; GLUT7; hGLUT7"
                     /note="solute carrier family 2 member 7"
                     /db_xref="GeneID:155184"
                     /db_xref="HGNC:HGNC:13445"
                     /db_xref="MIM:610371"
     exon            1..129
                     /gene="SLC2A7"
                     /gene_synonym="GLUT-7; GLUT7; hGLUT7"
                     /inference="alignment:Splign:2.1.0"
     CDS             79..1617
                     /gene="SLC2A7"
                     /gene_synonym="GLUT-7; GLUT7; hGLUT7"
                     /note="intestinal facilitative glucose transporter 7;
                     glucose transporter type 7; solute carrier family 2
                     (facilitated glucose transporter), member 7"
                     /codon_start=1
                     /product="solute carrier family 2, facilitated glucose
                     transporter member 7"
                     /protein_id="NP_997303.2"
                     /db_xref="CCDS:CCDS98.2"
                     /db_xref="GeneID:155184"
                     /db_xref="HGNC:HGNC:13445"
                     /db_xref="MIM:610371"
                     /translation="MENKEAGTPPPIPSREGRLQPTLLLATLSAAFGSAFQYGYNLSV
                     VNTPHKVFKSFYNETYFERHATFMDGKLMLLLWSCTVSMFPLGGLLGSLLVGLLVDSC
                     GRKGTLLINNIFAIIPAILMGVSKVAKAFELIVFSRVVLGVCAGISYSALPMYLGELA
                     PKNLRGMVGTMTEVFVIVGVFLAQIFSLQAILGNPAGWPVLLALTGVPALLQLLTLPF
                     FPESPRYSLIQKGDEATARQALRRLRGHTDMEAELEDMRAEARAERAEGHLSVLHLCA
                     LRSLRWQLLSIIVLMAGQQLSGINAINYYADTIYTSAGVEAAHSQYVTVGSGVVNIVM
                     TITSAVLVERLGRRHLLLAGYGICGSACLVLTVVLLFQNRVPELSYLGIICVFAYIAG
                     HSIGPSPVPSVVRTEIFLQSSRRAAFMVDGAVHWLTNFIIGFLFPSIQEAIGAYSFII
                     FAGICLLTAIYIYVVIPETKGKTFVEINRIFAKRNRVKLPEEKEETIDAGPPTASPAK
                     ETSF"
     exon            130..228
                     /gene="SLC2A7"
                     /gene_synonym="GLUT-7; GLUT7; hGLUT7"
                     /inference="alignment:Splign:2.1.0"
     exon            229..389
                     /gene="SLC2A7"
                     /gene_synonym="GLUT-7; GLUT7; hGLUT7"
                     /inference="alignment:Splign:2.1.0"
     exon            390..514
                     /gene="SLC2A7"
                     /gene_synonym="GLUT-7; GLUT7; hGLUT7"
                     /inference="alignment:Splign:2.1.0"
     exon            515..667
                     /gene="SLC2A7"
                     /gene_synonym="GLUT-7; GLUT7; hGLUT7"
                     /inference="alignment:Splign:2.1.0"
     exon            668..793
                     /gene="SLC2A7"
                     /gene_synonym="GLUT-7; GLUT7; hGLUT7"
                     /inference="alignment:Splign:2.1.0"
     exon            794..981
                     /gene="SLC2A7"
                     /gene_synonym="GLUT-7; GLUT7; hGLUT7"
                     /inference="alignment:Splign:2.1.0"
     exon            982..1092
                     /gene="SLC2A7"
                     /gene_synonym="GLUT-7; GLUT7; hGLUT7"
                     /inference="alignment:Splign:2.1.0"
     exon            1093..1194
                     /gene="SLC2A7"
                     /gene_synonym="GLUT-7; GLUT7; hGLUT7"
                     /inference="alignment:Splign:2.1.0"
     exon            1195..1270
                     /gene="SLC2A7"
                     /gene_synonym="GLUT-7; GLUT7; hGLUT7"
                     /inference="alignment:Splign:2.1.0"
     exon            1271..1398
                     /gene="SLC2A7"
                     /gene_synonym="GLUT-7; GLUT7; hGLUT7"
                     /inference="alignment:Splign:2.1.0"
     exon            1399..1944
                     /gene="SLC2A7"
                     /gene_synonym="GLUT-7; GLUT7; hGLUT7"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agccggtctt taggtggctg gcgcagagca ggtgtcactt gggaggtaga gcacacctgt
       61 tctcccacct gaacaaggat ggagaacaaa gaggcgggaa cccctccacc cattccatcc
      121 agggaggggc ggctccagcc gacgctgttg ctggcgacac tgagcgcggc ctttggctca
      181 gccttccagt acggctacaa cctctctgtg gtcaacacgc cgcacaaggt cttcaagtca
      241 ttttacaacg aaacctactt tgagcgacac gcaacattca tggacgggaa gctcatgctg
      301 cttctatggt cttgcaccgt ctccatgttt cctctgggcg gcctgttggg gtcattgctc
      361 gtgggcctgc tggttgatag ctgcggcaga aaggggaccc tgctgatcaa caacatcttt
      421 gccatcatcc ccgccatcct gatgggagtc agcaaagtgg ccaaggcttt tgagctgatc
      481 gtcttttccc gagtggtgct gggagtctgt gcaggcatct cctacagcgc ccttcccatg
      541 tacctgggag aactggcccc caagaacctg agaggcatgg tgggaacaat gaccgaggtt
      601 ttcgtcatcg ttggagtctt cctagcacag atcttcagcc tccaggccat cttgggcaac
      661 ccggcaggct ggccggtgct tctggcgctc acaggggtgc ccgccctgct gcagctgctg
      721 accctgccct tcttccccga aagcccccgc tactccctga ttcagaaagg agatgaagcc
      781 acagcgcgac aagctctgag gaggctgaga ggccacacgg acatggaggc cgagctggag
      841 gacatgcgtg cggaggcccg ggccgagcgc gccgagggcc acctgtctgt gctgcacctc
      901 tgtgccctgc ggtccctgcg ctggcagctc ctctccatca tcgtgctcat ggccggccag
      961 cagctgtcgg gcatcaatgc gatcaactac tatgcggaca ccatctacac atctgcgggc
     1021 gtggaggccg ctcactccca atatgtaacg gtgggctctg gcgtcgtcaa catagtgatg
     1081 accatcacct cggctgtcct tgtggagcgg ctgggacggc ggcacctcct gctggccggc
     1141 tacggcatct gcggctctgc ctgcctggtg ctgacggtgg tgctcctatt ccagaacagg
     1201 gtccccgagc tgtcctacct cggcatcatc tgtgtctttg cctacatcgc gggacattcc
     1261 attgggccca gtcctgtccc ctcggtggtg aggaccgaga tcttcctgca gtcctcccgg
     1321 cgggcagctt tcatggtgga cggggcagtg cactggctca ccaacttcat cataggcttc
     1381 ctgttcccat ccatccagga ggccatcggt gcctacagtt tcatcatctt tgccggaatc
     1441 tgcctcctca ctgcgattta catctacgtg gttattccgg agaccaaggg caaaacattt
     1501 gtggagataa accgcatttt tgccaagaga aacagggtga agcttccaga ggagaaagaa
     1561 gaaaccattg atgctgggcc tcccacagcc tctcctgcca aggaaacttc cttttagtgg
     1621 ccctgcatga aggacgggag cccatattca aggcttcctt ctatgacaat gggcctcccg
     1681 gccccaggct ctggggagga taatagcacg gaggcttttg tcgttgcccc catttaactt
     1741 aattatggat attattaaat acccacaaca atgcatattt agctgagaag ttccaaggct
     1801 agccattgag gaatgacctg gaggaagggg ccggcacgtg aattttgatt ggttaagact
     1861 cgattttccg attctacatt ggcaccaaaa tttaaatgat gtatagatgc acttttttaa
     1921 agtaaaactt ttcaagttcc acaa
//
