LOCUS       NM_017585               2491 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens solute carrier family 2 member 6 (SLC2A6), transcript
            variant 1, mRNA.
ACCESSION   NM_017585
VERSION     NM_017585.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2491)
  AUTHORS   Cheng,C., Tu,J., Hu,Z., Chen,Y., Wang,Y., Zhang,T., Zhang,C.,
            Li,C., Wang,Y. and Niu,C.
  TITLE     SREBP2/Rab11s/GLUT1/6 network regulates proliferation and migration
            of glioblastoma
  JOURNAL   Pathol Res Pract 240, 154176 (2022)
   PUBMED   36327817
  REMARK    GeneRIF: SREBP2/Rab11s/GLUT1/6 network regulates proliferation and
            migration of glioblastoma.
REFERENCE   2  (bases 1 to 2491)
  AUTHORS   Caruana,B.T. and Byrne,F.L.
  TITLE     The NF-kappaB signalling pathway regulates GLUT6 expression in
            endometrial cancer
  JOURNAL   Cell Signal 73, 109688 (2020)
   PUBMED   32512041
  REMARK    GeneRIF: The NF-kappaB signalling pathway regulates GLUT6
            expression in endometrial cancer.
REFERENCE   3  (bases 1 to 2491)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 2491)
  AUTHORS   Maedera,S., Mizuno,T., Ishiguro,H., Ito,T., Soga,T. and Kusuhara,H.
  TITLE     GLUT6 is a lysosomal transporter that is regulated by inflammatory
            stimuli and modulates glycolysis in macrophages
  JOURNAL   FEBS Lett 593 (2), 195-208 (2019)
   PUBMED   30431159
REFERENCE   5  (bases 1 to 2491)
  AUTHORS   Urano,W., Taniguchi,A., Anzai,N., Inoue,E., Sekita,C., Endou,H.,
            Kamatani,N. and Yamanaka,H.
  TITLE     Association between GLUT9 and gout in Japanese men
  JOURNAL   Ann Rheum Dis 69 (5), 932-933 (2010)
   PUBMED   20413573
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   6  (bases 1 to 2491)
  AUTHORS   Fonteyne,P., Casneuf,V., Pauwels,P., Van Damme,N., Peeters,M.,
            Dierckx,R. and Van de Wiele,C.
  TITLE     Expression of hexokinases and glucose transporters in treated and
            untreated oesophageal adenocarcinoma
  JOURNAL   Histol Histopathol 24 (8), 971-977 (2009)
   PUBMED   19554504
  REMARK    GeneRIF: The expression pattern of GLUT9 is reported in newly
            diagnosed esophageal adenocarcinoma by means of
            immunohistochemistry.
REFERENCE   7  (bases 1 to 2491)
  AUTHORS   McArdle,P.F., Parsa,A., Chang,Y.P., Weir,M.R., O'Connell,J.R.,
            Mitchell,B.D. and Shuldiner,A.R.
  TITLE     Association of a common nonsynonymous variant in GLUT9 with serum
            uric acid levels in old order amish
  JOURNAL   Arthritis Rheum 58 (9), 2874-2881 (2008)
   PUBMED   18759275
REFERENCE   8  (bases 1 to 2491)
  AUTHORS   Li,S., Sanna,S., Maschio,A., Busonero,F., Usala,G., Mulas,A.,
            Lai,S., Dei,M., Orru,M., Albai,G., Bandinelli,S., Schlessinger,D.,
            Lakatta,E., Scuteri,A., Najjar,S.S., Guralnik,J., Naitza,S.,
            Crisponi,L., Cao,A., Abecasis,G., Ferrucci,L., Uda,M., Chen,W.M.
            and Nagaraja,R.
  TITLE     The GLUT9 gene is associated with serum uric acid levels in
            Sardinia and Chianti cohorts
  JOURNAL   PLoS Genet 3 (11), e194 (2007)
   PUBMED   17997608
REFERENCE   9  (bases 1 to 2491)
  AUTHORS   Richardson,S., Neama,G., Phillips,T., Bell,S., Carter,S.D.,
            Moley,K.H., Moley,J.F., Vannucci,S.J. and Mobasheri,A.
  TITLE     Molecular characterization and partial cDNA cloning of facilitative
            glucose transporters expressed in human articular chondrocytes;
            stimulation of 2-deoxyglucose uptake by IGF-I and elevated MMP-2
            secretion by glucose deprivation
  JOURNAL   Osteoarthritis Cartilage 11 (2), 92-101 (2003)
   PUBMED   12554125
REFERENCE   10 (bases 1 to 2491)
  AUTHORS   Doege,H., Bocianski,A., Joost,H.G. and Schurmann,A.
  TITLE     Activity and genomic organization of human glucose transporter 9
            (GLUT9), a novel member of the family of sugar-transport
            facilitators predominantly expressed in brain and leucocytes
  JOURNAL   Biochem J 350 Pt 3 (Pt 3), 771-776 (2000)
   PUBMED   10970791
  REMARK    Erratum:[Biochem J 2001 Sep 15;358(Pt 3):791-2]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DC305025.1, AK222919.1, AJ011372.2 and CA306069.1.
            
            On Nov 23, 2018 this sequence version replaced NM_017585.3.
            
            Summary: Hexose transport into mammalian cells is catalyzed by a
            family of membrane proteins, including SLC2A6, that contain 12
            transmembrane domains and a number of critical conserved
            residues.[supplied by OMIM, Jul 2002].
            
            Transcript Variant: This variant (1) represents the predominant
            transcript, and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.287590.1, AJ011372.2
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000371899.9/ ENSP00000360966.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-12                DC305025.1         56-67
            13-2008             AK222919.1         13-2008
            2009-2487           AJ011372.2         2006-2484
            2488-2491           CA306069.1         18-21               c
FEATURES             Location/Qualifiers
     source          1..2491
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q34.2"
     gene            1..2491
                     /gene="SLC2A6"
                     /gene_synonym="GLUT6; GLUT9; HSA011372"
                     /note="solute carrier family 2 member 6"
                     /db_xref="GeneID:11182"
                     /db_xref="HGNC:HGNC:11011"
                     /db_xref="MIM:606813"
     exon            1..132
                     /gene="SLC2A6"
                     /gene_synonym="GLUT6; GLUT9; HSA011372"
                     /inference="alignment:Splign:2.1.0"
     CDS             41..1564
                     /gene="SLC2A6"
                     /gene_synonym="GLUT6; GLUT9; HSA011372"
                     /note="isoform 1 is encoded by transcript variant 1;
                     GLUT-6; GLUT-9; glucose transporter type 6; glucose
                     transporter type 9; solute carrier family 2 (facilitated
                     glucose transporter), member 6"
                     /codon_start=1
                     /product="solute carrier family 2, facilitated glucose
                     transporter member 6 isoform 1"
                     /protein_id="NP_060055.2"
                     /db_xref="CCDS:CCDS6975.1"
                     /db_xref="GeneID:11182"
                     /db_xref="HGNC:HGNC:11011"
                     /db_xref="MIM:606813"
                     /translation="MQEPLLGAEGPDYDTFPEKPPPSPGDRARVGTLQNKRVFLATFA
                     AVLGNFSFGYALVYTSPVIPALERSLDPDLHLTKSQASWFGSVFTLGAAAGGLSAMIL
                     NDLLGRKLSIMFSAVPSAAGYALMAGAHGLWMLLLGRTLTGFAGGLTAACIPVYVSEI
                     APPGVRGALGATPQLMAVFGSLSLYALGLLLPWRWLAVAGEAPVLIMILLLSFMPNSP
                     RFLLSRGRDEEALRALAWLRGTDVDVHWEFEQIQDNVRRQSSRVSWAEARAPHVCRPI
                     TVALLMRLLQQLTGITPILVYLQSIFDSTAVLLPPKDDAAIVGAVRLLSVLIAALTMD
                     LAGRKVLLFVSAAIMFAANLTLGLYIHFGPRPLSPNSTAGLESESWGDLAQPLAAPAG
                     YLTLVPLLATMLFIMGYAVGWGPITWLLMSEVLPLRARGVASGLCVLASWLTAFVLTK
                     SFLPVVSTFGLQVPFFFFAAICLVSLVFTGCCVPETKGRSLEQIESFFRTGRRSFLR"
     exon            133..295
                     /gene="SLC2A6"
                     /gene_synonym="GLUT6; GLUT9; HSA011372"
                     /inference="alignment:Splign:2.1.0"
     exon            296..502
                     /gene="SLC2A6"
                     /gene_synonym="GLUT6; GLUT9; HSA011372"
                     /inference="alignment:Splign:2.1.0"
     exon            503..602
                     /gene="SLC2A6"
                     /gene_synonym="GLUT6; GLUT9; HSA011372"
                     /inference="alignment:Splign:2.1.0"
     exon            603..814
                     /gene="SLC2A6"
                     /gene_synonym="GLUT6; GLUT9; HSA011372"
                     /inference="alignment:Splign:2.1.0"
     exon            815..967
                     /gene="SLC2A6"
                     /gene_synonym="GLUT6; GLUT9; HSA011372"
                     /inference="alignment:Splign:2.1.0"
     exon            968..1076
                     /gene="SLC2A6"
                     /gene_synonym="GLUT6; GLUT9; HSA011372"
                     /inference="alignment:Splign:2.1.0"
     exon            1077..1262
                     /gene="SLC2A6"
                     /gene_synonym="GLUT6; GLUT9; HSA011372"
                     /inference="alignment:Splign:2.1.0"
     exon            1263..1408
                     /gene="SLC2A6"
                     /gene_synonym="GLUT6; GLUT9; HSA011372"
                     /inference="alignment:Splign:2.1.0"
     exon            1409..2491
                     /gene="SLC2A6"
                     /gene_synonym="GLUT6; GLUT9; HSA011372"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2471..2476
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC2A6"
                     /gene_synonym="GLUT6; GLUT9; HSA011372"
                     /note="hexamer: AATAAA"
     polyA_site      2491
                     /gene="SLC2A6"
                     /gene_synonym="GLUT6; GLUT9; HSA011372"
                     /note="major polyA site"
ORIGIN      
        1 agtctgagcg ccctccgctc gccccgagag agacccggcc atgcaggagc cgctgctggg
       61 agccgagggc ccggactacg acaccttccc cgagaagccg cccccgtcgc caggggacag
      121 ggcgcgggtc gggaccctgc agaacaaaag ggtgttcctg gccaccttcg ccgcagtgct
      181 cggcaatttc agctttgggt atgccctggt ctacacatcc cctgtcatcc cagccctgga
      241 gcgctccttg gatcctgacc tgcatctgac caaatcccag gcatcctggt ttgggtccgt
      301 gttcaccctg ggagcagcgg ccggaggcct gagtgccatg atcctcaacg acctcctggg
      361 ccggaagctg agcatcatgt tctcagctgt gccgtcggcg gccggctatg cgctcatggc
      421 gggtgcgcac ggcctctgga tgctgctgct cggaaggacg ctgacgggct tcgccggggg
      481 gctcacagct gcctgcatcc cggtgtacgt gtctgagatt gctcccccag gcgttcgtgg
      541 ggctctgggg gccacacccc agctcatggc agtgttcgga tccctgtccc tctacgccct
      601 tggcctcctg ctgccgtggc gctggctggc tgtggccggg gaggcgcctg tgctcatcat
      661 gatcctgctg ctcagcttca tgcccaactc gccgcgcttc ctgctctctc ggggcaggga
      721 cgaagaggcc ctgcgggcgc tggcctggct gcgtgggacg gacgtcgatg tccactggga
      781 gttcgagcag atccaggaca acgtccggag acagagcagc cgagtatcgt gggctgaggc
      841 acgggcccca cacgtgtgcc ggcccatcac cgtggccttg ctgatgcgcc tcctgcagca
      901 gctgacgggc atcacgccca tcctggtcta cctgcagtcc atcttcgaca gcaccgctgt
      961 cctgctgccc cccaaggacg acgcagccat cgttggggcc gtgcggctcc tgtccgtgct
     1021 gatcgccgcc ctcaccatgg acctcgcagg ccgcaaggtg ctgctcttcg tctcagcggc
     1081 catcatgttt gctgccaacc tgactctggg gctgtacatc cactttggcc ccaggcctct
     1141 gagccccaac agcactgcgg gcctggaaag cgagtcctgg ggggacttgg cgcagcccct
     1201 ggcagcaccc gctggctacc tcaccctggt gcccctgctg gccaccatgc tcttcatcat
     1261 gggctacgcc gtgggctggg gtcccatcac ctggctgctc atgtctgagg tcctgcccct
     1321 gcgtgcccgt ggcgtggcct cagggctctg cgtgctggcc agctggctca ccgccttcgt
     1381 cctcaccaag tccttcctgc cagtggtgag caccttcggc ctccaggtgc ctttcttctt
     1441 cttcgcggcc atctgcttgg tgagcctggt gttcacaggc tgctgtgtgc ccgagaccaa
     1501 gggacggtcc ctggagcaga tcgagtcctt cttccgcacg gggagaaggt ccttcttgcg
     1561 ctaggtcaag gtccccgcct ggagggggcc aaacccccag tggctgggcc tctgtgttgg
     1621 ctacaaacct gcaccctggg accaagaggc agcagtcatc cctgccacca gccagagcac
     1681 aggaagagca gtgtgatggg gcctcagcag cgggtgcccc tggctcggga caggtagcac
     1741 tgctgtccag ccacagcccc agcccaggca gcccacagtg ctgcacgtag ccatgggccg
     1801 caggagtgca tacaaccctg catccaggga cacggccctg ctgggtgacc tcaggcctag
     1861 tccctttccc ttgcgtgaag gacacgcccc acagaaggct acggggagga ctgagaggac
     1921 agggctggag gcagccaagt aacgtagtca tatcatcgcg ctctgatctg gtggcatctg
     1981 gctgtgcaag gaagacccgg ctttgccctc acaagtctta tgggcaccac agggaacatc
     2041 ctggacttaa aaagccaggg caggccgggc acagtggctc acgcctgtaa tcccagcact
     2101 ttgggaggcc aaagcaggtg gattacccaa ggccaggagt tcaagaccag cctggccaac
     2161 atggtgaaac cccgtctcta ctaaaaaata caaaaaagct gggtgtggtg gcacacaccc
     2221 gtagttccag ctacttggga ggctgaggca gcattgcttg aacccgggag gtggaggctg
     2281 caatgagctg agatcatgcc attgcactcc agcctgggca acgagagtga aactccgtcc
     2341 ccaccccctg ccaaaaaaaa aaaaaaaaaa gccagggcaa aggacctggc gtggccactt
     2401 cctcctgccc cagcccaacc tctgggaaca ggcagctcct atctgcaaac tgtgttcacc
     2461 cttttgtaaa aataaaggaa ctggacctgt a
//
