LOCUS       NM_003039               4085 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens solute carrier family 2 member 5 (SLC2A5), transcript
            variant 1, mRNA.
ACCESSION   NM_003039
VERSION     NM_003039.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4085)
  AUTHORS   Song,A., Mao,Y. and Wei,H.
  TITLE     GLUT5: structure, functions, diseases and potential applications
  JOURNAL   Acta Biochim Biophys Sin (Shanghai) 55 (10), 1519-1538 (2023)
   PUBMED   37674366
  REMARK    GeneRIF: GLUT5: structure, functions, diseases and potential
            applications.
            Review article
REFERENCE   2  (bases 1 to 4085)
  AUTHORS   Cui,Y., Liu,H., Wang,Z., Zhang,H., Tian,J., Wang,Z., Song,W.,
            Guo,H., Liu,L., Tian,R., Zuo,X., Ren,S., Zhang,F. and Niu,R.
  TITLE     Fructose promotes angiogenesis by improving vascular endothelial
            cell function and upregulating VEGF expression in cancer cells
  JOURNAL   J Exp Clin Cancer Res 42 (1), 184 (2023)
   PUBMED   37507736
  REMARK    GeneRIF: Fructose promotes angiogenesis by improving vascular
            endothelial cell function and upregulating VEGF expression in
            cancer cells.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4085)
  AUTHORS   Fiorentino,T.V., De Vito,F., Suraci,E., Marasco,R., Hribal,M.L.,
            Luzza,F. and Sesti,G.
  TITLE     Obesity and overweight are linked to increased sodium-glucose
            cotransporter 1 and glucose transporter 5 levels in duodenum
  JOURNAL   Obesity (Silver Spring) 31 (3), 724-731 (2023)
   PUBMED   36746764
  REMARK    GeneRIF: Obesity and overweight are linked to increased
            sodium-glucose cotransporter 1 and glucose transporter 5 levels in
            duodenum.
REFERENCE   4  (bases 1 to 4085)
  AUTHORS   Taneva,I., Grumann,D., Schmidt,D., Taneva,E., von Arnim,U.,
            Ansorge,T. and Wex,T.
  TITLE     Gene variants of the SLC2A5 gene encoding GLUT5, the major fructose
            transporter, do not contribute to clinical presentation of acquired
            fructose malabsorption
  JOURNAL   BMC Gastroenterol 22 (1), 167 (2022)
   PUBMED   35387598
  REMARK    GeneRIF: Gene variants of the SLC2A5 gene encoding GLUT5, the major
            fructose transporter, do not contribute to clinical presentation of
            acquired fructose malabsorption.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4085)
  AUTHORS   Trotta,M.C., Gesualdo,C., Petrillo,F., Cavasso,G., Corte,A.D.,
            D'Amico,G., Hermenean,A., Simonelli,F. and Rossi,S.
  TITLE     Serum Iba-1, GLUT5, and TSPO in Patients With Diabetic Retinopathy:
            New Biomarkers for Early Retinal Neurovascular Alterations? A Pilot
            Study
  JOURNAL   Transl Vis Sci Technol 11 (3), 16 (2022)
   PUBMED   35285861
  REMARK    GeneRIF: Serum Iba-1, GLUT5, and TSPO in Patients With Diabetic
            Retinopathy: New Biomarkers for Early Retinal Neurovascular
            Alterations? A Pilot Study.
REFERENCE   6  (bases 1 to 4085)
  AUTHORS   Mahraoui,L., Takeda,J., Mesonero,J., Chantret,I., Dussaulx,E.,
            Bell,G.I. and Brot-Laroche,E.
  TITLE     Regulation of expression of the human fructose transporter (GLUT5)
            by cyclic AMP
  JOURNAL   Biochem J 301 (Pt 1) (Pt 1), 169-175 (1994)
   PUBMED   8037665
REFERENCE   7  (bases 1 to 4085)
  AUTHORS   Rand,E.B., Depaoli,A.M., Davidson,N.O., Bell,G.I. and Burant,C.F.
  TITLE     Sequence, tissue distribution, and functional characterization of
            the rat fructose transporter GLUT5
  JOURNAL   Am J Physiol 264 (6 Pt 1), G1169-G1176 (1993)
   PUBMED   8333543
REFERENCE   8  (bases 1 to 4085)
  AUTHORS   Burant,C.F., Takeda,J., Brot-Laroche,E., Bell,G.I. and
            Davidson,N.O.
  TITLE     Fructose transporter in human spermatozoa and small intestine is
            GLUT5
  JOURNAL   J Biol Chem 267 (21), 14523-14526 (1992)
   PUBMED   1634504
REFERENCE   9  (bases 1 to 4085)
  AUTHORS   Davidson,N.O., Hausman,A.M., Ifkovits,C.A., Buse,J.B., Gould,G.W.,
            Burant,C.F. and Bell,G.I.
  TITLE     Human intestinal glucose transporter expression and localization of
            GLUT5
  JOURNAL   Am J Physiol 262 (3 Pt 1), C795-C800 (1992)
   PUBMED   1550217
REFERENCE   10 (bases 1 to 4085)
  AUTHORS   Kayano,T., Burant,C.F., Fukumoto,H., Gould,G.W., Fan,Y.S.,
            Eddy,R.L., Byers,M.G., Shows,T.B., Seino,S. and Bell,G.I.
  TITLE     Human facilitative glucose transporters. Isolation, functional
            characterization, and gene localization of cDNAs encoding an
            isoform (GLUT5) expressed in small intestine, kidney, muscle, and
            adipose tissue and an unusual glucose transporter pseudogene-like
            sequence (GLUT6)
  JOURNAL   J Biol Chem 265 (22), 13276-13282 (1990)
   PUBMED   1695905
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DC379829.1, M55531.1,
            CA309754.1 and AL158048.35.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_003039.2.
            
            Summary: The protein encoded by this gene is a fructose transporter
            responsible for fructose uptake by the small intestine. The encoded
            protein also is necessary for the increase in blood pressure due to
            high dietary fructose consumption. [provided by RefSeq, Jun 2016].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1). Variants 1 and 3
            both encode the same isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803613.179157.1,
                                           SRR1803617.129736.1 [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000377424.9/ ENSP00000366641.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-24                DC379829.1         194-217
            25-1998             M55531.1           1-1974
            1999-2245           CA309754.1         17-263              c
            2246-4085           AL158048.35        96176-98015
FEATURES             Location/Qualifiers
     source          1..4085
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p36.23"
     gene            1..4085
                     /gene="SLC2A5"
                     /gene_synonym="GLUT-5; GLUT5"
                     /note="solute carrier family 2 member 5"
                     /db_xref="GeneID:6518"
                     /db_xref="HGNC:HGNC:11010"
                     /db_xref="MIM:138230"
     exon            1..132
                     /gene="SLC2A5"
                     /gene_synonym="GLUT-5; GLUT5"
                     /inference="alignment:Splign:2.1.0"
     CDS             100..1605
                     /gene="SLC2A5"
                     /gene_synonym="GLUT-5; GLUT5"
                     /note="isoform 1 is encoded by transcript variant 1;
                     glucose transporter-like protein 5; glucose transporter
                     type 5, small intestine; solute carrier family 2
                     (facilitated glucose/fructose transporter), member 5;
                     testicular tissue protein Li 81"
                     /codon_start=1
                     /product="solute carrier family 2, facilitated glucose
                     transporter member 5 isoform 1"
                     /protein_id="NP_003030.1"
                     /db_xref="CCDS:CCDS99.1"
                     /db_xref="GeneID:6518"
                     /db_xref="HGNC:HGNC:11010"
                     /db_xref="MIM:138230"
                     /translation="MEQQDQSMKEGRLTLVLALATLIAAFGSSFQYGYNVAAVNSPAL
                     LMQQFYNETYYGRTGEFMEDFPLTLLWSVTVSMFPFGGFIGSLLVGPLVNKFGRKGAL
                     LFNNIFSIVPAILMGCSRVATSFELIIISRLLVGICAGVSSNVVPMYLGELAPKNLRG
                     ALGVVPQLFITVGILVAQIFGLRNLLANVDGWPILLGLTGVPAALQLLLLPFFPESPR
                     YLLIQKKDEAAAKKALQTLRGWDSVDREVAEIRQEDEAEKAAGFISVLKLFRMRSLRW
                     QLLSIIVLMGGQQLSGVNAIYYYADQIYLSAGVPEEHVQYVTAGTGAVNVVMTFCAVF
                     VVELLGRRLLLLLGFSICLIACCVLTAALALQDTVSWMPYISIVCVISYVIGHALGPS
                     PIPALLITEIFLQSSRPSAFMVGGSVHWLSNFTVGLIFPFIQEGLGPYSFIVFAVICL
                     LTTIYIFLIVPETKAKTFIEINQIFTKMNKVSEVYPEKEELKELPPVTSEQ"
     exon            133..231
                     /gene="SLC2A5"
                     /gene_synonym="GLUT-5; GLUT5"
                     /inference="alignment:Splign:2.1.0"
     exon            232..392
                     /gene="SLC2A5"
                     /gene_synonym="GLUT-5; GLUT5"
                     /inference="alignment:Splign:2.1.0"
     exon            393..517
                     /gene="SLC2A5"
                     /gene_synonym="GLUT-5; GLUT5"
                     /inference="alignment:Splign:2.1.0"
     exon            518..670
                     /gene="SLC2A5"
                     /gene_synonym="GLUT-5; GLUT5"
                     /inference="alignment:Splign:2.1.0"
     exon            671..796
                     /gene="SLC2A5"
                     /gene_synonym="GLUT-5; GLUT5"
                     /inference="alignment:Splign:2.1.0"
     exon            797..984
                     /gene="SLC2A5"
                     /gene_synonym="GLUT-5; GLUT5"
                     /inference="alignment:Splign:2.1.0"
     exon            985..1095
                     /gene="SLC2A5"
                     /gene_synonym="GLUT-5; GLUT5"
                     /inference="alignment:Splign:2.1.0"
     exon            1096..1197
                     /gene="SLC2A5"
                     /gene_synonym="GLUT-5; GLUT5"
                     /inference="alignment:Splign:2.1.0"
     exon            1198..1273
                     /gene="SLC2A5"
                     /gene_synonym="GLUT-5; GLUT5"
                     /inference="alignment:Splign:2.1.0"
     exon            1274..1401
                     /gene="SLC2A5"
                     /gene_synonym="GLUT-5; GLUT5"
                     /inference="alignment:Splign:2.1.0"
     exon            1402..4085
                     /gene="SLC2A5"
                     /gene_synonym="GLUT-5; GLUT5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1696..1701
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC2A5"
                     /gene_synonym="GLUT-5; GLUT5"
                     /note="hexamer: AATAAA"
     polyA_site      1718
                     /gene="SLC2A5"
                     /gene_synonym="GLUT-5; GLUT5"
                     /note="major polyA site"
     regulatory      2224..2229
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC2A5"
                     /gene_synonym="GLUT-5; GLUT5"
                     /note="hexamer: AATGAA"
     polyA_site      2248
                     /gene="SLC2A5"
                     /gene_synonym="GLUT-5; GLUT5"
                     /note="major polyA site"
     regulatory      4047..4052
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC2A5"
                     /gene_synonym="GLUT-5; GLUT5"
                     /note="hexamer: AGTAAA"
     polyA_site      4085
                     /gene="SLC2A5"
                     /gene_synonym="GLUT-5; GLUT5"
ORIGIN      
        1 atggccaaag tgcacccaga atgtcttctc tctccattca gtgcacgcgt tactttggct
       61 aaaaggaggt gagcggcact ctgcccttcc agagcaagca tggagcaaca ggatcagagc
      121 atgaaggaag ggaggctgac gcttgtgctt gccctggcaa ccctgatagc tgcctttggg
      181 tcatccttcc agtatgggta caacgtggct gctgtcaact ccccagcact gctcatgcaa
      241 caattttaca atgagactta ctatggtagg accggtgaat tcatggaaga cttccccttg
      301 acgttgctgt ggtctgtaac cgtgtccatg tttccatttg gagggtttat cggatccctc
      361 ctggtcggcc ccttggtgaa taaatttggc agaaaagggg ccttgctgtt caacaacata
      421 ttttctatcg tgcctgcgat cttaatggga tgcagcagag tcgccacatc atttgagctt
      481 atcattattt ccagactttt ggtgggaata tgtgcaggtg tatcttccaa cgtggtcccc
      541 atgtacttag gggagctggc ccctaaaaac ctgcgggggg ctctcggggt ggtgccccag
      601 ctcttcatca ctgttggcat ccttgtggcc cagatctttg gtcttcggaa tctccttgca
      661 aacgtagatg gctggccgat cctgctgggg ctgaccgggg tccccgcggc gctgcagctc
      721 cttctgctgc ccttcttccc cgagagcccc aggtacctgc tgattcagaa gaaagacgaa
      781 gcggccgcca agaaagccct acagacgctg cgcggctggg actctgtgga cagggaggtg
      841 gccgagatcc ggcaggagga tgaggcagag aaggccgcgg gcttcatctc cgtgctgaag
      901 ctgttccgga tgcgctcgct gcgctggcag ctgctgtcca tcatcgtcct catgggcggc
      961 cagcagctgt cgggcgtcaa cgctatctac tactacgcgg accagatcta cctgagcgcc
     1021 ggcgtgccgg aggagcacgt gcagtacgtg acggccggca ccggggccgt gaacgtggtc
     1081 atgaccttct gcgccgtgtt cgtggtggag ctcctgggtc ggaggctgct gctgctgctg
     1141 ggcttctcca tctgcctcat agcctgctgc gtgctcactg cagctctggc actgcaggac
     1201 acagtgtcct ggatgccata catcagcatc gtctgtgtca tctcctacgt cataggacat
     1261 gccctcgggc ccagtcccat acccgcgctg ctcatcactg agatcttcct gcagtcctct
     1321 cggccatctg ccttcatggt ggggggcagt gtgcactggc tctccaactt caccgtgggc
     1381 ttgatcttcc cgttcatcca ggagggcctc ggcccgtaca gcttcattgt cttcgccgtg
     1441 atctgcctcc tcaccaccat ctacatcttc ttgattgtcc cggagaccaa ggccaagacg
     1501 ttcatagaga tcaaccagat tttcaccaag atgaataagg tgtctgaagt gtacccggaa
     1561 aaggaggaac tgaaagagct tccacctgtc acttcggaac agtgactctg gagaggaagc
     1621 cagtggagct ggtctgccag gggcttccca ctttggctta tttttctgac ttctagctgt
     1681 ctgtgaatat ccagaaataa aacaactctg atgtggaatg cagtcctcat ctccagcctc
     1741 cccaccccag tgggaactgt gcaaagggct gccttgctgt tcttgaagct gggctgtctc
     1801 tctccatgtt ggcctgtcac cagacccgag tcaattaaac agctggtcct ccactttgct
     1861 ggttcagcct tcgtgtggct cctggtaacg tggctccacc ttgatgggtc aacctttgtg
     1921 tggctcctgg taacataaca acaacagtta ctatagtggt gagatggaag gaatcaaatt
     1981 ttgccagaga aactaacttg gtggccccga caggtcttcc ggggccatgg gcatttgttt
     2041 agagccaaat tcatcctctt accagatcct tttccagaaa tacctgtcta ggaaggtgtg
     2101 atgtcagaaa caatgacatc cagaaagctg aggaacaggt tcctgtggag acactgagtc
     2161 agaattcttc atcctaaatt attttgttag tggaaaatgg aattgcttct gtgtagtcaa
     2221 taaaatgaac ctgatcactt ttcaacaaga cgtgctgctg ttctttgagc aagtagaagg
     2281 caggaggaag ttccctgctc attcaggcag tgtttttttt gtttttattt ttgctttttt
     2341 tttttttttt aagacggagt ctcgctctgt cacccaggct ggagtgcagt ggtgcgatct
     2401 cagctcactg caaactccac ctcccgggtt cacaccattc tcctgcctca gcctcctgag
     2461 tagctgggac tacaggcgcc tgccaccacg cccggctaac ttttttgtat ttttagtaga
     2521 gactgggttt cactgtgttg gccaggatag tctcaatctc ctgacctcat gatccgccca
     2581 cctaggcccc tcaaagtgct gggattacag gtgtgagcca ctgcgcccgg ccacttcagg
     2641 cagtttgact gcacgagtgt cagttccttg agggcagggg cttggtcagt tttgtttatg
     2701 cctgaatccc cagcatctcg aagagggcct ctggaggctg aggtgggagg attgcttaag
     2761 cctgggaagt agaggttgca gtgagctgaa attgcaccct atactccagc ctgggcaaca
     2821 cagtgagatc ccatctcaaa aaaaattttt ttaattgggc atggtgacac gcctttgggg
     2881 tcccagctat ttgggaggct gaaatgggag gatcgcttga gcctgggagg tcaaggctgc
     2941 cctgagtcat gattgcatca ctgcacacca gcctgcatga cagaatgaga ccttgtctca
     3001 aataaataaa tacatgtaag attgaggaag cttccaaatg tcctcacata tgtaatgaaa
     3061 tcttgaggag tcttaaaatc ttgagactgt ggtgggggag gaagggaaaa ggaacagggt
     3121 cttgatatgg tttggctgtg tccccaccca aatctcatct tgaattgtag ctcccataat
     3181 tcccatgtgt tctgggaggg accctgtggg agataattga atcatggggg caatttcccc
     3241 catactgttc tcatggtagt gaatcagcct catgagatct gatggttctg taaggggtaa
     3301 aaccttttgc ttggttctca ttctctcttg cctgccacca ggtaagacgt gccttttgct
     3361 ttctggcatg attgtgaggc ctccccagcc atgtggaatg gcgagtccat taaatctctt
     3421 tttctttgca atttacccag tctctgatac atctttatca gcagcatgaa aatggtctaa
     3481 cacaggtctc tccccaaaaa tatagagagc tggaggtttt tcttagagat atgaataaag
     3541 ggtgtgagtg tgagtgtatg tgcaaaaata tggataaaac cttgaaagtg ctgaatggcc
     3601 tgtagcaaga agtgatgtct tctcatagat gggtggcaga ggctggtggc cgggagagag
     3661 agcagtggga cttgggagca ctttttgtgg gtatgtaatg gagattccac cagcaacaag
     3721 ctaaaccact cacaagcggg cccagaggaa gtaaacagaa cactgtggtt gaaccatcct
     3781 tggccttctg cagcaaggat ctgcagcctg gaaggggcac agaaacaacc aaagatgaag
     3841 gctctcagag ctgaggagag gccaggtcag aatatcagaa gtcaagaaac tgcagcacct
     3901 ctaacacagg ggaggctatg aagttcatgg ttctggatgt ctgctccctg ggttcaaacc
     3961 ttggtcctgc cacattagtt gtgcaacttg gaaagttact tggctttttt gtatctcagt
     4021 cttctcttct gttaaatggc actaatagta aatgtctcac atgtccattg tgagaattaa
     4081 atgac
//
