LOCUS       NM_020062               2361 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens SLC2A4 regulator (SLC2A4RG), mRNA.
ACCESSION   NM_020062
VERSION     NM_020062.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2361)
  AUTHORS   Chen,C.C., Hsu,C.Y., Lin,H.Y., Zeng,H.Q., Cheng,K.H., Wu,C.W.,
            Tsai,E.M. and Hsieh,T.H.
  TITLE     KRAS K104 modification affects the KRASG12D-GEF interaction and
            mediates cell growth and motility
  JOURNAL   Sci Rep 10 (1), 17447 (2020)
   PUBMED   33060649
  REMARK    GeneRIF: KRAS K104 modification affects the KRAS(G12D)-GEF
            interaction and mediates cell growth and motility.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2361)
  AUTHORS   Yun,D., Wang,H., Wang,Y., Chen,Y., Zhao,Z., Ma,J., Ji,Y., Huang,Q.,
            Chen,J., Chen,H. and Lu,D.
  TITLE     Shuttling SLC2A4RG is regulated by 14-3-3theta; to modulate cell
            survival via caspase-3 and caspase-6 in human glioma
  JOURNAL   EBioMedicine 40, 163-175 (2019)
   PUBMED   30686753
  REMARK    GeneRIF: our results demonstrate that nuclear SLC2A4RG induces cell
            apoptosis in a new manner via direct transactivation of caspase-3
            caspase-6 in glioma, but the interaction with 14-3-3theta; will
            result in sequestration of SLC2A4RG in the cytoplasm and then
            promote tumor progression.
REFERENCE   3  (bases 1 to 2361)
  AUTHORS   Eeles,R.A., Olama,A.A., Benlloch,S., Saunders,E.J.,
            Leongamornlert,D.A., Tymrakiewicz,M., Ghoussaini,M., Luccarini,C.,
            Dennis,J., Jugurnauth-Little,S., Dadaev,T., Neal,D.E., Hamdy,F.C.,
            Donovan,J.L., Muir,K., Giles,G.G., Severi,G., Wiklund,F.,
            Gronberg,H., Haiman,C.A., Schumacher,F., Henderson,B.E., Le
            Marchand,L., Lindstrom,S., Kraft,P., Hunter,D.J., Gapstur,S.,
            Chanock,S.J., Berndt,S.I., Albanes,D., Andriole,G., Schleutker,J.,
            Weischer,M., Canzian,F., Riboli,E., Key,T.J., Travis,R.C.,
            Campa,D., Ingles,S.A., John,E.M., Hayes,R.B., Pharoah,P.D.,
            Pashayan,N., Khaw,K.T., Stanford,J.L., Ostrander,E.A.,
            Signorello,L.B., Thibodeau,S.N., Schaid,D., Maier,C., Vogel,W.,
            Kibel,A.S., Cybulski,C., Lubinski,J., Cannon-Albright,L.,
            Brenner,H., Park,J.Y., Kaneva,R., Batra,J., Spurdle,A.B.,
            Clements,J.A., Teixeira,M.R., Dicks,E., Lee,A., Dunning,A.M.,
            Baynes,C., Conroy,D., Maranian,M.J., Ahmed,S., Govindasami,K.,
            Guy,M., Wilkinson,R.A., Sawyer,E.J., Morgan,A., Dearnaley,D.P.,
            Horwich,A., Huddart,R.A., Khoo,V.S., Parker,C.C., Van As,N.J.,
            Woodhouse,C.J., Thompson,A., Dudderidge,T., Ogden,C., Cooper,C.S.,
            Lophatananon,A., Cox,A., Southey,M.C., Hopper,J.L., English,D.R.,
            Aly,M., Adolfsson,J., Xu,J., Zheng,S.L., Yeager,M., Kaaks,R.,
            Diver,W.R., Gaudet,M.M., Stern,M.C., Corral,R., Joshi,A.D.,
            Shahabi,A., Wahlfors,T., Tammela,T.L., Auvinen,A., Virtamo,J.,
            Klarskov,P., Nordestgaard,B.G., Roder,M.A., Nielsen,S.F.,
            Bojesen,S.E., Siddiq,A., Fitzgerald,L.M., Kolb,S., Kwon,E.M.,
            Karyadi,D.M., Blot,W.J., Zheng,W., Cai,Q., McDonnell,S.K.,
            Rinckleb,A.E., Drake,B., Colditz,G., Wokolorczyk,D.,
            Stephenson,R.A., Teerlink,C., Muller,H., Rothenbacher,D.,
            Sellers,T.A., Lin,H.Y., Slavov,C., Mitev,V., Lose,F.,
            Srinivasan,S., Maia,S., Paulo,P., Lange,E., Cooney,K.A.,
            Antoniou,A.C., Vincent,D., Bacot,F., Tessier,D.C., Kote-Jarai,Z.
            and Easton,D.F.
  CONSRTM   COGS-Cancer Research UK GWAS-ELLIPSE (part of GAME-ON) Initiative;
            Australian Prostate Cancer Bioresource; UK Genetic Prostate Cancer
            Study Collaborators/British Association of Urological Surgeons'
            Section of Oncology; UK ProtecT (Prostate testing for cancer and
            Treatment) Study Collaborators; PRACTICAL (Prostate Cancer
            Association Group to Investigate Cancer-Associated Alterations in
            the Genome) Consortium
  TITLE     Identification of 23 new prostate cancer susceptibility loci using
            the iCOGS custom genotyping array
  JOURNAL   Nat Genet 45 (4), 385-391 (2013)
   PUBMED   23535732
REFERENCE   4  (bases 1 to 2361)
  AUTHORS   Jostins,L., Ripke,S., Weersma,R.K., Duerr,R.H., McGovern,D.P.,
            Hui,K.Y., Lee,J.C., Schumm,L.P., Sharma,Y., Anderson,C.A.,
            Essers,J., Mitrovic,M., Ning,K., Cleynen,I., Theatre,E.,
            Spain,S.L., Raychaudhuri,S., Goyette,P., Wei,Z., Abraham,C.,
            Achkar,J.P., Ahmad,T., Amininejad,L., Ananthakrishnan,A.N.,
            Andersen,V., Andrews,J.M., Baidoo,L., Balschun,T., Bampton,P.A.,
            Bitton,A., Boucher,G., Brand,S., Buning,C., Cohain,A., Cichon,S.,
            D'Amato,M., De Jong,D., Devaney,K.L., Dubinsky,M., Edwards,C.,
            Ellinghaus,D., Ferguson,L.R., Franchimont,D., Fransen,K.,
            Gearry,R., Georges,M., Gieger,C., Glas,J., Haritunians,T., Hart,A.,
            Hawkey,C., Hedl,M., Hu,X., Karlsen,T.H., Kupcinskas,L.,
            Kugathasan,S., Latiano,A., Laukens,D., Lawrance,I.C., Lees,C.W.,
            Louis,E., Mahy,G., Mansfield,J., Morgan,A.R., Mowat,C., Newman,W.,
            Palmieri,O., Ponsioen,C.Y., Potocnik,U., Prescott,N.J.,
            Regueiro,M., Rotter,J.I., Russell,R.K., Sanderson,J.D., Sans,M.,
            Satsangi,J., Schreiber,S., Simms,L.A., Sventoraityte,J.,
            Targan,S.R., Taylor,K.D., Tremelling,M., Verspaget,H.W., De Vos,M.,
            Wijmenga,C., Wilson,D.C., Winkelmann,J., Xavier,R.J., Zeissig,S.,
            Zhang,B., Zhang,C.K., Zhao,H., Silverberg,M.S., Annese,V.,
            Hakonarson,H., Brant,S.R., Radford-Smith,G., Mathew,C.G.,
            Rioux,J.D., Schadt,E.E., Daly,M.J., Franke,A., Parkes,M.,
            Vermeire,S., Barrett,J.C. and Cho,J.H.
  CONSRTM   International IBD Genetics Consortium (IIBDGC)
  TITLE     Host-microbe interactions have shaped the genetic architecture of
            inflammatory bowel disease
  JOURNAL   Nature 491 (7422), 119-124 (2012)
   PUBMED   23128233
REFERENCE   5  (bases 1 to 2361)
  AUTHORS   Anderson,C.A., Boucher,G., Lees,C.W., Franke,A., D'Amato,M.,
            Taylor,K.D., Lee,J.C., Goyette,P., Imielinski,M., Latiano,A.,
            Lagace,C., Scott,R., Amininejad,L., Bumpstead,S., Baidoo,L.,
            Baldassano,R.N., Barclay,M., Bayless,T.M., Brand,S., Buning,C.,
            Colombel,J.F., Denson,L.A., De Vos,M., Dubinsky,M., Edwards,C.,
            Ellinghaus,D., Fehrmann,R.S., Floyd,J.A., Florin,T.,
            Franchimont,D., Franke,L., Georges,M., Glas,J., Glazer,N.L.,
            Guthery,S.L., Haritunians,T., Hayward,N.K., Hugot,J.P., Jobin,G.,
            Laukens,D., Lawrance,I., Lemann,M., Levine,A., Libioulle,C.,
            Louis,E., McGovern,D.P., Milla,M., Montgomery,G.W., Morley,K.I.,
            Mowat,C., Ng,A., Newman,W., Ophoff,R.A., Papi,L., Palmieri,O.,
            Peyrin-Biroulet,L., Panes,J., Phillips,A., Prescott,N.J.,
            Proctor,D.D., Roberts,R., Russell,R., Rutgeerts,P., Sanderson,J.,
            Sans,M., Schumm,P., Seibold,F., Sharma,Y., Simms,L.A.,
            Seielstad,M., Steinhart,A.H., Targan,S.R., van den Berg,L.H.,
            Vatn,M., Verspaget,H., Walters,T., Wijmenga,C., Wilson,D.C.,
            Westra,H.J., Xavier,R.J., Zhao,Z.Z., Ponsioen,C.Y., Andersen,V.,
            Torkvist,L., Gazouli,M., Anagnou,N.P., Karlsen,T.H., Kupcinskas,L.,
            Sventoraityte,J., Mansfield,J.C., Kugathasan,S., Silverberg,M.S.,
            Halfvarson,J., Rotter,J.I., Mathew,C.G., Griffiths,A.M., Gearry,R.,
            Ahmad,T., Brant,S.R., Chamaillard,M., Satsangi,J., Cho,J.H.,
            Schreiber,S., Daly,M.J., Barrett,J.C., Parkes,M., Annese,V.,
            Hakonarson,H., Radford-Smith,G., Duerr,R.H., Vermeire,S.,
            Weersma,R.K. and Rioux,J.D.
  TITLE     Meta-analysis identifies 29 additional ulcerative colitis risk
            loci, increasing the number of confirmed associations to 47
  JOURNAL   Nat Genet 43 (3), 246-252 (2011)
   PUBMED   21297633
  REMARK    Erratum:[Nat Genet. 2011 Sep;43(9):919]
REFERENCE   6  (bases 1 to 2361)
  AUTHORS   McGee,S.L., Sparling,D., Olson,A.L. and Hargreaves,M.
  TITLE     Exercise increases MEF2- and GEF DNA-binding activity in human
            skeletal muscle
  JOURNAL   FASEB J 20 (2), 348-349 (2006)
   PUBMED   16368714
  REMARK    GeneRIF: Exercise increases MEF2 and GEF DNA binding and imply that
            these transcription factors could be potential targets for
            modulating GLUT4 expression in human skeletal muscle.
REFERENCE   7  (bases 1 to 2361)
  AUTHORS   Tanaka,K., Shouguchi-Miyata,J., Miyamoto,N. and Ikeda,J.E.
  TITLE     Novel nuclear shuttle proteins, HDBP1 and HDBP2, bind to neuronal
            cell-specific cis-regulatory element in the promoter for the human
            Huntington's disease gene
  JOURNAL   J Biol Chem 279 (8), 7275-7286 (2004)
   PUBMED   14625278
  REMARK    GeneRIF: HDBP1 and HDBP2 are novel transcription factors shuttling
            between nucleus and cytoplasm and bind to the specific GCCGGCG,
            which is an essential cis-element for HD gene expression in
            neuronal cells
REFERENCE   8  (bases 1 to 2361)
  AUTHORS   Knight,J.B., Eyster,C.A., Griesel,B.A. and Olson,A.L.
  TITLE     Regulation of the human GLUT4 gene promoter: interaction between a
            transcriptional activator and myocyte enhancer factor 2A
  JOURNAL   Proc Natl Acad Sci U S A 100 (25), 14725-14730 (2003)
   PUBMED   14630949
  REMARK    GeneRIF: GEF and MEF2A have roles in regulating the GLUT4 promoter
REFERENCE   9  (bases 1 to 2361)
  AUTHORS   Deloukas,P., Matthews,L.H., Ashurst,J., Burton,J., Gilbert,J.G.,
            Jones,M., Stavrides,G., Almeida,J.P., Babbage,A.K., Bagguley,C.L.,
            Bailey,J., Barlow,K.F., Bates,K.N., Beard,L.M., Beare,D.M.,
            Beasley,O.P., Bird,C.P., Blakey,S.E., Bridgeman,A.M., Brown,A.J.,
            Buck,D., Burrill,W., Butler,A.P., Carder,C., Carter,N.P.,
            Chapman,J.C., Clamp,M., Clark,G., Clark,L.N., Clark,S.Y.,
            Clee,C.M., Clegg,S., Cobley,V.E., Collier,R.E., Connor,R.,
            Corby,N.R., Coulson,A., Coville,G.J., Deadman,R., Dhami,P.,
            Dunn,M., Ellington,A.G., Frankland,J.A., Fraser,A., French,L.,
            Garner,P., Grafham,D.V., Griffiths,C., Griffiths,M.N., Gwilliam,R.,
            Hall,R.E., Hammond,S., Harley,J.L., Heath,P.D., Ho,S., Holden,J.L.,
            Howden,P.J., Huckle,E., Hunt,A.R., Hunt,S.E., Jekosch,K.,
            Johnson,C.M., Johnson,D., Kay,M.P., Kimberley,A.M., King,A.,
            Knights,A., Laird,G.K., Lawlor,S., Lehvaslaiho,M.H., Leversha,M.,
            Lloyd,C., Lloyd,D.M., Lovell,J.D., Marsh,V.L., Martin,S.L.,
            McConnachie,L.J., McLay,K., McMurray,A.A., Milne,S., Mistry,D.,
            Moore,M.J., Mullikin,J.C., Nickerson,T., Oliver,K., Parker,A.,
            Patel,R., Pearce,T.A., Peck,A.I., Phillimore,B.J.,
            Prathalingam,S.R., Plumb,R.W., Ramsay,H., Rice,C.M., Ross,M.T.,
            Scott,C.E., Sehra,H.K., Shownkeen,R., Sims,S., Skuce,C.D.,
            Smith,M.L., Soderlund,C., Steward,C.A., Sulston,J.E., Swann,M.,
            Sycamore,N., Taylor,R., Tee,L., Thomas,D.W., Thorpe,A., Tracey,A.,
            Tromans,A.C., Vaudin,M., Wall,M., Wallis,J.M., Whitehead,S.L.,
            Whittaker,P., Willey,D.L., Williams,L., Williams,S.A., Wilming,L.,
            Wray,P.W., Hubbard,T., Durbin,R.M., Bentley,D.R., Beck,S. and
            Rogers,J.
  TITLE     The DNA sequence and comparative analysis of human chromosome 20
  JOURNAL   Nature 414 (6866), 865-871 (2001)
   PUBMED   11780052
REFERENCE   10 (bases 1 to 2361)
  AUTHORS   Oshel,K.M., Knight,J.B., Cao,K.T., Thai,M.V. and Olson,A.L.
  TITLE     Identification of a 30-base pair regulatory element and novel DNA
            binding protein that regulates the human GLUT4 promoter in
            transgenic mice
  JOURNAL   J Biol Chem 275 (31), 23666-23673 (2000)
   PUBMED   10825161
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL121845.20, BC052306.1,
            BC028349.2, BM983611.1 and AV659783.2.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_020062.3.
            
            Summary: The protein encoded by this gene is a nuclear
            transcription factor involved in the activation of the solute
            carrier family 2 member 4 gene. The encoded protein interacts with
            another transcription factor, myocyte enhancer factor 2, to
            activate transcription of this gene. [provided by RefSeq, Jul
            2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC052306.1, AB052777.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1970526
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000266077.5/ ENSP00000266077.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-82                AL121845.20        43373-43454
            83-1430             BC052306.1         46-1393
            1431-1816           BC028349.2         544-929
            1817-1972           BM983611.1         406-561             c
            1973-1983           AV659783.2         227-237
            1984-2361           BM983611.1         18-395              c
FEATURES             Location/Qualifiers
     source          1..2361
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20q13.33"
     gene            1..2361
                     /gene="SLC2A4RG"
                     /gene_synonym="GEF; HDBP-1; HDBP1; Si-1-2; Si-1-2-19"
                     /note="SLC2A4 regulator"
                     /db_xref="GeneID:56731"
                     /db_xref="HGNC:HGNC:15930"
                     /db_xref="MIM:609493"
     exon            1..263
                     /gene="SLC2A4RG"
                     /gene_synonym="GEF; HDBP-1; HDBP1; Si-1-2; Si-1-2-19"
                     /inference="alignment:Splign:2.1.0"
     CDS             138..1301
                     /gene="SLC2A4RG"
                     /gene_synonym="GEF; HDBP-1; HDBP1; Si-1-2; Si-1-2-19"
                     /note="GLUT4 enhancer factor; Huntington's disease gene
                     regulatory region-binding protein 1"
                     /codon_start=1
                     /product="SLC2A4 regulator"
                     /protein_id="NP_064446.2"
                     /db_xref="CCDS:CCDS13537.1"
                     /db_xref="GeneID:56731"
                     /db_xref="HGNC:HGNC:15930"
                     /db_xref="MIM:609493"
                     /translation="MERPPPRAAGRDPSALRAEAPWLRAEGPGPRAAPVTVPTPPQGS
                     SVGGGFAGLEFARPQESEPRASDLGAPRTWTGAAAGPRTPSAHIPVPAQRATPGKARL
                     DEVMAAAALTSLSTSPLLLGAPVAAFSPEPGLEPWKEALVRPPGSYSSSSNSGDWGWD
                     LASDQSSPSTPSPPLPPEAAHFLFGEPTLRKRKSPAQVMFQCLWKSCGKVLSTASAMQ
                     RHIRLVHLGRQAEPEQSDGEEDFYYTELDVGVDTLTDGLSSLTPVSPTASMPPAFPRL
                     ELPELLEPPALPSPLRPPAPPLPPPPVLSTVANPQSCHSDRVYQGCLTPARLEPQPTE
                     VGACPPALSSRIGVTLRKPRGDAKKCRKVYGMERRDLWCTACRWKKACQRFLD"
     exon            264..418
                     /gene="SLC2A4RG"
                     /gene_synonym="GEF; HDBP-1; HDBP1; Si-1-2; Si-1-2-19"
                     /inference="alignment:Splign:2.1.0"
     exon            419..528
                     /gene="SLC2A4RG"
                     /gene_synonym="GEF; HDBP-1; HDBP1; Si-1-2; Si-1-2-19"
                     /inference="alignment:Splign:2.1.0"
     exon            529..716
                     /gene="SLC2A4RG"
                     /gene_synonym="GEF; HDBP-1; HDBP1; Si-1-2; Si-1-2-19"
                     /inference="alignment:Splign:2.1.0"
     exon            717..817
                     /gene="SLC2A4RG"
                     /gene_synonym="GEF; HDBP-1; HDBP1; Si-1-2; Si-1-2-19"
                     /inference="alignment:Splign:2.1.0"
     exon            818..1097
                     /gene="SLC2A4RG"
                     /gene_synonym="GEF; HDBP-1; HDBP1; Si-1-2; Si-1-2-19"
                     /inference="alignment:Splign:2.1.0"
     exon            1098..1189
                     /gene="SLC2A4RG"
                     /gene_synonym="GEF; HDBP-1; HDBP1; Si-1-2; Si-1-2-19"
                     /inference="alignment:Splign:2.1.0"
     exon            1190..2361
                     /gene="SLC2A4RG"
                     /gene_synonym="GEF; HDBP-1; HDBP1; Si-1-2; Si-1-2-19"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1791..1796
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC2A4RG"
                     /gene_synonym="GEF; HDBP-1; HDBP1; Si-1-2; Si-1-2-19"
                     /note="hexamer: ATTAAA"
     polyA_site      1816
                     /gene="SLC2A4RG"
                     /gene_synonym="GEF; HDBP-1; HDBP1; Si-1-2; Si-1-2-19"
                     /note="major polyA site"
     regulatory      2243..2248
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC2A4RG"
                     /gene_synonym="GEF; HDBP-1; HDBP1; Si-1-2; Si-1-2-19"
                     /note="hexamer: AATATA"
     polyA_site      2289
                     /gene="SLC2A4RG"
                     /gene_synonym="GEF; HDBP-1; HDBP1; Si-1-2; Si-1-2-19"
     regulatory      2341..2346
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC2A4RG"
                     /gene_synonym="GEF; HDBP-1; HDBP1; Si-1-2; Si-1-2-19"
                     /note="hexamer: AATAAA"
     polyA_site      2361
                     /gene="SLC2A4RG"
                     /gene_synonym="GEF; HDBP-1; HDBP1; Si-1-2; Si-1-2-19"
ORIGIN      
        1 agcctccggg cggcgcggcg cgggcggcgg ccggatccag ggcgggggtc ggcggcccgg
       61 ccagcccggc ccggcccggg gccgcgtcct gagagtcagc cctcgccgct gcagcctcgg
      121 cgcccggccg gccggccatg gagcgccccc cgccccgcgc cgccggccgg gaccccagtg
      181 cgctgcgggc cgaggcgccg tggctgcgcg cggagggtcc ggggccgcgc gccgcgcccg
      241 tgacggtgcc cacgccgccg cagggctctt ccgtgggcgg cggcttcgcg ggcttggagt
      301 tcgcgcggcc gcaggagtcg gagccgcggg cctcggacct gggggccccc cggacgtgga
      361 cgggggcggc ggcggggccc cggactccgt cggcgcacat ccccgtccca gcgcagagag
      421 ccaccccagg aaaagcccgg ctggacgagg tcatggctgc cgctgccctt acaagcctgt
      481 ccaccagccc tctccttctg ggggccccgg ttgcagcctt cagcccagag cctggcctgg
      541 agccctggaa ggaggccctg gtgcggcccc caggcagcta cagcagcagc agcaacagtg
      601 gagactgggg atgggacctg gccagtgacc agtcctctcc gtccaccccg tcacccccac
      661 tgccccccga ggcagcccac tttctgtttg gggagcccac cctgagaaaa aggaagagcc
      721 cggcccaggt catgttccag tgtctgtgga agagctgcgg gaaggtgctg agcacggcgt
      781 cggcgatgca gagacacatc cgcctggtgc acctggggag gcaggcagag cctgagcaga
      841 gtgatggtga ggaggacttc tactacacag agctggatgt tggtgtggac acgctgaccg
      901 acgggctgtc cagcctgact ccagtgtccc ccacggcctc catgccgcct gccttccccc
      961 gcctggagct gccagagctg ctggagcccc cagccctgcc tagtcccctg cggccgcctg
     1021 ccccgcccct gcccccgccc cctgtcctga gcaccgttgc taacccccag tcctgtcaca
     1081 gtgaccgtgt ctaccagggc tgcctgacgc ccgcccgcct ggagccgcag cccacggagg
     1141 tcggagcctg cccacccgcc ttgtcctcca ggatcggagt caccctgagg aagccccgcg
     1201 gcgacgcgaa gaagtgccgg aaggtgtatg gcatggagcg ccgggacctc tggtgcacag
     1261 cctgccgctg gaagaaagcc tgccagcggt tcctggacta agtccggctc gttcaagaac
     1321 ataagctacc accttctccc tccccacccc ctccaggccc ggggctgaaa cagcccgagg
     1381 acagccccag gggctggctt tcaccagctg cagggtctgc ttttacttgg ggtggggggg
     1441 cggggctgac cctgaaccct cccccccgcc aggtcgggga ggggtcccac cactcaaagt
     1501 gcctctaaag aaaccagctt tttgcactaa agccaaacca caccgctgtc cccttagccc
     1561 caagggccct gggggcagcc accctcccgc ctgtcggccc gtagatttat caagggtgtt
     1621 atgggcccag ctttgggggg ccagtcccga tgcactttga ggggtgttgg agaggggact
     1681 cccccactcg cacttaactc aacggctctc gggccctggg gctgttttta ccatgtttgt
     1741 ttttgaagct caggtgtctc acgtctgggc tgcaccaggc gaagagagaa attaaagatt
     1801 tgaggttttt ccagaagctt tgtctgcctc tcgggaggaa ggccgtgggg ctgggaccct
     1861 gtggtgggca agtgggtgga gtctggcagc tgcccacaga gggccgaggg tcacccgtcg
     1921 gccgccgcca ccccaggcga ggccggagga aggatcatct gagacgcagg aggcatctgc
     1981 tggagcagca atttcccaat ttattgaaag tgatcgcttt gcaaggatgt ctaagctaat
     2041 cccgtcacag aaaggaaacg cacaggcgcc taggcagaaa cttggagact caccgcagag
     2101 gccacgtgaa cccacggcca cagagaggca ggacggcaga gccatgattt cccaccgagc
     2161 gattacgaga acctcttccc ccaatagtag acacatctcc aatacaaaca caggtttata
     2221 ataagtaata ggaagtcaat ataatataga ttatccccag aaaaaaatca acaatcttca
     2281 aacactgccc tttttttgtg tgttttgttt ttgttgacag gttgaaagca tgttgaaaaa
     2341 aataaatatt taagaaaagc a
//
