LOCUS       NM_001042               3375 bp    mRNA    linear   PRI 27-APR-2025
DEFINITION  Homo sapiens solute carrier family 2 member 4 (SLC2A4), mRNA.
ACCESSION   NM_001042
VERSION     NM_001042.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3375)
  AUTHORS   Gaugel,J., Haacke,N., Sehgal,R., Jahnert,M., Jonas,W., Hoffmann,A.,
            Bluher,M., Ghosh,A., Noe,F., Wolfrum,C., Tan,J., Schurmann,A.,
            Fazakerley,D.J. and Vogel,H.
  TITLE     Picalm, a novel regulator of GLUT4-trafficking in adipose tissue
  JOURNAL   Mol Metab 88, 102014 (2024)
   PUBMED   39182843
  REMARK    GeneRIF: Picalm, a novel regulator of GLUT4-trafficking in adipose
            tissue.
REFERENCE   2  (bases 1 to 3375)
  AUTHORS   Querio,G., Antoniotti,S., Levi,R., Fleischmann,B.K., Gallo,M.P. and
            Malan,D.
  TITLE     Insulin-Activated Signaling Pathway and GLUT4 Membrane
            Translocation in hiPSC-Derived Cardiomyocytes
  JOURNAL   Int J Mol Sci 25 (15), 8197 (2024)
   PUBMED   39125765
  REMARK    GeneRIF: Insulin-Activated Signaling Pathway and GLUT4 Membrane
            Translocation in hiPSC-Derived Cardiomyocytes.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3375)
  AUTHORS   Barrett,J.S., Strauss,J.A., Chow,L.S., Shepherd,S.O.,
            Wagenmakers,A.J.M. and Wang,Y.
  TITLE     GLUT4 localisation with the plasma membrane is unaffected by an
            increase in plasma free fatty acid availability
  JOURNAL   Lipids Health Dis 23 (1), 94 (2024)
   PUBMED   38566151
  REMARK    GeneRIF: GLUT4 localisation with the plasma membrane is unaffected
            by an increase in plasma free fatty acid availability.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3375)
  AUTHORS   Kioumourtzoglou,D., Black,H.L., Al Tobi,M., Livingstone,R.,
            Petrie,J.R., Boyle,J.G., Gould,G.W. and Bryant,N.J.
  TITLE     Phosphorylation of Syntaxin 4 by the Insulin Receptor Drives
            Exocytic SNARE Complex Formation to Deliver GLUT4 to the Cell
            Surface
  JOURNAL   Biomolecules 13 (12), 1738 (2023)
   PUBMED   38136609
  REMARK    GeneRIF: Phosphorylation of Syntaxin 4 by the Insulin Receptor
            Drives Exocytic SNARE Complex Formation to Deliver GLUT4 to the
            Cell Surface.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3375)
  AUTHORS   Ray,A., Wen,J., Yammine,L., Culver,J., Parida,I.S., Garren,J.,
            Xue,L., Hales,K., Xiang,Q., Birnbaum,M.J., Zhang,B.B., Monetti,M.
            and McGraw,T.E.
  TITLE     Regulated dynamic subcellular GLUT4 localization revealed by
            proximal proteome mapping in human muscle cells
  JOURNAL   J Cell Sci 136 (23) (2023)
   PUBMED   38126809
  REMARK    GeneRIF: Regulated dynamic subcellular GLUT4 localization revealed
            by proximal proteome mapping in human muscle cells.
REFERENCE   6  (bases 1 to 3375)
  AUTHORS   Buse,J.B., Yasuda,K., Lay,T.P., Seo,T.S., Olson,A.L., Pessin,J.E.,
            Karam,J.H., Seino,S. and Bell,G.I.
  TITLE     Human GLUT4/muscle-fat glucose-transporter gene. Characterization
            and genetic variation
  JOURNAL   Diabetes 41 (11), 1436-1445 (1992)
   PUBMED   1397719
REFERENCE   7  (bases 1 to 3375)
  AUTHORS   Liu,M.L., Olson,A.L., Moye-Rowley,W.S., Buse,J.B., Bell,G.I. and
            Pessin,J.E.
  TITLE     Expression and regulation of the human GLUT4/muscle-fat
            facilitative glucose transporter gene in transgenic mice
  JOURNAL   J Biol Chem 267 (17), 11673-11676 (1992)
   PUBMED   1601840
REFERENCE   8  (bases 1 to 3375)
  AUTHORS   O'Rahilly,S., Krook,A., Morgan,R., Rees,A., Flier,J.S. and
            Moller,D.E.
  TITLE     Insulin receptor and insulin-responsive glucose transporter (GLUT
            4) mutations and polymorphisms in a Welsh type 2
            (non-insulin-dependent) diabetic population
  JOURNAL   Diabetologia 35 (5), 486-489 (1992)
   PUBMED   1521731
REFERENCE   9  (bases 1 to 3375)
  AUTHORS   Choi,W.H., O'Rahilly,S., Buse,J.B., Rees,A., Morgan,R., Flier,J.S.
            and Moller,D.E.
  TITLE     Molecular scanning of insulin-responsive glucose transporter
            (GLUT4) gene in NIDDM subjects
  JOURNAL   Diabetes 40 (12), 1712-1718 (1991)
   PUBMED   1756912
REFERENCE   10 (bases 1 to 3375)
  AUTHORS   Kusari,J., Verma,U.S., Buse,J.B., Henry,R.R. and Olefsky,J.M.
  TITLE     Analysis of the gene sequences of the insulin receptor and the
            insulin-sensitive glucose transporter (GLUT-4) in patients with
            common-type non-insulin-dependent diabetes mellitus
  JOURNAL   J Clin Invest 88 (4), 1323-1330 (1991)
   PUBMED   1918382
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC003688.1, CF594356.1,
            M20747.1, BC034387.1, AL521328.3 and BQ775137.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_001042.2.
            
            Summary: This gene is a member of the solute carrier family 2
            (facilitated glucose transporter) family and encodes a protein that
            functions as an insulin-regulated facilitative glucose transporter.
            In the absence of insulin, this integral membrane protein is
            sequestered within the cells of muscle and adipose tissue. Within
            minutes of insulin stimulation, the protein moves to the cell
            surface and begins to transport glucose across the cell membrane.
            Mutations in this gene have been associated with
            noninsulin-dependent diabetes mellitus (NIDDM). [provided by
            RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DRR138518.432463.1,
                                           DRR138518.403498.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000317370.13/ ENSP00000320935.8
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-17                AC003688.1         84114-84130
            18-72               CF594356.1         46-100
            73-73               M20747.1           1-1
            74-606              BC034387.1         57-589
            607-883             AL521328.3         589-865
            884-2200            M20747.1           812-2128
            2201-3161           AC003688.1         89479-90439
            3162-3166           BQ775137.1         18-22               c
            3167-3375           AC003688.1         90445-90653
FEATURES             Location/Qualifiers
     source          1..3375
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17p13.1"
     gene            1..3375
                     /gene="SLC2A4"
                     /gene_synonym="GLUT4"
                     /note="solute carrier family 2 member 4"
                     /db_xref="GeneID:6517"
                     /db_xref="HGNC:HGNC:11009"
                     /db_xref="MIM:138190"
     exon            1..250
                     /gene="SLC2A4"
                     /gene_synonym="GLUT4"
                     /inference="alignment:Splign:2.1.0"
     CDS             218..1747
                     /gene="SLC2A4"
                     /gene_synonym="GLUT4"
                     /note="insulin-responsive glucose transporter type 4;
                     GLUT-4; glucose transporter type 4, insulin-responsive;
                     solute carrier family 2 (facilitated glucose transporter),
                     member 4"
                     /codon_start=1
                     /product="solute carrier family 2, facilitated glucose
                     transporter member 4"
                     /protein_id="NP_001033.1"
                     /db_xref="CCDS:CCDS11097.1"
                     /db_xref="GeneID:6517"
                     /db_xref="HGNC:HGNC:11009"
                     /db_xref="MIM:138190"
                     /translation="MPSGFQQIGSEDGEPPQQRVTGTLVLAVFSAVLGSLQFGYNIGV
                     INAPQKVIEQSYNETWLGRQGPEGPSSIPPGTLTTLWALSVAIFSVGGMISSFLIGII
                     SQWLGRKRAMLVNNVLAVLGGSLMGLANAAASYEMLILGRFLIGAYSGLTSGLVPMYV
                     GEIAPTHLRGALGTLNQLAIVIGILIAQVLGLESLLGTASLWPLLLGLTVLPALLQLV
                     LLPFCPESPRYLYIIQNLEGPARKSLKRLTGWADVSGVLAELKDEKRKLERERPLSLL
                     QLLGSRTHRQPLIIAVVLQLSQQLSGINAVFYYSTSIFETAGVGQPAYATIGAGVVNT
                     VFTLVSVLLVERAGRRTLHLLGLAGMCGCAILMTVALLLLERVPAMSYVSIVAIFGFV
                     AFFEIGPGPIPWFIVAELFSQGPRPAAMAVAGFSNWTSNFIIGMGFQYVAEAMGPYVF
                     LLFAVLLLGFFIFTFLRVPETRGRTFDQISAAFHRTPSLLEQEVKPSTELEYLGPDEN
                     D"
     exon            251..367
                     /gene="SLC2A4"
                     /gene_synonym="GLUT4"
                     /inference="alignment:Splign:2.1.0"
     exon            368..540
                     /gene="SLC2A4"
                     /gene_synonym="GLUT4"
                     /inference="alignment:Splign:2.1.0"
     exon            541..665
                     /gene="SLC2A4"
                     /gene_synonym="GLUT4"
                     /inference="alignment:Splign:2.1.0"
     exon            666..781
                     /gene="SLC2A4"
                     /gene_synonym="GLUT4"
                     /inference="alignment:Splign:2.1.0"
     exon            782..944
                     /gene="SLC2A4"
                     /gene_synonym="GLUT4"
                     /inference="alignment:Splign:2.1.0"
     exon            945..1132
                     /gene="SLC2A4"
                     /gene_synonym="GLUT4"
                     /inference="alignment:Splign:2.1.0"
     exon            1133..1237
                     /gene="SLC2A4"
                     /gene_synonym="GLUT4"
                     /inference="alignment:Splign:2.1.0"
     exon            1238..1339
                     /gene="SLC2A4"
                     /gene_synonym="GLUT4"
                     /inference="alignment:Splign:2.1.0"
     exon            1340..1543
                     /gene="SLC2A4"
                     /gene_synonym="GLUT4"
                     /inference="alignment:Splign:2.1.0"
     exon            1544..3375
                     /gene="SLC2A4"
                     /gene_synonym="GLUT4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2929..2934
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC2A4"
                     /gene_synonym="GLUT4"
                     /note="hexamer: TATAAA"
     polyA_site      2954
                     /gene="SLC2A4"
                     /gene_synonym="GLUT4"
     regulatory      3121..3126
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC2A4"
                     /gene_synonym="GLUT4"
                     /note="hexamer: AATAAA"
     polyA_site      3138
                     /gene="SLC2A4"
                     /gene_synonym="GLUT4"
                     /note="major polyA site"
     polyA_site      3175
                     /gene="SLC2A4"
                     /gene_synonym="GLUT4"
     polyA_site      3183
                     /gene="SLC2A4"
                     /gene_synonym="GLUT4"
ORIGIN      
        1 gtcttttccc ccagccccgc tccaccagat ccgcgggagc cccactgctc tccgggtcct
       61 tggcttgtgg ctgtgggtcc catcgggccc gccctcgcac gtcactccgg gacccccgcg
      121 gcctccgcag gttctgcgct ccaggccgga gtcagagact ccaggatcgg ttctttcatc
      181 ttcgccgccc ctgcgcgtcc agctcttcta agacgagatg ccgtcgggct tccaacagat
      241 aggctccgaa gatggggaac cccctcagca gcgagtgact gggaccctgg tccttgctgt
      301 gttctctgcg gtgcttggct ccctgcagtt tgggtacaac attggggtca tcaatgcccc
      361 tcagaaggtg attgaacaga gctacaatga gacgtggctg gggaggcagg ggcctgaggg
      421 acccagctcc atccctccag gcaccctcac caccctctgg gccctctccg tggccatctt
      481 ttccgtgggc ggcatgattt cctccttcct cattggtatc atctctcagt ggcttggaag
      541 gaaaagggcc atgctggtca acaatgtcct ggcggtgctg gggggcagcc tcatgggcct
      601 ggccaatgct gctgcctcct atgaaatgct catccttgga cgattcctca ttggcgccta
      661 ctcagggctg acatcagggc tggtgcccat gtacgtgggg gagattgctc ccactcacct
      721 gcggggcgcc ctggggacgc tcaaccaact ggccattgtt atcggcattc tgatcgccca
      781 ggtgctgggc ttggagtccc tcctgggcac tgccagcctg tggccactgc tcctgggcct
      841 cacagtgcta cctgccctcc tgcagctggt cctgctgccc ttctgtcccg agagcccccg
      901 ctacctctac atcatccaga atctcgaggg gcctgccaga aagagtctga agcgcctgac
      961 aggctgggcc gatgtttctg gagtgctggc tgagctgaag gatgagaagc ggaagctgga
     1021 gcgtgagcgg ccactgtccc tgctccagct cctgggcagc cgtacccacc ggcagcccct
     1081 gatcattgcg gtcgtgctgc agctgagcca gcagctctct ggcatcaatg ctgttttcta
     1141 ttattcgacc agcatcttcg agacagcagg ggtaggccag cctgcctatg ccaccatagg
     1201 agctggtgtg gtcaacacag tcttcacctt ggtctcggtg ttgttggtgg agcgggcggg
     1261 gcgccggacg ctccatctcc tgggcctggc gggcatgtgt ggctgtgcca tcctgatgac
     1321 tgtggctctg ctcctgctgg agcgagttcc agccatgagc tacgtctcca ttgtggccat
     1381 ctttggcttc gtggcatttt ttgagattgg ccctggcccc attccttggt tcatcgtggc
     1441 cgagctcttc agccagggac cccgcccggc agccatggct gtggctggtt tctccaactg
     1501 gacgagcaac ttcatcattg gcatgggttt ccagtatgtt gcggaggcta tggggcccta
     1561 cgtcttcctt ctatttgcgg tcctcctgct gggcttcttc atcttcacct tcttaagagt
     1621 acctgaaact cgaggccgga cgtttgacca gatctcagct gccttccacc ggacaccctc
     1681 tcttttagag caggaggtga aacccagcac agaacttgag tatttagggc cagatgagaa
     1741 cgactgaggg gccaggcagg ggtgggagag ccagctctct ctacccggcc cagagacccc
     1801 ttcctttcct ctgcagcact ttaaccctct cttccctatt atttccgggt ggaaaagaat
     1861 ccctgcagcc tggtagaatt gggaagctgg gggaagggtg gtctgagcac cccctcattc
     1921 ccctcgtgtg actctcttgg attatttatg tgttgtggtt tggccgtggc catcagggtg
     1981 ggccactctc ccctccctct tccttccccc atcccctttc ctccccacct tccccagact
     2041 cagctccaga ataccttctt cgctgctaga gaagggggat tggagggaag acaggtctag
     2101 actttctcag tgggacaaac cagagcagag agcaggacag gagacaagaa atccagtttc
     2161 ccaccacctt ggactcctcc cacaatctgg gactttcact gaattcttgc cacgcagact
     2221 ctgggcaaag gggttttttt tttttttttt tttttttttt ttgagacagt ctcgctctgt
     2281 cgcccaggct cgagtgcagt ggcgtgatct tgcttcactg caagctgtct cccaggttca
     2341 cgccattctc ctgcctcagc ctccggagta gctgggacta caggcgcatg ccaccacacc
     2401 tggctaattt attttgtatt tttagtatat acgcggtttc accatgttag ccagaatggt
     2461 ctcgatctcc tgacctcgtg atctgcctgc ctcagcctcc caaagtgctg ggattacagg
     2521 cgtgagccac cgcgcctggc gaagggagtt ctctcttgac ccctgcaggg aaaaggactc
     2581 acctccctca ctgcaggctc agccttccag ggcaagaggg aacaggaaag tatgtgccca
     2641 tgtgtggcaa gatggaagga cggcaggctc ccgcctctag gcttggggct ctaccccgat
     2701 ggtttcccaa ggctgccaag aaggagccct aactttcttc ctctcccttc ctggaagggt
     2761 gctgcatcca caggcttttg accaactaag gcaaagaggg gatttgaaag gctgcctgga
     2821 aacactgggc tgggaggagc ctttggatat ttttatatac gtttgaaaag gggattgaga
     2881 gaagaaacca aaggtcggtt gtactaaatg tatatatata gatacttcta taaagtcact
     2941 gctgaagaca agcatcctat tgtggaggta cttgaggatg ggctgagaca gggaccataa
     3001 ctcttcaccc ctcttcctcc ctctgtcctg cctcagctca aggcctcaga atcttctgga
     3061 tgccattgct catgccccta ctcacatttc tactcgttgc tttattaata gtaaatgctc
     3121 aataaattgt agctgccagt gccgggcatt gctcttggca tttgcagaat actcactctg
     3181 tgagggaggt gtcagcccat gtcacagatg ggcagtgaaa cccatgatag gggcactctt
     3241 caccagggac acagctggag acatggcagc aaggatgcca ggccctgccc acggccccac
     3301 atcccctcct ccccaccttc aacagtgagt tactagcgat tctccaaaac agaagagatg
     3361 gagaccaaga ccaca
//
