LOCUS       NP_001033                509 aa            linear   PRI 27-APR-2025
DEFINITION  solute carrier family 2, facilitated glucose transporter member 4
            [Homo sapiens].
ACCESSION   NP_001033
VERSION     NP_001033.1
DBSOURCE    REFSEQ: accession NM_001042.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 509)
  AUTHORS   Gaugel,J., Haacke,N., Sehgal,R., Jahnert,M., Jonas,W., Hoffmann,A.,
            Bluher,M., Ghosh,A., Noe,F., Wolfrum,C., Tan,J., Schurmann,A.,
            Fazakerley,D.J. and Vogel,H.
  TITLE     Picalm, a novel regulator of GLUT4-trafficking in adipose tissue
  JOURNAL   Mol Metab 88, 102014 (2024)
   PUBMED   39182843
  REMARK    GeneRIF: Picalm, a novel regulator of GLUT4-trafficking in adipose
            tissue.
REFERENCE   2  (residues 1 to 509)
  AUTHORS   Querio,G., Antoniotti,S., Levi,R., Fleischmann,B.K., Gallo,M.P. and
            Malan,D.
  TITLE     Insulin-Activated Signaling Pathway and GLUT4 Membrane
            Translocation in hiPSC-Derived Cardiomyocytes
  JOURNAL   Int J Mol Sci 25 (15), 8197 (2024)
   PUBMED   39125765
  REMARK    GeneRIF: Insulin-Activated Signaling Pathway and GLUT4 Membrane
            Translocation in hiPSC-Derived Cardiomyocytes.
            Publication Status: Online-Only
REFERENCE   3  (residues 1 to 509)
  AUTHORS   Barrett,J.S., Strauss,J.A., Chow,L.S., Shepherd,S.O.,
            Wagenmakers,A.J.M. and Wang,Y.
  TITLE     GLUT4 localisation with the plasma membrane is unaffected by an
            increase in plasma free fatty acid availability
  JOURNAL   Lipids Health Dis 23 (1), 94 (2024)
   PUBMED   38566151
  REMARK    GeneRIF: GLUT4 localisation with the plasma membrane is unaffected
            by an increase in plasma free fatty acid availability.
            Publication Status: Online-Only
REFERENCE   4  (residues 1 to 509)
  AUTHORS   Kioumourtzoglou,D., Black,H.L., Al Tobi,M., Livingstone,R.,
            Petrie,J.R., Boyle,J.G., Gould,G.W. and Bryant,N.J.
  TITLE     Phosphorylation of Syntaxin 4 by the Insulin Receptor Drives
            Exocytic SNARE Complex Formation to Deliver GLUT4 to the Cell
            Surface
  JOURNAL   Biomolecules 13 (12), 1738 (2023)
   PUBMED   38136609
  REMARK    GeneRIF: Phosphorylation of Syntaxin 4 by the Insulin Receptor
            Drives Exocytic SNARE Complex Formation to Deliver GLUT4 to the
            Cell Surface.
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 509)
  AUTHORS   Ray,A., Wen,J., Yammine,L., Culver,J., Parida,I.S., Garren,J.,
            Xue,L., Hales,K., Xiang,Q., Birnbaum,M.J., Zhang,B.B., Monetti,M.
            and McGraw,T.E.
  TITLE     Regulated dynamic subcellular GLUT4 localization revealed by
            proximal proteome mapping in human muscle cells
  JOURNAL   J Cell Sci 136 (23) (2023)
   PUBMED   38126809
  REMARK    GeneRIF: Regulated dynamic subcellular GLUT4 localization revealed
            by proximal proteome mapping in human muscle cells.
REFERENCE   6  (residues 1 to 509)
  AUTHORS   Buse,J.B., Yasuda,K., Lay,T.P., Seo,T.S., Olson,A.L., Pessin,J.E.,
            Karam,J.H., Seino,S. and Bell,G.I.
  TITLE     Human GLUT4/muscle-fat glucose-transporter gene. Characterization
            and genetic variation
  JOURNAL   Diabetes 41 (11), 1436-1445 (1992)
   PUBMED   1397719
REFERENCE   7  (residues 1 to 509)
  AUTHORS   Liu,M.L., Olson,A.L., Moye-Rowley,W.S., Buse,J.B., Bell,G.I. and
            Pessin,J.E.
  TITLE     Expression and regulation of the human GLUT4/muscle-fat
            facilitative glucose transporter gene in transgenic mice
  JOURNAL   J Biol Chem 267 (17), 11673-11676 (1992)
   PUBMED   1601840
REFERENCE   8  (residues 1 to 509)
  AUTHORS   O'Rahilly,S., Krook,A., Morgan,R., Rees,A., Flier,J.S. and
            Moller,D.E.
  TITLE     Insulin receptor and insulin-responsive glucose transporter (GLUT
            4) mutations and polymorphisms in a Welsh type 2
            (non-insulin-dependent) diabetic population
  JOURNAL   Diabetologia 35 (5), 486-489 (1992)
   PUBMED   1521731
REFERENCE   9  (residues 1 to 509)
  AUTHORS   Choi,W.H., O'Rahilly,S., Buse,J.B., Rees,A., Morgan,R., Flier,J.S.
            and Moller,D.E.
  TITLE     Molecular scanning of insulin-responsive glucose transporter
            (GLUT4) gene in NIDDM subjects
  JOURNAL   Diabetes 40 (12), 1712-1718 (1991)
   PUBMED   1756912
REFERENCE   10 (residues 1 to 509)
  AUTHORS   Kusari,J., Verma,U.S., Buse,J.B., Henry,R.R. and Olefsky,J.M.
  TITLE     Analysis of the gene sequences of the insulin receptor and the
            insulin-sensitive glucose transporter (GLUT-4) in patients with
            common-type non-insulin-dependent diabetes mellitus
  JOURNAL   J Clin Invest 88 (4), 1323-1330 (1991)
   PUBMED   1918382
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC003688.1, CF594356.1,
            M20747.1, BC034387.1, AL521328.3 and BQ775137.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            Summary: This gene is a member of the solute carrier family 2
            (facilitated glucose transporter) family and encodes a protein that
            functions as an insulin-regulated facilitative glucose transporter.
            In the absence of insulin, this integral membrane protein is
            sequestered within the cells of muscle and adipose tissue. Within
            minutes of insulin stimulation, the protein moves to the cell
            surface and begins to transport glucose across the cell membrane.
            Mutations in this gene have been associated with
            noninsulin-dependent diabetes mellitus (NIDDM). [provided by
            RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DRR138518.432463.1,
                                           DRR138518.403498.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000317370.13/ ENSP00000320935.8
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..509
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17p13.1"
     Protein         1..509
                     /product="solute carrier family 2, facilitated glucose
                     transporter member 4"
                     /note="insulin-responsive glucose transporter type 4;
                     GLUT-4; glucose transporter type 4, insulin-responsive;
                     solute carrier family 2 (facilitated glucose transporter),
                     member 4"
                     /calculated_mol_wt=54656
     Region          7..13
                     /region_name="Interaction with SRFBP1.
                     /evidence=ECO:0000269|PubMed:16647043"
                     /note="propagated from UniProtKB/Swiss-Prot (P14672.1)"
     Site            10
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P19357; propagated from
                     UniProtKB/Swiss-Prot (P14672.1)"
     Site            25..45
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P14672.1)"
     Region          26..474
                     /region_name="MFS_GLUT_Class1"
                     /note="Class 1 Glucose transporters (GLUTs) of the Major
                     Facilitator Superfamily; cd17431"
                     /db_xref="CDD:340989"
     Site            order(38,42,177,180..181,184,298..299,303..304,307,333,
                     395..396,400,404,427,431)
                     /site_type="other"
                     /note="chemical substrate binding pocket [chemical
                     binding]"
                     /db_xref="CDD:340989"
     Site            57
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000269|PubMed:19349973; propagated from
                     UniProtKB/Swiss-Prot (P14672.1)"
     Site            82..102
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P14672.1)"
     Site            112..132
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P14672.1)"
     Site            143..163
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P14672.1)"
     Site            172..192
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P14672.1)"
     Site            202..222
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P14672.1)"
     Site            274
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by SGK1.
                     /evidence=ECO:0000269|PubMed:17382906; propagated from
                     UniProtKB/Swiss-Prot (P14672.1)"
     Site            288..308
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P14672.1)"
     Site            324..344
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P14672.1)"
     Site            354..374
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P14672.1)"
     Site            385..405
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P14672.1)"
     Site            418..438
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P14672.1)"
     Site            446..466
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P14672.1)"
     Site            486
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:P14142; propagated from
                     UniProtKB/Swiss-Prot (P14672.1)"
     Site            488
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P14142; propagated from
                     UniProtKB/Swiss-Prot (P14672.1)"
     Region          489..490
                     /region_name="Dileucine internalization motif.
                     /evidence=ECO:0000269|PubMed:8300557"
                     /note="propagated from UniProtKB/Swiss-Prot (P14672.1)"
     CDS             1..509
                     /gene="SLC2A4"
                     /gene_synonym="GLUT4"
                     /coded_by="NM_001042.3:218..1747"
                     /db_xref="CCDS:CCDS11097.1"
                     /db_xref="GeneID:6517"
                     /db_xref="HGNC:HGNC:11009"
                     /db_xref="MIM:138190"
ORIGIN      
        1 mpsgfqqigs edgeppqqrv tgtlvlavfs avlgslqfgy nigvinapqk vieqsynetw
       61 lgrqgpegps sippgtlttl walsvaifsv ggmissflig iisqwlgrkr amlvnnvlav
      121 lggslmglan aaasyemlil grfligaysg ltsglvpmyv geiapthlrg algtlnqlai
      181 vigiliaqvl glesllgtas lwplllgltv lpallqlvll pfcpespryl yiiqnlegpa
      241 rkslkrltgw advsgvlael kdekrklere rplsllqllg srthrqplii avvlqlsqql
      301 sginavfyys tsifetagvg qpayatigag vvntvftlvs vllveragrr tlhllglagm
      361 cgcailmtva llllervpam syvsivaifg fvaffeigpg pipwfivael fsqgprpaam
      421 avagfsnwts nfiigmgfqy vaeamgpyvf llfavlllgf fiftflrvpe trgrtfdqis
      481 aafhrtpsll eqevkpstel eylgpdend
//
