LOCUS       NM_006931               3827 bp    mRNA    linear   PRI 02-MAY-2024
DEFINITION  Homo sapiens solute carrier family 2 member 3 (SLC2A3), mRNA.
ACCESSION   NM_006931
VERSION     NM_006931.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3827)
  AUTHORS   Jiang,W., Xu,S. and Li,P.
  TITLE     SLC2A3 promotes tumor progression through lactic acid-promoted
            TGF-beta signaling pathway in oral squamous cell carcinoma
  JOURNAL   PLoS One 19 (4), e0301724 (2024)
   PUBMED   38625978
  REMARK    GeneRIF: SLC2A3 promotes tumor progression through lactic
            acid-promoted TGF-beta signaling pathway in oral squamous cell
            carcinoma.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3827)
  AUTHORS   Pucci,G., Minafra,L., Bravata,V., Calvaruso,M., Turturici,G.,
            Cammarata,F.P., Savoca,G., Abbate,B., Russo,G., Cavalieri,V. and
            Forte,G.I.
  TITLE     Glut-3 Gene Knockdown as a Potential Strategy to Overcome
            Glioblastoma Radioresistance
  JOURNAL   Int J Mol Sci 25 (4), 2079 (2024)
   PUBMED   38396757
  REMARK    GeneRIF: Glut-3 Gene Knockdown as a Potential Strategy to Overcome
            Glioblastoma Radioresistance.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3827)
  AUTHORS   Yu,D.M., Zhao,J., Lee,E.E., Kim,D., Mahapatra,R., Rose,E.K.,
            Zhou,Z., Hosler,C., El Kurdi,A., Choe,J.Y., Abel,E.D., Hoxhaj,G.,
            Westover,K.D., Cho,R.J., Cheng,J.B. and Wang,R.C.
  TITLE     GLUT3 promotes macrophage signaling and function via RAS-mediated
            endocytosis in atopic dermatitis and wound healing
  JOURNAL   J Clin Invest 133 (21), e170706 (2023)
   PUBMED   37721853
  REMARK    GeneRIF: GLUT3 promotes macrophage signaling and function via
            RAS-mediated endocytosis in atopic dermatitis and wound healing.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3827)
  AUTHORS   Kocaeli,A.A., Tekin,C., Ercelik,M., Tezcan,G., Aksoy,S.A.,
            Kocaeli,H., Bekar,A., Taskapilioglu,M.O., Tolunay,S. and Tunca,B.
  TITLE     Concurrent presence of diabetes affects the GLUT3 programming of
            glucose metabolism in glioblastoma
  JOURNAL   Eur Rev Med Pharmacol Sci 27 (17), 8110-8118 (2023)
   PUBMED   37750639
  REMARK    GeneRIF: Concurrent presence of diabetes affects the GLUT3
            programming of glucose metabolism in glioblastoma.
REFERENCE   5  (bases 1 to 3827)
  AUTHORS   Yan,B., Li,X., Peng,M., Zuo,Y., Wang,Y., Liu,P., Ren,W. and Jin,X.
  TITLE     The YTHDC1/GLUT3/RNF183 axis forms a positive feedback loop that
            modulates glucose metabolism and bladder cancer progression
  JOURNAL   Exp Mol Med 55 (6), 1145-1158 (2023)
   PUBMED   37258572
  REMARK    GeneRIF: The YTHDC1/GLUT3/RNF183 axis forms a positive feedback
            loop that modulates glucose metabolism and bladder cancer
            progression.
REFERENCE   6  (bases 1 to 3827)
  AUTHORS   Craik,J.D., Stewart,M. and Cheeseman,C.I.
  TITLE     GLUT-3 (brain-type) glucose transporter polypeptides in human blood
            platelets
  JOURNAL   Thromb Res 79 (5-6), 461-469 (1995)
   PUBMED   7502272
REFERENCE   7  (bases 1 to 3827)
  AUTHORS   Shepherd,P.R., Gould,G.W., Colville,C.A., McCoid,S.C., Gibbs,E.M.
            and Kahn,B.B.
  TITLE     Distribution of GLUT3 glucose transporter protein in human tissues
  JOURNAL   Biochem Biophys Res Commun 188 (1), 149-154 (1992)
   PUBMED   1417839
REFERENCE   8  (bases 1 to 3827)
  AUTHORS   Kayano,T., Burant,C.F., Fukumoto,H., Gould,G.W., Fan,Y.S.,
            Eddy,R.L., Byers,M.G., Shows,T.B., Seino,S. and Bell,G.I.
  TITLE     Human facilitative glucose transporters. Isolation, functional
            characterization, and gene localization of cDNAs encoding an
            isoform (GLUT5) expressed in small intestine, kidney, muscle, and
            adipose tissue and an unusual glucose transporter pseudogene-like
            sequence (GLUT6)
  JOURNAL   J Biol Chem 265 (22), 13276-13282 (1990)
   PUBMED   1695905
REFERENCE   9  (bases 1 to 3827)
  AUTHORS   Fukumoto,H., Kayano,T., Buse,J.B., Edwards,Y., Pilch,P.F.,
            Bell,G.I. and Seino,S.
  TITLE     Cloning and characterization of the major insulin-responsive
            glucose transporter expressed in human skeletal muscle and other
            insulin-responsive tissues
  JOURNAL   J Biol Chem 264 (14), 7776-7779 (1989)
   PUBMED   2656669
REFERENCE   10 (bases 1 to 3827)
  AUTHORS   Kayano,T., Fukumoto,H., Eddy,R.L., Fan,Y.S., Byers,M.G., Shows,T.B.
            and Bell,G.I.
  TITLE     Evidence for a family of human glucose transporter-like proteins.
            Sequence and gene localization of a protein expressed in fetal
            skeletal muscle and other tissues
  JOURNAL   J Biol Chem 263 (30), 15245-15248 (1988)
   PUBMED   3170580
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC007536.10.
            
            On Nov 22, 2018 this sequence version replaced NM_006931.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M20681.1, BC039196.1 [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000075120.12/ ENSP00000075120.7
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-168               AC007536.10        61746-61913         c
            169-261             AC007536.10        59536-59628         c
            262-422             AC007536.10        58713-58873         c
            423-663             AC007536.10        56971-57211         c
            664-826             AC007536.10        56206-56368         c
            827-1014            AC007536.10        55410-55597         c
            1015-1119           AC007536.10        51570-51674         c
            1120-1221           AC007536.10        50136-50237         c
            1222-1425           AC007536.10        48547-48750         c
            1426-3827           AC007536.10        44956-47357         c
FEATURES             Location/Qualifiers
     source          1..3827
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12p13.31"
     gene            1..3827
                     /gene="SLC2A3"
                     /gene_synonym="GLUT3"
                     /note="solute carrier family 2 member 3"
                     /db_xref="GeneID:6515"
                     /db_xref="HGNC:HGNC:11007"
                     /db_xref="MIM:138170"
     exon            1..168
                     /gene="SLC2A3"
                     /gene_synonym="GLUT3"
                     /inference="alignment:Splign:2.1.0"
     CDS             154..1644
                     /gene="SLC2A3"
                     /gene_synonym="GLUT3"
                     /note="glucose transporter type 3, brain; GLUT-3; solute
                     carrier family 2 (facilitated glucose transporter), member
                     3"
                     /codon_start=1
                     /product="solute carrier family 2, facilitated glucose
                     transporter member 3"
                     /protein_id="NP_008862.1"
                     /db_xref="CCDS:CCDS8586.1"
                     /db_xref="GeneID:6515"
                     /db_xref="HGNC:HGNC:11007"
                     /db_xref="MIM:138170"
                     /translation="MGTQKVTPALIFAITVATIGSFQFGYNTGVINAPEKIIKEFINK
                     TLTDKGNAPPSEVLLTSLWSLSVAIFSVGGMIGSFSVGLFVNRFGRRNSMLIVNLLAV
                     TGGCFMGLCKVAKSVEMLILGRLVIGLFCGLCTGFVPMYIGEISPTALRGAFGTLNQL
                     GIVVGILVAQIFGLEFILGSEELWPLLLGFTILPAILQSAALPFCPESPRFLLINRKE
                     EENAKQILQRLWGTQDVSQDIQEMKDESARMSQEKQVTVLELFRVSSYRQPIIISIVL
                     QLSQQLSGINAVFYYSTGIFKDAGVQEPIYATIGAGVVNTIFTVVSLFLVERAGRRTL
                     HMIGLGGMAFCSTLMTVSLLLKDNYNGMSFVCIGAILVFVAFFEIGPGPIPWFIVAEL
                     FSQGPRPAAMAVAGCSNWTSNFLVGLLFPSAAHYLGAYVFIIFTGFLITFLAFTFFKV
                     PETRGRTFEDITRAFEGQAHGADRSGKDGVMEMNSIEPAKETTTNV"
     exon            169..261
                     /gene="SLC2A3"
                     /gene_synonym="GLUT3"
                     /inference="alignment:Splign:2.1.0"
     exon            262..422
                     /gene="SLC2A3"
                     /gene_synonym="GLUT3"
                     /inference="alignment:Splign:2.1.0"
     exon            423..663
                     /gene="SLC2A3"
                     /gene_synonym="GLUT3"
                     /inference="alignment:Splign:2.1.0"
     exon            664..826
                     /gene="SLC2A3"
                     /gene_synonym="GLUT3"
                     /inference="alignment:Splign:2.1.0"
     exon            827..1014
                     /gene="SLC2A3"
                     /gene_synonym="GLUT3"
                     /inference="alignment:Splign:2.1.0"
     exon            1015..1119
                     /gene="SLC2A3"
                     /gene_synonym="GLUT3"
                     /inference="alignment:Splign:2.1.0"
     exon            1120..1221
                     /gene="SLC2A3"
                     /gene_synonym="GLUT3"
                     /inference="alignment:Splign:2.1.0"
     exon            1222..1425
                     /gene="SLC2A3"
                     /gene_synonym="GLUT3"
                     /inference="alignment:Splign:2.1.0"
     exon            1426..3827
                     /gene="SLC2A3"
                     /gene_synonym="GLUT3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2490..2495
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC2A3"
                     /gene_synonym="GLUT3"
                     /note="hexamer: AATAAA"
     polyA_site      2514
                     /gene="SLC2A3"
                     /gene_synonym="GLUT3"
     regulatory      3804..3809
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC2A3"
                     /gene_synonym="GLUT3"
                     /note="hexamer: AATAAA"
     polyA_site      3827
                     /gene="SLC2A3"
                     /gene_synonym="GLUT3"
                     /note="major polyA site"
ORIGIN      
        1 agagatgctg taatggtaag actttggatc cttcctgagg acgtggagaa aacttgctgc
       61 tgagaaggac attttgaagg ttttgttggc tgaaaaagct gtttctggaa tcacccctag
      121 atctttcttg aagacttgaa ttagattaca gcgatgggga cacagaaggt caccccagct
      181 ctgatatttg ccatcacagt tgctacaatc ggctctttcc aatttggcta caacactggg
      241 gtcatcaatg ctcctgagaa gatcataaag gaatttatca ataaaacttt gacggacaag
      301 ggaaatgccc caccctctga ggtgctgctc acgtctctct ggtccttgtc tgtggccata
      361 ttttccgtcg ggggtatgat cggctccttt tccgtcggac tcttcgtcaa ccgctttggc
      421 aggcgcaatt caatgctgat tgtcaacctg ttggctgtca ctggtggctg ctttatggga
      481 ctgtgtaaag tagctaagtc ggttgaaatg ctgatcctgg gtcgcttggt tattggcctc
      541 ttctgcggac tctgcacagg ttttgtgccc atgtacattg gagagatctc gcctactgcc
      601 ctgcggggtg cctttggcac tctcaaccag ctgggcatcg ttgttggaat tctggtggcc
      661 cagatctttg gtctggaatt catccttggg tctgaagagc tatggccgct gctactgggt
      721 tttaccatcc ttcctgctat cctacaaagt gcagcccttc cattttgccc tgaaagtccc
      781 agatttttgc tcattaacag aaaagaagag gagaatgcta agcagatcct ccagcggttg
      841 tggggcaccc aggatgtatc ccaagacatc caggagatga aagatgagag tgcaaggatg
      901 tcacaagaaa agcaagtcac cgtgctagag ctctttagag tgtccagcta ccgacagccc
      961 atcatcattt ccattgtgct ccagctctct cagcagctct ctgggatcaa tgctgtgttc
     1021 tattactcaa caggaatctt caaggatgca ggtgttcaag agcccatcta tgccaccatc
     1081 ggcgcgggtg tggttaatac tatcttcact gtagtttctc tatttctggt ggaaagggca
     1141 ggaagaagga ctctgcatat gataggcctt ggagggatgg ctttttgttc cacgctcatg
     1201 actgtttctt tgttattaaa ggataactat aatgggatga gctttgtctg tattggggct
     1261 atcttggtct ttgtagcctt ctttgaaatt ggaccaggcc ccattccctg gtttattgtg
     1321 gccgaactct tcagccaggg cccccgccca gctgcgatgg cagtggccgg ctgctccaac
     1381 tggacctcca acttcctagt cggattgctc ttcccctccg ctgctcacta tttaggagcc
     1441 tacgttttta ttatcttcac cggcttcctc attaccttct tggcttttac cttcttcaaa
     1501 gtccctgaga cccgtggcag gacttttgag gatatcacac gggcctttga agggcaggca
     1561 cacggtgcag atagatctgg aaaggacggc gtcatggaga tgaacagcat cgagcctgct
     1621 aaggagacca ccaccaatgt ctaagtcgtg cctccttcca cctccctccc ggcatgggaa
     1681 agccacctct ccctcaacaa gggagagacc tcatcaggat gaacccagga cgcttctgaa
     1741 tgctgctact taattccttt ctcatcccac gcactccatg agcaccccaa ggctgcggtt
     1801 tgttggatct tcaatggctt tttaaatttt atttcctgga catcctcttc tgcttaggag
     1861 agaccgagtg aacctacctt catttcagga gggattggcc gcttggcaca tgacaacttt
     1921 gccagctttt cctcccttgg gttctgatat tgccgcacta ggggatatag gagaggaaaa
     1981 gtaaggtgca gttcccccaa cctcagactt accaggaagc agatacatat gagtgtggaa
     2041 gccggagggt gtttatgtaa gagcaccttc ctcacttcca tacagctcta cgtggcaaat
     2101 taacttgagt tttatttatt ttatcctctg gtttaattac ataatttttt ttttttaact
     2161 ttaagtttca ggatacatgt gccgaatgtg caggtttgtt acataggtat atatatgcca
     2221 tgatggaaat atttattttt ttaagcgtaa ttttgccaaa taataaaaac agaaggaaat
     2281 tgagattaga gggaggtgtt taaagagagg ttatagagta gaagatttga tgctggagag
     2341 gttaaggtgc aataagaatt tagggagaaa tgttgttcat tattggaggg taaatgatgt
     2401 ggtgcctgag gtctgtacgt tacctcttaa caatttctgt ccttcagatg gaaactcttt
     2461 aacttctcgt aaaagtcata tacctatata ataaagctac tgatttcctt tggagctttt
     2521 ttctttaaga taatagttta catgtagtag tacttgaaat ctaggattat taactaatat
     2581 gggcattgta gttaatgatg gttgatgggt tctaattttg gatggagtcc agggaagaga
     2641 aagtgatttc tagaaagcct gttcccctca ctggatgaaa taactccttc ttgtagtagt
     2701 ctcattactt ttgaagtaat cccgccacct atctcgtggg agagccatcc aaataagaaa
     2761 cctaaaataa ttggttcttg gtagagattc attatttttc cactttgttc tttaggagat
     2821 tttaggtgtt gattttctgt tgtattttaa ctcatacctt taaaggaatt ccccaaagaa
     2881 tgtttatagc aaacttggaa tttgtaacct cagctctggg agaggatttt tttctgagcg
     2941 attattatct aaagtgtgtt gttgctttag gctcacggca cgcttgcgta tgtctgttac
     3001 catgtcactg tggtcctatg ccgaatgccc tcaggggact tgaatctttc caataaacca
     3061 ggtttagaca gtatgagtca atgtgcagtg tagcccacac ttgagaggat gaatgtatgt
     3121 gcactgtcac tttgctctgg gtggaagtac gttattgttg acttattttc tctgtgtttg
     3181 ttcctacagc ccctttttca tatgttgctc agtctccctt tcccttcttg gtgcttacac
     3241 atctcagacc ctttagccaa acccttgtca gtgacagtat tttggttctt agttctcact
     3301 gttccctctg ctcctggagc ctttgaataa aaatgcacgt agctgaggcc ggatgcggtg
     3361 gctcacgcct gtaatcccag cactttggga ggcctaggcg ggcggtcagg ggttcgagac
     3421 cagtctggcc aacatcgtga aaccctgtct ctactaaaaa tgcaaaaatt agccgggcgt
     3481 ggtggcgggc gcctgtaatc ccagctactt gggaagctga ggcgggagaa tcatgtgaac
     3541 ccgggacgca ggggttgcag tgagcggaga tcgcatcatt gcactctagc ctgggccaca
     3601 gggcgagact ccgtctcaaa aaaaaaaaaa tgcacatagc tatcaagtgt gctttagctt
     3661 gaaaaggtga ccttgcaact tcatgtcaac ttctggctcc tcaaacagta ggttggcagt
     3721 aaggcagggt cccatttctc actgagaaga ttgtgaatat ttccatatgg attttctatt
     3781 gttactctgg ttctttgttt taaaataaaa attctgaatg tacacga
//
