LOCUS       NM_000340               3181 bp    mRNA    linear   PRI 18-NOV-2024
DEFINITION  Homo sapiens solute carrier family 2 member 2 (SLC2A2), transcript
            variant 1, mRNA.
ACCESSION   NM_000340
VERSION     NM_000340.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3181)
  AUTHORS   Fu,H., Vuononvirta,J., Fanti,S., Bonacina,F., D'Amati,A., Wang,G.,
            Poobalasingam,T., Fankhaenel,M., Lucchesi,D., Coleby,R.,
            Tarussio,D., Thorens,B., Hearnden,R.J., Longhi,M.P., Grevitt,P.,
            Sheikh,M.H., Solito,E., Godinho,S.A., Bombardieri,M., Smith,D.M.,
            Cooper,D., Iqbal,A.J., Rathmell,J.C., Schaefer,S., Morales,V.,
            Bianchi,K., Norata,G.D. and Marelli-Berg,F.M.
  TITLE     The glucose transporter 2 regulates CD8+ T cell function via
            environment sensing
  JOURNAL   Nat Metab 5 (11), 1969-1985 (2023)
   PUBMED   37884694
  REMARK    GeneRIF: The glucose transporter 2 regulates CD8[+] T cell function
            via environment sensing.
REFERENCE   2  (bases 1 to 3181)
  AUTHORS   Liu,L., Ma,F., Liu,Q., Yu,X. and Zeng,X.
  TITLE     Association Between the SLC2A2 Gene rs1499821 Polymorphism and
            Caries Susceptibility
  JOURNAL   Genet Test Mol Biomarkers 27 (5), 149-156 (2023)
   PUBMED   37257183
  REMARK    GeneRIF: Association Between the SLC2A2 Gene rs1499821 Polymorphism
            and Caries Susceptibility.
REFERENCE   3  (bases 1 to 3181)
  AUTHORS   Chen,H., Zhang,X., Liao,N., Ji,Y., Mi,L., Gan,Y., Su,Y. and Wen,F.
  TITLE     Decreased expression of Glucagon-like peptide-1 receptor and
            Sodium-glucose co-transporter 2 in patients with proliferative
            diabetic retinopathy
  JOURNAL   Front Endocrinol (Lausanne) 13, 1020252 (2022)
   PUBMED   36465606
  REMARK    GeneRIF: Decreased expression of Glucagon-like peptide-1 receptor
            and Sodium-glucose co-transporter 2 in patients with proliferative
            diabetic retinopathy.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3181)
  AUTHORS   Grunert,S.C., Schumann,A., Baronio,F., Tsiakas,K., Murko,S.,
            Spiekerkoetter,U. and Santer,R.
  TITLE     Evidence for a Genotype-Phenotype Correlation in Patients with
            Pathogenic GLUT2 (SLC2A2) Variants
  JOURNAL   Genes (Basel) 12 (11), 1785 (2021)
   PUBMED   34828390
  REMARK    GeneRIF: Evidence for a Genotype-Phenotype Correlation in Patients
            with Pathogenic GLUT2 (SLC2A2) Variants.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3181)
  AUTHORS   Ban,N., Yamada,Y., Someya,Y., Miyawaki,K., Ihara,Y., Hosokawa,M.,
            Toyokuni,S., Tsuda,K. and Seino,Y.
  TITLE     Hepatocyte nuclear factor-1alpha recruits the transcriptional
            co-activator p300 on the GLUT2 gene promoter
  JOURNAL   Diabetes 51 (5), 1409-1418 (2002)
   PUBMED   11978637
  REMARK    GeneRIF: Hepatocyte nuclear factor-1alpha recruits the
            transcriptional co-activator p300 on the GLUT2 gene promoter.
REFERENCE   6  (bases 1 to 3181)
  AUTHORS   De Leon,D.D. and Pinney,S.E.
  TITLE     Permanent Neonatal Diabetes Mellitus
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301620
REFERENCE   7  (bases 1 to 3181)
  AUTHORS   Patel,P., Lo,Y.M., Bell,G.I., Turner,R.C. and Wainscoat,J.S.
  TITLE     Dinucleotide repeat polymorphism at the human GLUT2 locus
  JOURNAL   Nucleic Acids Res 19 (14), 4017 (1991)
   PUBMED   1862003
REFERENCE   8  (bases 1 to 3181)
  AUTHORS   Froguel,P., Zouali,H., Sun,F., Velho,G., Fukumoto,H., Passa,P. and
            Cohen,D.
  TITLE     CA repeat polymorphism in the glucose transporter GLUT 2 gene
  JOURNAL   Nucleic Acids Res 19 (13), 3754 (1991)
   PUBMED   1852621
REFERENCE   9  (bases 1 to 3181)
  AUTHORS   Fukumoto,H., Kayano,T., Buse,J.B., Edwards,Y., Pilch,P.F.,
            Bell,G.I. and Seino,S.
  TITLE     Cloning and characterization of the major insulin-responsive
            glucose transporter expressed in human skeletal muscle and other
            insulin-responsive tissues
  JOURNAL   J Biol Chem 264 (14), 7776-7779 (1989)
   PUBMED   2656669
REFERENCE   10 (bases 1 to 3181)
  AUTHORS   Fukumoto,H., Seino,S., Imura,H., Seino,Y., Eddy,R.L., Fukushima,Y.,
            Byers,M.G., Shows,T.B. and Bell,G.I.
  TITLE     Sequence, tissue distribution, and chromosomal localization of mRNA
            encoding a human glucose transporter-like protein
  JOURNAL   Proc Natl Acad Sci U S A 85 (15), 5434-5438 (1988)
   PUBMED   3399500
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC092918.6, J03810.1 and
            AC061708.17.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_000340.1.
            
            Summary: This gene encodes an integral plasma membrane glycoprotein
            of the liver, islet beta cells, intestine, and kidney epithelium.
            The encoded protein mediates facilitated bidirectional glucose
            transport. Because of its low affinity for glucose, it has been
            suggested as a glucose sensor. Mutations in this gene are
            associated with susceptibility to diseases, including
            Fanconi-Bickel syndrome and noninsulin-dependent diabetes mellitus
            (NIDDM). Alternative splicing results in multiple transcript
            variants of this gene. [provided by RefSeq, Jul 2013].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments and
            experimental data in the literature (PMID: 11978637).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK313622.1, J03810.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN04284274 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000314251.8/ ENSP00000323568.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-12                AC092918.6         6969-6980           c
            13-3180             J03810.1           1-3168
            3181-3181           AC061708.17        141586-141586       c
FEATURES             Location/Qualifiers
     source          1..3181
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q26.2"
     gene            1..3181
                     /gene="SLC2A2"
                     /gene_synonym="GLUT2"
                     /note="solute carrier family 2 member 2"
                     /db_xref="GeneID:6514"
                     /db_xref="HGNC:HGNC:11006"
                     /db_xref="MIM:138160"
     exon            1..65
                     /gene="SLC2A2"
                     /gene_synonym="GLUT2"
                     /inference="alignment:Splign:2.1.0"
     CDS             51..1625
                     /gene="SLC2A2"
                     /gene_synonym="GLUT2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     glucose transporter type 2, liver; solute carrier family 2
                     (facilitated glucose transporter), member 2"
                     /codon_start=1
                     /product="solute carrier family 2, facilitated glucose
                     transporter member 2 isoform 1"
                     /protein_id="NP_000331.1"
                     /db_xref="CCDS:CCDS3215.1"
                     /db_xref="GeneID:6514"
                     /db_xref="HGNC:HGNC:11006"
                     /db_xref="MIM:138160"
                     /translation="MTEDKVTGTLVFTVITAVLGSFQFGYDIGVINAPQQVIISHYRH
                     VLGVPLDDRKAINNYVINSTDELPTISYSMNPKPTPWAEEETVAAAQLITMLWSLSVS
                     SFAVGGMTASFFGGWLGDTLGRIKAMLVANILSLVGALLMGFSKLGPSHILIIAGRSI
                     SGLYCGLISGLVPMYIGEIAPTALRGALGTFHQLAIVTGILISQIIGLEFILGNYDLW
                     HILLGLSGVRAILQSLLLFFCPESPRYLYIKLDEEVKAKQSLKRLRGYDDVTKDINEM
                     RKEREEASSEQKVSIIQLFTNSSYRQPILVALMLHVAQQFSGINGIFYYSTSIFQTAG
                     ISKPVYATIGVGAVNMVFTAVSVFLVEKAGRRSLFLIGMSGMFVCAIFMSVGLVLLNK
                     FSWMSYVSMIAIFLFVSFFEIGPGPIPWFMVAEFFSQGPRPAALAIAAFSNWTCNFIV
                     ALCFQYIADFCGPYVFFLFAGVLLAFTLFTFFKVPETKGKSFEEIAAEFQKKSGSAHR
                     PKAAVEMKFLGATETV"
     exon            66..158
                     /gene="SLC2A2"
                     /gene_synonym="GLUT2"
                     /inference="alignment:Splign:2.1.0"
     exon            159..421
                     /gene="SLC2A2"
                     /gene_synonym="GLUT2"
                     /inference="alignment:Splign:2.1.0"
     exon            422..546
                     /gene="SLC2A2"
                     /gene_synonym="GLUT2"
                     /inference="alignment:Splign:2.1.0"
     exon            547..662
                     /gene="SLC2A2"
                     /gene_synonym="GLUT2"
                     /inference="alignment:Splign:2.1.0"
     exon            663..825
                     /gene="SLC2A2"
                     /gene_synonym="GLUT2"
                     /inference="alignment:Splign:2.1.0"
     exon            826..1013
                     /gene="SLC2A2"
                     /gene_synonym="GLUT2"
                     /inference="alignment:Splign:2.1.0"
     exon            1014..1118
                     /gene="SLC2A2"
                     /gene_synonym="GLUT2"
                     /inference="alignment:Splign:2.1.0"
     exon            1119..1220
                     /gene="SLC2A2"
                     /gene_synonym="GLUT2"
                     /inference="alignment:Splign:2.1.0"
     exon            1221..1424
                     /gene="SLC2A2"
                     /gene_synonym="GLUT2"
                     /inference="alignment:Splign:2.1.0"
     exon            1425..3181
                     /gene="SLC2A2"
                     /gene_synonym="GLUT2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3163..3168
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC2A2"
                     /gene_synonym="GLUT2"
                     /note="hexamer: AAGAAA"
     polyA_site      3181
                     /gene="SLC2A2"
                     /gene_synonym="GLUT2"
                     /note="major polyA site"
ORIGIN      
        1 gtgccacact cacacaagac ctggaattga caggactccc aactagtaca atgacagaag
       61 ataaggtcac tgggaccctg gttttcactg tcatcactgc tgtgctgggt tccttccagt
      121 ttggatatga cattggtgtg atcaatgcac ctcaacaggt aataatatct cactatagac
      181 atgttttggg tgttccactg gatgaccgaa aagctatcaa caactatgtt atcaacagta
      241 cagatgaact gcccacaatc tcatactcaa tgaacccaaa accaacccct tgggctgagg
      301 aagagactgt ggcagctgct caactaatca ccatgctctg gtccctgtct gtatccagct
      361 ttgcagttgg tggaatgact gcatcattct ttggtgggtg gcttggggac acacttggaa
      421 gaatcaaagc catgttagta gcaaacattc tgtcattagt tggagctctc ttgatggggt
      481 tttcaaaatt gggaccatct catatactta taattgctgg aagaagcata tcaggactat
      541 attgtgggct aatttcaggc ctggttccta tgtatatcgg tgaaattgct ccaaccgctc
      601 tcaggggagc acttggcact tttcatcagc tggccatcgt cacgggcatt cttattagtc
      661 agattattgg tcttgaattt atcttgggca attatgatct gtggcacatc ctgcttggcc
      721 tgtctggtgt gcgagccatc cttcagtctc tgctactctt tttctgtcca gaaagcccca
      781 gataccttta catcaagtta gatgaggaag tcaaagcaaa acaaagcttg aaaagactca
      841 gaggatatga tgatgtcacc aaagatatta atgaaatgag aaaagaaaga gaagaagcat
      901 cgagtgagca gaaagtctct ataattcagc tcttcaccaa ttccagctac cgacagccta
      961 ttctagtggc actgatgctg catgtggctc agcaattttc cggaatcaat ggcatttttt
     1021 actactcaac cagcattttt cagacggctg gtatcagcaa acctgtttat gcaaccattg
     1081 gagttggcgc tgtaaacatg gttttcactg ctgtctctgt attccttgtg gagaaggcag
     1141 ggcgacgttc tctctttcta attggaatga gtgggatgtt tgtttgtgcc atcttcatgt
     1201 cagtgggact tgtgctgctg aataagttct cttggatgag ttatgtgagc atgatagcca
     1261 tcttcctctt tgtcagcttc tttgaaattg ggccaggccc gatcccctgg ttcatggtgg
     1321 ctgagttttt cagtcaagga ccacgtcctg ctgctttagc aatagctgca ttcagcaatt
     1381 ggacctgcaa tttcattgta gctctgtgtt tccagtacat tgcggacttc tgtggacctt
     1441 atgtgttttt cctctttgct ggagtgctcc tggcctttac cctgttcaca ttttttaaag
     1501 ttccagaaac caaaggaaag tcttttgagg aaattgctgc agaattccaa aagaagagtg
     1561 gctcagccca caggccaaaa gctgctgtag aaatgaaatt cctaggagct acagagactg
     1621 tgtaaaaaaa aaaccctgct ttttgacatg aacagaaaca ataagggaac cgtctgtttt
     1681 taaatgatga ttccttgagc attttatatc cacatcttta agtattgttt tatttttatg
     1741 tgctctcatc agaaatgtca tcaaatatta ccaaaaaagt atttttttaa gttagagaat
     1801 atatttttga tggtaagact gtaattaagt aaaccaaaaa ggctagttta ttttgttaca
     1861 ctaaagggca ggtggttcta atatttttag ctctgttctt tataacaagg ttcttctaaa
     1921 attgaagaga tttcaacata tcattttttt aacacataac tagaaacctg aggatgcaac
     1981 aaatatttat atatttgaat atcattaaat tggaattttc ttacccatat atcttatgtt
     2041 aaaggagata tggctagtgg caataagttc catgttaaaa tagacaactc ttccatttat
     2101 tgcactcagc ttttttcttg agtactagaa tttgtatttt gcttaaaatt ttacttttgt
     2161 tctgtatttt catgtggaat ggattataga gtatactaaa aaatgtctat agagaaaaac
     2221 tttcattttt ggtaggctta tcaaaatctt tcagcactca gaaaagaaaa ccattttagt
     2281 tcctttattt aatggccaaa tggtttttgc aagatttaac actaaaaagg tttcacctga
     2341 tcatatagcg tgggttatca gttaacatta acatctatta taaaaccatg ttgattccct
     2401 tctggtacaa tcctttgagt tatagtttgc tttgcttttt aattgaggac agcctggttt
     2461 tcacatacac tcaaacaatc atgagtcaga catttggtat attacctcaa attcctaata
     2521 agtttgatca aatctaatgt aagaaaattt gaagtaaagg attgatcact ttgttaaaaa
     2581 tattttctga attattatgt ctcaaaataa gttgaaaagg tagggtttga ggattcctga
     2641 gtgtgggctt ctgaaacttc ataaatgttc agcttcagac ttttatcaaa atccctattt
     2701 aattttcctg gaaagactga ttgttttatg gtgtgttcct aacataaaat aatcgtctcc
     2761 tttgacattt ccttctttgt cttagctgta tacagattct agccaaacta ttctatggcc
     2821 attactaaca cgcattgtac actatctatc tgcctttacc tacataggca aattggaaat
     2881 acacagatga ttaaacagac tttagcttac agtcaatttt acaattatgg aaatatagtt
     2941 ctgatgggtc ccaaaagctt agcagggtgc taacgtatct ctaggctgtt ttctccacca
     3001 actggagcac tgatcaatcc ttcttatgtt tgctttaatg tgtattgaag aaaagcactt
     3061 tttaaaaagt actctttaag agtgaaataa ttaaaaacca ctgaacattt gctttgtttt
     3121 ctaaagttgt tcacatatat gtaatttagc agtccaaaga acaagaaatt gtttcttttc
     3181 a
//
