LOCUS       NM_001286234            3462 bp    mRNA    linear   PRI 06-APR-2024
DEFINITION  Homo sapiens solute carrier family 2 member 14 (SLC2A14),
            transcript variant 3, mRNA.
ACCESSION   NM_001286234 XM_005253314
VERSION     NM_001286234.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3462)
  AUTHORS   Valli,A., Morotti,M., Zois,C.E., Albers,P.K., Soga,T.,
            Feldinger,K., Fischer,R., Frejno,M., McIntyre,A., Bridges,E.,
            Haider,S., Buffa,F.M., Baban,D., Rodriguez,M., Yanes,O.,
            Whittington,H.J., Lake,H.A., Zervou,S., Lygate,C.A., Kessler,B.M.
            and Harris,A.L.
  TITLE     Adaptation to HIF1alpha Deletion in Hypoxic Cancer Cells by
            Upregulation of GLUT14 and Creatine Metabolism
  JOURNAL   Mol Cancer Res 17 (7), 1531-1544 (2019)
   PUBMED   30885992
  REMARK    GeneRIF: Under hypoxia and HIF1 blockade, cancer cells adapt their
            energy metabolism via upregulation of the GLUT14 glucose
            transporter and creatine metabolism providing new avenues for drug
            targeting.
REFERENCE   2  (bases 1 to 3462)
  AUTHORS   Amir Shaghaghi,M., Zhouyao,H., Tu,H., El-Gabalawy,H., Crow,G.H.,
            Levine,M., Bernstein,C.N. and Eck,P.
  TITLE     The SLC2A14 gene, encoding the novel glucose/dehydroascorbate
            transporter GLUT14, is associated with inflammatory bowel disease
  JOURNAL   Am J Clin Nutr 106 (6), 1508-1513 (2017)
   PUBMED   28971850
  REMARK    GeneRIF: Three alleles in the SLC2A14 gene associated independently
            with inflammatory bowel disease.
REFERENCE   3  (bases 1 to 3462)
  AUTHORS   Amir Shaghaghi,M., Murphy,B. and Eck,P.
  TITLE     The SLC2A14 gene: genomic locus, tissue expression, splice
            variants, and subcellular localization of the protein
  JOURNAL   Biochem Cell Biol 94 (4), 331-335 (2016)
   PUBMED   27460888
  REMARK    GeneRIF: report presents an expanded SLC2A14 gene locus and a more
            diverse tissue expression, concurring with the existing evidence
            for disease associations
REFERENCE   4  (bases 1 to 3462)
  AUTHORS   Berlth,F., Monig,S., Pinther,B., Grimminger,P., Maus,M.,
            Schlosser,H., Plum,P., Warnecke-Eberz,U., Harismendy,O.,
            Drebber,U., Bollschweiler,E., Holscher,A. and Alakus,H.
  TITLE     Both GLUT-1 and GLUT-14 are Independent Prognostic Factors in
            Gastric Adenocarcinoma
  JOURNAL   Ann Surg Oncol 22 Suppl 3, S822-S831 (2015)
   PUBMED   26183839
  REMARK    GeneRIF: High expression of GLUT-14 was associated with Gastric
            Adenocarcinoma.
REFERENCE   5  (bases 1 to 3462)
  AUTHORS   Wang,W., Yu,J.T., Zhang,W., Cui,W.Z., Wu,Z.C., Zhang,Q. and Tan,L.
  TITLE     Genetic association of SLC2A14 polymorphism with Alzheimer's
            disease in a Han Chinese population
  JOURNAL   J Mol Neurosci 47 (3), 481-484 (2012)
   PUBMED   22421804
  REMARK    GeneRIF: SLC2A14 polymorphism has a possible role in changing the
            genetic susceptibility to late Alzheimer disease age of onset in a
            Han Chinese population.
REFERENCE   6  (bases 1 to 3462)
  AUTHORS   de Mateo,S., Castillo,J., Estanyol,J.M., Ballesca,J.L. and Oliva,R.
  TITLE     Proteomic characterization of the human sperm nucleus
  JOURNAL   Proteomics 11 (13), 2714-2726 (2011)
   PUBMED   21630459
REFERENCE   7  (bases 1 to 3462)
  AUTHORS   Wu,X. and Freeze,H.H.
  TITLE     GLUT14, a duplicon of GLUT3, is specifically expressed in testis as
            alternative splice forms
  JOURNAL   Genomics 80 (6), 553-557 (2002)
   PUBMED   12504846
REFERENCE   8  (bases 1 to 3462)
  AUTHORS   Joost,H.G., Bell,G.I., Best,J.D., Birnbaum,M.J., Charron,M.J.,
            Chen,Y.T., Doege,H., James,D.E., Lodish,H.F., Moley,K.H.,
            Moley,J.F., Mueckler,M., Rogers,S., Schurmann,A., Seino,S. and
            Thorens,B.
  TITLE     Nomenclature of the GLUT/SLC2A family of sugar/polyol transport
            facilitators
  JOURNAL   Am J Physiol Endocrinol Metab 282 (4), E974-E976 (2002)
   PUBMED   11882521
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB069339.1, DB082816.1, BC060766.1, AC006517.46 and AY357941.1.
            
            On Jun 2, 2019 this sequence version replaced NM_001286234.1.
            
            Summary: Members of the glucose transporter (GLUT) family,
            including SLC2A14, are highly conserved integral membrane proteins
            that transport hexoses such as glucose and fructose into all
            mammalian cells. GLUTs show tissue and cell-type specific
            expression (Wu and Freeze, 2002 [PubMed 12504846]).[supplied by
            OMIM, Mar 2008].
            
            Transcript Variant: This variant (3) differs in the 5' UTR, lacks a
            portion of the 5' coding region, and initiates translation at an
            alternate upstream start codon, compared to variant 1. The encoded
            isoform (b) has a distinct N-terminus and is shorter than isoform
            a. Variants 3 and 4 encode the same isoform (b).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC060766.1, SRR18074967.453424.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000431042.7/ ENSP00000407287.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-19                DB069339.1         125-143
            20-29               DB082816.1         21-30
            30-2814             BC060766.1         1-2785
            2815-2815           AC006517.46        52566-52566
            2816-3457           BC060766.1         2787-3428
            3458-3462           AY357941.1         3561-3565
FEATURES             Location/Qualifiers
     source          1..3462
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12p13.31"
     gene            1..3462
                     /gene="SLC2A14"
                     /gene_synonym="GLUT14; SLC2A3P3"
                     /note="solute carrier family 2 member 14"
                     /db_xref="GeneID:144195"
                     /db_xref="HGNC:HGNC:18301"
                     /db_xref="MIM:611039"
     exon            1..109
                     /gene="SLC2A14"
                     /gene_synonym="GLUT14; SLC2A3P3"
                     /inference="alignment:Splign:2.1.0"
     exon            110..184
                     /gene="SLC2A14"
                     /gene_synonym="GLUT14; SLC2A3P3"
                     /inference="alignment:Splign:2.1.0"
     CDS             167..1660
                     /gene="SLC2A14"
                     /gene_synonym="GLUT14; SLC2A3P3"
                     /note="isoform b is encoded by transcript variant 3;
                     solute carrier family 2 (facilitated glucose transporter),
                     member 3 pseudogene 3; glucose transporter type 14; solute
                     carrier family 2 (facilitated glucose transporter), member
                     14"
                     /codon_start=1
                     /product="solute carrier family 2, facilitated glucose
                     transporter member 14 isoform b"
                     /protein_id="NP_001273163.1"
                     /db_xref="CCDS:CCDS66301.1"
                     /db_xref="GeneID:144195"
                     /db_xref="HGNC:HGNC:18301"
                     /db_xref="MIM:611039"
                     /translation="MDNRQNVTPALIFAITVATIGSFQFGYNTGVINAPETIIKEFIN
                     KTLTDKANAPPSEVLLTNLWSLSVAIFSVGGMIGSFSVGLFVNRFGRRNSMLIVNLLA
                     ATGGCLMGLCKIAESVEMLILGRLVIGLFCGLCTGFVPMYIGEISPTALRGAFGTLNQ
                     LGIVIGILVAQIFGLELILGSEELWPVLLGFTILPAILQSAALPCCPESPRFLLINRK
                     KEENATRILQRLWGTQDVSQDIQEMKDESARMSQEKQVTVLELFRVSSYRQPIIISIV
                     LQLSQQLSGINAVFYYSTGIFKDAGVQQPIYATISAGVVNTIFTLLSLFLVERAGRRT
                     LHMIGLGGMAFCSTLMTVSLLLKNHYNGMSFVCIGAILVFVACFEIGPGPIPWFIVAE
                     LFSQGPRPAAMAVAGCSNWTSNFLVGLLFPSAAYYLGAYVFIIFTGFLITFLAFTFFK
                     VPETRGRTFEDITRAFEGQAHGADRSGKDGVMGMNSIEPAKETTTNV"
     exon            185..277
                     /gene="SLC2A14"
                     /gene_synonym="GLUT14; SLC2A3P3"
                     /inference="alignment:Splign:2.1.0"
     exon            278..438
                     /gene="SLC2A14"
                     /gene_synonym="GLUT14; SLC2A3P3"
                     /inference="alignment:Splign:2.1.0"
     exon            439..679
                     /gene="SLC2A14"
                     /gene_synonym="GLUT14; SLC2A3P3"
                     /inference="alignment:Splign:2.1.0"
     exon            680..842
                     /gene="SLC2A14"
                     /gene_synonym="GLUT14; SLC2A3P3"
                     /inference="alignment:Splign:2.1.0"
     exon            843..1030
                     /gene="SLC2A14"
                     /gene_synonym="GLUT14; SLC2A3P3"
                     /inference="alignment:Splign:2.1.0"
     exon            1031..1135
                     /gene="SLC2A14"
                     /gene_synonym="GLUT14; SLC2A3P3"
                     /inference="alignment:Splign:2.1.0"
     exon            1136..1237
                     /gene="SLC2A14"
                     /gene_synonym="GLUT14; SLC2A3P3"
                     /inference="alignment:Splign:2.1.0"
     exon            1238..1441
                     /gene="SLC2A14"
                     /gene_synonym="GLUT14; SLC2A3P3"
                     /inference="alignment:Splign:2.1.0"
     exon            1442..3462
                     /gene="SLC2A14"
                     /gene_synonym="GLUT14; SLC2A3P3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2422..2427
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC2A14"
                     /gene_synonym="GLUT14; SLC2A3P3"
                     /note="hexamer: AATAAA"
     polyA_site      2447
                     /gene="SLC2A14"
                     /gene_synonym="GLUT14; SLC2A3P3"
     regulatory      3439..3444
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC2A14"
                     /gene_synonym="GLUT14; SLC2A3P3"
                     /note="hexamer: AATAAA"
     polyA_site      3462
                     /gene="SLC2A14"
                     /gene_synonym="GLUT14; SLC2A3P3"
                     /note="major polyA site"
ORIGIN      
        1 gttagtgggt cccaacggct gcaggcgggg ccggcggggg cgcagcggcc cgggaggtgc
       61 gtggttgagc gaagccgcgg ggcccaaccg cagtcgcggg gtctgggagg aagcagtacc
      121 ttgaagagaa attggagagg gagtcaattc ctaggatagc agagagatgg acaacagaca
      181 gaatgtcacc ccagctctga tctttgccat cacagttgct acaatcggct ctttccagtt
      241 tggctacaac actggggtca tcaatgctcc tgagacgatc ataaaggaat ttatcaataa
      301 aactttgacg gacaaggcaa atgcccctcc ctctgaggtg ctgctcacga atctctggtc
      361 cttgtctgtg gccatatttt ccgtcggggg tatgatcggc tccttttccg tcggactctt
      421 tgttaaccgc tttggcaggc gcaattcaat gctgattgtc aacctgttgg ctgccactgg
      481 tggctgcctt atgggactgt gtaaaatagc tgagtcagtt gaaatgctga tcctgggccg
      541 cttggttatt ggcctcttct gcggactctg cacaggtttt gtgcccatgt acattggaga
      601 gatctcgcct actgccctga ggggtgcctt tggcactctc aaccagctgg gcatagttat
      661 tggaattctg gtggcccaga tctttggtct ggaactcatc cttgggtctg aagagctatg
      721 gccggtgcta ttaggcttta ccatccttcc agctatcctg caaagtgcag cccttccatg
      781 ttgccctgaa agtcccagat ttttgctcat taacagaaaa aaagaggaga atgctacgcg
      841 gatcctccag cggttgtggg gcacccagga tgtatcccaa gacatccagg agatgaaaga
      901 tgagagtgca aggatgtcac aagaaaagca agtcaccgtg ctggagctct ttagagtgtc
      961 cagctaccga cagcccatca tcatttccat tgtgctccag ctctctcagc agctctctgg
     1021 gatcaatgct gtgttctatt actcaacagg aatcttcaag gatgcaggtg ttcaacagcc
     1081 catctatgcc accatcagcg cgggtgtggt taatactatc ttcactttac tttctctatt
     1141 tctggtggaa agggcaggaa gaaggactct gcatatgata ggccttggag ggatggcttt
     1201 ttgttccacg ctcatgactg tttctttgtt attaaagaat cactataatg ggatgagctt
     1261 tgtctgtatt ggggctatct tggtctttgt ggcctgtttt gaaattggac caggccccat
     1321 tccctggttt attgtggccg aactcttcag ccagggcccc cgcccagctg cgatggcagt
     1381 ggccggctgc tccaactgga cctccaactt cctagtcgga ttgctcttcc cctctgctgc
     1441 ttactattta ggagcctacg tttttattat cttcaccggc ttcctcatta ccttcttggc
     1501 ctttaccttc ttcaaagtcc ctgagacccg tggcaggact tttgaggata tcacacgggc
     1561 ctttgaaggg caggcacacg gtgcagatag atctgggaag gacggcgtca tggggatgaa
     1621 cagcatcgag cctgctaagg agaccaccac caatgtctaa gtcatgcctc cttccacctc
     1681 cctcccggca tgggaaagcc acctctccct caacaaggga gagactttat caggatgaac
     1741 ccaggactgc ttctgaatgc tgctacttga tttctttctc atcccacgca ctccatgagc
     1801 accccaaggc tgcagtttgt tggatcttca atggcttttt aaattttatt tcctggacat
     1861 cctcttctgc ttaggagaga ccgagtgaac ctaccttcat ttcaggaggg attggccgct
     1921 tggcacatga caactttgcc agcttttcct cccttgggtt ctgatattgc cgcactagag
     1981 gatataggag aggaaaagta aggtgcagtt gccccaacct cagacttacc aggaagcaga
     2041 tacatatgag tgtggaagcc ggagggtgtt tatgtaagag caccttcctc acttccatac
     2101 agctctacgc ggcaaattaa cttgagtttt atttatctta tcctctggtt taattacata
     2161 aatatttatt ttttaagtgt aattttgcca aataataaaa acagaaggaa attgagatta
     2221 gagggaggtg tttaaagaga ggttatagag taaaagattt gatgctggag aggttaaggt
     2281 gcaataagaa ttcagggaga aatgttgttc attattggag ggtaaatgat gtggtgcctg
     2341 aggtctgtac attacctctt aacaatttct gtccttcaga tggaaactct ttgatttctc
     2401 agaaaagttg tatgcctatt taataaagct actcatttcc tttggaactt tatctttaag
     2461 ataatagttt acatgtagta gtacttgaaa tctaggatta ttaactaata tgggcattgt
     2521 agttaatggc ggttgatggg ttctaatttt ggatggagtc cagggaagag aaagtgattt
     2581 ctagaaagcc tgttcccctc actggacgaa ataactcctt gtagtagtct cattactttt
     2641 gaagtaatcc cgccacctat ctagtgggag agccatccaa atgagaaacc taaaataatt
     2701 ggttcttggt agagattcat tatttctcca ctttgttctt taggagattt taggtgttga
     2761 ttttctgttt tattttaact cataccttta aaggaattcc ccaaagaatg tttacagcaa
     2821 acttggaatt tgtaacctca gctctgggag aggatttttt tctgagcgat tattatctaa
     2881 agtgtgttgt tgctttaggc tcacggcacg cttgcgtatg tctgttacca tgtcactgtg
     2941 gtcctatgcc gaatgccctc aggggacttg aatctttcca ataaaccagg tttagacagt
     3001 atgagtcaat gtgcagtgca gcccacactt gagaggatga atgtatgtgc actgtcactt
     3061 tgctctgggt ggaagtatgt tattgttgac ttattttctc tgtgtttgtt cctacagccc
     3121 ctttttcata tgttgctcag tctccctttc ccttcttggt gcttacacat ctcagaccct
     3181 ttagccaaac ccttgccagt gacagtattt tggttctcag ttctcactgt tccctctgct
     3241 cctggagcct ttgaataaaa atgcacgtag ctatggagtg gggtttagct ggaaaggtgg
     3301 ccttccaact tcacgtcaac ttctggctcc tcagtttggc agtaaggcag ggaagttgtt
     3361 ttcctatttc tcactgagaa gattgtgaat atttccatat ggattttcca ttattgtttg
     3421 tttgattctt tgttttaaaa taaaaattct gaatgtacat ga
//
