LOCUS       NM_145176               5572 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens solute carrier family 2 member 12 (SLC2A12), mRNA.
ACCESSION   NM_145176
VERSION     NM_145176.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5572)
  AUTHORS   Li,M., Li,L., Cheng,X., Li,L. and Tu,K.
  TITLE     Hypoxia promotes the growth and metastasis of ovarian cancer cells
            by suppressing ferroptosis via upregulating SLC2A12
  JOURNAL   Exp Cell Res 433 (2), 113851 (2023)
   PUBMED   37940066
  REMARK    GeneRIF: Hypoxia promotes the growth and metastasis of ovarian
            cancer cells by suppressing ferroptosis via upregulating SLC2A12.
REFERENCE   2  (bases 1 to 5572)
  AUTHORS   Cao,B., Zhao,R., Li,H., Xu,X., Gao,J., Chen,L. and Wei,B.
  TITLE     Inhibition of androgen receptor enhanced the anticancer effects of
            everolimus through targeting glucose transporter 12
  JOURNAL   Int J Biol Sci 19 (1), 104-119 (2023)
   PUBMED   36594084
  REMARK    GeneRIF: Inhibition of androgen receptor enhanced the anticancer
            effects of everolimus through targeting glucose transporter 12.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5572)
  AUTHORS   Pehlivanoglu,S., Sahan,O.B., Pehlivanoglu,S. and Aktas Kont,K.
  TITLE     Epithelial mesenchymal transition regulator TWIST1 transcription
            factor stimulates glucose uptake through upregulation of GLUT1,
            GLUT3, and GLUT12 in vitro
  JOURNAL   In Vitro Cell Dev Biol Anim 57 (10), 933-943 (2021)
   PUBMED   34791627
  REMARK    GeneRIF: Epithelial mesenchymal transition regulator TWIST1
            transcription factor stimulates glucose uptake through upregulation
            of GLUT1, GLUT3, and GLUT12 in vitro.
REFERENCE   4  (bases 1 to 5572)
  AUTHORS   Shi,Y., Zhang,Y., Ran,F., Liu,J., Lin,J., Hao,X., Ding,L. and Ye,Q.
  TITLE     Let-7a-5p inhibits triple-negative breast tumor growth and
            metastasis through GLUT12-mediated warburg effect
  JOURNAL   Cancer Lett 495, 53-65 (2020)
   PUBMED   32946964
  REMARK    GeneRIF: Let-7a-5p inhibits triple-negative breast tumor growth and
            metastasis through GLUT12-mediated warburg effect.
REFERENCE   5  (bases 1 to 5572)
  AUTHORS   Alexander,C.M., Martin,J.A., Oxman,E., Kasza,I., Senn,K.A. and
            Dvinge,H.
  TITLE     Alternative Splicing and Cleavage of GLUT8
  JOURNAL   Mol Cell Biol 41 (1), e00480-20 (2020)
   PUBMED   33077497
  REMARK    GeneRIF: Alternative Splicing and Cleavage of GLUT8.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5572)
  AUTHORS   Rogers,S., Chandler,J.D., Clarke,A.L., Petrou,S. and Best,J.D.
  TITLE     Glucose transporter GLUT12-functional characterization in Xenopus
            laevis oocytes
  JOURNAL   Biochem Biophys Res Commun 308 (3), 422-426 (2003)
   PUBMED   12914765
  REMARK    GeneRIF: Glucose transport properties and hexose affinities of
            GLUT12.
REFERENCE   7  (bases 1 to 5572)
  AUTHORS   Wood,I.S., Hunter,L. and Trayhurn,P.
  TITLE     Expression of Class III facilitative glucose transporter genes
            (GLUT-10 and GLUT-12) in mouse and human adipose tissues
  JOURNAL   Biochem Biophys Res Commun 308 (1), 43-49 (2003)
   PUBMED   12890477
  REMARK    GeneRIF: expression in adipose tissue
REFERENCE   8  (bases 1 to 5572)
  AUTHORS   Baumann,M.U., Deborde,S. and Illsley,N.P.
  TITLE     Placental glucose transfer and fetal growth
  JOURNAL   Endocrine 19 (1), 13-22 (2002)
   PUBMED   12583599
  REMARK    GeneRIF: Embedded in microvillous (maternal-facing) and basal
            (fetal-facing) membranes of syncytiotrophoblast, main placental
            barrier layer. (review)
            Review article
REFERENCE   9  (bases 1 to 5572)
  AUTHORS   Rogers,S., Macheda,M.L., Docherty,S.E., Carty,M.D., Henderson,M.A.,
            Soeller,W.C., Gibbs,E.M., James,D.E. and Best,J.D.
  TITLE     Identification of a novel glucose transporter-like protein-GLUT-12
  JOURNAL   Am J Physiol Endocrinol Metab 282 (3), E733-E738 (2002)
   PUBMED   11832379
REFERENCE   10 (bases 1 to 5572)
  AUTHORS   Joost,H.G. and Thorens,B.
  TITLE     The extended GLUT-family of sugar/polyol transport facilitators:
            nomenclature, sequence characteristics, and potential function of
            its novel members (review)
  JOURNAL   Mol Membr Biol 18 (4), 247-256 (2001)
   PUBMED   11780753
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB253903.1, AY046419.1, AL833602.1 and AL035699.4.
            
            On May 17, 2019 this sequence version replaced NM_145176.2.
            
            Summary: SLC2A12 belongs to a family of transporters that catalyze
            the uptake of sugars through facilitated diffusion (Rogers et al.,
            2002). This family of transporters show conservation of 12
            transmembrane helices as well as functionally significant amino
            acid residues (Joost and Thorens, 2001 [PubMed 11780753]).[supplied
            by OMIM, Mar 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803614.5491.1,
                                           SRR1803613.257515.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145774, SAMEA2159368
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000275230.6/ ENSP00000275230.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-11                DB253903.1         29-39
            12-1137             AY046419.1         1-1126
            1138-1142           AL833602.1         1149-1153
            1143-2660           AY046419.1         1132-2649
            2661-5572           AL035699.4         15635-18546
FEATURES             Location/Qualifiers
     source          1..5572
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q23.2"
     gene            1..5572
                     /gene="SLC2A12"
                     /gene_synonym="GLUT12; GLUT8"
                     /note="solute carrier family 2 member 12"
                     /db_xref="GeneID:154091"
                     /db_xref="HGNC:HGNC:18067"
                     /db_xref="MIM:610372"
     exon            1..247
                     /gene="SLC2A12"
                     /gene_synonym="GLUT12; GLUT8"
                     /inference="alignment:Splign:2.1.0"
     CDS             145..1998
                     /gene="SLC2A12"
                     /gene_synonym="GLUT12; GLUT8"
                     /note="GLUT-12; glucose transporter type 12; solute
                     carrier family 2 (facilitated glucose transporter), member
                     12"
                     /codon_start=1
                     /product="solute carrier family 2, facilitated glucose
                     transporter member 12"
                     /protein_id="NP_660159.1"
                     /db_xref="CCDS:CCDS5169.1"
                     /db_xref="GeneID:154091"
                     /db_xref="HGNC:HGNC:18067"
                     /db_xref="MIM:610372"
                     /translation="MVPVENTEGPSLLNQKGTAVETEGSGSRHPPWARGCGMFTFLSS
                     VTAAVSGLLVGYELGIISGALLQIKTLLALSCHEQEMVVSSLVIGALLASLTGGVLID
                     RYGRRTAIILSSCLLGLGSLVLILSLSYTVLIVGRIAIGVSISLSSIATCVYIAEIAP
                     QHRRGLLVSLNELMIVIGILSAYISNYAFANVFHGWKYMFGLVIPLGVLQAIAMYFLP
                     PSPRFLVMKGQEGAASKVLGRLRALSDTTEELTVIKSSLKDEYQYSFWDLFRSKDNMR
                     TRIMIGLTLVFFVQITGQPNILFYASTVLKSVGFQSNEAASLASTGVGVVKVISTIPA
                     TLLVDHVGSKTFLCIGSSVMAASLVTMGIVNLNIHMNFTHICRSHNSINQSLDESVIY
                     GPGNLSTNNNTLRDHFKGISSHSRSSLMPLRNDVDKRGETTSASLLNAGLSHTEYQIV
                     TDPGDVPAFLKWLSLASLLVYVAAFSIGLGPMPWLVLSEIFPGGIRGRAMALTSSMNW
                     GINLLISLTFLTVTDLIGLPWVCFIYTIMSLASLLFVVMFIPETKGCSLEQISMELAK
                     VNYVKNNICFMSHHQEELVPKQPQKRKPQEQLLECNKLCGRGQSRQLSPET"
     exon            248..1588
                     /gene="SLC2A12"
                     /gene_synonym="GLUT12; GLUT8"
                     /inference="alignment:Splign:2.1.0"
     exon            1589..1711
                     /gene="SLC2A12"
                     /gene_synonym="GLUT12; GLUT8"
                     /inference="alignment:Splign:2.1.0"
     exon            1712..1844
                     /gene="SLC2A12"
                     /gene_synonym="GLUT12; GLUT8"
                     /inference="alignment:Splign:2.1.0"
     exon            1845..5572
                     /gene="SLC2A12"
                     /gene_synonym="GLUT12; GLUT8"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2992..2997
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC2A12"
                     /gene_synonym="GLUT12; GLUT8"
                     /note="hexamer: AATAAA"
     polyA_site      3013
                     /gene="SLC2A12"
                     /gene_synonym="GLUT12; GLUT8"
                     /note="major polyA site"
     regulatory      3141..3146
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC2A12"
                     /gene_synonym="GLUT12; GLUT8"
                     /note="hexamer: AATAAA"
     polyA_site      3165
                     /gene="SLC2A12"
                     /gene_synonym="GLUT12; GLUT8"
     regulatory      4301..4306
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC2A12"
                     /gene_synonym="GLUT12; GLUT8"
                     /note="hexamer: AATGAA"
     polyA_site      4325
                     /gene="SLC2A12"
                     /gene_synonym="GLUT12; GLUT8"
     regulatory      4402..4407
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC2A12"
                     /gene_synonym="GLUT12; GLUT8"
                     /note="hexamer: AATAAA"
     polyA_site      4434
                     /gene="SLC2A12"
                     /gene_synonym="GLUT12; GLUT8"
     regulatory      4684..4689
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC2A12"
                     /gene_synonym="GLUT12; GLUT8"
                     /note="hexamer: AATACA"
     polyA_site      4707
                     /gene="SLC2A12"
                     /gene_synonym="GLUT12; GLUT8"
ORIGIN      
        1 ggtcacaaat cacattagct ttgcccgaag tttttcccca cactcttctt tagcatgcta
       61 ttatggggaa agtgaccact cctgggagcg ggggtggtcg gggcggtttg gtggcgggga
      121 agcggctgta acttctacgt gaccatggta cctgttgaaa acaccgaggg ccccagtctg
      181 ctgaaccaga aggggacagc cgtggagacg gagggcagcg gcagccggca tcctccctgg
      241 gcgagaggct gcggcatgtt taccttcctg tcatctgtca ctgctgctgt cagtggcctc
      301 ctggtgggtt atgaacttgg gatcatctct ggggctcttc ttcagatcaa aaccttatta
      361 gccctgagct gccatgagca ggaaatggtt gtgagctccc tcgtcattgg agccctcctt
      421 gcctcactca ccggaggggt cctgatagac agatatggaa gaaggacagc aatcatcttg
      481 tcatcctgcc tgcttggact cggaagctta gtcttgatcc tcagtttatc ctacacggtt
      541 cttatagtgg gacgcattgc cataggggtc tccatctccc tctcttccat tgccacttgt
      601 gtttacatcg cagagattgc tcctcaacac agaagaggcc ttcttgtgtc actgaatgag
      661 ctgatgattg tcatcggcat tctttctgcc tatatttcaa attacgcatt tgccaatgtt
      721 ttccatggct ggaagtacat gtttggtctt gtgattccct tgggagtttt gcaagcaatt
      781 gcaatgtatt ttcttcctcc aagccctcgg tttctggtga tgaaaggaca agagggagct
      841 gctagcaagg ttcttggaag gttaagagca ctctcagata caactgagga actcactgtg
      901 atcaaatcct ccctgaaaga tgaatatcag tacagttttt gggatctgtt tcgttcaaaa
      961 gacaacatgc ggacccgaat aatgatagga ctaacactag tattttttgt acaaatcact
     1021 ggccaaccaa acatattgtt ctatgcatca actgttttga agtcagttgg atttcaaagc
     1081 aatgaggcag ctagcctcgc ctccactggg gttggagtcg tcaaggtcat tagcaccatc
     1141 cctgccactc ttcttgtaga ccatgtcggc agcaaaacat tcctctgcat tggctcctct
     1201 gtgatggcag cttcgttggt gaccatgggc atcgtaaatc tcaacatcca catgaacttc
     1261 acccatatct gcagaagcca caattctatc aaccagtcct tggatgagtc tgtgatttat
     1321 ggaccaggaa acctgtcaac caacaacaat actctcagag accacttcaa agggatttct
     1381 tcccatagca gaagctcact catgcccctg agaaatgatg tggataagag aggggagacg
     1441 acctcagcat ccttgctaaa tgctggatta agccacactg aataccagat agtcacagac
     1501 cctggggacg tcccagcttt tttgaaatgg ctgtccttag ccagcttgct tgtttatgtt
     1561 gctgcttttt caattggtct aggaccaatg ccctggctgg tgctcagcga gatctttcct
     1621 ggtgggatca gaggacgagc catggcttta acttctagca tgaactgggg catcaatctc
     1681 ctcatctcgc tgacattttt gactgtaact gatcttattg gcctgccatg ggtgtgcttt
     1741 atatatacaa tcatgagtct agcatccctg ctttttgttg ttatgtttat acctgagaca
     1801 aagggatgct ctttggaaca aatatcaatg gagctagcaa aagtgaacta tgtgaaaaac
     1861 aacatttgtt ttatgagtca tcaccaagaa gaattagtgc caaaacagcc tcaaaaaaga
     1921 aaaccccagg agcagctctt ggagtgtaac aagctgtgtg gtaggggcca atccaggcag
     1981 ctttctccag agacctaatg gcctcaacac cttctgaacg tggatagtgc cagaacactt
     2041 aggagggtgt ctttggacca atgcatagtt gcgactcctg tgctctcttt tcagtgtcat
     2101 ggaactggtt ttgaagagac actctgaaat gataaagaca gcctttaatc cccctcctcc
     2161 ccagaaggaa cctcaaaagg tagatgaggt acaaggtcct aagtgatctc tttttctgag
     2221 caggatatca ggttaaaaaa aaaaagttac tggctggttt aatactttct accttcttca
     2281 cagagcagcc tttgaataga ctatgtccta gtgaagacat caacctccgc cttaagctat
     2341 gtatgtatgg aggccagtcg cagctttatt atgcagacac acaagtggtc tggacatgag
     2401 ggtacagttt ctgcctacca agacactact tgcactggat cttacgcaaa aaagaaccag
     2461 aacacacagt gtggacaact gcccatatat tctatctaga ttaggagagg gtcctggcta
     2521 ggattttagt ggtaattcct agttacattc aacaagtata aagattatag agcttatttt
     2581 atgaactata aactataatt taatgcaaaa tatcctttta tgaatttcat gttaatattg
     2641 tgaaatatta aaataattcc acaatagttg agaaaaatga gcattttttt ccatttttaa
     2701 aaaatgcata gaaaagacaa ttttaaaatc ctgggaccat atttatttag aagtagctgt
     2761 tagtaaaaca ttagaaaagg agtcaggcca ttaggttatt tatccaaatc tctaagcaat
     2821 taggttgaag ttattaagtc aagcctagaa aagctgcctc cttgtaaggc tttcatgaca
     2881 atgtatagta atccacagtg tccaattctt cacactcctc aggaatatca ctacctcagg
     2941 ttacggtaca caggctataa ttgatgatga tgttcagata actgaagaca caataaatga
     3001 cattcagaca tcaggacaat tccctcatgt tcttttctat gatggccacc tgtaccagca
     3061 acgtgggttt cacccacaca acgatgaact gttctcttac ttctccagtt gattttaaag
     3121 acttgttaag aggtcttact aataaaattt gggtatgata gaaaatccac aatcaaatct
     3181 tgaaccaaat aacatattaa attactaata tttaagtgat ggaagacaca caaaaaactt
     3241 aaaagcacga acaacctaac ttgaaaaaga attttaaaat atgattaacc tgaagaaaag
     3301 agaatcctaa gagccaaagc tcctttttat ttagcttgga attttcctat tggttcctaa
     3361 caaactgtcc caatgtcata taaggaaaca tgatctatta cattccttta taacaatgtg
     3421 gagagactat aaacctatgt aagtagtaaa actatatcag agactcagga gactgactaa
     3481 aaggcctgga tctgcagtgt attatctgta taaaaattgg cagggggaag ctaaaaggaa
     3541 aggagattgg agatctcaat tctatcatgg tgtatttcat acgcaaatca gagcatgcat
     3601 tgttttttgt ttttggaaag agaagggaag tgtgttctgc cccatgtttc cttccgtgtt
     3661 tatagttcaa actctatata tacttcaggt attttttgtt tagcccttca ttataaatgg
     3721 gcaggaaatt gtttatcaac ctagccagtt tattactagt gaccttgact tcagtatctt
     3781 gagcattctt ttatattttt cttttattat cctgagtctg taactaaaca attttgtctt
     3841 caaattttta tccaatatcc attgcaccac accaaatcaa gcttcttgat tttcaaaaat
     3901 aaaaaggggg aaatacttac aacttgtaca tatatattca cagtttttat ttataaaaaa
     3961 aatttacagt acttatggag agccagcaga agacatcaga gcactcactt cttcccatct
     4021 ttgttaaggt tagcgaatta cccatggaca ctgttaggtg aggctcattc ggcagccctg
     4081 aaaacaaacc tggtcacact gtctttaccc tctcccttca gataaagcac ttcgattatc
     4141 tattgatctg cccagttttc aagtcatgcg aatactaaaa aggttacatc atctggatct
     4201 gtaccttggc tatataagca tgttttcccc ctattctatg tttctttttt tggtgaacat
     4261 tgaaaaacag gaggtgactt attactgtta attaaaacta aatgaaaaat gtcaagtctt
     4321 taaaacagtg agcttgtaac tctttcatgt aattttattc tctatgaatt tggctatcct
     4381 actgaatctt aaaataaagg aaataaacac ttttttttta aaaaaaagga aaaatacaag
     4441 tctaaaaatc tcaatgaaat atttcacaag aaggaaaaat gtaagttagc ctttgctttc
     4501 cactttggaa taagcaggag gttagggaag gcattgagaa gaaaaaagat aaaaataata
     4561 tgtgttgttc agtgcagtgc ctaagctagg ttttcaagat tttataatac agtaaggaaa
     4621 atgtactata tatggagatt aggatgttgc aatttttcca caaaggttta aaaacatttt
     4681 ggaaatacaa gtttttgtgg aacattgtgt tggaatattg tccccattaa gtttctcctg
     4741 agaagctaat tggactctcc actcagcttt atttctaggt ataatcactg ttggttacac
     4801 taaactccta aacctaaatg acagggcaca actacagctt gatcctgtat taccacatca
     4861 gggctcctgg gtgagccaga gacactgttt cataaatgca tatttattat aactttaaga
     4921 gtagcaatct catatactga atagtcactc tttaactcca ttaaataaga tacagcaagg
     4981 ggaaggacag tatcacacaa aatggctttc aaattcaagt ggggctattt gataattaca
     5041 ctgtggcaca gaggcagctt atgggcactt cttgttaaaa catctccatg ttaccaactt
     5101 ctgacaagac tcttagtata ggcttgggca tcaacccaag attaaagtca agaacctcaa
     5161 tcacttctct acaactacag gtgttgagtc tttccagaaa aacaaaggtc caaatgaggc
     5221 accattcatc acagcttctt tctcatttcc atctagtggg taagaggttt ctcttcttaa
     5281 aactacaatt tcttaacctt tacaagttat ttaacatttt ctatcatatt aaattagcaa
     5341 cataaaacat tatcctttat ctataaactt ctagtctggt tccctagagt ttatatacac
     5401 gtttttattt ctaatctgca agaaaaaaaa ttcctatttg ttatttggta acagagcatt
     5461 aaaagatact atacacatgt ggtgcatata tatatatata tatacacaca cacacacaca
     5521 cacacacaaa atacacttca aaaagaagcc aacacacttt agccaaagtc tt
//
