LOCUS       NM_001024939            3088 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens solute carrier family 2 member 11 (SLC2A11),
            transcript variant 2, mRNA.
ACCESSION   NM_001024939
VERSION     NM_001024939.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3088)
  AUTHORS   McBrayer,S.K., Cheng,J.C., Singhal,S., Krett,N.L., Rosen,S.T. and
            Shanmugam,M.
  TITLE     Multiple myeloma exhibits novel dependence on GLUT4, GLUT8, and
            GLUT11: implications for glucose transporter-directed therapy
  JOURNAL   Blood 119 (20), 4686-4697 (2012)
   PUBMED   22452979
  REMARK    GeneRIF: Critical roles for novel GLUT family members highlight a
            therapeutic strategy entailing selective GLUT inhibition to
            specifically target aberrant glucose metabolism in cancer.
REFERENCE   2  (bases 1 to 3088)
  AUTHORS   Manolescu,A.R., Augustin,R., Moley,K. and Cheeseman,C.
  TITLE     A highly conserved hydrophobic motif in the exofacial vestibule of
            fructose transporting SLC2A proteins acts as a critical determinant
            of their substrate selectivity
  JOURNAL   Mol Membr Biol 24 (5-6), 455-463 (2007)
   PUBMED   17710649
  REMARK    GeneRIF: GLUT11 can also transport fructose, but it has the motif
            DSV at the same position, which appears to function in the same
            manner as NXI and when all three residues are replaced with NAV
            fructose transport lost.
REFERENCE   3  (bases 1 to 3088)
  AUTHORS   Scheepers,A., Schmidt,S., Manolescu,A., Cheeseman,C.I., Bell,A.,
            Zahn,C., Joost,H.G. and Schurmann,A.
  TITLE     Characterization of the human SLC2A11 (GLUT11) gene: alternative
            promoter usage, function, expression, and subcellular distribution
            of three isoforms, and lack of mouse orthologue
  JOURNAL   Mol Membr Biol 22 (4), 339-351 (2005)
   PUBMED   16154905
  REMARK    GeneRIF: Different promoters and splicing generate three SLC2A11
            isoforms which are expressed in a tissue specific manner but do not
            appear to differ in their functional characteristics.
REFERENCE   4  (bases 1 to 3088)
  AUTHORS   Gaster,M., Handberg,A., Schurmann,A., Joost,H.G., Beck-Nielsen,H.
            and Schroder,H.D.
  TITLE     GLUT11, but not GLUT8 or GLUT12, is expressed in human skeletal
            muscle in a fibre type-specific pattern
  JOURNAL   Pflugers Arch 448 (1), 105-113 (2004)
   PUBMED   14704796
REFERENCE   5  (bases 1 to 3088)
  AUTHORS   Wu,X., Li,W., Sharma,V., Godzik,A. and Freeze,H.H.
  TITLE     Cloning and characterization of glucose transporter 11, a novel
            sugar transporter that is alternatively spliced in various tissues
  JOURNAL   Mol Genet Metab 76 (1), 37-45 (2002)
   PUBMED   12175779
  REMARK    GeneRIF: a novel sugar transporter that is alternatively spliced in
            various tissues
REFERENCE   6  (bases 1 to 3088)
  AUTHORS   Sasaki,T., Minoshima,S., Shiohama,A., Shintani,A., Shimizu,A.,
            Asakawa,S., Kawasaki,K. and Shimizu,N.
  TITLE     Molecular cloning of a member of the facilitative glucose
            transporter gene family GLUT11 (SLC2A11) and identification of
            transcription variants
  JOURNAL   Biochem Biophys Res Commun 289 (5), 1218-1224 (2001)
   PUBMED   11741323
REFERENCE   7  (bases 1 to 3088)
  AUTHORS   Doege,H., Bocianski,A., Scheepers,A., Axer,H., Eckel,J., Joost,H.G.
            and Schurmann,A.
  TITLE     Characterization of human glucose transporter (GLUT) 11 (encoded by
            SLC2A11), a novel sugar-transport facilitator specifically
            expressed in heart and skeletal muscle
  JOURNAL   Biochem J 359 (Pt 2), 443-449 (2001)
   PUBMED   11583593
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DC303452.1, AP000350.1 and
            AK092466.1.
            
            On Jun 2, 2019 this sequence version replaced NM_001024939.3.
            
            Summary: This gene belongs to a family of proteins that mediate the
            transport of sugars across the cell membrane. The encoded protein
            transports glucose and fructose. Alternative splicing results in
            multiple transcript variants. [provided by RefSeq, Sep 2013].
            
            Transcript Variant: This variant (2, also known as SLC2A11-c)
            differs in the 5' UTR, lacks a portion of the 5' coding region, and
            initiates translation at an alternate start codon, compared to
            variant 1. The encoded isoform (b) is shorter and has a distinct
            N-terminus, compared to isoform a.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803613.120305.1,
                                           SRR1803612.91305.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000316185.9/ ENSP00000326748.8
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-117               DC303452.1         24-140
            118-155             AP000350.1         52036-52073
            156-254             AP000350.1         56148-56246
            255-415             AP000350.1         62525-62685
            416-540             AP000350.1         69161-69285
            541-670             AP000350.1         71086-71215
            671-819             AP000350.1         71765-71913
            820-1007            AP000350.1         76503-76690
            1008-1118           AP000350.1         76803-76913
            1119-1220           AP000350.1         77816-77917
            1221-1296           AP000350.1         77993-78068
            1297-1424           AP000350.1         78346-78473
            1425-1679           AP000350.1         78693-78947
            1680-2312           AK092466.1         1726-2358
            2313-3088           AP000350.1         79581-80356
FEATURES             Location/Qualifiers
     source          1..3088
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q11.23"
     gene            1..3088
                     /gene="SLC2A11"
                     /gene_synonym="GLUT10; GLUT11"
                     /note="solute carrier family 2 member 11"
                     /db_xref="GeneID:66035"
                     /db_xref="HGNC:HGNC:14239"
                     /db_xref="MIM:610367"
     exon            1..155
                     /gene="SLC2A11"
                     /gene_synonym="GLUT10; GLUT11"
                     /inference="alignment:Splign:2.1.0"
     CDS             126..1625
                     /gene="SLC2A11"
                     /gene_synonym="GLUT10; GLUT11"
                     /note="isoform b is encoded by transcript variant 2;
                     glucose transporter protein 11; glucose transporter
                     protein 10; solute carrier family 2 (facilitated glucose
                     transporter), member 11; facilitative glucose transporter
                     GLUT11; glucose transporter-like protein XI; glucose
                     transporter type 10; glucose transporter type 11"
                     /codon_start=1
                     /product="solute carrier family 2, facilitated glucose
                     transporter member 11 isoform b"
                     /protein_id="NP_001020110.1"
                     /db_xref="CCDS:CCDS33616.1"
                     /db_xref="GeneID:66035"
                     /db_xref="HGNC:HGNC:14239"
                     /db_xref="MIM:610367"
                     /translation="MLHALLRSRMIQGRILLLTICAAGIGGTFQFGYNLSIINAPTLH
                     IQEFTNETWQARTGEPLPDHLVLLMWSLIVSLYPLGGLFGALLAGPLAITLGRKKSLL
                     VNNIFVVSAAILFGFSRKAGSFEMIMLGRLLVGVNAGVSMNIQPMYLGESAPKELRGA
                     VAMSSAIFTALGIVMGQVVGLRELLGGPQAWPLLLASCLVPGALQLASLPLLPESPRY
                     LLIDCGDTEACLAALRRLRGSGDLAGELEELEEERAACQGCRARRPWELFQHRALRRQ
                     VTSLVVLGSAMELCGNDSVYAYASSVFRKAGVPEAKIQYAIIGTGSCELLTAVVSCVV
                     IERVGRRVLLIGGYSLMTCWGSIFTVALCLQSSFPWTLYLAMACIFAFILSFGIGPAG
                     VTGILATELFDQMARPAACMVCGALMWIMLILVGLGFPFIMEALSHFLYVPFLGVCVC
                     GAIYTGLFLPETKGKTFQEISKELHRLNFPRRAQGPTWRSLEVIQSTEL"
     exon            156..254
                     /gene="SLC2A11"
                     /gene_synonym="GLUT10; GLUT11"
                     /inference="alignment:Splign:2.1.0"
     exon            255..415
                     /gene="SLC2A11"
                     /gene_synonym="GLUT10; GLUT11"
                     /inference="alignment:Splign:2.1.0"
     exon            416..540
                     /gene="SLC2A11"
                     /gene_synonym="GLUT10; GLUT11"
                     /inference="alignment:Splign:2.1.0"
     exon            541..670
                     /gene="SLC2A11"
                     /gene_synonym="GLUT10; GLUT11"
                     /inference="alignment:Splign:2.1.0"
     exon            671..819
                     /gene="SLC2A11"
                     /gene_synonym="GLUT10; GLUT11"
                     /inference="alignment:Splign:2.1.0"
     exon            820..1007
                     /gene="SLC2A11"
                     /gene_synonym="GLUT10; GLUT11"
                     /inference="alignment:Splign:2.1.0"
     exon            1008..1118
                     /gene="SLC2A11"
                     /gene_synonym="GLUT10; GLUT11"
                     /inference="alignment:Splign:2.1.0"
     exon            1119..1220
                     /gene="SLC2A11"
                     /gene_synonym="GLUT10; GLUT11"
                     /inference="alignment:Splign:2.1.0"
     exon            1221..1296
                     /gene="SLC2A11"
                     /gene_synonym="GLUT10; GLUT11"
                     /inference="alignment:Splign:2.1.0"
     exon            1297..1424
                     /gene="SLC2A11"
                     /gene_synonym="GLUT10; GLUT11"
                     /inference="alignment:Splign:2.1.0"
     exon            1425..3088
                     /gene="SLC2A11"
                     /gene_synonym="GLUT10; GLUT11"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3058..3063
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC2A11"
                     /gene_synonym="GLUT10; GLUT11"
                     /note="hexamer: AATAAA"
     polyA_site      3088
                     /gene="SLC2A11"
                     /gene_synonym="GLUT10; GLUT11"
                     /note="major polyA site"
ORIGIN      
        1 ctctttcacc actgggcgct gcgcgctgcc cttccctccg cgcacaggct gccggctcac
       61 cgcttgctaa tggcagccgg ggtctccctg ggacagcaag acctccgctc aggcccctct
      121 ttcgaatgct ccacgccctc ctgcgatcta gaatgattca gggcaggatc ctgctcctga
      181 ccatctgcgc tgccggcatt ggtgggactt ttcagtttgg ctataacctc tctatcatca
      241 atgccccgac cttgcacatt caggaattca ccaatgagac atggcaggcg cgtactggag
      301 agccactgcc cgatcaccta gtcctgctta tgtggtccct catcgtgtct ctgtatcccc
      361 tgggaggcct ctttggagca ctgcttgcag gtcccttggc catcacgctg ggaaggaaga
      421 agtccctcct ggtgaataac atctttgtgg tgtcagcagc aatcctgttt ggattcagcc
      481 gcaaagcagg ctcctttgag atgatcatgc tgggaagact gctcgtggga gtcaatgcag
      541 gtgtgagcat gaacatccag cccatgtacc tgggggagag cgcccctaag gagctccgag
      601 gagctgtggc catgagctca gccatcttta cggctctggg gatcgtgatg ggacaggtgg
      661 tcggactcag ggagctccta ggtggccctc aggcctggcc cctgctgctg gccagctgcc
      721 tggtgcccgg ggcgctccag ctcgcctccc tgcctctgct ccctgaaagc ccgcgctacc
      781 tcctcattga ctgtggagac accgaggcct gcctggcagc actacggcgg ctccggggct
      841 ccggggactt ggcaggggag ctggaggagc tggaggagga gcgcgctgcc tgccagggct
      901 gccgtgcccg gcgcccatgg gagctgttcc agcatcgggc cctgaggaga caggtgacaa
      961 gcctcgtggt tctgggcagt gccatggagc tctgcgggaa tgactcggtg tacgcctacg
     1021 cctcctccgt gttccggaag gcaggagtgc cggaagcgaa gatccagtac gcgatcatcg
     1081 ggactgggag ctgcgagctg ctcacggcgg ttgttagttg tgtggtaatc gagagggtgg
     1141 gtcggcgcgt gctgctcatc ggtgggtaca gcctgatgac ctgctggggg agcatcttca
     1201 ctgtggccct gtgcctgcag agctccttcc cctggacact ctacctggcc atggcctgca
     1261 tctttgcctt catcctcagc tttggcattg gccctgccgg agtgacgggg atcctggcca
     1321 cagagctgtt tgaccagatg gccaggcctg ctgcctgcat ggtctgcggg gcgctcatgt
     1381 ggatcatgct catcctggtc ggcctgggat ttccctttat catggaggcc ttgtcccact
     1441 tcctctatgt ccctttcctt ggtgtctgtg tctgtggggc catctacact ggcctgttcc
     1501 ttcctgagac caaaggcaag accttccaag agatctccaa ggaattacac agactcaact
     1561 tccccaggcg ggcccagggc cccacgtgga ggagcctgga ggttatccag tcaacagaac
     1621 tctagtccca aaggggtggc cagagccaaa gccagctact gtcctgtcct ctgcttcctg
     1681 ccagggccct ggtcctcact ccctcctgca ttcctcattt aaggagtgtt tattgagcac
     1741 cctttgtgtg cagacatggc tccaggtgct tagcaatcaa tggtgagcgt ggtattccag
     1801 gctaaaggta attaactgac agaaaatcag taacaacata attacaggct ggttgtggca
     1861 gctcatgact gtaatcccag cactttggga ggccaaggtg ggaggatcaa ttgaggccag
     1921 agtttgaaac cagcctaggt aacatagtga gaccccctat ctctacaaaa aattttaaac
     1981 attagctggg catggtggta tgtgctaaca gctctagcta ctcaggaggc tgaggcagca
     2041 ggatcacttg agtccaagag ttcaaggtag cagtaagcta caatcacacc actgcatgcc
     2101 agactgggtg acagagggag acttcatctc tttaaaacat aataataata attacagact
     2161 caggaaatgc agtgaaagaa aaatacaggt tggccaggtg aggtggctga tgcctgtaat
     2221 cccagcactt tgggaggcca agatgggaag attgctttga gaccagaagt ttgagaccag
     2281 cctgggccac atagtaagat cctgtttcta ccaaaaaaaa aaaaaaaaaa aattagctgg
     2341 gtgtggtggt acatgcctgt ggtcccagct actcaggagg ctgaaatggg aggatcactt
     2401 gagcctggga ggtcgaggct gcagtgagtc ctaattgagc cactgcactc cagcctggac
     2461 aacagaaaga gaccatgttt caaaaaaaat aaatacaggt tgtagtgggt atgggtatgc
     2521 ataccaggag gcccgacctc gtctgagagg ggagtggtca gaaaagaatt ttctgaggaa
     2581 ttgatgtttt taatcaactt tattgaggta taatttatac ataaccaact gcatccattt
     2641 taagtatata tttggcgagt tttgagttct aagtatagtt ttggtgagtg tatacacttg
     2701 ggaaacacca ccgtgatcaa gatggaacct ttaccctacc ccaaggcacc cacatgccca
     2761 tttgctatca gtaacccacc ccagtcccag acctggggaa ccactgacct gctttctgcc
     2821 tcaattggtc agatttgcct tttttcagaa tctgaagtca ttccgtactg tatgtacaca
     2881 tttgtgtctg gcttggctcc agataaagtt tttgggattc atgaatgttg ttgcacgtat
     2941 taggagagac tcctttgtat tgctgagtag tattcccctc tgtggttaga ccatgattta
     3001 tttatccatc tacctgttgg tgaacatttt ggctgtttct aattcttggc catcatgaat
     3061 aaaactgctg tgaatgttcc tacaataa
//
