LOCUS       NM_030777               4227 bp    mRNA    linear   PRI 08-OCT-2024
DEFINITION  Homo sapiens solute carrier family 2 member 10 (SLC2A10), mRNA.
ACCESSION   NM_030777
VERSION     NM_030777.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4227)
  AUTHORS   Lin,W.S. and Hsu,T.R.
  TITLE     Revisiting the roles of glucose transporters in skeletal muscle
            physiology: is GLUT10 a novel player?
  JOURNAL   Biochem Biophys Res Commun 696, 149494 (2024)
   PUBMED   38219491
  REMARK    GeneRIF: Revisiting the roles of glucose transporters in skeletal
            muscle physiology: is GLUT10 a novel player?
            Review article
REFERENCE   2  (bases 1 to 4227)
  AUTHORS   Bai,Y., Ye,B., Li,T., Wang,R. and Qi,X.
  TITLE     H22954, a long non-coding RNA, inhibits glucose uptake in leukemia
            cells in a GLUT10-dependent manner
  JOURNAL   Hematology 27 (1), 469-475 (2022)
   PUBMED   35413230
  REMARK    GeneRIF: H22954, a long non-coding RNA, inhibits glucose uptake in
            leukemia cells in a GLUT10-dependent manner.
REFERENCE   3  (bases 1 to 4227)
  AUTHORS   Segade,F., Allred,D.C. and Bowden,D.W.
  TITLE     Functional characterization of the promoter of the human glucose
            transporter 10 gene
  JOURNAL   Biochim Biophys Acta 1730 (2), 147-158 (2005)
   PUBMED   16051383
  REMARK    GeneRIF: Complex regulatory mechanism of SLC2A10 expression through
            interaction of multiple transcription factors on basal promotor and
            prescence of distal repressor sequence suggests fine modulation of
            GLUT10 levels critical for glucose homeostasis.
REFERENCE   4  (bases 1 to 4227)
  AUTHORS   Zaidi,S.H., Peltekova,V., Meyer,S., Lindinger,A., Paterson,A.D.,
            Tsui,L.C., Faiyaz-Ul-Haque,M. and Teebi,A.S.
  TITLE     A family exhibiting arterial tortuosity syndrome displays
            homozygosity for markers in the arterial tortuosity locus at
            chromosome 20q13
  JOURNAL   Clin Genet 67 (2), 183-188 (2005)
   PUBMED   15679832
REFERENCE   5  (bases 1 to 4227)
  AUTHORS   Richardson,S., Neama,G., Phillips,T., Bell,S., Carter,S.D.,
            Moley,K.H., Moley,J.F., Vannucci,S.J. and Mobasheri,A.
  TITLE     Molecular characterization and partial cDNA cloning of facilitative
            glucose transporters expressed in human articular chondrocytes;
            stimulation of 2-deoxyglucose uptake by IGF-I and elevated MMP-2
            secretion by glucose deprivation
  JOURNAL   Osteoarthritis Cartilage 11 (2), 92-101 (2003)
   PUBMED   12554125
REFERENCE   6  (bases 1 to 4227)
  AUTHORS   Dawson,P.A., Mychaleckyj,J.C., Fossey,S.C., Mihic,S.J.,
            Craddock,A.L. and Bowden,D.W.
  TITLE     Sequence and functional analysis of GLUT10: a glucose transporter
            in the Type 2 diabetes-linked region of chromosome 20q12-13.1
  JOURNAL   Mol Genet Metab 74 (1-2), 186-199 (2001)
   PUBMED   11592815
REFERENCE   7  (bases 1 to 4227)
  AUTHORS   McVie-Wylie,A.J., Lamson,D.R. and Chen,Y.T.
  TITLE     Molecular cloning of a novel member of the GLUT family of
            transporters, SLC2a10 (GLUT10), localized on chromosome 20q13.1: a
            candidate gene for NIDDM susceptibility
  JOURNAL   Genomics 72 (1), 113-117 (2001)
   PUBMED   11247674
REFERENCE   8  (bases 1 to 4227)
  AUTHORS   Callewaert,B., De Paepe,A. and Coucke,P.
  TITLE     Arterial Tortuosity Syndrome
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   25392904
REFERENCE   9  (bases 1 to 4227)
  AUTHORS   Longoni,M., Pober,B.R. and High,F.A.
  TITLE     Congenital Diaphragmatic Hernia Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301533
REFERENCE   10 (bases 1 to 4227)
  AUTHORS   Milewicz,D.M. and Cecchi,A.C.
  TITLE     Heritable Thoracic Aortic Disease Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301299
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AF248053.1 and AF321240.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_030777.3.
            
            Summary: This gene encodes a member of the class III facilitative
            glucose transporter family. The encoded protein plays a role in
            regulation of glucose homeostasis. Mutations in this gene have been
            associated with arterial tortuosity syndrome.[provided by RefSeq,
            Dec 2009].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF248053.1, SRR1660807.206632.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000359271.4/ ENSP00000352216.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-36                AF248053.1         163-198
            37-4203             AF321240.1         1-4167
            4204-4227           AF248053.1         4365-4388
FEATURES             Location/Qualifiers
     source          1..4227
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20q13.12"
     gene            1..4227
                     /gene="SLC2A10"
                     /gene_synonym="ATORS; ATS; GLUT10"
                     /note="solute carrier family 2 member 10"
                     /db_xref="GeneID:81031"
                     /db_xref="HGNC:HGNC:13444"
                     /db_xref="MIM:606145"
     exon            1..92
                     /gene="SLC2A10"
                     /gene_synonym="ATORS; ATS; GLUT10"
                     /inference="alignment:Splign:2.1.0"
     CDS             89..1714
                     /gene="SLC2A10"
                     /gene_synonym="ATORS; ATS; GLUT10"
                     /note="GLUT-10; glucose transporter type 10; solute
                     carrier family 2 (facilitated glucose transporter), member
                     10; facilitative glucose transporter GLUT10"
                     /codon_start=1
                     /product="solute carrier family 2, facilitated glucose
                     transporter member 10"
                     /protein_id="NP_110404.1"
                     /db_xref="CCDS:CCDS13402.1"
                     /db_xref="GeneID:81031"
                     /db_xref="HGNC:HGNC:13444"
                     /db_xref="MIM:606145"
                     /translation="MGHSPPVLPLCASVSLLGGLTFGYELAVISGALLPLQLDFGLSC
                     LEQEFLVGSLLLGALLASLVGGFLIDCYGRKQAILGSNLVLLAGSLTLGLAGSLAWLV
                     LGRAVVGFAISLSSMACCIYVSELVGPRQRGVLVSLYEAGITVGILLSYALNYALAGT
                     PWGWRHMFGWATAPAVLQSLSLLFLPAGTDETATHKDLIPLQGGEAPKLGPGRPRYSF
                     LDLFRARDNMRGRTTVGLGLVLFQQLTGQPNVLCYASTIFSSVGFHGGSSAVLASVGL
                     GAVKVAATLTAMGLVDRAGRRALLLAGCALMALSVSGIGLVSFAVPMDSGPSCLAVPN
                     ATGQTGLPGDSGLLQDSSLPPIPRTNEDQREPILSTAKKTKPHPRSGDPSAPPRLALS
                     SALPGPPLPARGHALLRWTALLCLMVFVSAFSFGFGPVTWLVLSEIYPVEIRGRAFAF
                     CNSFNWAANLFISLSFLDLIGTIGLSWTFLLYGLTAVLGLGFIYLFVPETKGQSLAEI
                     DQQFQKRRFTLSFGHRQNSTGIPYSRIEISAAS"
     exon            93..1376
                     /gene="SLC2A10"
                     /gene_synonym="ATORS; ATS; GLUT10"
                     /inference="alignment:Splign:2.1.0"
     exon            1377..1499
                     /gene="SLC2A10"
                     /gene_synonym="ATORS; ATS; GLUT10"
                     /inference="alignment:Splign:2.1.0"
     exon            1500..1635
                     /gene="SLC2A10"
                     /gene_synonym="ATORS; ATS; GLUT10"
                     /inference="alignment:Splign:2.1.0"
     exon            1636..4227
                     /gene="SLC2A10"
                     /gene_synonym="ATORS; ATS; GLUT10"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4185..4190
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC2A10"
                     /gene_synonym="ATORS; ATS; GLUT10"
                     /note="hexamer: AATAAA"
     regulatory      4201..4206
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC2A10"
                     /gene_synonym="ATORS; ATS; GLUT10"
                     /note="hexamer: AATAAA"
     polyA_site      4206
                     /gene="SLC2A10"
                     /gene_synonym="ATORS; ATS; GLUT10"
                     /note="major polyA site"
     polyA_site      4227
                     /gene="SLC2A10"
                     /gene_synonym="ATORS; ATS; GLUT10"
ORIGIN      
        1 gtccggcggc agcggcgttg gggactccgg cgggggatgc gcgcccggcc cctcagcgcc
       61 cccagcacgc cgccgagtcc cgctcgccat gggccactcc ccacctgtcc tgcctttgtg
      121 tgcctctgtg tctttgctgg gtggcctgac ctttggttat gaactggcag tcatatcagg
      181 tgccctgctg ccactgcagc ttgactttgg gctaagctgc ttggagcagg agttcctggt
      241 gggcagcctg ctcctggggg ctctcctcgc ctccctggtt ggtggcttcc tcattgactg
      301 ctatggcagg aagcaagcca tcctcgggag caacttggtg ctgctggcag gcagcctgac
      361 cctgggcctg gctggttccc tggcctggct ggtcctgggc cgcgctgtgg ttggcttcgc
      421 catttccctc tcctccatgg cttgctgtat ctacgtgtca gagctggtgg ggccacggca
      481 gcggggagtg ctggtgtccc tctatgaggc aggcatcacc gtgggcatcc tgctctccta
      541 tgccctcaac tatgcactgg ctggtacccc ctggggatgg aggcacatgt tcggctgggc
      601 cactgcacct gctgtcctgc aatccctcag cctcctcttc ctccctgctg gtacagatga
      661 gactgcaaca cacaaggacc tcatcccact ccagggaggt gaggccccca agctgggccc
      721 ggggaggcca cggtactcct ttctggacct cttcagggca cgcgataaca tgcgaggccg
      781 gaccacagtg ggcctggggc tggtgctctt ccagcaacta acagggcagc ccaacgtgct
      841 gtgctatgcc tccaccatct tcagctccgt tggtttccat gggggatcct cagccgtgct
      901 ggcctctgtg gggcttggcg cagtgaaggt ggcagctacc ctgaccgcca tggggctggt
      961 ggaccgtgca ggccgcaggg ctctgttgct agctggctgt gccctcatgg ccctgtccgt
     1021 cagtggcata ggcctcgtca gctttgccgt gcccatggac tcaggcccaa gctgtctggc
     1081 tgtgcccaat gccaccgggc agacaggcct ccctggagac tctggcctgc tgcaggactc
     1141 ctctctacct cccattccaa ggaccaatga ggaccaaagg gagccaatct tgtccactgc
     1201 taagaaaacc aagccccatc ccagatctgg agacccctca gcccctcctc ggctggccct
     1261 gagctctgcc ctccctgggc cccctctgcc cgctcggggg catgcactgc tgcgctggac
     1321 cgcactgctg tgcctgatgg tctttgtcag tgccttctcc tttgggtttg ggccagtgac
     1381 ctggcttgtc ctcagcgaga tctaccctgt ggagatacga ggaagagcct tcgccttctg
     1441 caacagcttc aactgggcgg ccaacctctt catcagcctc tccttcctcg atctcattgg
     1501 caccatcggc ttgtcctgga ccttcctgct ctacggactg accgctgtcc tcggcctggg
     1561 cttcatctat ttatttgttc ctgaaacaaa aggccagtcg ttggcagaga tagaccagca
     1621 gttccagaag agacggttca ccctgagctt tggccacagg cagaactcca ctggcatccc
     1681 gtacagccgc atcgagatct ctgcggcctc ctgaggaatc cgtctgcctg gaaattctgg
     1741 aactgtggct ttggcagacc atctccagca tcctgcttcc taggccccag agcacaagtt
     1801 ccagctggtc ttttgggagt ggcccctgcc cccaaaggtg gtctgctttt gctggggtaa
     1861 aaaggatgaa agtctgagaa tgcccaactc ttcattttga gtctcaggcc ctgaaggttc
     1921 ctgaggatct agcttcatgc ctcagtttcc ccattgactt gcacatctct gcagtattta
     1981 taagaagaat attctatgaa gtctttgttg caccatggac ttttctcaaa gaatctcaag
     2041 ggtaccaatc ctggcaggaa gtctctcccg atatcacccc taaatccaaa tgaggatatc
     2101 atcttttcta atctcttttt tcaactggct gggacatttt cggaaggggg aagtctcttt
     2161 ttttactctt atcatttttt ttttttgagg tggagtctca ttctgttgcc caggctggcc
     2221 tgatcttggc tcactgcaac ctccacctcc tgagttcaag cgattcttgt gcctcagcct
     2281 cctaagcagc tgggactaca ggcgcatgca accataccca gctaatttat ttttagcaga
     2341 gatggggttt cactgtgttg gccaggctgg tcgtgaactc ctgagctcaa gtgatccacc
     2401 cacctcagcc tcccagagtg ctaggattac aggccttttg actcttttat ctgagtttta
     2461 ttgacccctc taattctctt acccagaata tttatccttc accagcaact ctgactcttt
     2521 gacgggaggc ctcagttcta gtccttggtc tgctggtgtc attgctgtag gaatgaccac
     2581 gggcctcagt ttccccattt gtataatggg aagcctgtac caggtcattc ttaagatttc
     2641 tcctgactcc agtgagctgg aattctaaat gctggtctag gagctgtctc caggatggtg
     2701 caggatggct ttgcggaaag gagatgggtt tggaggccaa caaacctgct tgtcaatatt
     2761 gcctttgcct cttggcagcc cttgaacttg agtaaataac aactccctga acctcagttt
     2821 cctcatctgc agaatgggga taattatgtc ccaggggtat atttagaccc tgtttccttt
     2881 caggagggtc cccagctggt ccagggcctg ggaaatttct acttatcctc attacccagg
     2941 tccctccttt ggaccctgta aagggtcagg gtgaatcaga tgggggactg agcaagtagc
     3001 tatgactgca gatcatgtaa ggaagggact gacaagaagc tcccagatgc tggggagaat
     3061 gaagagctaa aatagatcct aggtgctgga tgctttgtca tccatgcgtg cacatatggg
     3121 tgctggcaga gcccccaagg actctggcct ctcgagttct cctatcttct ccattctaga
     3181 tgcttccctt gtatccagtg atgtgctgga gctggctttg ccaagcttgt gagagctggt
     3241 tgctacattt tcaggatttt tacaagttgg taaacacagc cattataaaa aattaaatga
     3301 tttaaattta taattaagta aattacatta aaacaaaaaa attatactca aaattcatta
     3361 cttaatttta ctacctgtta ctattatctg tgcttttgag gctatttcta catagtaact
     3421 cttatggaga cctaggggag acaccgcgca tctcttcctg attccccact caatgacatc
     3481 atgttagtct ttggttgctt aactggctgt ggggagtgtt tttgtatcac aaagattaga
     3541 gaggactaca catcagggct tgatttattg tttgttgatt ttctagactt cagaacatgc
     3601 tggataaaat gtcagtaatg caaattaaac tttaaagtat gtcttgtttg tagccaatac
     3661 atggtgtata gcaccaaaaa atggagggat tattcttcca gtagttgaac actgtcatcc
     3721 gtttcagctg acagctgctc aaatcattta agaaggagtt ctgacattca ttttcattgt
     3781 tttacttttg tcttcctcac tagtgtaaac aaaaatttca accagcattc atgccgaacc
     3841 tatacccatt cttcagtgcc tagctgtaca gttatcaggg atttttattt gtagtctaat
     3901 tttgtcaaat catggccaaa tcgcagtgat agttgacttt ggatacaagg tttggcaaaa
     3961 aaaaaaatat taacaaaata ttctgtaaga atcaattgtc tatatggaat ttaggataaa
     4021 gaatatttac aataaagaat atttacaata aagagtttat tattatttgt aagttgtgtg
     4081 caacaaacat accctttatc tctgtaaaat ttatacacac aaaaattaac aaaagattct
     4141 gtaagaatta attggctata tggaatttag gatagaatat ttacaataaa gagtatttac
     4201 aataaagagt ttgttattat ttgtaaa
//
