LOCUS       NM_001372327            2083 bp    mRNA    linear   PRI 12-OCT-2024
DEFINITION  Homo sapiens solute carrier family 29 member 1 (Augustine blood
            group) (SLC29A1), transcript variant 7, mRNA.
ACCESSION   NM_001372327
VERSION     NM_001372327.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2083)
  AUTHORS   Sahin,T.K., Isik,A., Guven,D.C., Ceylan,F., Babaoglu,B., Akyol,A.,
            Yalcin,S. and Dizdar,O.
  TITLE     The prognostic and predictive role of class III beta-Tubulin and
            hENT1 expression in patients with advanced pancreatic ductal
            adenocarcinoma
  JOURNAL   Pancreatology 24 (2), 279-288 (2024)
   PUBMED   38272717
  REMARK    GeneRIF: The prognostic and predictive role of class III
            beta-Tubulin and hENT1 expression in patients with advanced
            pancreatic ductal adenocarcinoma.
REFERENCE   2  (bases 1 to 2083)
  AUTHORS   Chen,C., Xie,T., Zhang,Y., Wang,Y., Yu,F., Lin,L., Zhang,W.,
            Brown,B.C., Zhang,X., Kellems,R.E., D'Alessandro,A. and Xia,Y.
  TITLE     Erythrocyte ENT1-AMPD3 Axis is an Essential Purinergic Hypoxia
            Sensor and Energy Regulator Combating CKD in a Mouse Model
  JOURNAL   J Am Soc Nephrol 34 (10), 1647-1671 (2023)
   PUBMED   37725437
  REMARK    GeneRIF: Erythrocyte ENT1-AMPD3 Axis is an Essential Purinergic
            Hypoxia Sensor and Energy Regulator Combating CKD in a Mouse Model.
REFERENCE   3  (bases 1 to 2083)
  AUTHORS   Koehl,B., Claude,L., Reminy,K., Tarer,V., Baccini,V., Romana,M.,
            Colin-Aronovicz,Y., Damaraju,V.L., Sawyer,M., Peyrard,T.,
            Etienne-Julan,M., Le Van Kim,C., Azouzi,S. and Reininger,L.
  TITLE     Erythrocyte type 1 equilibrative nucleoside transporter expression
            in sickle cell disease and sickle cell trait
  JOURNAL   Br J Haematol 200 (6), 812-820 (2023)
   PUBMED   36464247
  REMARK    GeneRIF: Erythrocyte type 1 equilibrative nucleoside transporter
            expression in sickle cell disease and sickle cell trait.
REFERENCE   4  (bases 1 to 2083)
  AUTHORS   Kutyna,M.M., Loone,S., Saunders,V.A., White,D.L., Kok,C.H. and
            Hiwase,D.K.
  TITLE     Solute Carrier Family 29A1 Mediates In Vitro Resistance to
            Azacitidine in Acute Myeloid Leukemia Cell Lines
  JOURNAL   Int J Mol Sci 24 (4), 3553 (2023)
   PUBMED   36834962
  REMARK    GeneRIF: Solute Carrier Family 29A1 Mediates In Vitro Resistance to
            Azacitidine in Acute Myeloid Leukemia Cell Lines.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2083)
  AUTHORS   Niemann,B., Haufs-Brusberg,S., Puetz,L., Feickert,M.,
            Jaeckstein,M.Y., Hoffmann,A., Zurkovic,J., Heine,M.,
            Trautmann,E.M., Muller,C.E., Tonjes,A., Schlein,C., Jafari,A.,
            Eltzschig,H.K., Gnad,T., Bluher,M., Krahmer,N., Kovacs,P.,
            Heeren,J. and Pfeifer,A.
  TITLE     Apoptotic brown adipocytes enhance energy expenditure via
            extracellular inosine
  JOURNAL   Nature 609 (7926), 361-368 (2022)
   PUBMED   35790189
REFERENCE   6  (bases 1 to 2083)
  AUTHORS   Ward,J.L., Sherali,A., Mo,Z.P. and Tse,C.M.
  TITLE     Kinetic and pharmacological properties of cloned human
            equilibrative nucleoside transporters, ENT1 and ENT2, stably
            expressed in nucleoside transporter-deficient PK15 cells. Ent2
            exhibits a low affinity for guanosine and cytidine but a high
            affinity for inosine
  JOURNAL   J Biol Chem 275 (12), 8375-8381 (2000)
   PUBMED   10722669
REFERENCE   7  (bases 1 to 2083)
  AUTHORS   Lum,P.Y., Ngo,L.Y., Bakken,A.H. and Unadkat,J.D.
  TITLE     Human intestinal es nucleoside transporter: molecular
            characterization and nucleoside inhibitory profiles
  JOURNAL   Cancer Chemother Pharmacol 45 (4), 273-278 (2000)
   PUBMED   10755314
REFERENCE   8  (bases 1 to 2083)
  AUTHORS   Griffiths,M., Yao,S.Y., Abidi,F., Phillips,S.E., Cass,C.E.,
            Young,J.D. and Baldwin,S.A.
  TITLE     Molecular cloning and characterization of a
            nitrobenzylthioinosine-insensitive (ei) equilibrative nucleoside
            transporter from human placenta
  JOURNAL   Biochem J 328 (Pt 3) (Pt 3), 739-743 (1997)
   PUBMED   9396714
REFERENCE   9  (bases 1 to 2083)
  AUTHORS   Coe,I.R., Griffiths,M., Young,J.D., Baldwin,S.A. and Cass,C.E.
  TITLE     Assignment of the human equilibrative nucleoside transporter
            (hENT1) to 6p21.1-p21.2
  JOURNAL   Genomics 45 (2), 459-460 (1997)
   PUBMED   9344680
REFERENCE   10 (bases 1 to 2083)
  AUTHORS   Griffiths,M., Beaumont,N., Yao,S.Y., Sundaram,M., Boumah,C.E.,
            Davies,A., Kwong,F.Y., Coe,I., Cass,C.E., Young,J.D. and
            Baldwin,S.A.
  TITLE     Cloning of a human nucleoside transporter implicated in the
            cellular uptake of adenosine and chemotherapeutic drugs
  JOURNAL   Nat Med 3 (1), 89-93 (1997)
   PUBMED   8986748
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL139392.10.
            This sequence is a reference standard in the RefSeqGene project.
            
            Summary: This gene is a member of the equilibrative nucleoside
            transporter family. The gene encodes a transmembrane glycoprotein
            that localizes to the plasma and mitochondrial membranes and
            mediates the cellular uptake of nucleosides from the surrounding
            medium. The protein is categorized as an equilibrative (as opposed
            to concentrative) transporter that is sensitive to inhibition by
            nitrobenzylthioinosine (NBMPR). Nucleoside transporters are
            required for nucleotide synthesis in cells that lack de novo
            nucleoside synthesis pathways, and are also necessary for the
            uptake of cytotoxic nucleosides used for cancer and viral
            chemotherapies. Multiple alternatively spliced variants, encoding
            the same protein, have been found for this gene. [provided by
            RefSeq, Jul 2008].
            
            Transcript Variant: This variant (7) differs in the 5' UTR compared
            to variant 1. Variants 1, 2 and 7 encode the same isoform (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC001382.2, SRR11853559.27989.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: PMID: 14607828
            MANE Ensembl match                 :: ENST00000371755.9/
                                                  ENSP00000360820.3
            RefSeq Select criteria             :: based on manual assertion,
                                                  conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-47                AL139392.10        8072-8118
            48-127              AL139392.10        11740-11819
            128-209             AL139392.10        13867-13948
            210-412             AL139392.10        14066-14268
            413-552             AL139392.10        14384-14523
            553-687             AL139392.10        14824-14958
            688-785             AL139392.10        15045-15142
            786-864             AL139392.10        15288-15366
            865-962             AL139392.10        15841-15938
            963-1071            AL139392.10        16475-16583
            1072-1157           AL139392.10        16820-16905
            1158-1357           AL139392.10        17284-17483
            1358-2083           AL139392.10        17894-18619
FEATURES             Location/Qualifiers
     source          1..2083
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p21.1"
     gene            1..2083
                     /gene="SLC29A1"
                     /gene_synonym="AUG; ENT1; hENT1"
                     /note="solute carrier family 29 member 1 (Augustine blood
                     group)"
                     /db_xref="GeneID:2030"
                     /db_xref="HGNC:HGNC:11003"
                     /db_xref="MIM:602193"
     exon            1..47
                     /gene="SLC29A1"
                     /gene_synonym="AUG; ENT1; hENT1"
                     /inference="alignment:Splign:2.1.0"
     exon            48..127
                     /gene="SLC29A1"
                     /gene_synonym="AUG; ENT1; hENT1"
                     /inference="alignment:Splign:2.1.0"
     CDS             99..1469
                     /gene="SLC29A1"
                     /gene_synonym="AUG; ENT1; hENT1"
                     /note="isoform 1 is encoded by transcript variant 7;
                     nucleoside transporter, es-type; equilibrative
                     nitrobenzylmercaptopurine riboside (NBMPR)-sensitive
                     nucleoside transporter; equilibrative nucleoside
                     transporter 1; solute carrier family 29 (nucleoside
                     transporters), member 1; solute carrier family 29
                     (equilibrative nucleoside transporter), member 1; es
                     nucleoside transporter"
                     /codon_start=1
                     /product="equilibrative nucleoside transporter 1 isoform
                     1"
                     /protein_id="NP_001359256.1"
                     /db_xref="CCDS:CCDS4908.1"
                     /db_xref="GeneID:2030"
                     /db_xref="HGNC:HGNC:11003"
                     /db_xref="MIM:602193"
                     /translation="MTTSHQPQDRYKAVWLIFFMLGLGTLLPWNFFMTATQYFTNRLD
                     MSQNVSLVTAELSKDAQASAAPAAPLPERNSLSAIFNNVMTLCAMLPLLLFTYLNSFL
                     HQRIPQSVRILGSLVAILLVFLITAILVKVQLDALPFFVITMIKIVLINSFGAILQGS
                     LFGLAGLLPASYTAPIMSGQGLAGFFASVAMICAIASGSELSESAFGYFITACAVIIL
                     TIICYLGLPRLEFYRYYQQLKLEGPGEQETKLDLISKGEEPRAGKEESGVSVSNSQPT
                     NESHSIKAILKNISVLAFSVCFIFTITIGMFPAVTVEVKSSIAGSSTWERYFIPVSCF
                     LTFNIFDWLGRSLTAVFMWPGKDSRWLPSLVLARLVFVPLLLLCNIKPRRYLTVVFEH
                     DAWFIFFMAAFAFSNGYLASLCMCFGPKKVKPAEAETAGAIMAFFLCLGLALGAVFSF
                     LFRAIV"
     exon            128..209
                     /gene="SLC29A1"
                     /gene_synonym="AUG; ENT1; hENT1"
                     /inference="alignment:Splign:2.1.0"
     exon            210..412
                     /gene="SLC29A1"
                     /gene_synonym="AUG; ENT1; hENT1"
                     /inference="alignment:Splign:2.1.0"
     exon            413..552
                     /gene="SLC29A1"
                     /gene_synonym="AUG; ENT1; hENT1"
                     /inference="alignment:Splign:2.1.0"
     exon            553..687
                     /gene="SLC29A1"
                     /gene_synonym="AUG; ENT1; hENT1"
                     /inference="alignment:Splign:2.1.0"
     exon            688..785
                     /gene="SLC29A1"
                     /gene_synonym="AUG; ENT1; hENT1"
                     /inference="alignment:Splign:2.1.0"
     exon            786..864
                     /gene="SLC29A1"
                     /gene_synonym="AUG; ENT1; hENT1"
                     /inference="alignment:Splign:2.1.0"
     exon            865..962
                     /gene="SLC29A1"
                     /gene_synonym="AUG; ENT1; hENT1"
                     /inference="alignment:Splign:2.1.0"
     exon            963..1071
                     /gene="SLC29A1"
                     /gene_synonym="AUG; ENT1; hENT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1072..1157
                     /gene="SLC29A1"
                     /gene_synonym="AUG; ENT1; hENT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1158..1357
                     /gene="SLC29A1"
                     /gene_synonym="AUG; ENT1; hENT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1358..2083
                     /gene="SLC29A1"
                     /gene_synonym="AUG; ENT1; hENT1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2015..2020
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC29A1"
                     /gene_synonym="AUG; ENT1; hENT1"
                     /note="hexamer: AATATA"
     polyA_site      2034
                     /gene="SLC29A1"
                     /gene_synonym="AUG; ENT1; hENT1"
                     /note="major polyA site"
     regulatory      2061..2066
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC29A1"
                     /gene_synonym="AUG; ENT1; hENT1"
                     /note="hexamer: AATAAA"
     polyA_site      2066
                     /gene="SLC29A1"
                     /gene_synonym="AUG; ENT1; hENT1"
     polyA_site      2083
                     /gene="SLC29A1"
                     /gene_synonym="AUG; ENT1; hENT1"
                     /note="major polyA site"
ORIGIN      
        1 agcgagagcg cgcggatctc agcgcgggag cagtgcttct gcggcaggcc cctgagggag
       61 ggagctgtca gccagggaaa accgagaaca ccatcaccat gacaaccagt caccagcctc
      121 aggacagata caaagctgtc tggcttatct tcttcatgct gggtctggga acgctgctcc
      181 cgtggaattt tttcatgacg gccactcagt atttcacaaa ccgcctggac atgtcccaga
      241 atgtgtcctt ggtcactgct gaactgagca aggacgccca ggcgtcagcc gcccctgcag
      301 cacccttgcc tgagcggaac tctctcagtg ccatcttcaa caatgtcatg accctatgtg
      361 ccatgctgcc cctgctgtta ttcacctacc tcaactcctt cctgcatcag aggatccccc
      421 agtccgtacg gatcctgggc agcctggtgg ccatcctgct ggtgtttctg atcactgcca
      481 tcctggtgaa ggtgcagctg gatgctctgc ccttctttgt catcaccatg atcaagatcg
      541 tgctcattaa ttcatttggt gccatcctgc agggcagcct gtttggtctg gctggccttc
      601 tgcctgccag ctacacggcc cccatcatga gtggccaggg cctagcaggc ttctttgcct
      661 ccgtggccat gatctgcgct attgccagtg gctcggagct atcagaaagt gccttcggct
      721 actttatcac agcctgtgct gttatcattt tgaccatcat ctgttacctg ggcctgcccc
      781 gcctggaatt ctaccgctac taccagcagc tcaagcttga aggacccggg gagcaggaga
      841 ccaagttgga cctcattagc aaaggagagg agccaagagc aggcaaagag gaatctggag
      901 tttcagtctc caactctcag cccaccaatg aaagccactc tatcaaagcc atcctgaaaa
      961 atatctcagt cctggctttc tctgtctgct tcatcttcac tatcaccatt gggatgtttc
     1021 cagccgtgac tgttgaggtc aagtccagca tcgcaggcag cagcacctgg gaacgttact
     1081 tcattcctgt gtcctgtttc ttgactttca atatctttga ctggttgggc cggagcctca
     1141 cagctgtatt catgtggcct gggaaggaca gccgctggct gccaagcctg gtgctggccc
     1201 ggctggtgtt tgtgccactg ctgctgctgt gcaacattaa gccccgccgc tacctgactg
     1261 tggtcttcga gcacgatgcc tggttcatct tcttcatggc tgcctttgcc ttctccaacg
     1321 gctacctcgc cagcctctgc atgtgcttcg ggcccaagaa agtgaagcca gctgaggcag
     1381 agaccgcagg agccatcatg gccttcttcc tgtgtctggg tctggcactg ggggctgttt
     1441 tctccttcct gttccgggca attgtgtgac aaaggatgga cagaaggact gcctgcctcc
     1501 ctccctgtct gcctcctgcc ccttccttct gccaggggtg atcctgagtg gtctggcggt
     1561 tttttcttct aactgacttc tgctttccac ggcgtgtgct gggcccggat ctccaggccc
     1621 tggggaggga gcctctggac ggacagtggg gacattgtgg gtttggggct cagagtcgag
     1681 ggacggggtg tagcctcggc atttgcttga gtttctccac tcttggctct gactgatccc
     1741 tgcttgtgca ggccagtgga ggctcttggg cttggagaac acgtgtgtct ctgtgtatgt
     1801 gtctgtgtgt ctgcgtccgt gtctgtcaga ctgtctgcct gtcctggggt ggctaggagc
     1861 tgggtctgac cgttgtatgg tttgacctga tatactccat tctcccctgc gcctcctcct
     1921 ctgtgttctc tccatgtccc cctcccaact ccccatgccc agttcttacc catcatgcac
     1981 cctgtacagt tgccacgtta ctgccttttt taaaaatata tttgacagaa accaggtgcc
     2041 ttcagaggct ctctgattta aataaacctt tcttgttttt ttc
//
