LOCUS       NM_001017372            2863 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens solute carrier family 27 member 6 (SLC27A6),
            transcript variant 2, mRNA.
ACCESSION   NM_001017372
VERSION     NM_001017372.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2863)
  AUTHORS   Liu,C., Wang,J., Li,D., Ni,R., Zhao,M., Huang,C. and Liu,S.
  TITLE     Solute Carrier Family 27 Member 6 (SLC27A6) Possibly Promotes the
            Proliferation of Papillary Thyroid Cancer by Regulating c-MYC
  JOURNAL   Biochem Genet 60 (6), 2313-2326 (2022)
   PUBMED   35348939
  REMARK    GeneRIF: Solute Carrier Family 27 Member 6 (SLC27A6) Possibly
            Promotes the Proliferation of Papillary Thyroid Cancer by
            Regulating c-MYC.
REFERENCE   2  (bases 1 to 2863)
  AUTHORS   Yen,M.C., Chou,S.K., Kan,J.Y., Kuo,P.L., Hou,M.F. and Hsu,Y.L.
  TITLE     New Insight on Solute Carrier Family 27 Member 6 (SLC27A6) in
            Tumoral and Non-Tumoral Breast Cells
  JOURNAL   Int J Med Sci 16 (3), 366-375 (2019)
   PUBMED   30911270
  REMARK    GeneRIF: Inverse correlation between SLC27A6 expression and breast
            tumoral tissues.SLC27A6role in the cell growth and cell cycle
            regulation in non-tumorigenic breast cells.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2863)
  AUTHORS   Auinger,A., Helwig,U., Pfeuffer,M., Rubin,D., Luedde,M.,
            Rausche,T., Eddine El Mokhtari,N., Folsch,U.R., Schreiber,S.,
            Frey,N. and Schrezenmeir,J.
  TITLE     A variant in the heart-specific fatty acid transport protein 6 is
            associated with lower fasting and postprandial TAG, blood pressure
            and left ventricular hypertrophy
  JOURNAL   Br J Nutr 107 (10), 1422-1428 (2012)
   PUBMED   21920065
  REMARK    GeneRIF: The FATP6-7T>A polymorphism may protect from traits of the
            metabolic syndrome and CVD.
REFERENCE   4  (bases 1 to 2863)
  AUTHORS   Watkins,P.A., Maiguel,D., Jia,Z. and Pevsner,J.
  TITLE     Evidence for 26 distinct acyl-coenzyme A synthetase genes in the
            human genome
  JOURNAL   J Lipid Res 48 (12), 2736-2750 (2007)
   PUBMED   17762044
REFERENCE   5  (bases 1 to 2863)
  AUTHORS   Gimeno,R.E., Ortegon,A.M., Patel,S., Punreddy,S., Ge,P., Sun,Y.,
            Lodish,H.F. and Stahl,A.
  TITLE     Characterization of a heart-specific fatty acid transport protein
  JOURNAL   J Biol Chem 278 (18), 16039-16044 (2003)
   PUBMED   12556534
  REMARK    GeneRIF: FATP6 is involved in heart LCFA uptake, in which it may
            play a role in the pathogenesis of lipid-related cardiac disorders.
REFERENCE   6  (bases 1 to 2863)
  AUTHORS   Steinberg,S.J., Mihalik,S.J., Kim,D.G., Cuebas,D.A. and
            Watkins,P.A.
  TITLE     The human liver-specific homolog of very long-chain acyl-CoA
            synthetase is cholate:CoA ligase
  JOURNAL   J Biol Chem 275 (21), 15605-15608 (2000)
   PUBMED   10749848
REFERENCE   7  (bases 1 to 2863)
  AUTHORS   Steinberg,S.J., Wang,S.J., McGuinness,M.C. and Watkins,P.A.
  TITLE     Human liver-specific very-long-chain acyl-coenzyme A synthetase:
            cDNA cloning and characterization of a second enzymatically active
            protein
  JOURNAL   Mol Genet Metab 68 (1), 32-42 (1999)
   PUBMED   10479480
REFERENCE   8  (bases 1 to 2863)
  AUTHORS   Watkins,P.A., Pevsner,J. and Steinberg,S.J.
  TITLE     Human very long-chain acyl-CoA synthetase and two human homologs:
            initial characterization and relationship to fatty acid transport
            protein
  JOURNAL   Prostaglandins Leukot Essent Fatty Acids 60 (5-6), 323-328 (1999)
   PUBMED   10471116
REFERENCE   9  (bases 1 to 2863)
  AUTHORS   Hirsch,D., Stahl,A. and Lodish,H.F.
  TITLE     A family of fatty acid transporters conserved from mycobacterium to
            man
  JOURNAL   Proc Natl Acad Sci U S A 95 (15), 8625-8629 (1998)
   PUBMED   9671728
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC004636.1, AL833117.1,
            AF064254.1, AA614135.1 and BX537383.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001017372.2.
            
            Summary: This gene encodes a member of the fatty acid transport
            protein family (FATP). FATPs are involved in the uptake of
            long-chain fatty acids and have unique expression patterns.
            Alternatively spliced transcript variants encoding the same protein
            have been found for this gene. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (2) has an additional segment in
            the 5' UTR, compared to variant 1. Variants 1, 2, and 3 encode the
            same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660805.66017.1,
                                           SRR1803613.216789.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000262462.9/ ENSP00000262462.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-67                AC004636.1         52907-52973
            68-2222             AL833117.1         2-2156
            2223-2524           AF064254.1         1726-2027
            2525-2861           AA614135.1         1-337               c
            2862-2863           BX537383.1         2608-2609
FEATURES             Location/Qualifiers
     source          1..2863
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q23.3"
     gene            1..2863
                     /gene="SLC27A6"
                     /gene_synonym="ACSVL2; FACVL2; FATP6; VLCS-H1"
                     /note="solute carrier family 27 member 6"
                     /db_xref="GeneID:28965"
                     /db_xref="HGNC:HGNC:11000"
                     /db_xref="MIM:604196"
     exon            1..1131
                     /gene="SLC27A6"
                     /gene_synonym="ACSVL2; FACVL2; FATP6; VLCS-H1"
                     /inference="alignment:Splign:2.1.0"
     CDS             651..2510
                     /gene="SLC27A6"
                     /gene_synonym="ACSVL2; FACVL2; FATP6; VLCS-H1"
                     /EC_number="6.2.1.3"
                     /EC_number="6.2.1.15"
                     /note="fatty-acid-Coenzyme A ligase, very long-chain 2;
                     very long-chain acyl-CoA synthetase homolog 1; solute
                     carrier family 27 (fatty acid transporter), member 6;
                     long-chain-fatty-acid--CoA ligase; acyl-CoA synthetase
                     very long chain family, member 2; arachidonate--CoA
                     ligase"
                     /codon_start=1
                     /product="long-chain fatty acid transport protein 6"
                     /protein_id="NP_001017372.1"
                     /db_xref="CCDS:CCDS4145.1"
                     /db_xref="GeneID:28965"
                     /db_xref="HGNC:HGNC:11000"
                     /db_xref="MIM:604196"
                     /translation="MLLSWLTVLGAGMVVLHFLQKLLFPYFWDDFWFVLKVVLIIIRL
                     KKYEKRGELVTVLDKFLSHAKRQPRKPFIIYEGDIYTYQDVDKRSSRVAHVFLNHSSL
                     KKGDTVALLMSNEPDFVHVWFGLAKLGCVVAFLNTNIRSNSLLNCIRACGPRALVVGA
                     DLLGTVEEILPSLSENISVWGMKDSVPQGVISLKEKLSTSPDEPVPRSHHVVSLLKST
                     CLYIFTSGTTGLPKAAVISQLQVLRGSAVLWAFGCTAHDIVYITLPLYHSSAAILGIS
                     GCVELGATCVLKKKFSASQFWSDCKKYDVTVFQYIGELCRYLCKQSKREGEKDHKVRL
                     AIGNGIRSDVWREFLDRFGNIKVCELYAATESSISFMNYTGRIGAIGRTNLFYKLLST
                     FDLIKYDFQKDEPMRNEQGWCIHVKKGEPGLLISRVNAKNPFFGYAGPYKHTKDKLLC
                     DVFKKGDVYLNTGDLIVQDQDNFLYFWDRTGDTFRWKGENVATTEVADVIGMLDFIQE
                     ANVYGVAISGYEGRAGMASIILKPNTSLDLEKVYEQVVTFLPAYACPRFLRIQEKMEA
                     TGTFKLLKHQLVEDGFNPLKISEPLYFMDNLKKSYVLLTRELYDQIMLGEIKL"
     exon            1132..1335
                     /gene="SLC27A6"
                     /gene_synonym="ACSVL2; FACVL2; FATP6; VLCS-H1"
                     /inference="alignment:Splign:2.1.0"
     exon            1336..1494
                     /gene="SLC27A6"
                     /gene_synonym="ACSVL2; FACVL2; FATP6; VLCS-H1"
                     /inference="alignment:Splign:2.1.0"
     exon            1495..1619
                     /gene="SLC27A6"
                     /gene_synonym="ACSVL2; FACVL2; FATP6; VLCS-H1"
                     /inference="alignment:Splign:2.1.0"
     exon            1620..1814
                     /gene="SLC27A6"
                     /gene_synonym="ACSVL2; FACVL2; FATP6; VLCS-H1"
                     /inference="alignment:Splign:2.1.0"
     exon            1815..1905
                     /gene="SLC27A6"
                     /gene_synonym="ACSVL2; FACVL2; FATP6; VLCS-H1"
                     /inference="alignment:Splign:2.1.0"
     exon            1906..2104
                     /gene="SLC27A6"
                     /gene_synonym="ACSVL2; FACVL2; FATP6; VLCS-H1"
                     /inference="alignment:Splign:2.1.0"
     exon            2105..2202
                     /gene="SLC27A6"
                     /gene_synonym="ACSVL2; FACVL2; FATP6; VLCS-H1"
                     /inference="alignment:Splign:2.1.0"
     exon            2203..2333
                     /gene="SLC27A6"
                     /gene_synonym="ACSVL2; FACVL2; FATP6; VLCS-H1"
                     /inference="alignment:Splign:2.1.0"
     exon            2334..2863
                     /gene="SLC27A6"
                     /gene_synonym="ACSVL2; FACVL2; FATP6; VLCS-H1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2847..2852
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC27A6"
                     /gene_synonym="ACSVL2; FACVL2; FATP6; VLCS-H1"
                     /note="hexamer: ATTAAA"
     polyA_site      2863
                     /gene="SLC27A6"
                     /gene_synonym="ACSVL2; FACVL2; FATP6; VLCS-H1"
                     /note="major polyA site"
ORIGIN      
        1 aacccgctgg ccctgaggcc acggaccgag acgtggtgct gagcccctgc gcggtttctg
       61 gtgcgtagag actgtaaatc gctgcgcttc tcagtcatca tcatcccagc ttttcccggc
      121 tcgaattcag cctccaactc aagctcgcgg gaaagactac ctgagaggag aaaagcttct
      181 gtccctggac cttcttctga gggtggtgag gtttgtttag ggtcgcagaa gcagggagga
      241 ctgactcagc cctcacagag aagaggtctg gaaagtcctg gggaactcgc agggcacggg
      301 ccgctgtcgc ggttgggagg cgagggcgca gcgctggggt tgtagattcc aagacccctg
      361 agggtggctg tgttggtttc tcgcaggagt cggaggctcc ctgctttcca gccgcccagt
      421 gacccaagct taatcttcag caccacttgg ggcgaccttt tcggtgcaaa cctacgattc
      481 tgtttctcag gattcctccc catcccgctt cgccccggaa aagctgacaa gaacttcagg
      541 tgtaagccct gagtagtgag gatctgcggt ctccgtggag agctgtgcct ggaagagaag
      601 gacgctggtg ggggctgaga tcagagctgt cttctggccc agttgccccc atgcttctgt
      661 catggctaac agttctaggg gctggaatgg tcgtcctgca cttcttgcag aaactcctgt
      721 tcccttactt ttgggatgac ttctggttcg tgttgaaggt ggtgctcatt ataattcggc
      781 tgaagaagta tgaaaagaga ggggagctgg tgactgtgct ggataaattc ttgagtcatg
      841 ccaaaagaca acctcggaaa cctttcatca tctatgaggg agacatctac acctatcagg
      901 atgtagacaa aaggagcagc agagtggccc atgtcttcct gaaccattcc tctctgaaaa
      961 agggggacac ggtggctctg ctgatgagca atgagccgga cttcgttcac gtgtggttcg
     1021 gcctcgccaa gctgggctgc gtggtggcct ttctcaacac caacattcgc tccaactccc
     1081 tcctgaattg catccgcgcc tgtgggccca gagccctagt ggtgggcgca gatttgcttg
     1141 gaacggtaga agaaatcctt ccaagcctct cagaaaatat cagtgtttgg gggatgaaag
     1201 attctgttcc acaaggtgta atttcactca aagaaaaact gagcacctca cctgatgagc
     1261 ccgtgccacg cagccaccat gttgtctcac tcctcaagtc tacttgtctt tacattttta
     1321 cctctggaac aacaggtcta ccaaaagcag ctgtgattag tcagctgcag gttttaaggg
     1381 gttctgctgt cctgtgggct tttggttgta ctgctcatga cattgtttat ataacccttc
     1441 ctctgtatca tagttcagca gctatcctgg gaatttctgg atgtgttgag ttgggtgcca
     1501 cttgtgtgtt aaagaagaaa ttttcagcaa gccagttttg gagtgactgc aagaagtatg
     1561 atgtgactgt gtttcagtat attggagaac tttgtcgcta cctttgcaaa caatctaaga
     1621 gagaaggaga aaaggatcat aaggtgcgtt tggcaattgg aaatggcata cggagtgatg
     1681 tatggagaga atttttagac agatttggaa atataaaggt gtgtgaactt tatgcagcta
     1741 ccgaatcaag catatctttc atgaactaca ctgggagaat tggagcaatt gggagaacaa
     1801 atttgtttta caaacttctt tccacttttg acttaataaa gtatgacttt cagaaagatg
     1861 aacccatgag aaatgagcag ggttggtgta ttcatgtgaa aaaaggagaa cctggacttc
     1921 tcatttctcg agtgaatgca aaaaatccct tctttggcta tgctgggcct tataagcaca
     1981 caaaagacaa attgctttgt gatgttttta agaagggaga tgtttacctt aatactggag
     2041 acttaatagt ccaggatcag gacaatttcc tttatttttg ggaccgtact ggagacactt
     2101 tcagatggaa aggagaaaat gtcgcaacca ctgaggttgc tgatgttatt ggaatgttgg
     2161 atttcataca ggaagcaaac gtctatggtg tggctatatc aggttatgaa ggaagagcag
     2221 gaatggcttc tattatttta aaaccaaata catctttaga tttggaaaaa gtttatgaac
     2281 aagttgtaac atttctacca gcttatgctt gtccacgatt tttaagaatt caggaaaaaa
     2341 tggaagcaac aggaacattc aaactattga agcatcagtt ggtggaagat ggatttaatc
     2401 cactgaaaat ttctgaacca ctttacttca tggataactt gaaaaagtct tatgttctac
     2461 tgaccaggga actttatgat caaataatgt taggggaaat aaaactttaa gatttttata
     2521 tctagaactt tcatatgctt tcttaggaag agtgagaggg gggtatatga ttctttatga
     2581 aatggggaaa gggagctaac attaattatg catgtactat atttccttaa tatgagagat
     2641 aattttttaa ttgcataaga attttaattt cttttaattg atataaacag tagttgatta
     2701 ttctttttat ctatttggag attcagtgca taactaagta ttttccttaa tactaaagat
     2761 tttaaataat aaatagtggc tagcggtttg gacaatcact aaaaatgtac tttctaataa
     2821 gtaaaatttc taattttgaa taaaagatta aattttactg aaa
//
