LOCUS       NM_012254               2292 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens solute carrier family 27 member 5 (SLC27A5),
            transcript variant 1, mRNA.
ACCESSION   NM_012254
VERSION     NM_012254.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2292)
  AUTHORS   Nie,D., Tang,X., Deng,H., Yang,X., Tao,J., Xu,F., Liu,Y., Wu,K.,
            Wang,K., Mei,Z., Huang,A. and Tang,N.
  TITLE     Metabolic Enzyme SLC27A5 Regulates PIP4K2A pre-mRNA Splicing as a
            Noncanonical Mechanism to Suppress Hepatocellular Carcinoma
            Metastasis
  JOURNAL   Adv Sci (Weinh) 11 (5), e2305374 (2024)
   PUBMED   38059827
  REMARK    GeneRIF: Metabolic Enzyme SLC27A5 Regulates PIP4K2A pre-mRNA
            Splicing as a Noncanonical Mechanism to Suppress Hepatocellular
            Carcinoma Metastasis.
REFERENCE   2  (bases 1 to 2292)
  AUTHORS   Wu,K., Liu,Y., Xia,J., Liu,J., Wang,K., Liang,H., Xu,F., Liu,D.,
            Nie,D., Tang,X., Huang,A., Chen,C. and Tang,N.
  TITLE     Loss of SLC27A5 Activates Hepatic Stellate Cells and Promotes Liver
            Fibrosis via Unconjugated Cholic Acid
  JOURNAL   Adv Sci (Weinh) 11 (2), e2304408 (2024)
   PUBMED   37957540
  REMARK    GeneRIF: Loss of SLC27A5 Activates Hepatic Stellate Cells and
            Promotes Liver Fibrosis via Unconjugated Cholic Acid.
REFERENCE   3  (bases 1 to 2292)
  AUTHORS   Li,X., Wang,J., Guo,Z., Ma,Y., Xu,D., Fan,D., Dai,P., Chen,Y.,
            Liu,Q., Jiao,J., Fan,J., Wu,N., Li,X. and Li,G.
  TITLE     Copper metabolism-related risk score identifies hepatocellular
            carcinoma subtypes and SLC27A5 as a potential regulator of
            cuproptosis
  JOURNAL   Aging (Albany NY) 15 (24), 15084-15113 (2023)
   PUBMED   38157255
  REMARK    GeneRIF: Copper metabolism-related risk score identifies
            hepatocellular carcinoma subtypes and SLC27A5 as a potential
            regulator of cuproptosis.
REFERENCE   4  (bases 1 to 2292)
  AUTHORS   Xu,F.L., Wu,X.H., Chen,C., Wang,K., Huang,L.Y., Xia,J., Liu,Y.,
            Shan,X.F. and Tang,N.
  TITLE     SLC27A5 promotes sorafenib-induced ferroptosis in hepatocellular
            carcinoma by downregulating glutathione reductase
  JOURNAL   Cell Death Dis 14 (1), 22 (2023)
   PUBMED   36635256
  REMARK    GeneRIF: SLC27A5 promotes sorafenib-induced ferroptosis in
            hepatocellular carcinoma by downregulating glutathione reductase.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2292)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 2292)
  AUTHORS   Steinberg,S.J., Mihalik,S.J., Kim,D.G., Cuebas,D.A. and
            Watkins,P.A.
  TITLE     The human liver-specific homolog of very long-chain acyl-CoA
            synthetase is cholate:CoA ligase
  JOURNAL   J Biol Chem 275 (21), 15605-15608 (2000)
   PUBMED   10749848
REFERENCE   7  (bases 1 to 2292)
  AUTHORS   Steinberg,S.J., Wang,S.J., McGuinness,M.C. and Watkins,P.A.
  TITLE     Human liver-specific very-long-chain acyl-coenzyme A synthetase:
            cDNA cloning and characterization of a second enzymatically active
            protein
  JOURNAL   Mol Genet Metab 68 (1), 32-42 (1999)
   PUBMED   10479480
REFERENCE   8  (bases 1 to 2292)
  AUTHORS   Watkins,P.A., Pevsner,J. and Steinberg,S.J.
  TITLE     Human very long-chain acyl-CoA synthetase and two human homologs:
            initial characterization and relationship to fatty acid transport
            protein
  JOURNAL   Prostaglandins Leukot Essent Fatty Acids 60 (5-6), 323-328 (1999)
   PUBMED   10471116
REFERENCE   9  (bases 1 to 2292)
  AUTHORS   Hirsch,D., Stahl,A. and Lodish,H.F.
  TITLE     A family of fatty acid transporters conserved from mycobacterium to
            man
  JOURNAL   Proc Natl Acad Sci U S A 95 (15), 8625-8629 (1998)
   PUBMED   9671728
REFERENCE   10 (bases 1 to 2292)
  AUTHORS   Berger,J., Truppe,C., Neumann,H. and Forss-Petter,S.
  TITLE     A novel relative of the very-long-chain acyl-CoA synthetase and
            fatty acid transporter protein genes with a distinct expression
            pattern
  JOURNAL   Biochem Biophys Res Commun 247 (2), 255-260 (1998)
   PUBMED   9642112
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK123036.1 and BX103174.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_012254.2.
            
            Summary: The protein encoded by this gene is an isozyme of very
            long-chain acyl-CoA synthetase (VLCS). It is capable of activating
            very long-chain fatty-acids containing 24- and 26-carbons. It is
            expressed in liver and associated with endoplasmic reticulum but
            not with peroxisomes. Its primary role is in fatty acid elongation
            or complex lipid synthesis rather than in degradation. This gene
            has a mouse ortholog. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK123036.1, AF064255.2 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000263093.7/ ENSP00000263093.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2037              AK123036.1         74-2110
            2038-2292           BX103174.1         253-507
FEATURES             Location/Qualifiers
     source          1..2292
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.43"
     gene            1..2292
                     /gene="SLC27A5"
                     /gene_synonym="ACSB; ACSVL6; BACS; BAL; FACVL3; FATP-5;
                     FATP5; VLACSR; VLCS-H2; VLCSH2"
                     /note="solute carrier family 27 member 5"
                     /db_xref="GeneID:10998"
                     /db_xref="HGNC:HGNC:10999"
                     /db_xref="MIM:603314"
     exon            1..725
                     /gene="SLC27A5"
                     /gene_synonym="ACSB; ACSVL6; BACS; BAL; FACVL3; FATP-5;
                     FATP5; VLACSR; VLCS-H2; VLCSH2"
                     /inference="alignment:Splign:2.1.0"
     CDS             38..2110
                     /gene="SLC27A5"
                     /gene_synonym="ACSB; ACSVL6; BACS; BAL; FACVL3; FATP-5;
                     FATP5; VLACSR; VLCS-H2; VLCSH2"
                     /EC_number="6.2.1.3"
                     /EC_number="6.2.1.7"
                     /note="isoform 1 is encoded by transcript variant 1; very
                     long-chain acyl-CoA synthetase homolog 2; very long-chain
                     acyl-CoA synthetase-related protein; fatty-acid-Coenzyme A
                     ligase, very long-chain 3; bile acyl-CoA synthetase;
                     BA-CoA ligase; VLACS-related; cholate--CoA ligase; bile
                     acid-CoA ligase; fatty acid transport protein 5; solute
                     carrier family 27 (fatty acid transporter), member 5;
                     long-chain-fatty-acid--CoA ligase; long-chain fatty acid
                     transport protein 5"
                     /codon_start=1
                     /product="long-chain fatty acid transport protein 5
                     isoform 1"
                     /protein_id="NP_036386.1"
                     /db_xref="CCDS:CCDS12983.1"
                     /db_xref="GeneID:10998"
                     /db_xref="HGNC:HGNC:10999"
                     /db_xref="MIM:603314"
                     /translation="MGVRQQLALLLLLLLLLWGLGQPVWPVAVALTLRWLLGDPTCCV
                     LLGLAMLARPWLGPWVPHGLSLAAAALALTLLPARLPPGLRWLPADVIFLAKILHLGL
                     KIRGCLSRQPPDTFVDAFERRARAQPGRALLVWTGPGAGSVTFGELDARACQAAWALK
                     AELGDPASLCAGEPTALLVLASQAVPALCMWLGLAKLGCPTAWINPHGRGMPLAHSVL
                     SSGARVLVVDPDLRESLEEILPKLQAENIRCFYLSHTSPTPGVGALGAALDAAPSHPV
                     PADLRAGITWRSPALFIYTSGTTGLPKPAILTHERVLQMSKMLSLSGATADDVVYTVL
                     PLYHVMGLVVGILGCLDLGATCVLAPKFSTSCFWDDCRQHGVTVILYVGELLRYLCNI
                     PQQPEDRTHTVRLAMGNGLRADVWETFQQRFGPIRIWEVYGSTEGNMGLVNYVGRCGA
                     LGKMSCLLRMLSPFELVQFDMEAAEPVRDNQGFCIPVGLGEPGLLLTKVVSQQPFVGY
                     RGPRELSERKLVRNVRQSGDVYYNTGDVLAMDREGFLYFRDRLGDTFRWKGENVSTHE
                     VEGVLSQVDFLQQVNVYGVCVPGCEGKVGMAAVQLAPGQTFDGEKLYQHVRAWLPAYA
                     TPHFIRIQDAMEVTSTFKLMKTRLVREGFNVGIVVDPLFVLDNRAQSFRPLTAEMYQA
                     VCEGTWRL"
     exon            726..935
                     /gene="SLC27A5"
                     /gene_synonym="ACSB; ACSVL6; BACS; BAL; FACVL3; FATP-5;
                     FATP5; VLACSR; VLCS-H2; VLCSH2"
                     /inference="alignment:Splign:2.1.0"
     exon            936..1094
                     /gene="SLC27A5"
                     /gene_synonym="ACSB; ACSVL6; BACS; BAL; FACVL3; FATP-5;
                     FATP5; VLACSR; VLCS-H2; VLCSH2"
                     /inference="alignment:Splign:2.1.0"
     exon            1095..1219
                     /gene="SLC27A5"
                     /gene_synonym="ACSB; ACSVL6; BACS; BAL; FACVL3; FATP-5;
                     FATP5; VLACSR; VLCS-H2; VLCSH2"
                     /inference="alignment:Splign:2.1.0"
     exon            1220..1414
                     /gene="SLC27A5"
                     /gene_synonym="ACSB; ACSVL6; BACS; BAL; FACVL3; FATP-5;
                     FATP5; VLACSR; VLCS-H2; VLCSH2"
                     /inference="alignment:Splign:2.1.0"
     exon            1415..1505
                     /gene="SLC27A5"
                     /gene_synonym="ACSB; ACSVL6; BACS; BAL; FACVL3; FATP-5;
                     FATP5; VLACSR; VLCS-H2; VLCSH2"
                     /inference="alignment:Splign:2.1.0"
     exon            1506..1704
                     /gene="SLC27A5"
                     /gene_synonym="ACSB; ACSVL6; BACS; BAL; FACVL3; FATP-5;
                     FATP5; VLACSR; VLCS-H2; VLCSH2"
                     /inference="alignment:Splign:2.1.0"
     exon            1705..1802
                     /gene="SLC27A5"
                     /gene_synonym="ACSB; ACSVL6; BACS; BAL; FACVL3; FATP-5;
                     FATP5; VLACSR; VLCS-H2; VLCSH2"
                     /inference="alignment:Splign:2.1.0"
     exon            1803..1933
                     /gene="SLC27A5"
                     /gene_synonym="ACSB; ACSVL6; BACS; BAL; FACVL3; FATP-5;
                     FATP5; VLACSR; VLCS-H2; VLCSH2"
                     /inference="alignment:Splign:2.1.0"
     exon            1934..2292
                     /gene="SLC27A5"
                     /gene_synonym="ACSB; ACSVL6; BACS; BAL; FACVL3; FATP-5;
                     FATP5; VLACSR; VLCS-H2; VLCSH2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2268..2273
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC27A5"
                     /gene_synonym="ACSB; ACSVL6; BACS; BAL; FACVL3; FATP-5;
                     FATP5; VLACSR; VLCS-H2; VLCSH2"
                     /note="hexamer: AATAAA"
     polyA_site      2292
                     /gene="SLC27A5"
                     /gene_synonym="ACSB; ACSVL6; BACS; BAL; FACVL3; FATP-5;
                     FATP5; VLACSR; VLCS-H2; VLCSH2"
                     /note="major polyA site"
ORIGIN      
        1 actccacagc tgctgctcct agggaggagc tggtaccatg ggtgtcaggc aacagttggc
       61 cttgctgctg ctgctgctgc tcctgctctg gggcctgggg cagccagtgt ggccagtcgc
      121 tgtggccttg accctgcgct ggctcctggg ggatcccaca tgttgcgtgc tacttgggct
      181 ggccatgtta gcacggccct ggctcggccc ctgggtgccc catgggctga gcctggcagc
      241 tgcggccctg gcactaaccc tcctgccagc acggctgccc ccaggactac gctggctgcc
      301 ggctgatgtg atcttcttgg ccaagatcct ccacctgggc ctgaagatca ggggatgctt
      361 gagccggcag ccgcctgaca cctttgtaga tgccttcgag cggcgagcac gagcgcagcc
      421 tggcagggca ctcttggtgt ggacggggcc tggggccggc tcagtcacct ttggtgagct
      481 ggatgcccgg gcctgccagg cggcatgggc cctgaaggct gagctgggtg accctgcgag
      541 cctgtgtgcc ggggagccta ctgccctcct tgtgctggct tcccaggccg ttccagccct
      601 gtgtatgtgg ctggggctgg ccaagctggg ctgcccaaca gcctggatca acccgcatgg
      661 ccgggggatg cccctggcgc actctgtgct gagctctggg gcccgggtgc tggtggtgga
      721 cccagacctc cgggagagcc tggaggagat ccttcccaag ctgcaggctg agaacatccg
      781 ctgcttctac ctcagccata cctcccctac accaggggtg ggggctctgg gggctgccct
      841 ggatgcagcg ccctcccacc cagtgcctgc tgacctgcgt gctgggatca catggagaag
      901 ccctgccctc ttcatctata cctcggggac cactggcctc ccgaagccag ccatcctcac
      961 gcatgagcgg gtactgcaga tgagcaagat gctgtcctta tctggggcca cagctgatga
     1021 tgtggtttac acggtcctgc ctctgtacca cgtgatggga cttgtcgttg ggatcctcgg
     1081 ctgcttagat ctcggagcca cctgtgttct ggcccccaag ttctctactt cctgcttctg
     1141 ggatgactgt cggcagcatg gcgtgacagt gatcctgtat gtgggcgagc tcctgcggta
     1201 cttgtgtaac attccccagc aaccagagga ccggacacat acagtccgcc tggcaatggg
     1261 caatggacta cgggctgatg tgtgggagac cttccagcag cgcttcggtc ctattcggat
     1321 ctgggaagtc tacggctcca cagaaggcaa catgggctta gtcaactatg tggggcgctg
     1381 cggggccctg ggcaagatga gctgcctcct ccgaatgctg tccccctttg agctggtgca
     1441 gttcgacatg gaggcggcgg agcctgtgag ggacaatcag ggcttctgca tccctgtagg
     1501 gctaggggag ccggggctgc tgctgaccaa ggtggtaagc cagcaaccct tcgtgggcta
     1561 ccgcggcccc cgagagctgt cggaacggaa gctggtgcgc aacgtgcggc aatcgggcga
     1621 cgtttactac aacaccgggg acgtactggc catggaccgc gaaggcttcc tctacttccg
     1681 cgaccgcctc ggggacacct tccgatggaa gggcgagaac gtgtccacgc acgaggtgga
     1741 gggcgtgttg tcgcaggtgg acttcttgca acaggttaac gtgtatggcg tgtgcgtgcc
     1801 aggttgtgag ggtaaggtgg gcatggctgc tgtgcagcta gcccccggcc agactttcga
     1861 cggggagaag ttgtaccagc acgttcgcgc ttggctccct gcctacgcta ccccccattt
     1921 catccgcatc caggacgcca tggaggtcac cagcacgttc aaactgatga agacccggtt
     1981 ggtgcgtgag ggcttcaatg tggggatcgt ggttgaccct ctgtttgtac tggacaaccg
     2041 ggcccagtcc ttccggcccc tgacggcaga aatgtaccag gctgtgtgtg agggaacctg
     2101 gaggctctga tcacctggcc aacccactgg ggtagggatc aaagccagcc acccccaccc
     2161 caacacactc ggtgtccctt tcatcctggg cctgtgtgaa tcccagcctg gccataccct
     2221 caacctcagt gggctggaaa tgacagtggg ccctgtagca gtggcagaat aaactcagat
     2281 gtgttcacag aa
//
