LOCUS       NM_005094               3229 bp    mRNA    linear   PRI 09-OCT-2024
DEFINITION  Homo sapiens solute carrier family 27 member 4 (SLC27A4), mRNA.
ACCESSION   NM_005094
VERSION     NM_005094.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3229)
  AUTHORS   Miner,G.E., So,C.M., Edwards,W., Ragusa,J.V., Wine,J.T., Wong
            Gutierrez,D., Airola,M.V., Herring,L.E., Coleman,R.A., Klett,E.L.
            and Cohen,S.
  TITLE     PLIN5 interacts with FATP4 at membrane contact sites to promote
            lipid droplet-to-mitochondria fatty acid transport
  JOURNAL   Dev Cell 58 (14), 1250-1265 (2023)
   PUBMED   37290445
  REMARK    GeneRIF: PLIN5 interacts with FATP4 at membrane contact sites to
            promote lipid droplet-to-mitochondria fatty acid transport.
REFERENCE   2  (bases 1 to 3229)
  AUTHORS   Li,Z., Liao,X., Hu,Y., Li,M., Tang,M., Zhang,S., Mo,S., Li,X.,
            Chen,S., Qian,W., Feng,R., Yu,R., Xu,Y., Yuan,S., Xie,C. and Li,J.
  TITLE     SLC27A4-mediated selective uptake of mono-unsaturated fatty acids
            promotes ferroptosis defense in hepatocellular carcinoma
  JOURNAL   Free Radic Biol Med 201, 41-54 (2023)
   PUBMED   36924851
  REMARK    GeneRIF: SLC27A4-mediated selective uptake of mono-unsaturated
            fatty acids promotes ferroptosis defense in hepatocellular
            carcinoma.
REFERENCE   3  (bases 1 to 3229)
  AUTHORS   Al-Khenaizan,S., AlSwailem,A. and AlBalwi,M.A.
  TITLE     Ichthyosis Prematurity Syndrome: A Rare Form but Easily
            Recognizable Ichthyosis
  JOURNAL   Case Rep Dermatol 13 (3), 470-473 (2021)
   PUBMED   34720920
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3229)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   5  (bases 1 to 3229)
  AUTHORS   Ibrahim,A., Yucel,N., Kim,B. and Arany,Z.
  TITLE     Local Mitochondrial ATP Production Regulates Endothelial Fatty Acid
            Uptake and Transport
  JOURNAL   Cell Metab 32 (2), 309-319 (2020)
   PUBMED   32521232
REFERENCE   6  (bases 1 to 3229)
  AUTHORS   Fitscher,B.A., Riedel,H.D., Young,K.C. and Stremmel,W.
  TITLE     Tissue distribution and cDNA cloning of a human fatty acid
            transport protein (hsFATP4)
  JOURNAL   Biochim Biophys Acta 1443 (3), 381-385 (1998)
   PUBMED   9878842
REFERENCE   7  (bases 1 to 3229)
  AUTHORS   Hirsch,D., Stahl,A. and Lodish,H.F.
  TITLE     A family of fatty acid transporters conserved from mycobacterium to
            man
  JOURNAL   Proc Natl Acad Sci U S A 95 (15), 8625-8629 (1998)
   PUBMED   9671728
REFERENCE   8  (bases 1 to 3229)
  AUTHORS   Brusasco,A., Gelmetti,C., Tadini,G. and Caputo,R.
  TITLE     Ichthyosis congenita type IV: a new case resembling diffuse
            cutaneous mastocytosis
  JOURNAL   Br J Dermatol 136 (3), 377-379 (1997)
   PUBMED   9115920
REFERENCE   9  (bases 1 to 3229)
  AUTHORS   Adams,M.D., Kerlavage,A.R., Fields,C. and Venter,J.C.
  TITLE     3,400 new expressed sequence tags identify diversity of transcripts
            in human brain
  JOURNAL   Nat Genet 4 (3), 256-267 (1993)
   PUBMED   8358434
REFERENCE   10 (bases 1 to 3229)
  AUTHORS   Richard,G.
  TITLE     Autosomal Recessive Congenital Ichthyosis
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301593
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL359091.10, AK290222.1,
            BC065003.1, AA350218.1, AI478495.1 and H16504.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 25, 2018 this sequence version replaced NM_005094.3.
            
            Summary: This gene encodes a member of a family of fatty acid
            transport proteins, which are involved in translocation of
            long-chain fatty acids cross the plasma membrane. This protein is
            expressed at high levels on the apical side of mature enterocytes
            in the small intestine, and appears to be the principal fatty acid
            transporter in enterocytes. Clinical studies suggest this gene as a
            candidate gene for the insulin resistance syndrome. Mutations in
            this gene have been associated with ichthyosis prematurity
            syndrome. [provided by RefSeq, Apr 2010].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803613.267184.1, BC065003.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000300456.5/ ENSP00000300456.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-33                AL359091.10        39723-39755
            34-2669             AK290222.1         1-2636
            2670-2982           BC065003.1         2636-2948
            2983-3163           AA350218.1         66-246              c
            3164-3223           AI478495.1         10-69               c
            3224-3229           H16504.1           9-14                c
FEATURES             Location/Qualifiers
     source          1..3229
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q34.11"
     gene            1..3229
                     /gene="SLC27A4"
                     /gene_synonym="ACSVL4; FATP4; IPS"
                     /note="solute carrier family 27 member 4"
                     /db_xref="GeneID:10999"
                     /db_xref="HGNC:HGNC:10998"
                     /db_xref="MIM:604194"
     exon            1..312
                     /gene="SLC27A4"
                     /gene_synonym="ACSVL4; FATP4; IPS"
                     /inference="alignment:Splign:2.1.0"
     exon            313..479
                     /gene="SLC27A4"
                     /gene_synonym="ACSVL4; FATP4; IPS"
                     /inference="alignment:Splign:2.1.0"
     CDS             319..2250
                     /gene="SLC27A4"
                     /gene_synonym="ACSVL4; FATP4; IPS"
                     /EC_number="6.2.1.3"
                     /EC_number="6.2.1.15"
                     /note="solute carrier family 27 (fatty acid transporter),
                     member 4; arachidonate--CoA ligase;
                     long-chain-fatty-acid--CoA ligase; very long-chain
                     acyl-CoA synthetase 4; acyl-CoA synthetase very long chain
                     family member 4"
                     /codon_start=1
                     /product="long-chain fatty acid transport protein 4"
                     /protein_id="NP_005085.2"
                     /db_xref="CCDS:CCDS6899.1"
                     /db_xref="GeneID:10999"
                     /db_xref="HGNC:HGNC:10998"
                     /db_xref="MIM:604194"
                     /translation="MLLGASLVGVLLFSKLVLKLPWTQVGFSLLFLYLGSGGWRFIRV
                     FIKTIRRDIFGGLVLLKVKAKVRQCLQERRTVPILFASTVRRHPDKTALIFEGTDTHW
                     TFRQLDEYSSSVANFLQARGLASGDVAAIFMENRNEFVGLWLGMAKLGVEAALINTNL
                     RRDALLHCLTTSRARALVFGSEMASAICEVHASLDPSLSLFCSGSWEPGAVPPSTEHL
                     DPLLKDAPKHLPSCPDKGFTDKLFYIYTSGTTGLPKAAIVVHSRYYRMAALVYYGFRM
                     RPNDIVYDCLPLYHSAGNIVGIGQCLLHGMTVVIRKKFSASRFWDDCIKYNCTIVQYI
                     GELCRYLLNQPPREAENQHQVRMALGNGLRQSIWTNFSSRFHIPQVAEFYGATECNCS
                     LGNFDSQVGACGFNSRILSFVYPIRLVRVNEDTMELIRGPDGVCIPCQPGEPGQLVGR
                     IIQKDPLRRFDGYLNQGANNKKIAKDVFKKGDQAYLTGDVLVMDELGYLYFRDRTGDT
                     FRWKGENVSTTEVEGTLSRLLDMADVAVYGVEVPGTEGRAGMAAVASPTGNCDLERFA
                     QVLEKELPLYARPIFLRLLPELHKTGTYKFQKTELRKEGFDPAIVKDPLFYLDAQKGR
                     YVPLDQEAYSRIQAGEEKL"
     exon            480..874
                     /gene="SLC27A4"
                     /gene_synonym="ACSVL4; FATP4; IPS"
                     /inference="alignment:Splign:2.1.0"
     exon            875..1033
                     /gene="SLC27A4"
                     /gene_synonym="ACSVL4; FATP4; IPS"
                     /inference="alignment:Splign:2.1.0"
     exon            1034..1103
                     /gene="SLC27A4"
                     /gene_synonym="ACSVL4; FATP4; IPS"
                     /inference="alignment:Splign:2.1.0"
     exon            1104..1195
                     /gene="SLC27A4"
                     /gene_synonym="ACSVL4; FATP4; IPS"
                     /inference="alignment:Splign:2.1.0"
     exon            1196..1305
                     /gene="SLC27A4"
                     /gene_synonym="ACSVL4; FATP4; IPS"
                     /inference="alignment:Splign:2.1.0"
     exon            1306..1515
                     /gene="SLC27A4"
                     /gene_synonym="ACSVL4; FATP4; IPS"
                     /inference="alignment:Splign:2.1.0"
     exon            1516..1642
                     /gene="SLC27A4"
                     /gene_synonym="ACSVL4; FATP4; IPS"
                     /inference="alignment:Splign:2.1.0"
     exon            1643..1780
                     /gene="SLC27A4"
                     /gene_synonym="ACSVL4; FATP4; IPS"
                     /inference="alignment:Splign:2.1.0"
     exon            1781..1945
                     /gene="SLC27A4"
                     /gene_synonym="ACSVL4; FATP4; IPS"
                     /inference="alignment:Splign:2.1.0"
     exon            1946..2092
                     /gene="SLC27A4"
                     /gene_synonym="ACSVL4; FATP4; IPS"
                     /inference="alignment:Splign:2.1.0"
     exon            2093..3229
                     /gene="SLC27A4"
                     /gene_synonym="ACSVL4; FATP4; IPS"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2957..2962
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC27A4"
                     /gene_synonym="ACSVL4; FATP4; IPS"
                     /note="hexamer: AATAAA"
     polyA_site      2982
                     /gene="SLC27A4"
                     /gene_synonym="ACSVL4; FATP4; IPS"
                     /note="major polyA site"
     polyA_site      3229
                     /gene="SLC27A4"
                     /gene_synonym="ACSVL4; FATP4; IPS"
ORIGIN      
        1 aggcgcgctg gggctgcgct gcgccgccgg ctctgtggct tgccggcttc ggggaaggtg
       61 cggcaggcgg tgctgcggcc tggcacagca ggtttggggt gcgggaggcg ggcggggtag
      121 gagcgcggcg ggcggggccg ggcggcgggc ggggctggcg gggcggccgg gccatgcagg
      181 gcgcagagcc ggctaaaccc tgctgagacc cggctccgtg cgtccagggg cggctaatgc
      241 ccctcacgct gtctacgctg ctgcaaccgg gccgcatctg gacggggcgc cgcgcggcgg
      301 agccgacgcc gggccacaat gctgcttgga gcctctctgg tgggggtgct gctgttctcc
      361 aagctggtgc tgaaactgcc ctggacccag gtgggattct ccctgttgtt cctctacttg
      421 ggatctggcg gctggcgctt catccgggtc ttcatcaaga ccatcaggcg cgatatcttt
      481 ggcggcctgg tcctcctgaa ggtgaaggca aaggtgcgac agtgcctgca ggagcggcgg
      541 acagtgccca ttttgtttgc ctctaccgtt cggcgccacc ccgacaagac ggccctgatc
      601 ttcgagggca cagataccca ctggaccttc cgccagctgg atgagtactc aagcagtgta
      661 gccaacttcc tgcaggcccg gggcctggcc tcgggcgatg tggctgccat cttcatggag
      721 aaccgcaatg agttcgtggg cctatggctg ggcatggcca agctcggtgt ggaggcagcc
      781 ctcatcaaca ccaacctgcg gcgggatgct ctgctccact gcctcaccac ctcgcgcgca
      841 cgggcccttg tctttggcag cgaaatggcc tcagccatct gtgaggtcca tgccagcctg
      901 gacccctcgc tcagcctctt ctgctctggc tcctgggagc ccggtgcggt gcctccaagc
      961 acagaacacc tggaccctct gctgaaagat gctcccaagc accttcccag ttgccctgac
     1021 aagggcttca cagataaact gttctacatc tacacatccg gcaccacagg gctgcccaag
     1081 gccgccatcg tggtgcacag caggtattac cgcatggctg ccctggtgta ctatggattc
     1141 cgcatgcggc ccaacgacat cgtctatgac tgcctccccc tctaccactc agcaggaaac
     1201 atcgtgggaa tcggccagtg cctgctgcat ggcatgacgg tggtgattcg gaagaagttc
     1261 tcagcctccc ggttctggga cgattgtatc aagtacaact gcacgattgt gcagtacatt
     1321 ggtgaactgt gccgctacct cctgaaccag ccaccgcggg aggcagaaaa ccagcaccag
     1381 gttcgcatgg cactaggcaa tggcctccgg cagtccatct ggaccaactt ttccagccgc
     1441 ttccacatac cccaggtggc tgagttctac ggggccacag agtgcaactg tagcctgggc
     1501 aacttcgaca gccaggtggg ggcctgtggt ttcaatagcc gcatcctgtc cttcgtgtac
     1561 cccatccggt tggtacgtgt caacgaggac accatggagc tgatccgggg gcccgacggc
     1621 gtctgcattc cctgccagcc aggtgagccg ggccagctgg tgggccgcat catccagaaa
     1681 gaccccctgc gccgcttcga tggctacctc aaccagggcg ccaacaacaa gaagattgcc
     1741 aaggatgtct tcaagaaggg ggaccaggcc taccttactg gtgatgtgct ggtgatggac
     1801 gagctgggct acctgtactt ccgagaccgc actggggaca cgttccgctg gaaaggtgag
     1861 aacgtgtcca ccaccgaggt ggaaggcaca ctcagccgcc tgctggacat ggctgacgtg
     1921 gccgtgtatg gtgtcgaggt gccaggaacc gagggccggg ccggaatggc tgctgtggcc
     1981 agccccactg gcaactgtga cctggagcgc tttgctcagg tcttggagaa ggaactgccc
     2041 ctgtatgcgc gccccatctt cctgcgcctc ctgcctgagc tgcacaaaac aggaacctac
     2101 aagttccaga agacagagct acggaaggag ggctttgacc cggctattgt gaaagacccg
     2161 ctgttctatc tagatgccca gaagggccgc tacgtcccgc tggaccaaga ggcctacagc
     2221 cgcatccagg caggcgagga gaagctgtga ttccccccat ccctctgagg gccggcggat
     2281 gctggatccg gagccccagg ttccgcccca gagcggtcct ggacaaggcc agaccaaagc
     2341 aagcagggcc tggcacctcc atcctgaggt gctgcccctc catccaaaac tgccaagtga
     2401 ctcattgcct tcccaaccct tccagaggct ttctgtgaaa gtctcatgtc caagttccgt
     2461 cttctgggct gggcaggccc tctggttccc aggctgagac tgacgggttt tctcaggatg
     2521 atgtcttggg tgagggtagg gagaggacaa ggggtcaccg agcccttccc agagagcagg
     2581 gagcttataa atggaaccag agcagaagtc cccagactca ggaagtcaac agagtgggca
     2641 gggacagtgg tagcatccat ctggtggcca aagagaatcg tagccccaga gctgcccaag
     2701 ttcactgggc tccaccccca cctccaggag gggaggagag gacctgacat ctgtaggtgg
     2761 cccctgatgc cccatctaca gcaggaggtc aggaccacgc ccctggcctc tccccactcc
     2821 cccatcctcc tccctgggtg gctgcctgat tatccctcag gcagggcctc tcagtccttg
     2881 tgggtctgtg tcacctccat ctcagtcttg gcctggctat gaggggagga ggaatgggag
     2941 agggggctca ggggccaata aactctgcct tgagtcctcc tagcctgtgt gcaaaccacc
     3001 caagcccacc ctgaccccag aaccccacag ccccactgtg gccgcttgat cccccacgcc
     3061 aaccccctgg cccattgacc cgcctcatct gttcattcac ttatctaagc tgagggtgta
     3121 gcaggtaaga tgccgcagcc cctgcctcca atgtgctggt tcagccgggg gcagtgccca
     3181 tgtgaatctg gcaaggtgtt taacagtgtg ggcttgaaag tccaaacca
//
