LOCUS       NM_024330               2298 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens solute carrier family 27 member 3 (SLC27A3),
            transcript variant 1, mRNA.
ACCESSION   NM_024330
VERSION     NM_024330.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2298)
  AUTHORS   Ibrahim,A., Yucel,N., Kim,B. and Arany,Z.
  TITLE     Local Mitochondrial ATP Production Regulates Endothelial Fatty Acid
            Uptake and Transport
  JOURNAL   Cell Metab 32 (2), 309-319 (2020)
   PUBMED   32521232
REFERENCE   2  (bases 1 to 2298)
  AUTHORS   Hirschmugl,B., Desoye,G., Catalano,P., Klymiuk,I., Scharnagl,H.,
            Payr,S., Kitzinger,E., Schliefsteiner,C., Lang,U., Wadsack,C. and
            Hauguel-de Mouzon,S.
  TITLE     Maternal obesity modulates intracellular lipid turnover in the
            human term placenta
  JOURNAL   Int J Obes (Lond) 41 (2), 317-323 (2017)
   PUBMED   27780978
REFERENCE   3  (bases 1 to 2298)
  AUTHORS   Maekawa,M., Iwayama,Y., Ohnishi,T., Toyoshima,M., Shimamoto,C.,
            Hisano,Y., Toyota,T., Balan,S., Matsuzaki,H., Iwata,Y., Takagai,S.,
            Yamada,K., Ota,M., Fukuchi,S., Okada,Y., Akamatsu,W., Tsujii,M.,
            Kojima,N., Owada,Y., Okano,H., Mori,N. and Yoshikawa,T.
  TITLE     Investigation of the fatty acid transporter-encoding genes SLC27A3
            and SLC27A4 in autism
  JOURNAL   Sci Rep 5, 16239 (2015)
   PUBMED   26548558
  REMARK    GeneRIF: we resequenced the SLC27A3 and SLC27A4 genes using 267
            autism spectrum disorders(ASD) patient and 1140 control samples and
            detected 47 and 30 variants for the SLC27A3 and SLC27A4, revealing
            that they are highly polymorphic with multiple rare variants.
            Erratum:[Sci Rep. 2016 Jan 29;6:20268. doi: 10.1038/srep20268..
            PMID: 26822806]
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2298)
  AUTHORS   Sun,P., Xia,S., Lal,B., Shi,X., Yang,K.S., Watkins,P.A. and
            Laterra,J.
  TITLE     Lipid metabolism enzyme ACSVL3 supports glioblastoma stem cell
            maintenance and tumorigenicity
  JOURNAL   BMC Cancer 14, 401 (2014)
   PUBMED   24893952
  REMARK    GeneRIF: Our findings indicate that the lipid metabolism enzyme
            ACSVL3 is involved in GBM stem cell maintenance and the
            tumor-initiating capacity of GBM stem cell enriched-neurospheres in
            animals
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2298)
  AUTHORS   Anderson,C.M. and Stahl,A.
  TITLE     SLC27 fatty acid transport proteins
  JOURNAL   Mol Aspects Med 34 (2-3), 516-528 (2013)
   PUBMED   23506886
  REMARK    Review article
REFERENCE   6  (bases 1 to 2298)
  AUTHORS   Pei,Z., Sun,P., Huang,P., Lal,B., Laterra,J. and Watkins,P.A.
  TITLE     Acyl-CoA synthetase VL3 knockdown inhibits human glioma cell
            proliferation and tumorigenicity
  JOURNAL   Cancer Res 69 (24), 9175-9182 (2009)
   PUBMED   19920185
  REMARK    GeneRIF: ACSVL3 maintains oncogenic properties of malignant glioma
            cells via a mechanism that involves, in part, the regulation of Akt
            function.
REFERENCE   7  (bases 1 to 2298)
  AUTHORS   Watkins,P.A., Maiguel,D., Jia,Z. and Pevsner,J.
  TITLE     Evidence for 26 distinct acyl-coenzyme A synthetase genes in the
            human genome
  JOURNAL   J Lipid Res 48 (12), 2736-2750 (2007)
   PUBMED   17762044
REFERENCE   8  (bases 1 to 2298)
  AUTHORS   Pei,Z., Fraisl,P., Berger,J., Jia,Z., Forss-Petter,S. and
            Watkins,P.A.
  TITLE     Mouse very long-chain Acyl-CoA synthetase 3/fatty acid transport
            protein 3 catalyzes fatty acid activation but not fatty acid
            transport in MA-10 cells
  JOURNAL   J Biol Chem 279 (52), 54454-54462 (2004)
   PUBMED   15469937
REFERENCE   9  (bases 1 to 2298)
  AUTHORS   Stahl,A.
  TITLE     A current review of fatty acid transport proteins (SLC27)
  JOURNAL   Pflugers Arch 447 (5), 722-727 (2004)
   PUBMED   12856180
  REMARK    Review article
REFERENCE   10 (bases 1 to 2298)
  AUTHORS   Hirsch,D., Stahl,A. and Lodish,H.F.
  TITLE     A family of fatty acid transporters conserved from mycobacterium to
            man
  JOURNAL   Proc Natl Acad Sci U S A 95 (15), 8625-8629 (1998)
   PUBMED   9671728
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC003041.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_024330.3.
            
            Summary: This gene belongs to a family of integral membrane
            proteins and encodes a protein that is involved in lipid
            metabolism. The increased expression of this gene in human neural
            stem cells derived from induced pluripotent stem cells suggests
            that it plays an important role in early brain development.
            Naturally occurring mutations in this gene are associated with
            autism spectrum disorders. Alternative splicing results in multiple
            transcript variants. [provided by RefSeq, Feb 2017].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC009916.2, AK075377.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            MANE Ensembl match               :: ENST00000624995.4/
                                                ENSP00000485061.2
            RefSeq Select criteria           :: based on manual assertion,
                                                conservation, expression,
                                                longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2298              BC003041.1         116-2413
FEATURES             Location/Qualifiers
     source          1..2298
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q21.3"
     gene            1..2298
                     /gene="SLC27A3"
                     /gene_synonym="ACSVL3; FATP3; VLCS-3"
                     /note="solute carrier family 27 member 3"
                     /db_xref="GeneID:11000"
                     /db_xref="HGNC:HGNC:10997"
                     /db_xref="MIM:604193"
     exon            1..758
                     /gene="SLC27A3"
                     /gene_synonym="ACSVL3; FATP3; VLCS-3"
                     /inference="alignment:Splign:2.1.0"
     CDS             92..2143
                     /gene="SLC27A3"
                     /gene_synonym="ACSVL3; FATP3; VLCS-3"
                     /EC_number="6.2.1.3"
                     /EC_number="6.2.1.15"
                     /note="isoform 1 is encoded by transcript variant 1;
                     long-chain fatty acid transport protein 3; very long-chain
                     acyl-CoA synthetase homolog 3; solute carrier family 27
                     (fatty acid transporter), member 3; arachidonate--CoA
                     ligase; long-chain-fatty-acid--CoA ligase"
                     /codon_start=1
                     /product="long-chain fatty acid transport protein 3
                     isoform 1"
                     /protein_id="NP_077306.3"
                     /db_xref="CCDS:CCDS1053.3"
                     /db_xref="GeneID:11000"
                     /db_xref="HGNC:HGNC:10997"
                     /db_xref="MIM:604193"
                     /translation="MAALLLLPLLLLLPLLLLKLHLWPQLRWLPADLAFAVRALCCKR
                     ALRARALAAAAADPEGPEGGCSLAWRLAELAQQRAAHTFLIHGSRRFSYSEAERESNR
                     AARAFLRALGWDWGPDGGDSGEGSAGEGERAAPGAGDAAAGSGAEFAGGDGAARGGGA
                     AAPLSPGATVALLLPAGPEFLWLWFGLAKAGLRTAFVPTALRRGPLLHCLRSCGARAL
                     VLAPEFLESLEPDLPALRAMGLHLWAAGPGTHPAGISDLLAEVSAEVDGPVPGYLSSP
                     QSITDTCLYIFTSGTTGLPKAARISHLKILQCQGFYQLCGVHQEDVIYLALPLYHMSG
                     SLLGIVGCMGIGATVVLKSKFSAGQFWEDCQQHRVTVFQYIGELCRYLVNQPPSKAER
                     GHKVRLAVGSGLRPDTWERFVRRFGPLQVLETYGLTEGNVATINYTGQRGAVGRASWL
                     YKHIFPFSLIRYDVTTGEPIRDPQGHCMATSPGEPGLLVAPVSQQSPFLGYAGGPELA
                     QGKLLKDVFRPGDVFFNTGDLLVCDDQGFLRFHDRTGDTFRWKGENVATTEVAEVFEA
                     LDFLQEVNVYGVTVPGHEGRAGMAALVLRPPHALDLMQLYTHVSENLPPYARPRFLRL
                     QESLATTETFKQQKVRMANEGFDPSTLSDPLYVLDQAVGAYLPLTTARYSALLAGNLR
                     I"
     exon            759..968
                     /gene="SLC27A3"
                     /gene_synonym="ACSVL3; FATP3; VLCS-3"
                     /inference="alignment:Splign:2.1.0"
     exon            969..1127
                     /gene="SLC27A3"
                     /gene_synonym="ACSVL3; FATP3; VLCS-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1128..1252
                     /gene="SLC27A3"
                     /gene_synonym="ACSVL3; FATP3; VLCS-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1253..1447
                     /gene="SLC27A3"
                     /gene_synonym="ACSVL3; FATP3; VLCS-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1448..1538
                     /gene="SLC27A3"
                     /gene_synonym="ACSVL3; FATP3; VLCS-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1539..1737
                     /gene="SLC27A3"
                     /gene_synonym="ACSVL3; FATP3; VLCS-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1738..1835
                     /gene="SLC27A3"
                     /gene_synonym="ACSVL3; FATP3; VLCS-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1836..1966
                     /gene="SLC27A3"
                     /gene_synonym="ACSVL3; FATP3; VLCS-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1967..2298
                     /gene="SLC27A3"
                     /gene_synonym="ACSVL3; FATP3; VLCS-3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2257..2262
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC27A3"
                     /gene_synonym="ACSVL3; FATP3; VLCS-3"
                     /note="hexamer: AATAAA"
     polyA_site      2298
                     /gene="SLC27A3"
                     /gene_synonym="ACSVL3; FATP3; VLCS-3"
                     /note="major polyA site"
ORIGIN      
        1 agaacgagcg gccctaggtt ttcggaaggg aggatcaggg atgtttgcga gcggctggaa
       61 ccagacggtg ccgatagagg aagcgggctc catggctgcc ctcctgctgc tgcccctgct
      121 gctgttgcta ccgctgctgc tgctgaagct acacctctgg ccgcagttgc gctggcttcc
      181 ggcggacttg gcctttgcgg tgcgagctct gtgctgcaaa agggctcttc gagctcgcgc
      241 cctggccgcg gctgccgccg acccggaagg tcccgagggg ggctgcagcc tggcctggcg
      301 cctcgcggaa ctggcccagc agcgcgccgc gcacaccttt ctcattcacg gctcgcggcg
      361 ctttagctac tcagaggcgg agcgcgagag taacagggct gcacgcgcct tcctacgtgc
      421 gctaggctgg gactggggac ccgacggcgg cgacagcggc gaggggagcg ctggagaagg
      481 cgagcgggca gcgccgggag ccggagatgc agcggccgga agcggcgcgg agtttgccgg
      541 aggggacggt gccgccagag gtggaggagc cgccgcccct ctgtcacctg gagcaactgt
      601 ggcgctgctc ctccccgctg gcccagagtt tctgtggctc tggttcgggc tggccaaggc
      661 cggcctgcgc actgcctttg tgcccaccgc cctgcgccgg ggccccctgc tgcactgcct
      721 ccgcagctgc ggcgcgcgcg cgctggtgct ggcgccagag tttctggagt ccctggagcc
      781 ggacctgccc gccctgagag ccatggggct ccacctgtgg gctgcaggcc caggaaccca
      841 ccctgctgga attagcgatt tgctggctga agtgtccgct gaagtggatg ggccagtgcc
      901 aggatacctc tcttcccccc agagcataac agacacgtgc ctgtacatct tcacctctgg
      961 caccacgggc ctccccaagg ctgctcggat cagtcatctg aagatcctgc aatgccaggg
     1021 cttctatcag ctgtgtggtg tccaccagga agatgtgatc tacctcgccc tcccactcta
     1081 ccacatgtcc ggttccctgc tgggcatcgt gggctgcatg ggcattgggg ccacagtggt
     1141 gctgaaatcc aagttctcgg ctggtcagtt ctgggaagat tgccagcagc acagggtgac
     1201 ggtgttccag tacattgggg agctgtgccg ataccttgtc aaccagcccc cgagcaaggc
     1261 agaacgtggc cataaggtcc ggctggcagt gggcagcggg ctgcgcccag atacctggga
     1321 gcgttttgtg cggcgcttcg ggcccctgca ggtgctggag acatatggac tgacagaggg
     1381 caacgtggcc accatcaact acacaggaca gcggggcgct gtggggcgtg cttcctggct
     1441 ttacaagcat atcttcccct tctccttgat tcgctatgat gtcaccacag gagagccaat
     1501 tcgggacccc caggggcact gtatggccac atctccaggt gagccagggc tgctggtggc
     1561 cccggtaagc cagcagtccc cattcctggg ctatgctggc gggccagagc tggcccaggg
     1621 gaagttgcta aaggatgtct tccggcctgg ggatgttttc ttcaacactg gggacctgct
     1681 ggtctgcgat gaccaaggtt ttctccgctt ccatgatcgt actggagaca ccttcaggtg
     1741 gaagggggag aatgtggcca caaccgaggt ggcagaggtc ttcgaggccc tagattttct
     1801 tcaggaggtg aacgtctatg gagtcactgt gccagggcat gaaggcaggg ctggaatggc
     1861 agccctagtt ctgcgtcccc cccacgcttt ggaccttatg cagctctaca cccacgtgtc
     1921 tgagaacttg ccaccttatg cccggccccg attcctcagg ctccaggagt ctttggccac
     1981 cacagagacc ttcaaacagc agaaagttcg gatggcaaat gagggcttcg accccagcac
     2041 cctgtctgac ccactgtacg ttctggacca ggctgtaggt gcctacctgc ccctcacaac
     2101 tgcccggtac agcgccctcc tggcaggaaa ccttcgaatc tgagaacttc cacacctgag
     2161 gcacctgaga gaggaactct gtggggtggg ggccgttgca ggtgtactgg gctgtcaggg
     2221 atcttttcta taccagaact gcggtcacta ttttgtaata aatgtggctg gagctgatcc
     2281 agctgtctct gacctaca
//
