LOCUS       NM_003645               2384 bp    mRNA    linear   PRI 20-FEB-2025
DEFINITION  Homo sapiens solute carrier family 27 member 2 (SLC27A2),
            transcript variant 1, mRNA.
ACCESSION   NM_003645
VERSION     NM_003645.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2384)
  AUTHORS   Chen,Y., Zhao,Y., Deng,Y., Yang,Y., Xu,L. and Fu,J.
  TITLE     FATP2 regulates non-small cell lung cancer by mediating lipid
            metabolism through ACSL1
  JOURNAL   Tissue Cell 82, 102105 (2023)
   PUBMED   37172427
  REMARK    GeneRIF: FATP2 regulates non-small cell lung cancer by mediating
            lipid metabolism through ACSL1.
REFERENCE   2  (bases 1 to 2384)
  AUTHORS   Shi,X., Pang,S., Zhou,J., Yan,G., Sun,J. and Tan,W.
  TITLE     Feedback loop between fatty acid transport protein 2 and receptor
            interacting protein 3 pathways promotes polymorphonuclear
            neutrophil myeloid-derived suppressor cells-potentiated suppressive
            immunity in bladder cancer
  JOURNAL   Mol Biol Rep 49 (12), 11643-11652 (2022)
   PUBMED   36169895
  REMARK    GeneRIF: Feedback loop between fatty acid transport protein 2 and
            receptor interacting protein 3 pathways promotes polymorphonuclear
            neutrophil myeloid-derived suppressor cells-potentiated suppressive
            immunity in bladder cancer.
REFERENCE   3  (bases 1 to 2384)
  AUTHORS   Feng,K., Ma,R., Li,H., Yin,K., Du,G., Chen,X., Liu,Z. and Yin,D.
  TITLE     Upregulated SLC27A2/FATP2 in differentiated thyroid carcinoma
            promotes tumor proliferation and migration
  JOURNAL   J Clin Lab Anal 36 (1), e24148 (2022)
   PUBMED   34854499
  REMARK    GeneRIF: Upregulated SLC27A2/FATP2 in differentiated thyroid
            carcinoma promotes tumor proliferation and migration.
REFERENCE   4  (bases 1 to 2384)
  AUTHORS   Chen,Y., Yan,Q., Lv,M., Song,K., Dai,Y., Huang,Y., Zhang,L.,
            Zhang,C. and Gao,H.
  TITLE     Involvement of FATP2-mediated tubular lipid metabolic reprogramming
            in renal fibrogenesis
  JOURNAL   Cell Death Dis 11 (11), 994 (2020)
   PUBMED   33219209
  REMARK    GeneRIF: Involvement of FATP2-mediated tubular lipid metabolic
            reprogramming in renal fibrogenesis.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2384)
  AUTHORS   Veglia,F., Tyurin,V.A., Blasi,M., De Leo,A., Kossenkov,A.V.,
            Donthireddy,L., To,T.K.J., Schug,Z., Basu,S., Wang,F.,
            Ricciotti,E., DiRusso,C., Murphy,M.E., Vonderheide,R.H.,
            Lieberman,P.M., Mulligan,C., Nam,B., Hockstein,N., Masters,G.,
            Guarino,M., Lin,C., Nefedova,Y., Black,P., Kagan,V.E. and
            Gabrilovich,D.I.
  TITLE     Fatty acid transport protein 2 reprograms neutrophils in cancer
  JOURNAL   Nature 569 (7754), 73-78 (2019)
   PUBMED   30996346
  REMARK    GeneRIF: mouse and human polymorphonuclear myeloid-derived
            suppressor cells (PMN-MDSCs) exclusively upregulate fatty acid
            transport protein 2 (FATP2); FATP2 mediates the acquisition of
            immunosuppressive activity by PMN-MDSCs and represents a target to
            inhibit the functions of PMN-MDSCs selectively and to improve the
            efficiency of cancer therapy
REFERENCE   6  (bases 1 to 2384)
  AUTHORS   Steinberg,S.J., Wang,S.J., Kim,D.G., Mihalik,S.J. and Watkins,P.A.
  TITLE     Human very-long-chain acyl-CoA synthetase: cloning, topography, and
            relevance to branched-chain fatty acid metabolism
  JOURNAL   Biochem Biophys Res Commun 257 (2), 615-621 (1999)
   PUBMED   10198260
REFERENCE   7  (bases 1 to 2384)
  AUTHORS   Hirsch,D., Stahl,A. and Lodish,H.F.
  TITLE     A family of fatty acid transporters conserved from mycobacterium to
            man
  JOURNAL   Proc Natl Acad Sci U S A 95 (15), 8625-8629 (1998)
   PUBMED   9671728
REFERENCE   8  (bases 1 to 2384)
  AUTHORS   Verhoeven,N.M., Jakobs,C., Carney,G., Somers,M.P., Wanders,R.J. and
            Rizzo,W.B.
  TITLE     Involvement of microsomal fatty aldehyde dehydrogenase in the
            alpha-oxidation of phytanic acid
  JOURNAL   FEBS Lett 429 (3), 225-228 (1998)
   PUBMED   9662422
REFERENCE   9  (bases 1 to 2384)
  AUTHORS   Wakui,K., Aoyama,T., Uchiyama,A., Hashimoto,T. and Fukushima,Y.
  TITLE     Assignment of human fatty-acid-coenzyme A ligase, very long-chain 1
            gene (FACVL1) to human chromosome band 15q21.2 by fluorescence in
            situ hybridization
  JOURNAL   Cytogenet Cell Genet 81 (3-4), 292-293 (1998)
   PUBMED   9730624
REFERENCE   10 (bases 1 to 2384)
  AUTHORS   Uchiyama,A., Aoyama,T., Kamijo,K., Uchida,Y., Kondo,N., Orii,T. and
            Hashimoto,T.
  TITLE     Molecular cloning of cDNA encoding rat very long-chain acyl-CoA
            synthetase
  JOURNAL   J Biol Chem 271 (48), 30360-30365 (1996)
   PUBMED   8939997
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK290262.1 and AK223145.1.
            
            On Nov 22, 2018 this sequence version replaced NM_003645.3.
            
            Summary: The protein encoded by this gene is an isozyme of
            long-chain fatty-acid-coenzyme A ligase family. Although differing
            in substrate specificity, subcellular localization, and tissue
            distribution, all isozymes of this family convert free long-chain
            fatty acids into fatty acyl-CoA esters, and thereby play a key role
            in lipid biosynthesis and fatty acid degradation. This isozyme
            activates long-chain, branched-chain and very-long-chain fatty
            acids containing 22 or more carbons to their CoA derivatives. It is
            expressed primarily in liver and kidney, and is present in both
            endoplasmic reticulum and peroxisomes, but not in mitochondria. Its
            decreased peroxisomal enzyme activity is in part responsible for
            the biochemical pathology in X-linked adrenoleukodystrophy.
            Alternatively spliced transcript variants encoding different
            isoforms have been found for this gene. [provided by RefSeq, Apr
            2009].
            
            Transcript Variant: This variant (1) represents the predominant
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK290262.1, SRR1660807.53854.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000267842.10/ ENSP00000267842.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-373               AK290262.1         1-373
            374-2384            AK223145.1         343-2353
FEATURES             Location/Qualifiers
     source          1..2384
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q21.2"
     gene            1..2384
                     /gene="SLC27A2"
                     /gene_synonym="ACSVL1; FACVL1; FATP2; hFACVL1; HsT17226;
                     VLACS; VLCS"
                     /note="solute carrier family 27 member 2"
                     /db_xref="GeneID:11001"
                     /db_xref="HGNC:HGNC:10996"
                     /db_xref="MIM:603247"
     exon            1..710
                     /gene="SLC27A2"
                     /gene_synonym="ACSVL1; FACVL1; FATP2; hFACVL1; HsT17226;
                     VLACS; VLCS"
                     /inference="alignment:Splign:2.1.0"
     CDS             233..2095
                     /gene="SLC27A2"
                     /gene_synonym="ACSVL1; FACVL1; FATP2; hFACVL1; HsT17226;
                     VLACS; VLCS"
                     /EC_number="6.2.1.3"
                     /EC_number="6.2.1.7"
                     /EC_number="6.2.1.15"
                     /EC_number="6.2.1.24"
                     /note="isoform 1 is encoded by transcript variant 1; very
                     long-chain fatty-acid-coenzyme A ligase 1; solute carrier
                     family 27 (fatty acid transporter), member 2; very
                     long-chain acyl-CoA synthetase; fatty acid transport
                     protein 2; FATP-2; THCA-CoA ligase;
                     long-chain-fatty-acid--CoA ligase; very
                     long-chain-fatty-acid-CoA ligase; fatty-acid-coenzyme A
                     ligase, very long-chain 1; phytanate--CoA ligase;
                     arachidonate--CoA ligase; long-chain fatty acid transport
                     protein 2"
                     /codon_start=1
                     /product="long-chain fatty acid transport protein 2
                     isoform 1"
                     /protein_id="NP_003636.2"
                     /db_xref="CCDS:CCDS10133.1"
                     /db_xref="GeneID:11001"
                     /db_xref="HGNC:HGNC:10996"
                     /db_xref="MIM:603247"
                     /translation="MLSAIYTVLAGLLFLPLLVNLCCPYFFQDIGYFLKVAAVGRRVR
                     SYGKRRPARTILRAFLEKARQTPHKPFLLFRDETLTYAQVDRRSNQVARALHDHLGLR
                     QGDCVALLMGNEPAYVWLWLGLVKLGCAMACLNYNIRAKSLLHCFQCCGAKVLLVSPE
                     LQAAVEEILPSLKKDDVSIYYVSRTSNTDGIDSFLDKVDEVSTEPIPESWRSEVTFST
                     PALYIYTSGTTGLPKAAMITHQRIWYGTGLTFVSGLKADDVIYITLPFYHSAALLIGI
                     HGCIVAGATLALRTKFSASQFWDDCRKYNVTVIQYIGELLRYLCNSPQKPNDRDHKVR
                     LALGNGLRGDVWRQFVKRFGDICIYEFYAATEGNIGFMNYARKVGAVGRVNYLQKKII
                     TYDLIKYDVEKDEPVRDENGYCVRVPKGEVGLLVCKITQLTPFNGYAGAKAQTEKKKL
                     RDVFKKGDLYFNSGDLLMVDHENFIYFHDRVGDTFRWKGENVATTEVADTVGLVDFVQ
                     EVNVYGVHVPDHEGRIGMASIKMKENHEFDGKKLFQHIADYLPSYARPRFLRIQDTIE
                     ITGTFKHRKMTLVEEGFNPAVIKDALYFLDDTAKMYVPMTEDIYNAISAKTLKL"
     exon            711..920
                     /gene="SLC27A2"
                     /gene_synonym="ACSVL1; FACVL1; FATP2; hFACVL1; HsT17226;
                     VLACS; VLCS"
                     /inference="alignment:Splign:2.1.0"
     exon            921..1079
                     /gene="SLC27A2"
                     /gene_synonym="ACSVL1; FACVL1; FATP2; hFACVL1; HsT17226;
                     VLACS; VLCS"
                     /inference="alignment:Splign:2.1.0"
     exon            1080..1204
                     /gene="SLC27A2"
                     /gene_synonym="ACSVL1; FACVL1; FATP2; hFACVL1; HsT17226;
                     VLACS; VLCS"
                     /inference="alignment:Splign:2.1.0"
     exon            1205..1399
                     /gene="SLC27A2"
                     /gene_synonym="ACSVL1; FACVL1; FATP2; hFACVL1; HsT17226;
                     VLACS; VLCS"
                     /inference="alignment:Splign:2.1.0"
     exon            1400..1490
                     /gene="SLC27A2"
                     /gene_synonym="ACSVL1; FACVL1; FATP2; hFACVL1; HsT17226;
                     VLACS; VLCS"
                     /inference="alignment:Splign:2.1.0"
     exon            1491..1689
                     /gene="SLC27A2"
                     /gene_synonym="ACSVL1; FACVL1; FATP2; hFACVL1; HsT17226;
                     VLACS; VLCS"
                     /inference="alignment:Splign:2.1.0"
     exon            1690..1787
                     /gene="SLC27A2"
                     /gene_synonym="ACSVL1; FACVL1; FATP2; hFACVL1; HsT17226;
                     VLACS; VLCS"
                     /inference="alignment:Splign:2.1.0"
     exon            1788..1918
                     /gene="SLC27A2"
                     /gene_synonym="ACSVL1; FACVL1; FATP2; hFACVL1; HsT17226;
                     VLACS; VLCS"
                     /inference="alignment:Splign:2.1.0"
     exon            1919..2384
                     /gene="SLC27A2"
                     /gene_synonym="ACSVL1; FACVL1; FATP2; hFACVL1; HsT17226;
                     VLACS; VLCS"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2362..2367
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC27A2"
                     /gene_synonym="ACSVL1; FACVL1; FATP2; hFACVL1; HsT17226;
                     VLACS; VLCS"
                     /note="hexamer: ATTAAA"
     polyA_site      2384
                     /gene="SLC27A2"
                     /gene_synonym="ACSVL1; FACVL1; FATP2; hFACVL1; HsT17226;
                     VLACS; VLCS"
                     /note="major polyA site"
ORIGIN      
        1 agtcctgccc ggaacccccg gcaacgcgca tacgactaca cctgctccgg agcccgcggc
       61 ggtacctgca gcggaggagc tctgtcttcc ccttcatctc acgcgagccc ggcgtcccgc
      121 cgcgtgcgcc ccggcgcagc ccgccagtcc gcccggagcc cgcccagtcg ccgcgctgca
      181 cgcccggggt gaaccctctg ccctcgctgg gacagagggc cccgcagccg tcatgctttc
      241 cgccatctac acagtcctgg cgggactgct gttcctgccg ctcctggtga acctctgctg
      301 cccatacttc ttccaggaca taggctactt cttgaaggtg gccgccgtgg gccggagggt
      361 gcgcagctac gggaagcggc ggccggcgcg caccatcctg cgggcgttcc tggagaaagc
      421 gcgccagacg ccacacaagc cttttctgct cttccgcgac gagactctca cctacgcgca
      481 ggtggaccgg cgcagcaatc aagtggcccg ggcgctgcac gaccacctcg gcctgcgcca
      541 gggagactgc gtggcgctcc ttatgggtaa cgagccggcc tacgtgtggc tgtggctggg
      601 gctggtgaag ctgggctgtg ccatggcgtg cctcaattac aacatccgcg cgaagtccct
      661 gctgcactgc ttccagtgct gcggggcgaa ggtgctgctg gtgtcgccag aactacaagc
      721 agctgtcgaa gagatactgc caagccttaa aaaagatgat gtgtccatct attatgtgag
      781 cagaacttct aacacagatg ggattgactc tttcctggac aaagtggatg aagtatcaac
      841 tgaacctatc ccagagtcat ggaggtctga agtcactttt tccactcctg ccttatacat
      901 ttatacttct ggaaccacag gtcttccaaa agcagccatg atcactcatc agcgcatatg
      961 gtatggaact ggcctcactt ttgtaagcgg attgaaggca gatgatgtca tctatatcac
     1021 tctgcccttt taccacagtg ctgcactact gattggcatt cacggatgta ttgtggctgg
     1081 tgctactctt gccttgcgga ctaaattttc agccagccag ttttgggatg actgcagaaa
     1141 atacaacgtc actgtcattc agtatatcgg tgaactgctt cggtatttat gcaactcacc
     1201 acagaaacca aatgaccgtg atcataaagt gagactggca ctgggaaatg gcttacgagg
     1261 agatgtgtgg agacaatttg tcaagagatt tggggacata tgcatctatg agttctatgc
     1321 tgccactgaa ggcaatattg gatttatgaa ttatgcgaga aaagttggtg ctgttggaag
     1381 agtaaactac ctacagaaaa aaatcataac ttatgacctg attaaatatg atgtggagaa
     1441 agatgaacct gtccgtgatg aaaatggata ttgcgtcaga gttcccaaag gtgaagttgg
     1501 acttctggtt tgcaaaatca cacaacttac accatttaat ggctatgctg gagcaaaggc
     1561 tcagacagag aagaaaaaac tgagagatgt ctttaagaaa ggagacctct atttcaacag
     1621 tggagatctc ttaatggttg accatgaaaa tttcatctat ttccacgaca gagttggaga
     1681 tacattccgg tggaaagggg aaaatgtggc caccactgaa gttgctgata cagttggact
     1741 ggttgatttt gtccaagaag taaatgttta tggagtgcat gtgccagatc atgagggtcg
     1801 cattggcatg gcctccatca aaatgaaaga aaaccatgaa tttgatggaa agaaactctt
     1861 tcagcacatt gctgattacc tacctagtta tgcaaggccc cggtttctaa gaatacagga
     1921 caccattgag atcactggaa cttttaaaca ccgcaaaatg accctggtgg aggagggctt
     1981 taaccctgct gtcatcaaag atgccttgta tttcttggat gacacagcaa aaatgtatgt
     2041 gcctatgact gaggacatct ataatgccat aagtgctaaa accctgaaac tctgaatatt
     2101 cccaggagga taactcaaca tttccagaaa gaaactgaat ggacagccac ttgatataat
     2161 ccaactttaa tttgattgaa gattgtgagg aaattttgta ggaaatttgc atacccgtaa
     2221 agggagactt ttttaaataa cagttgagtc tttgcaagta aaaagattta gagattatta
     2281 tttttcagtg tgcacctact gtttgtattt gcaaactgag cttgttggag ggaaggcatt
     2341 attttttaaa atacttagta aattaaatga acaccaacat gtga
//
