LOCUS       NM_198580               3514 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens solute carrier family 27 member 1 (SLC27A1), mRNA.
ACCESSION   NM_198580 XM_352251
VERSION     NM_198580.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3514)
  AUTHORS   Huang,J., Zhu,R. and Shi,D.
  TITLE     The role of FATP1 in lipid accumulation: a review
  JOURNAL   Mol Cell Biochem 476 (4), 1897-1903 (2021)
   PUBMED   33486652
  REMARK    GeneRIF: The role of FATP1 in lipid accumulation: a review.
            Review article
REFERENCE   2  (bases 1 to 3514)
  AUTHORS   Mendes,C., Lopes-Coelho,F., Ramos,C., Martins,F., Santos,I.,
            Rodrigues,A., Silva,F., Andre,S. and Serpa,J.
  TITLE     Unraveling FATP1, regulated by ER-beta, as a targeted breast cancer
            innovative therapy
  JOURNAL   Sci Rep 9 (1), 14107 (2019)
   PUBMED   31575907
  REMARK    GeneRIF: Unraveling FATP1, regulated by ER-beta, as a targeted
            breast cancer innovative therapy.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3514)
  AUTHORS   Ochiai,Y., Uchida,Y., Tachikawa,M., Couraud,P.O. and Terasaki,T.
  TITLE     Amyloid beta25-35 impairs docosahexaenoic acid efflux by
            down-regulating fatty acid transport protein 1 (FATP1/SLC27A1)
            protein expression in human brain capillary endothelial cells
  JOURNAL   J Neurochem 150 (4), 385-401 (2019)
   PUBMED   31091338
  REMARK    GeneRIF: we have established for the first time that FATP1 is a
            major contributor to docosahexaenoic acid efflux from human brain
            capillary endothelial cells
REFERENCE   4  (bases 1 to 3514)
  AUTHORS   Li,D., Zhao,Y.G., Li,D., Zhao,H., Huang,J., Miao,G., Feng,D.,
            Liu,P., Li,D. and Zhang,H.
  TITLE     The ER-Localized Protein DFCP1 Modulates ER-Lipid Droplet Contact
            Formation
  JOURNAL   Cell Rep 27 (2), 343-358 (2019)
   PUBMED   30970241
REFERENCE   5  (bases 1 to 3514)
  AUTHORS   Ye,G., Gao,H., Wang,Z., Lin,Y., Liao,X., Zhang,H., Chi,Y., Zhu,H.
            and Dong,S.
  TITLE     PPARalpha and PPARgamma activation attenuates total free fatty acid
            and triglyceride accumulation in macrophages via the inhibition of
            Fatp1 expression
  JOURNAL   Cell Death Dis 10 (2), 39 (2019)
   PUBMED   30674874
  REMARK    GeneRIF: The inhibition of Fatp1 by tumor necrosis factor alpha
            alleviated oleate-induced total FFA and TG accumulation in
            macrophages.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3514)
  AUTHORS   Gertow,K., Skoglund-Andersson,C., Eriksson,P., Boquist,S.,
            Orth-Gomer,K., Schenck-Gustafsson,K., Hamsten,A. and Fisher,R.M.
  TITLE     A common polymorphism in the fatty acid transport protein-1 gene
            associated with elevated post-prandial lipaemia and alterations in
            LDL particle size distribution
  JOURNAL   Atherosclerosis 167 (2), 265-273 (2003)
   PUBMED   12818409
  REMARK    GeneRIF: FATP1 might play a role in post-prandial lipid metabolism
            and development of cardiovascular disease.
            GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 3514)
  AUTHORS   Hatch,G.M., Smith,A.J., Xu,F.Y., Hall,A.M. and Bernlohr,D.A.
  TITLE     FATP1 channels exogenous FA into 1,2,3-triacyl-sn-glycerol and
            down-regulates sphingomyelin and cholesterol metabolism in growing
            293 cells
  JOURNAL   J Lipid Res 43 (9), 1380-1389 (2002)
   PUBMED   12235169
  REMARK    GeneRIF: exogenously supplied fatty acids are preferentially
            channeled by an FATP1-linked mechanism into the TG biosynthetic
            pathway; such internalized lipids downregulate de novo
            sphingomyelin and cholesterol metabolism in growing 293 cells
REFERENCE   8  (bases 1 to 3514)
  AUTHORS   Martin,G., Nemoto,M., Gelman,L., Geffroy,S., Najib,J.,
            Fruchart,J.C., Roevens,P., de Martinville,B., Deeb,S. and Auwerx,J.
  TITLE     The human fatty acid transport protein-1 (SLC27A1; FATP-1) cDNA and
            gene: organization, chromosomal localization, and expression
  JOURNAL   Genomics 66 (3), 296-304 (2000)
   PUBMED   10873384
REFERENCE   9  (bases 1 to 3514)
  AUTHORS   Hirsch,D., Stahl,A. and Lodish,H.F.
  TITLE     A family of fatty acid transporters conserved from mycobacterium to
            man
  JOURNAL   Proc Natl Acad Sci U S A 95 (15), 8625-8629 (1998)
   PUBMED   9671728
REFERENCE   10 (bases 1 to 3514)
  AUTHORS   Schaffer,J.E. and Lodish,H.F.
  TITLE     Expression cloning and characterization of a novel adipocyte long
            chain fatty acid transport protein
  JOURNAL   Cell 79 (3), 427-436 (1994)
   PUBMED   7954810
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC059399.1 and AC010618.9.
            
            On Nov 23, 2018 this sequence version replaced NM_198580.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC059399.1, SRR1660807.12379.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000252595.12/ ENSP00000252595.6
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2451              BC059399.1         34-2484
            2452-2708           AC010618.9         15346-15602
            2709-3514           BC059399.1         2742-3547
FEATURES             Location/Qualifiers
     source          1..3514
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.11"
     gene            1..3514
                     /gene="SLC27A1"
                     /gene_synonym="ACSVL5; FATP; FATP-1; FATP1"
                     /note="solute carrier family 27 member 1"
                     /db_xref="GeneID:376497"
                     /db_xref="HGNC:HGNC:10995"
                     /db_xref="MIM:600691"
     exon            1..184
                     /gene="SLC27A1"
                     /gene_synonym="ACSVL5; FATP; FATP-1; FATP1"
                     /inference="alignment:Splign:2.1.0"
     CDS             18..1958
                     /gene="SLC27A1"
                     /gene_synonym="ACSVL5; FATP; FATP-1; FATP1"
                     /EC_number="6.2.1.3"
                     /EC_number="6.2.1.15"
                     /note="fatty acid transport protein 1; solute carrier
                     family 27 (fatty acid transporter), member 1;
                     arachidonate--CoA ligase; long-chain-fatty-acid--CoA
                     ligase; very long-chain acyl-CoA synthetase"
                     /codon_start=1
                     /product="long-chain fatty acid transport protein 1"
                     /protein_id="NP_940982.1"
                     /db_xref="CCDS:CCDS32953.1"
                     /db_xref="GeneID:376497"
                     /db_xref="HGNC:HGNC:10995"
                     /db_xref="MIM:600691"
                     /translation="MRAPGAGAASVVSLALLWLLGLPWTWSAAAALGVYVGSGGWRFL
                     RIVCKTARRDLFGLSVLIRVRLELRRHQRAGHTIPRIFQAVVQRQPERLALVDAGTGE
                     CWTFAQLDAYSNAVANLFRQLGFAPGDVVAIFLEGRPEFVGLWLGLAKAGMEAALLNV
                     NLRREPLAFCLGTSGAKALIFGGEMVAAVAEVSGHLGKSLIKFCSGDLGPEGILPDTH
                     LLDPLLKEASTAPLAQIPSKGMDDRLFYIYTSGTTGLPKAAIVVHSRYYRMAAFGHHA
                     YRMQAADVLYDCLPLYHSAGNIIGVGQCLIYGLTVVLRKKFSASRFWDDCIKYNCTVV
                     QYIGEICRYLLKQPVREAERRHRVRLAVGNGLRPAIWEEFTERFGVRQIGEFYGATEC
                     NCSIANMDGKVGSCGFNSRILPHVYPIRLVKVNEDTMELLRDAQGLCIPCQAGEPGLL
                     VGQINQQDPLRRFDGYVSESATSKKIAHSVFSKGDSAYLSGDVLVMDELGYMYFRDRS
                     GDTFRWRGENVSTTEVEGVLSRLLGQTDVAVYGVAVPGVEGKAGMAAVADPHSLLDPN
                     AIYQELQKVLAPYARPIFLRLLPQVDTTGTFKIQKTRLQREGFDPRQTSDRLFFLDLK
                     QGHYLPLNEAVYTRICSGAFAL"
     exon            185..579
                     /gene="SLC27A1"
                     /gene_synonym="ACSVL5; FATP; FATP-1; FATP1"
                     /inference="alignment:Splign:2.1.0"
     exon            580..741
                     /gene="SLC27A1"
                     /gene_synonym="ACSVL5; FATP; FATP-1; FATP1"
                     /inference="alignment:Splign:2.1.0"
     exon            742..811
                     /gene="SLC27A1"
                     /gene_synonym="ACSVL5; FATP; FATP-1; FATP1"
                     /inference="alignment:Splign:2.1.0"
     exon            812..903
                     /gene="SLC27A1"
                     /gene_synonym="ACSVL5; FATP; FATP-1; FATP1"
                     /inference="alignment:Splign:2.1.0"
     exon            904..1013
                     /gene="SLC27A1"
                     /gene_synonym="ACSVL5; FATP; FATP-1; FATP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1014..1223
                     /gene="SLC27A1"
                     /gene_synonym="ACSVL5; FATP; FATP-1; FATP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1224..1350
                     /gene="SLC27A1"
                     /gene_synonym="ACSVL5; FATP; FATP-1; FATP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1351..1488
                     /gene="SLC27A1"
                     /gene_synonym="ACSVL5; FATP; FATP-1; FATP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1489..1653
                     /gene="SLC27A1"
                     /gene_synonym="ACSVL5; FATP; FATP-1; FATP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1654..1800
                     /gene="SLC27A1"
                     /gene_synonym="ACSVL5; FATP; FATP-1; FATP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1801..3514
                     /gene="SLC27A1"
                     /gene_synonym="ACSVL5; FATP; FATP-1; FATP1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3496..3501
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC27A1"
                     /gene_synonym="ACSVL5; FATP; FATP-1; FATP1"
                     /note="hexamer: AATAAA"
     polyA_site      3514
                     /gene="SLC27A1"
                     /gene_synonym="ACSVL5; FATP; FATP-1; FATP1"
                     /note="major polyA site"
ORIGIN      
        1 ctctctgctt ccccaggatg cgggctccgg gtgcgggcgc ggcctcggtg gtctcgctgg
       61 cgctgttgtg gctgctgggg ctgccgtgga cctggagcgc ggcagcggcg ctcggcgtgt
      121 acgtgggcag cggcggctgg cgcttcctgc gcatcgtctg caagaccgcg aggcgagacc
      181 tcttcggtct ctctgtgctg atccgcgtgc gcctggagct gcggcggcac cagcgtgccg
      241 gccacaccat cccgcgcatc tttcaggcgg tagtgcagcg acagcccgag cgcctggcgc
      301 tggtggatgc cgggaccggc gagtgctgga cctttgcgca gctggacgcc tactccaatg
      361 cggtagccaa cctcttccgc cagctgggct tcgcgccggg cgacgtggtg gccatcttcc
      421 tggagggccg gccggagttc gtggggctgt ggctgggcct ggccaaggcg ggcatggagg
      481 ccgcgctgct caacgtgaac ctgcggcgcg agcccctggc cttctgcctg ggcacctcgg
      541 gcgctaaggc cctgatcttt ggaggagaaa tggtggcggc ggtggccgaa gtgagcgggc
      601 atctggggaa aagtttgatc aagttctgct ctggagactt ggggcccgag ggcatcttgc
      661 cggacaccca cctcctggac ccgctgctga aggaggcctc tactgccccc ttggcacaga
      721 tccccagcaa gggcatggac gatcgtcttt tctacatcta cacgtcgggg accaccgggc
      781 tgcccaaggc tgccattgtc gtgcacagca ggtactaccg catggcagcc ttcggccacc
      841 acgcctaccg catgcaggcg gctgacgtgc tctatgactg cctgcccctg taccactcgg
      901 caggaaacat catcggcgtg gggcagtgtc tcatctatgg gctgacagtc gtcctccgca
      961 agaaattctc ggccagccgc ttctgggacg actgcatcaa gtacaactgc acggtggttc
     1021 agtacatcgg ggagatctgc cgctacctgc tgaagcagcc ggtgcgcgag gcggagaggc
     1081 gacaccgcgt gcgcctggcg gtggggaacg ggctgcgtcc tgccatctgg gaggagttca
     1141 cggagcgctt cggcgtacgc caaatcgggg agttctacgg cgccaccgag tgcaactgca
     1201 gcattgccaa catggacggc aaggtcggct cctgtggttt caacagccgc atcctgcccc
     1261 acgtgtaccc catccggctg gtgaaggtca atgaggacac aatggagctg ctgcgggatg
     1321 cccagggcct ctgcatcccc tgccaggccg gggagcctgg cctccttgtg ggtcagatca
     1381 accaacagga cccgctgcgc cgcttcgatg gctatgtcag cgagagcgcc accagcaaga
     1441 agatcgccca cagcgtcttc agcaagggcg acagcgccta cctctcaggt gacgtgctag
     1501 tgatggatga gctgggctac atgtacttcc gggaccgtag cggggacacc ttccgctggc
     1561 gaggggagaa cgtctccacc accgaggtgg agggcgtgct gagccgcctg ctgggccaga
     1621 cagacgtggc cgtctatggg gtggctgttc caggagtgga gggtaaggca gggatggcgg
     1681 ccgtcgcaga cccccacagc ctgctggacc ccaacgcgat ataccaggag ctgcagaagg
     1741 tgctggcacc ctatgcccgg cccatcttcc tgcgcctcct gccccaggtg gacaccacag
     1801 gcaccttcaa gatccagaag acgaggctgc agcgagaggg ctttgaccca cgccagacct
     1861 cagaccggct cttcttcctg gacctgaagc agggccacta cctgccctta aatgaggcag
     1921 tctacactcg catctgctcg ggcgccttcg ccctctgaag ctgttcctct actggccaca
     1981 aactctgggc ctggtgggag aggccagctt gagccagaca gcgctgccca ggggtggccg
     2041 cctagtacac acccacctgg ccgagctgta cctggcacgg cccatcctgg actgagaaac
     2101 tggaacctca gaggaacccg tgcctctctg ctgccttggt gcccctgtgt ctgcctcctc
     2161 tccctgcttt tcagcctctg tctccttcca tccctgtccc tgtctggcct taactcttcc
     2221 ctctttttct tttctttctt tctttctttt ttttttaaga tagagtctca ctctgctgcc
     2281 cgggctagag tgcagtggtg ggatctcggc tcactgcaac ctctgcctcc tggggttcaa
     2341 gtgatcctcc cacctcagcc tcctgagtag ctgggattac aggcacccgc caccacgtcc
     2401 agctaatttt tatattttta gtagagacgg ggtttcacca tgttggtcag gttggtcttg
     2461 aactcctgac ctcaggtgat ccgctggcct cggcctccca gagtgctggg attataggcg
     2521 tgagcctctg gcccggcctt tcctttttcc tctcctctcc tgccgagagt ggaacacgcg
     2581 tgtcctggga gctgcatctt gtgtagggtc cagctgcttt tggggactgc aggaatcatc
     2641 tcccctgggc cctggactcg gactggggcc tccccacctc cctctcggct gtgccttacg
     2701 gagccccgat ccaggcctcc tgtggctgtt gggttccaga tgctgcagct ccatgtgact
     2761 tccaagcagg ccctccgccc tccctgctga atggaggagc cgggggtccc ccaggccaac
     2821 tggaaaatct cccaggctag gccaattgcc ttttgcactt ccccgttcct gtcacatttc
     2881 cccagcccca ccttcccctc ctgatgccct gaaagcttcc ggaattgact gtgaccactt
     2941 ggatgtcacc actgtcagcc cctgccttga tgtccccatt tagccatctc catggagctc
     3001 ctgctggagg gccctgaacc ctgcactgcg tggctgccca gccagctgcc tcctgtcctg
     3061 ggaggaggcc tcctgggtgt cctcatctgg tgtgtctact ggagggtccc acaggagagg
     3121 cagcagaggg gtcaggggag gtctcctgcc gggggttggc ctctcaagcc tcaggggttc
     3181 tagcctgttg aatatacccc acctggtggt ggcccctccg atgtccccac tgatggctct
     3241 gacaccgtgt tggtggcgat gtcccagaca atcccaccag gacggcccag acatccctac
     3301 tggcttcgct ggtggctcat ctcgaacatc cacgccagcc tttctggggc cggccaccca
     3361 ggccgcctgt ccgtctgtcc tccctccagc agcaccccct ggcccctgga gtggtggggc
     3421 catggcaaga gacaccgtgg cgtctcatgt gaactttcct gggcactgtg gttttatttc
     3481 ctaattgatt taagaaataa acctgaagac cgtc
//
