LOCUS       NM_052934               4791 bp    mRNA    linear   PRI 06-AUG-2024
DEFINITION  Homo sapiens solute carrier family 26 member 9 (SLC26A9),
            transcript variant 1, mRNA.
ACCESSION   NM_052934
VERSION     NM_052934.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4791)
  AUTHORS   Luo,S., Rollins,S., Schmitz-Abe,K., Tam,A., Li,Q., Shi,J., Lin,J.,
            Wang,R. and Agrawal,P.B.
  TITLE     The solute carrier family 26 member 9 modifies rapidly progressing
            cystic fibrosis associated with homozygous F508del CFTR mutation
  JOURNAL   Clin Chim Acta 561, 119765 (2024)
   PUBMED   38852790
  REMARK    GeneRIF: The solute carrier family 26 member 9 modifies rapidly
            progressing cystic fibrosis associated with homozygous F508del CFTR
            mutation.
REFERENCE   2  (bases 1 to 4791)
  AUTHORS   Omori,S., Hanazono,Y., Nishi,H. and Kinoshita,K.
  TITLE     The role of the STAS domain in SLC26A9 for chloride ion transporter
            function
  JOURNAL   Biophys J 123 (12), 1751-1762 (2024)
   PUBMED   38773769
  REMARK    GeneRIF: The role of the STAS domain in SLC26A9 for chloride ion
            transporter function.
REFERENCE   3  (bases 1 to 4791)
  AUTHORS   Kunzelmann,K., Ousingsawat,J., Kraus,A., Park,J.H., Marquardt,T.,
            Schreiber,R. and Buchholz,B.
  TITLE     Pathogenic Relationships in Cystic Fibrosis and Renal Diseases:
            CFTR, SLC26A9 and Anoctamins
  JOURNAL   Int J Mol Sci 24 (17), 13278 (2023)
   PUBMED   37686084
  REMARK    GeneRIF: Pathogenic Relationships in Cystic Fibrosis and Renal
            Diseases: CFTR, SLC26A9 and Anoctamins.
            Review article
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4791)
  AUTHORS   Santos,L.G., Pereira,S.V., Kmit,A.H.P., Bonadia,L.C.,
            Bertuzzo,C.S., Ribeiro,J.D., Mazzola,T.N. and Marson,F.A.L.
  TITLE     Identification of single nucleotide variants in SLC26A9 gene in
            patients with cystic fibrosis (p.Phe508del homozygous) and its
            association to Orkambi(R) (Lumacaftor and Ivacaftor) response in
            vitro
  JOURNAL   Gene 871, 147428 (2023)
   PUBMED   37068695
  REMARK    GeneRIF: Identification of single nucleotide variants in SLC26A9
            gene in patients with cystic fibrosis (p.Phe508del homozygous) and
            its association to Orkambi(R) (Lumacaftor and Ivacaftor) response
            in vitro.
REFERENCE   5  (bases 1 to 4791)
  AUTHORS   Liu,X., Li,T., Ma,Z., Riederer,B., Yuan,D., Zhu,J., Li,Y., An,J.,
            Wen,G., Jin,H., Yang,X., Seidler,U. and Tuo,B.
  TITLE     SLC26A9 deficiency causes gastric intraepithelial neoplasia in mice
            and aggressive gastric cancer in humans
  JOURNAL   Cell Oncol (Dordr) 45 (3), 381-398 (2022)
   PUBMED   35426084
  REMARK    GeneRIF: SLC26A9 deficiency causes gastric intraepithelial
            neoplasia in mice and aggressive gastric cancer in humans.
REFERENCE   6  (bases 1 to 4791)
  AUTHORS   Dorwart,M.R., Shcheynikov,N., Wang,Y., Stippec,S. and Muallem,S.
  TITLE     SLC26A9 is a Cl(-) channel regulated by the WNK kinases
  JOURNAL   J Physiol 584 (Pt 1), 333-345 (2007)
   PUBMED   17673510
  REMARK    GeneRIF: SLC26A9 is a highly selective Cl(-) channel with minimal
            OH(-)/HCO(3)(-) permeability that is regulated by the WNK kinases.
REFERENCE   7  (bases 1 to 4791)
  AUTHORS   Romero,M.F., Chang,M.H., Plata,C., Zandi-Nejad,K., Mercado,A.,
            Broumand,V., Sussman,C.R. and Mount,D.B.
  TITLE     Physiology of electrogenic SLC26 paralogues
  JOURNAL   Novartis Found Symp 273, 126-38 (2006)
   PUBMED   17120765
  REMARK    GeneRIF: Slc26a9 functions as an electrogenic nCl-/HCO3- exchanger,
            suggesting a role in pulmonary and gastric HCO3- secretion and/or
            CO2 transport.
REFERENCE   8  (bases 1 to 4791)
  AUTHORS   Xu,J., Henriksnas,J., Barone,S., Witte,D., Shull,G.E., Forte,J.G.,
            Holm,L. and Soleimani,M.
  TITLE     SLC26A9 is expressed in gastric surface epithelial cells, mediates
            Cl-/HCO3- exchange, and is inhibited by NH4+
  JOURNAL   Am J Physiol Cell Physiol 289 (2), C493-C505 (2005)
   PUBMED   15800055
REFERENCE   9  (bases 1 to 4791)
  AUTHORS   Lohi,H., Kujala,M., Makela,S., Lehtonen,E., Kestila,M.,
            Saarialho-Kere,U., Markovich,D. and Kere,J.
  TITLE     Functional characterization of three novel tissue-specific anion
            exchangers SLC26A7, -A8, and -A9
  JOURNAL   J Biol Chem 277 (16), 14246-14254 (2002)
   PUBMED   11834742
REFERENCE   10 (bases 1 to 4791)
  AUTHORS   Markovich,D.
  TITLE     Physiological roles and regulation of mammalian sulfate
            transporters
  JOURNAL   Physiol Rev 81 (4), 1499-1533 (2001)
   PUBMED   11581495
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AF331525.1, BC037978.1 and
            AF314958.1.
            
            On Nov 23, 2018 this sequence version replaced NM_052934.3.
            
            Summary: This gene is one member of a family of sulfate/anion
            transporter genes. Family members are well conserved in their
            genomic (number and size of exons) and protein (aa length among
            species) structures yet have markedly different tissue expression
            patterns. The product of this gene is a highly selective chloride
            ion channel regulated by WNK kinases. Alternative splicing results
            in multiple transcript variants encoding differing
            isoforms.[provided by RefSeq, Dec 2008].
            
            Transcript Variant: This variant (1) is the longer transcript and
            encodes isoform a.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF331525.1, BC136538.1 [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000367135.8/ ENSP00000356103.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2696              AF331525.1         5-2700
            2697-3696           BC037978.1         340-1339
            3697-4787           AF331525.1         3701-4791
            4788-4791           AF314958.1         4503-4506
FEATURES             Location/Qualifiers
     source          1..4791
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q32.1"
     gene            1..4791
                     /gene="SLC26A9"
                     /note="solute carrier family 26 member 9"
                     /db_xref="GeneID:115019"
                     /db_xref="HGNC:HGNC:14469"
                     /db_xref="MIM:608481"
     exon            1..92
                     /gene="SLC26A9"
                     /inference="alignment:Splign:2.1.0"
     exon            93..235
                     /gene="SLC26A9"
                     /inference="alignment:Splign:2.1.0"
     CDS             111..2486
                     /gene="SLC26A9"
                     /note="isoform a is encoded by transcript variant 1; anion
                     transporter/exchanger-9; anion transporter/exchanger
                     protein 9; solute carrier family 26 (anion exchanger),
                     member 9"
                     /codon_start=1
                     /product="solute carrier family 26 member 9 isoform a"
                     /protein_id="NP_443166.1"
                     /db_xref="CCDS:CCDS30990.1"
                     /db_xref="GeneID:115019"
                     /db_xref="HGNC:HGNC:14469"
                     /db_xref="MIM:608481"
                     /translation="MSQPRPRYVVDRAAYSLTLFDDEFEKKDRTYPVGEKLRNAFRCS
                     SAKIKAVVFGLLPVLSWLPKYKIKDYIIPDLLGGLSGGSIQVPQGMAFALLANLPAVN
                     GLYSSFFPLLTYFFLGGVHQMVPGTFAVISILVGNICLQLAPESKFQVFNNATNESYV
                     DTAAMEAERLHVSATLACLTAIIQMGLGFMQFGFVAIYLSESFIRGFMTAAGLQILIS
                     VLKYIFGLTIPSYTGPGSIVFTFIDICKNLPHTNIASLIFALISGAFLVLVKELNARY
                     MHKIRFPIPTEMIVVVVATAISGGCKMPKKYHMQIVGEIQRGFPTPVSPVVSQWKDMI
                     GTAFSLAIVSYVINLAMGRTLANKHGYDVDSNQEMIALGCSNFFGSFFKIHVICCALS
                     VTLAVDGAGGKSQVASLCVSLVVMITMLVLGIYLYPLPKSVLGALIAVNLKNSLKQLT
                     DPYYLWRKSKLDCCIWVVSFLSSFFLSLPYGVAVGVAFSVLVVVFQTQFRNGYALAQV
                     MDTDIYVNPKTYNRAQDIQGIKIITYCSPLYFANSEIFRQKVIAKTGMDPQKVLLAKQ
                     KYLKKQEKRRMRPTQQRRSLFMKTKTVSLQELQQDFENAPPTDPNNNQTPANGTSVSY
                     ITFSPDSSSPAQSEPPASAEAPGEPSDMLASVPPFVTFHTLILDMSGVSFVDLMGIKA
                     LAKLSSTYGKIGVKVFLVNIHAQVYNDISHGGVFEDGSLECKHVFPSIHDAVLFAQAN
                     ARDVTPGHNFQGAPGDAELSLYDSEEDIRSYWDLEQEMFGSMFHAETLTAL"
     exon            236..375
                     /gene="SLC26A9"
                     /inference="alignment:Splign:2.1.0"
     exon            376..486
                     /gene="SLC26A9"
                     /inference="alignment:Splign:2.1.0"
     exon            487..662
                     /gene="SLC26A9"
                     /inference="alignment:Splign:2.1.0"
     exon            663..827
                     /gene="SLC26A9"
                     /inference="alignment:Splign:2.1.0"
     exon            828..980
                     /gene="SLC26A9"
                     /inference="alignment:Splign:2.1.0"
     exon            981..1063
                     /gene="SLC26A9"
                     /inference="alignment:Splign:2.1.0"
     exon            1064..1211
                     /gene="SLC26A9"
                     /inference="alignment:Splign:2.1.0"
     exon            1212..1325
                     /gene="SLC26A9"
                     /inference="alignment:Splign:2.1.0"
     exon            1326..1403
                     /gene="SLC26A9"
                     /inference="alignment:Splign:2.1.0"
     exon            1404..1499
                     /gene="SLC26A9"
                     /inference="alignment:Splign:2.1.0"
     exon            1500..1606
                     /gene="SLC26A9"
                     /inference="alignment:Splign:2.1.0"
     exon            1607..1676
                     /gene="SLC26A9"
                     /inference="alignment:Splign:2.1.0"
     exon            1677..1769
                     /gene="SLC26A9"
                     /inference="alignment:Splign:2.1.0"
     exon            1770..1883
                     /gene="SLC26A9"
                     /inference="alignment:Splign:2.1.0"
     exon            1884..2165
                     /gene="SLC26A9"
                     /inference="alignment:Splign:2.1.0"
     exon            2166..2220
                     /gene="SLC26A9"
                     /inference="alignment:Splign:2.1.0"
     exon            2221..2366
                     /gene="SLC26A9"
                     /inference="alignment:Splign:2.1.0"
     exon            2367..2438
                     /gene="SLC26A9"
                     /inference="alignment:Splign:2.1.0"
     exon            2439..4791
                     /gene="SLC26A9"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4768..4773
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC26A9"
                     /note="hexamer: AATAAA"
     polyA_site      4791
                     /gene="SLC26A9"
                     /note="major polyA site"
ORIGIN      
        1 agagcccttt cacacacctc aggaacacct ttcggctgcc cgctccccag acacacctgc
       61 agccctgccc agccggcttt gctcacccac tgcttgtaaa tgccccagat atgagccagc
      121 ccaggccccg ctacgtggta gacagagccg catactccct taccctcttc gacgatgagt
      181 ttgagaagaa ggaccggaca tacccagtgg gagagaaact tcgcaatgcc ttcagatgtt
      241 cctcagccaa gatcaaagct gtggtgtttg ggctgctgcc tgtgctctcc tggctcccca
      301 agtacaagat taaagactac atcattcctg acctgctcgg tggactcagc gggggatcca
      361 tccaggtccc acaaggcatg gcatttgctc tgctggccaa ccttcctgca gtcaatggcc
      421 tctactcctc cttcttcccc ctcctgacct acttcttcct ggggggtgtt caccagatgg
      481 tgccaggtac ctttgccgtt atcagcatcc tggtgggtaa catctgtctg cagctggccc
      541 cagagtcgaa attccaggtc ttcaacaatg ccaccaatga gagctatgtg gacacagcag
      601 ccatggaggc tgagaggctg cacgtgtcag ctacgctagc ctgcctcacc gccatcatcc
      661 agatgggtct gggcttcatg cagtttggct ttgtggccat ctacctctcc gagtccttca
      721 tccggggctt catgacggcc gccggcctgc agatcctgat ttcggtgctc aagtacatct
      781 tcggactgac catcccctcc tacacaggcc cagggtccat cgtctttacc ttcattgaca
      841 tttgcaaaaa cctcccccac accaacatcg cctcgctcat cttcgctctc atcagcggtg
      901 ccttcctggt gctggtgaag gagctcaatg ctcgctacat gcacaagatt cgcttcccca
      961 tccctacaga gatgattgtg gtggtggtgg caacagctat ctccgggggc tgtaagatgc
     1021 ccaaaaagta tcacatgcag atcgtgggag aaatccaacg cgggttcccc accccggtgt
     1081 cgcctgtggt ctcacagtgg aaggacatga taggcacagc cttctcccta gccatcgtga
     1141 gctacgtcat caacctggct atgggccgga ccctggccaa caagcacggc tacgacgtgg
     1201 attcgaacca ggagatgatc gctctcggct gcagcaactt ctttggctcc ttctttaaaa
     1261 ttcatgtcat ttgctgtgcg ctttctgtca ctctggctgt ggatggagct ggaggaaaat
     1321 cccaggtggc cagcctgtgt gtgtctctgg tggtgatgat caccatgctg gtcctgggga
     1381 tctatctgta tcctctccct aagtctgtgc taggagccct gatcgctgtc aatctcaaga
     1441 actccctcaa gcaactcacc gacccctact acctgtggag gaagagcaag ctggactgtt
     1501 gcatctgggt agtgagcttc ctctcctcct tcttcctcag cctgccctat ggtgtggcag
     1561 tgggtgtcgc cttctccgtc ctggtcgtgg tcttccagac tcagtttcga aatggctatg
     1621 cactggccca ggtcatggac actgacattt atgtgaatcc caagacctat aatagggccc
     1681 aggatatcca ggggattaaa atcatcacgt actgctcccc tctctacttt gccaactcag
     1741 agatcttcag gcaaaaggtc atcgccaaga caggcatgga cccccagaaa gtattactag
     1801 ccaagcaaaa atacctcaag aagcaggaga agcggagaat gaggcccaca caacagagga
     1861 ggtctctatt catgaaaacc aagactgtct ccctgcagga gctgcagcag gactttgaga
     1921 atgcgccccc caccgacccc aacaacaacc agaccccggc taacggcacc agcgtgtcct
     1981 atatcacctt cagccctgac agctcctcac ctgcccagag tgagccacca gcctccgctg
     2041 aggcccccgg cgagcccagt gacatgctgg ccagcgtccc acccttcgtc accttccaca
     2101 ccctcatcct ggacatgagt ggagtcagct tcgtggactt gatgggcatc aaggccctgg
     2161 ccaagctgag ctccacctat gggaagatcg gcgtgaaggt cttcttggtg aacatccatg
     2221 cccaggtgta caatgacatt agccatggag gcgtctttga ggatgggagt ctagaatgca
     2281 agcacgtctt tcccagcata catgacgcag tcctctttgc ccaggcaaat gctagagacg
     2341 tgaccccagg acacaacttc caaggggctc caggggatgc tgagctctcc ttgtacgact
     2401 cagaggagga cattcgcagc tactgggact tagagcagga gatgttcggg agcatgtttc
     2461 acgcagagac cctgaccgcc ctgtgagggc tcagccagtc ctcatgctgc ctacagagtg
     2521 cctggcactt gggacttcca taaaggatga gcctggggtc acagggggtg tcgggcggag
     2581 gaaagtgcat cccccagagc ttgggttcct ctctcctctc cccctctctc ctcccttcct
     2641 tccctccccg catctccaga gagagcctct cagcagcagg ggggtgctac ccttacagga
     2701 gtgagagtct ggtgagccca ctcttcaccc gtcaggccct ggccgcaatg gacaagcctc
     2761 ctgctcactc caccccaccc acctctgccc tgtccttggc agctgaagga caccttgact
     2821 tccagctttt acgagtgagc caaaaacaga aggacaagta caactgtgct ggcctgctgt
     2881 acaagcttca aaaagtgtcc cagagcccac acggctcggt gtcagatggt gtcaggctgt
     2941 cacggacata gggataaact tggttaggac tctggcttgc cttccccagc tgcctcaact
     3001 ctgtctctgg cagctctgca cccagggacc atgtgctctc cacacccagg agtctaggcc
     3061 ttggtaacta tgcgcccccc ctccatcatc cccaaggctg cccaaaccac cactgctgtc
     3121 agcaagcaca tcagactcta gcctggacag tggccaggac cgtcgagacc accagagcta
     3181 cctccccggg gacagcccac taaggttctg cctcagcctc ctgaaacatc actgccctca
     3241 gaggctgctc ccttcccctg gaggctggct agaaacccca aagaggggga tgggtagctg
     3301 gcagaatcat ctggcatcct agtaatagat accagttatt ctgcacaaaa cttttgggaa
     3361 ttcctctttg cacccagaga ctcagagggg aagagggtgc tagtaccaac acagggaaaa
     3421 cggatgggac ctgggcccag acagtccccc ttgaccccag ggcccatcag ggaaatgcct
     3481 ccctttggta aatctgcctt atccttcttt acctggcaaa gagccaatca tgttaactct
     3541 tccttatcag cctgtggccc agagacacaa tggggtcctt ctgtaggcaa aggtggaagt
     3601 cctccaggga tccgctacat cccctaactg catgcagatg tggaaagggg ctgatccaga
     3661 ttgggtcttc ctgcacagga agactcttta acacccttag gacctcaggc catcttctcc
     3721 tatgaagatg aaaatagggg ttaagttttc catatgtaca aggaggtatt gagaggaacc
     3781 ctactgttga cttgaaaata aataggttcc atgtgtaagt gttttgtaaa atttcagtgg
     3841 aaatgcacag aaaatcttct ggcctctcat cactgctttt ctcaagcttc ttcagcttaa
     3901 caaccccttc cctaacaggt tgggctggcc cagcctagga aaacatcccc atttctaact
     3961 tcagccagac ctgcgttgtg tgtctgtgtg ttgagtgagc tggtcagcta acaagtcttc
     4021 ttagagttaa aggagggggt gctggccaag agccaacaca ttcttggccc aggagcattg
     4081 cttttctgtg aattcattat gccatctggc tgccaatgga actcaaaact tggaaggcga
     4141 aggacaatgt tatctgggat tcaccgtgcc cagcacccga agtgccaaat tccaggagga
     4201 caagagcctt agccaatgac aactcactct cccctactcc acctccttcc aagtccagct
     4261 caggcccagg aggtgggaga aggtcacaga gcctcaggaa tttccaagtc agagtcccct
     4321 ttgaaccaag tatctagatc ccctgaggac ttgatgaagt gatccttaac ccccaagtaa
     4381 tcattaaccc ccagaccagc ctcagaactg aaggagattg ttgacccagt gacctggagt
     4441 tgaggctcag ggagagatct gccacatgtc tgagggttgc agagcccgct gtggaggtaa
     4501 gattggaaac acatgaggca gagggaagac attgaagaaa acatctctgc tggaatattt
     4561 ggaaaagaac actcttctgg acctggttga agcaggaaag atggaggcaa agtagtgaaa
     4621 taatccagaa tttcaatgct tttgaatgtt cttagtgata ctgacctgtg ataatataat
     4681 tcccagggag gactgggaac cttatctctt gagatatttg cataatttat ttaatttaag
     4741 cctcattctc cttttgttca ttttggtaat aaactggatt tgaattgtga a
//
