LOCUS       NM_052832               5237 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens solute carrier family 26 member 7 (SLC26A7),
            transcript variant 1, mRNA.
ACCESSION   NM_052832
VERSION     NM_052832.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5237)
  AUTHORS   Calvete,O., Reyes,J., Valdes-Socin,H., Martin,P., Marazuela,M.,
            Barroso,A., Escalada,J., Castells,A., Torres-Ruiz,R.,
            Rodriguez-Perales,S., Curras-Freixes,M. and Benitez,J.
  TITLE     Alterations in SLC4A2, SLC26A7 and SLC26A9 Drive Acid-Base
            Imbalance in Gastric Neuroendocrine Tumors and Uncover a Novel
            Mechanism for a Co-Occurring Polyautoimmune Scenario
  JOURNAL   Cells 10 (12), 3500 (2021)
   PUBMED   34944008
  REMARK    GeneRIF: Alterations in SLC4A2, SLC26A7 and SLC26A9 Drive Acid-Base
            Imbalance in Gastric Neuroendocrine Tumors and Uncover a Novel
            Mechanism for a Co-Occurring Polyautoimmune Scenario.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5237)
  AUTHORS   Huang,F., Xiao,J., Wang,L., Xie,Y. and Jia,H.
  TITLE     Relationships between SLC26A7 expressions and extra-thyroid
            metastasis of papillary thyroid carcinoma
  JOURNAL   Chin Med J (Engl) 135 (2), 225-227 (2021)
   PUBMED   34593695
  REMARK    GeneRIF: Relationships between SLC26A7 expressions and
            extra-thyroid metastasis of papillary thyroid carcinoma.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5237)
  AUTHORS   Cao,X., Soleimani,M. and Hughes,B.A.
  TITLE     SLC26A7 constitutes the thiocyanate-selective anion conductance of
            the basolateral membrane of the retinal pigment epithelium
  JOURNAL   Am J Physiol Cell Physiol 319 (4), C641-C656 (2020)
   PUBMED   32726161
  REMARK    GeneRIF: SLC26A7 constitutes the thiocyanate-selective anion
            conductance of the basolateral membrane of the retinal pigment
            epithelium.
REFERENCE   4  (bases 1 to 5237)
  AUTHORS   Ullah,A.K.M.S., Rumley,A.C., Peleh,V., Fernandes,D., Almomani,E.Y.,
            Berrini,M., Lashhab,R., Touret,N., Alexander,R.T., Herrmann,J.M.
            and Cordat,E.
  TITLE     SLC26A7 protein is a chloride/bicarbonate exchanger and its
            abundance is osmolarity- and pH-dependent in renal epithelial cells
  JOURNAL   Biochim Biophys Acta Biomembr 1862 (6), 183238 (2020)
   PUBMED   32119864
REFERENCE   5  (bases 1 to 5237)
  AUTHORS   Ishii,J., Suzuki,A., Kimura,T., Tateyama,M., Tanaka,T., Yazawa,T.,
            Arimasu,Y., Chen,I.S., Aoyama,K., Kubo,Y., Saitoh,S., Mizuno,H. and
            Kamma,H.
  TITLE     Congenital goitrous hypothyroidism is caused by dysfunction of the
            iodide transporter SLC26A7
  JOURNAL   Commun Biol 2, 270 (2019)
   PUBMED   31372509
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5237)
  AUTHORS   Petrovic,S., Ju,X., Barone,S., Seidler,U., Alper,S.L., Lohi,H.,
            Kere,J. and Soleimani,M.
  TITLE     Identification of a basolateral Cl-/HCO3- exchanger specific to
            gastric parietal cells
  JOURNAL   Am J Physiol Gastrointest Liver Physiol 284 (6), G1093-G1103 (2003)
   PUBMED   12736153
REFERENCE   7  (bases 1 to 5237)
  AUTHORS   Lohi,H., Kujala,M., Makela,S., Lehtonen,E., Kestila,M.,
            Saarialho-Kere,U., Markovich,D. and Kere,J.
  TITLE     Functional characterization of three novel tissue-specific anion
            exchangers SLC26A7, -A8, and -A9
  JOURNAL   J Biol Chem 277 (16), 14246-14254 (2002)
   PUBMED   11834742
REFERENCE   8  (bases 1 to 5237)
  AUTHORS   Vincourt,J.B., Jullien,D., Kossida,S., Amalric,F. and Girard,J.P.
  TITLE     Molecular cloning of SLC26A7, a novel member of the SLC26
            sulfate/anion transporter family, from high endothelial venules and
            kidney
  JOURNAL   Genomics 79 (2), 249-256 (2002)
   PUBMED   11829495
  REMARK    GeneRIF: the molecular cloning from human HEVEC of a 2.9-kb cDNA
            encoding SLC26A7, a novel member of the SLC26 (solute carrier 26)
            sulfate/anion exchanger family
REFERENCE   9  (bases 1 to 5237)
  AUTHORS   Markovich,D.
  TITLE     Physiological roles and regulation of mammalian sulfate
            transporters
  JOURNAL   Physiol Rev 81 (4), 1499-1533 (2001)
   PUBMED   11581495
  REMARK    Review article
REFERENCE   10 (bases 1 to 5237)
  AUTHORS   Mocellin,R. and Buhlmeyer,K.
  TITLE     Late banding operation in children with ventricular septal defect
            and pulmonary arterial hypertension
  JOURNAL   Eur J Cardiol 3 (3), 205-211 (1975)
   PUBMED   1183472
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AJ413229.2, BC094730.1,
            AF331521.1 and AI758950.1.
            
            On Nov 23, 2018 this sequence version replaced NM_052832.3.
            
            Summary: This gene is one member of a family of sulfate/anion
            transporter genes. Family members are well conserved in gene
            structure and protein length yet have markedly different tissue
            expression patterns. This gene has abundant and specific expression
            in the kidney. Alternatively spliced transcript variants that
            encode different isoforms have been described. [provided by RefSeq,
            Aug 2013].
            
            Transcript Variant: This variant (1) differs in the 5' UTR,
            compared to variant 3. Variants 1 and 3 encode the same protein
            (isoform a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ413228.1, AF331521.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1970526, SAMEA2142348
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000276609.8/ ENSP00000276609.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-601               AJ413229.2         33-633
            602-2838            BC094730.1         670-2906
            2839-5232           AF331521.1         2840-5233
            5233-5237           AI758950.1         29-33               c
FEATURES             Location/Qualifiers
     source          1..5237
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q21.3"
     gene            1..5237
                     /gene="SLC26A7"
                     /gene_synonym="SUT2"
                     /note="solute carrier family 26 member 7"
                     /db_xref="GeneID:115111"
                     /db_xref="HGNC:HGNC:14467"
                     /db_xref="MIM:608479"
     exon            1..95
                     /gene="SLC26A7"
                     /gene_synonym="SUT2"
                     /inference="alignment:Splign:2.1.0"
     exon            96..401
                     /gene="SLC26A7"
                     /gene_synonym="SUT2"
                     /inference="alignment:Splign:2.1.0"
     CDS             209..2179
                     /gene="SLC26A7"
                     /gene_synonym="SUT2"
                     /note="isoform a is encoded by transcript variant 1;
                     sulfate anion transporter; anion exchange transporter;
                     solute carrier family 26 (anion exchanger), member 7;
                     solute carrier family 6 member 7; sulfate anion
                     transporter 2"
                     /codon_start=1
                     /product="anion exchange transporter isoform a"
                     /protein_id="NP_439897.1"
                     /db_xref="CCDS:CCDS6254.1"
                     /db_xref="GeneID:115111"
                     /db_xref="HGNC:HGNC:14467"
                     /db_xref="MIM:608479"
                     /translation="MTGAKRKKKSMLWSKMHTPQCEDIIQWCRRRLPILDWAPHYNLK
                     ENLLPDTVSGIMLAVQQVTQGLAFAVLSSVHPVFGLYGSLFPAIIYAIFGMGHHVATG
                     TFALTSLISANAVERIVPQNMQNLTTQSNTSVLGLSDFEMQRIHVAAAVSFLGGVIQV
                     AMFVLQLGSATFVVTEPVISAMTTGAATHVVTSQVKYLLGMKMPYISGPLGFFYIYAY
                     VFENIKSVRLEALLLSLLSIVVLVLVKELNEQFKRKIKVVLPVDLVLIIAASFACYCT
                     NMENTYGLEVVGHIPQGIPSPRAPPMNILSAVITEAFGVALVGYVASLALAQGSAKKF
                     KYSIDDNQEFLAHGLSNIVSSFFFCIPSAAAMGRTAGLYSTGAKTQVACLISCIFVLI
                     VIYAIGPLLYWLPMCVLASIIVVGLKGMLIQFRDLKKYWNVDKIDWGIWVSTYVFTIC
                     FAANVGLLFGVVCTIAIVIGRFPRAMTVSIKNMKEMEFKVKTEMDSETLQQVKIISIN
                     NPLVFLNAKKFYTDLMNMIQKENACNQPLDDISKCEQNTLLNSLSNGNCNEEASQSCP
                     NEKCYLILDCSGFTFFDYSGVSMLVEVYMDCKGRSVDVLLAHCTASLIKAMTYYGNLD
                     SEKPIFFESVSAAISHIHSNKNLSKLSDHSEV"
     exon            402..512
                     /gene="SLC26A7"
                     /gene_synonym="SUT2"
                     /inference="alignment:Splign:2.1.0"
     exon            513..685
                     /gene="SLC26A7"
                     /gene_synonym="SUT2"
                     /inference="alignment:Splign:2.1.0"
     exon            686..850
                     /gene="SLC26A7"
                     /gene_synonym="SUT2"
                     /inference="alignment:Splign:2.1.0"
     exon            851..1003
                     /gene="SLC26A7"
                     /gene_synonym="SUT2"
                     /inference="alignment:Splign:2.1.0"
     exon            1004..1086
                     /gene="SLC26A7"
                     /gene_synonym="SUT2"
                     /inference="alignment:Splign:2.1.0"
     exon            1087..1234
                     /gene="SLC26A7"
                     /gene_synonym="SUT2"
                     /inference="alignment:Splign:2.1.0"
     exon            1235..1348
                     /gene="SLC26A7"
                     /gene_synonym="SUT2"
                     /inference="alignment:Splign:2.1.0"
     exon            1349..1426
                     /gene="SLC26A7"
                     /gene_synonym="SUT2"
                     /inference="alignment:Splign:2.1.0"
     exon            1427..1522
                     /gene="SLC26A7"
                     /gene_synonym="SUT2"
                     /inference="alignment:Splign:2.1.0"
     exon            1523..1629
                     /gene="SLC26A7"
                     /gene_synonym="SUT2"
                     /inference="alignment:Splign:2.1.0"
     exon            1630..1696
                     /gene="SLC26A7"
                     /gene_synonym="SUT2"
                     /inference="alignment:Splign:2.1.0"
     exon            1697..1834
                     /gene="SLC26A7"
                     /gene_synonym="SUT2"
                     /inference="alignment:Splign:2.1.0"
     exon            1835..1883
                     /gene="SLC26A7"
                     /gene_synonym="SUT2"
                     /inference="alignment:Splign:2.1.0"
     exon            1884..1984
                     /gene="SLC26A7"
                     /gene_synonym="SUT2"
                     /inference="alignment:Splign:2.1.0"
     exon            1985..2039
                     /gene="SLC26A7"
                     /gene_synonym="SUT2"
                     /inference="alignment:Splign:2.1.0"
     exon            2040..2143
                     /gene="SLC26A7"
                     /gene_synonym="SUT2"
                     /inference="alignment:Splign:2.1.0"
     exon            2144..5237
                     /gene="SLC26A7"
                     /gene_synonym="SUT2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5204..5209
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC26A7"
                     /gene_synonym="SUT2"
                     /note="hexamer: AATAAA"
     polyA_site      5237
                     /gene="SLC26A7"
                     /gene_synonym="SUT2"
                     /note="major polyA site"
ORIGIN      
        1 gtagaccaac ttaacactga acccattact tttccaagac cagaaaaaaa tattacatga
       61 acaggaacta cttctccttc agataagaat tcaagctttg acattgtaaa ccacagacga
      121 attggagctt ggcattgaaa ggaggtgttc tgcaatgatt ttttttcttg tttagagaag
      181 tttacttcta caagaagaaa tctgaaaaat gacaggagca aagaggaaaa agaaaagcat
      241 gctttggagc aagatgcata ccccccagtg tgaagacatt atacagtggt gtagaaggcg
      301 actgcccatt ttggattggg caccacatta caatctgaaa gaaaacttgc ttccagacac
      361 tgtgtctggg ataatgttgg cagttcaaca ggtgacccaa ggattggcct ttgctgttct
      421 ctcatctgtg cacccagtgt ttggtttata tgggtctctg tttcctgcca taatttatgc
      481 catatttgga atgggacatc atgttgccac aggcaccttt gccttgacat ccttaatatc
      541 agccaacgcc gtggaacgga ttgtccctca gaacatgcag aatctcacca cacagagtaa
      601 cacaagcgtg ctgggcttat ccgactttga aatgcaaagg atccacgttg ctgcagcagt
      661 ttccttcttg ggaggtgtga ttcaggtggc catgtttgtg ctgcaactgg gcagtgccac
      721 atttgtggtc acagagcctg tgatcagcgc aatgacaact ggggctgcca cccatgtggt
      781 gacttcacaa gtcaaatatc tcttgggaat gaaaatgcca tatatatccg gaccacttgg
      841 attcttttat atttatgcat atgtttttga aaacatcaag tctgtgcgac tggaagcatt
      901 gcttttatcc ttgctgagca ttgtggtcct tgttcttgtt aaagagctga atgaacagtt
      961 taaaaggaaa attaaagttg ttcttcctgt agatttagtt ttgattattg ctgcatcatt
     1021 tgcttgttat tgcaccaata tggaaaacac atatggatta gaagtagttg gtcatattcc
     1081 acaaggaatt ccctcaccta gagctccccc gatgaacatc ctctctgcgg tgatcactga
     1141 agctttcgga gtggcacttg taggctatgt ggcctcactg gctcttgctc aaggatctgc
     1201 caaaaaattc aaatattcaa ttgatgacaa ccaggaattt ttggcccatg gcctcagcaa
     1261 tatagtttct tcatttttct tctgcatacc aagtgctgct gccatgggaa ggacggctgg
     1321 cctgtacagc acaggagcga agacacaggt ggcttgtcta atatcttgca ttttcgtcct
     1381 tatagtcatc tatgcaatag gacctttgct ttactggctg cccatgtgtg tccttgcaag
     1441 cattattgtt gtgggactga agggaatgct aatacagttc cgagatttaa aaaaatattg
     1501 gaatgtggat aaaatcgatt ggggaatatg ggtcagtaca tatgtattta caatatgctt
     1561 tgctgccaat gtgggactgc tgtttggtgt tgtttgtacc atagctatag tgataggacg
     1621 cttcccaaga gcaatgactg taagtataaa aaatatgaaa gaaatggaat ttaaagtgaa
     1681 gacagaaatg gacagtgaaa ccctgcagca ggtgaaaatt atctcaataa acaacccgct
     1741 tgttttcctg aatgcaaaaa aattttatac tgatttaatg aacatgatcc aaaaggaaaa
     1801 tgcctgtaat cagccacttg atgatatcag caagtgtgaa caaaacacat tgcttaattc
     1861 cctatccaat ggcaactgca atgaagaagc ttcacagtcc tgccctaatg agaagtgtta
     1921 tttaatcctg gattgcagtg gatttacctt ttttgactat tctggagtct ccatgcttgt
     1981 tgaggtttac atggactgta aaggcaggag tgtggatgta ttgttagccc attgtacagc
     2041 ttccttgata aaagcaatga cgtattatgg aaacctagac tcagagaaac caattttttt
     2101 tgaatcggta tctgctgcaa taagtcatat ccattcaaat aagaatttga gcaaactcag
     2161 tgaccacagt gaagtctgag acccttttgt cacagtacag ctcttgtctt taccaactgc
     2221 ctgaagaggc catatgctgg cattttgcac aactttttgg ttgtttagat cctacagatg
     2281 acctctgcta caataagtac gatgtgactt agtaactgca tagcagttgg aaagaactgc
     2341 caactttttt ttctcatttt tgttagtaag aagattcgct tagttatttt atgtaaaaat
     2401 cagtatgtgt ttagttttag tgtactgaag ggtaaacatg gttttatttt attttaccat
     2461 attattttgt gttgttttat ttctattgtg ctgtaagttg atgtttaaaa ttgagaaata
     2521 cttttgtcat aggtaatttg gaacatttac aagccatttg taaaatttta agataatctg
     2581 taactaatac ataaaaacaa cttagcaaat gtgccatttt cacacaactt ctctctgtat
     2641 aggcctctga aatatcaata aggctaaata ttactttaca cagtaagatg tgaaattcac
     2701 aaaaagtaaa ccaaacaaaa cgaatgaaaa actggaaata attcgtttcc atatctttcc
     2761 atacatccat ttctgaagta ttcaggaatg ttttcataat cgaaagaaac gggtatccaa
     2821 ataaaaccaa gttcttgaca ttggtctgtt ttgctgtgaa tattggaaat gcttaggatc
     2881 ttcagaccca atagctctaa ttttaacatt tctacccaat aagaggctct gttttccact
     2941 gaagctttgt tggagaaaga gaatatgaaa attacacatt ttataatttt tagatgagaa
     3001 aataccacta gcagaatagc tttgtgctat tccagtataa gatgaactgt aataattttt
     3061 gacttcccta tttcagagat agtcaatata atatgtttat ctatatccat atggatggat
     3121 aggtaggtag atcttcatag attttttttt cttttgttag aggagagctt gatgtgatta
     3181 tcttcaaacc caccaaacca acaggataat tgacaaataa acgccatagg ctaggctgaa
     3241 ctgtatgtta ctgttttcat gcttatacat atattttcaa tcacatacaa gtacatagaa
     3301 tttcacattt taatttagca aattgattta cctaggaaaa aattatcacc ttcaaagata
     3361 ggcatagaca cataattatg cttaagcttt taacagcatt ttaaccgctc taaaaattac
     3421 cagagtaaga aaaagctagg tactttaaag tgagtttgag aaacaagttg aaactaaaat
     3481 taaaatacca gccatttagg tgctttctct ggcatctata aaagtaaatt ctagtgcctg
     3541 ccaagtgatg gattataatg gtctctagca aatgtgtggt aaacattcat atggccatta
     3601 attttaacat taaatcgtag gtagggcaat gtagtaaaat gaaagagaat taagaaaggt
     3661 tttgaattct tataacatat ccagccattt caattttgat tgaaatgaac tacaaagaat
     3721 agtgtttgtc cctatggtag cctcagtctc tttatcacta acttggattg aaatgagtga
     3781 ggccaactca cattcccatc aaacactctt ccaaggaaaa gcagaagtaa taattggagg
     3841 taaagtttcc ttagagaaaa taattttatt ctgctttgtc caattaaatt attccaatgg
     3901 cggatggtaa tattcaccat ctctaattca ttggtcactg gtaggtaagc atgagttaag
     3961 gaaagtcaaa aatgaaaata tattttgctg tgtataaatt gatattttgc tatgcaactc
     4021 ctgtaattga atttgtataa tgcaggcact ttctaattta ttagagatta tggatcagtt
     4081 ctgacattaa aatcatagtt aattgatgga tggtttttat agtttgttga taaagtggac
     4141 acagtattgt ctgagcagtt atattttaat gcatttcagt gtttatagta gaagtttagt
     4201 ggataaaact ttaagtccaa taacttgggg gtcaaatgct aatgttttat tcaatgtaaa
     4261 ggaagaccaa accatgtacc ttatgaagac ctttgtttta agacttccac acaccaaggc
     4321 tacaatgact gttaacctgg aggaagtctc tggtatggag ttctgagagc ttaagagcta
     4381 aacatgagtt tagacacaca agattctaaa atgcaaatgt ttattttgaa gcaggcattg
     4441 acaacacaaa aactgtgtag tggtcttgat gctggattgt ttctagagtc acaatgaatt
     4501 atttttatga gattacctta tttttatata tgacaaacta cttctataat gcttattatg
     4561 gtaaaataaa attggaaaaa attaaaactg acctataaga gtgttaagga cctaatagag
     4621 tgacatatat aaattaagca taaaatatgt aaccaggaaa agactgttaa cattacattt
     4681 atgcaaatta aatgccctta aatttcacca tttgtctttc attttaaagg ttatttgctc
     4741 ccgattatat gattcaagtg ttataagttt tagcttgaac tactttgcag taatttattt
     4801 gacagatctc tattctataa atgtgtaatg tgatgaagaa agagatcttt cttttttaat
     4861 gaaaacatta atgtgttaat accctgtatg gataatgctt gacatttagt ggtttccaaa
     4921 atatattagt atattgttga acatacatta tgccttagaa atgcacattc tgtattttgt
     4981 gggatgataa tctaattcag tatagaatat gctgtttggc aatgagtttg tggccagatt
     5041 tcaaataggg agttaagtgg tactttcaca atccaaagat ttttagttaa aaatcatgta
     5101 gtctaatatg ctgcagttat ttttttatat ttttcaatgc atttaattat cttttttata
     5161 attctttgta ctaactcagc atgtaacaac caatttacat ggaaataaat cgaaatatga
     5221 taactattat gcttaaa
//
