LOCUS       NM_022911               2611 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens solute carrier family 26 member 6 (SLC26A6),
            transcript variant 1, mRNA.
ACCESSION   NM_022911
VERSION     NM_022911.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2611)
  AUTHORS   Ochiai-Homma,F., Kuribayashi-Okuma,E., Tsurutani,Y., Ishizawa,K.,
            Fujii,W., Odajima,K., Kawagoe,M., Tomomitsu,Y., Murakawa,M.,
            Asakawa,S., Hirohama,D., Nagura,M., Arai,S., Yamazaki,O.,
            Tamura,Y., Fujigaki,Y., Nishikawa,T. and Shibata,S.
  TITLE     Characterization of pendrin in urinary extracellular vesicles in a
            rat model of aldosterone excess and in human primary aldosteronism
  JOURNAL   Hypertens Res 44 (12), 1557-1567 (2021)
   PUBMED   34326480
  REMARK    GeneRIF: Characterization of pendrin in urinary extracellular
            vesicles in a rat model of aldosterone excess and in human primary
            aldosteronism.
REFERENCE   2  (bases 1 to 2611)
  AUTHORS   Yang,X., Yao,S., An,J., Jin,H., Wang,H. and Tuo,B.
  TITLE     SLC26A6 and NADC-1: Future direction of nephrolithiasis and
            calculus-related hypertension research (Review)
  JOURNAL   Mol Med Rep 24 (5) (2021)
   PUBMED   34458928
  REMARK    GeneRIF: SLC26A6 and NADC1: Future direction of nephrolithiasis and
            calculusrelated hypertension research (Review).
            Review article
REFERENCE   3  (bases 1 to 2611)
  AUTHORS   Zhu,Y., Huang,Y., Chen,L., Guo,L., Wang,L., Li,M. and Liang,Y.
  TITLE     Up-Regulation of SLC26A6 in Hepatocellular Carcinoma and Its
            Diagnostic and Prognostic Significance
  JOURNAL   Crit Rev Eukaryot Gene Expr 31 (5), 79-94 (2021)
   PUBMED   34591393
  REMARK    GeneRIF: Up-Regulation of SLC26A6 in Hepatocellular Carcinoma and
            Its Diagnostic and Prognostic Significance.
REFERENCE   4  (bases 1 to 2611)
  AUTHORS   Rehman,T., Thornell,I.M., Pezzulo,A.A., Thurman,A.L., Romano
            Ibarra,G.S., Karp,P.H., Tan,P., Duffey,M.E. and Welsh,M.J.
  TITLE     TNFalpha and IL-17 alkalinize airway surface liquid through CFTR
            and pendrin
  JOURNAL   Am J Physiol Cell Physiol 319 (2), C331-C344 (2020)
   PUBMED   32432926
  REMARK    GeneRIF: TNFalpha and IL-17 alkalinize airway surface liquid
            through CFTR and pendrin.
REFERENCE   5  (bases 1 to 2611)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 2611)
  AUTHORS   Xie,Q., Welch,R., Mercado,A., Romero,M.F. and Mount,D.B.
  TITLE     Molecular characterization of the murine Slc26a6 anion exchanger:
            functional comparison with Slc26a1
  JOURNAL   Am J Physiol Renal Physiol 283 (4), F826-F838 (2002)
   PUBMED   12217875
REFERENCE   7  (bases 1 to 2611)
  AUTHORS   Markovich,D.
  TITLE     Physiological roles and regulation of mammalian sulfate
            transporters
  JOURNAL   Physiol Rev 81 (4), 1499-1533 (2001)
   PUBMED   11581495
  REMARK    Review article
REFERENCE   8  (bases 1 to 2611)
  AUTHORS   Waldegger,S., Moschen,I., Ramirez,A., Smith,R.J., Ayadi,H., Lang,F.
            and Kubisch,C.
  TITLE     Cloning and characterization of SLC26A6, a novel member of the
            solute carrier 26 gene family
  JOURNAL   Genomics 72 (1), 43-50 (2001)
   PUBMED   11247665
  REMARK    Erratum:[Genomics 2001 Sep;77(1-2):115]
REFERENCE   9  (bases 1 to 2611)
  AUTHORS   Lohi,H., Kujala,M., Kerkela,E., Saarialho-Kere,U., Kestila,M. and
            Kere,J.
  TITLE     Mapping of five new putative anion transporter genes in human and
            characterization of SLC26A6, a candidate gene for pancreatic anion
            exchanger
  JOURNAL   Genomics 70 (1), 102-112 (2000)
   PUBMED   11087667
REFERENCE   10 (bases 1 to 2611)
  AUTHORS   Ignatovich,O., Tomlinson,I.M., Popov,A.V., Bruggemann,M. and
            Winter,G.
  TITLE     Dominance of intrinsic genetic factors in shaping the human
            immunoglobulin Vlambda repertoire
  JOURNAL   J Mol Biol 294 (2), 457-465 (1999)
   PUBMED   10610771
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA702248.1, AF288410.1 and
            AL050170.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_022911.2.
            
            Summary: This gene belongs to the solute carrier 26 family, whose
            members encode anion transporter proteins. This particular family
            member encodes a protein involved in transporting chloride,
            oxalate, sulfate and bicarbonate. Alternatively spliced transcript
            variants encoding distinct isoforms have been described. [provided
            by RefSeq, Aug 2013].
            
            Transcript Variant: This variant (1), also known as L+Q, encodes
            the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF288410.1, SRR14038196.1385052.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000395550.7/ ENSP00000378920.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-20                DA702248.1         33-52
            21-2609             AF288410.1         1-2589
            2610-2611           AL050170.1         429-430
FEATURES             Location/Qualifiers
     source          1..2611
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p21.31"
     gene            1..2611
                     /gene="SLC26A6"
                     /note="solute carrier family 26 member 6"
                     /db_xref="GeneID:65010"
                     /db_xref="HGNC:HGNC:14472"
                     /db_xref="MIM:610068"
     exon            1..91
                     /gene="SLC26A6"
                     /inference="alignment:Splign:2.1.0"
     CDS             69..2348
                     /gene="SLC26A6"
                     /note="isoform 1 is encoded by transcript variant 1;
                     pendrin L1; sulfate anion transporter; anion transporter
                     1; anion exchange transporter; solute carrier family 26
                     (anion exchanger), member 6"
                     /codon_start=1
                     /product="solute carrier family 26 member 6 isoform 1"
                     /protein_id="NP_075062.2"
                     /db_xref="CCDS:CCDS43087.1"
                     /db_xref="GeneID:65010"
                     /db_xref="HGNC:HGNC:14472"
                     /db_xref="MIM:610068"
                     /translation="MGLADASGPRDTQALLSATQAMDLRRRDYHMERPLLNQEHLEEL
                     GRWGSAPRTHQWRTWLQCSRARAYALLLQHLPVLVWLPRYPVRDWLLGDLLSGLSVAI
                     MQLPQGLAYALLAGLPPVFGLYSSFYPVFIYFLFGTSRHISVGTFAVMSVMVGSVTES
                     LAPQALNDSMINETARDAARVQVASTLSVLVGLFQVGLGLIHFGFVVTYLSEPLVRGY
                     TTAAAVQVFVSQLKYVFGLHLSSHSGPLSLIYTVLEVCWKLPQSKVGTVVTAAVAGVV
                     LVVVKLLNDKLQQQLPMPIPGELLTLIGATGISYGMGLKHRFEVDVVGNIPAGLVPPV
                     APNTQLFSKLVGSAFTIAVVGFAIAISLGKIFALRHGYRVDSNQELVALGLSNLIGGI
                     FQCFPVSCSMSRSLVQESTGGNSQVAGAISSLFILLIIVKLGELFHDLPKAVLAAIII
                     VNLKGMLRQLSDMRSLWKANRADLLIWLVTFTATILLNLDLGLVVAVIFSLLLVVVRT
                     QMPHYSVLGQVPDTDIYRDVAEYSEAKEVRGVKVFRSSATVYFANAEFYSDALKQRCG
                     VDVDFLISQKKKLLKKQEQLKLKQLQKEEKLRKQAASPKGASVSINVNTSLEDMRSNN
                     VEDCKMMQVSSGDKMEDATANGQEDSKAPDGSTLKALGLPQPDFHSLILDLGALSFVD
                     TVCLKSLKNIFHDFREIEVEVYMAACHSPVVSQLEAGHFFDASITKKHLFASVHDAVT
                     FALQHPRPVPDSPVSVTRL"
     exon            92..250
                     /gene="SLC26A6"
                     /inference="alignment:Splign:2.1.0"
     exon            251..390
                     /gene="SLC26A6"
                     /inference="alignment:Splign:2.1.0"
     exon            391..501
                     /gene="SLC26A6"
                     /inference="alignment:Splign:2.1.0"
     exon            502..653
                     /gene="SLC26A6"
                     /inference="alignment:Splign:2.1.0"
     exon            654..818
                     /gene="SLC26A6"
                     /inference="alignment:Splign:2.1.0"
     exon            819..971
                     /gene="SLC26A6"
                     /inference="alignment:Splign:2.1.0"
     exon            972..1054
                     /gene="SLC26A6"
                     /inference="alignment:Splign:2.1.0"
     exon            1055..1202
                     /gene="SLC26A6"
                     /inference="alignment:Splign:2.1.0"
     exon            1203..1316
                     /gene="SLC26A6"
                     /inference="alignment:Splign:2.1.0"
     exon            1317..1394
                     /gene="SLC26A6"
                     /inference="alignment:Splign:2.1.0"
     exon            1395..1490
                     /gene="SLC26A6"
                     /inference="alignment:Splign:2.1.0"
     exon            1491..1597
                     /gene="SLC26A6"
                     /inference="alignment:Splign:2.1.0"
     exon            1598..1667
                     /gene="SLC26A6"
                     /inference="alignment:Splign:2.1.0"
     exon            1668..1760
                     /gene="SLC26A6"
                     /inference="alignment:Splign:2.1.0"
     exon            1761..1868
                     /gene="SLC26A6"
                     /inference="alignment:Splign:2.1.0"
     exon            1869..1961
                     /gene="SLC26A6"
                     /inference="alignment:Splign:2.1.0"
     exon            1962..2141
                     /gene="SLC26A6"
                     /inference="alignment:Splign:2.1.0"
     exon            2142..2196
                     /gene="SLC26A6"
                     /inference="alignment:Splign:2.1.0"
     exon            2197..2333
                     /gene="SLC26A6"
                     /inference="alignment:Splign:2.1.0"
     exon            2334..2611
                     /gene="SLC26A6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2591..2596
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC26A6"
                     /note="hexamer: AATAAA"
     polyA_site      2611
                     /gene="SLC26A6"
                     /note="major polyA site"
ORIGIN      
        1 gccttccgga gcgtagcggc ctctagctcg agcagcagga gcagcccgca ccggacaact
       61 tgcgagccat ggggctggcg gatgcgtcgg gaccgaggga cacacaggca ctgctgtctg
      121 caacacaagc aatggacctg cggaggcgag actaccacat ggaacggccg ctgctgaacc
      181 aggagcattt ggaggagctg gggcgctggg gctcagcacc taggacccac cagtggcgga
      241 cctggttgca gtgctcccgt gctcgggcct atgcccttct gctccaacac ctcccggttt
      301 tggtctggtt accccggtat cctgtgcgtg actggctcct gggtgacctg ttatccggcc
      361 tgagtgtggc catcatgcag cttccgcagg gcttggccta cgccctcctg gctggattgc
      421 cccccgtgtt tggcctctat agctccttct accctgtctt catctacttc ctgtttggca
      481 cttcccggca catctccgtg gggacctttg ctgtcatgtc tgtgatggtg ggcagtgtga
      541 cagaatccct ggccccgcag gccttgaacg actccatgat caatgagaca gccagagatg
      601 ctgcccgggt acaggtggcc tccacactca gtgtcctggt tggcctcttc caggtggggc
      661 tgggcctgat ccacttcggc ttcgtggtca cctacctgtc agaacctctt gtccgaggct
      721 ataccacagc tgcagctgtg caggtcttcg tctcacagct caagtatgtg tttggcctcc
      781 atctgagcag ccactctggg ccactgtccc tcatctatac agtgctggag gtctgctgga
      841 agctgcccca gagcaaggtt ggcaccgtgg tcactgcagc tgtggctggg gtggtgctcg
      901 tggtggtgaa gctgttgaat gacaagctgc agcagcagct gcccatgccg atacccgggg
      961 agctgctcac gctcatcggg gccacaggca tctcctatgg catgggtcta aagcacagat
     1021 ttgaggtaga tgtcgtgggc aacatccctg cagggctggt gcccccagtg gcccccaaca
     1081 cccagctgtt ctcaaagctc gtgggcagcg ccttcaccat cgctgtggtt gggtttgcca
     1141 ttgccatctc actggggaag atcttcgccc tgaggcacgg ctaccgggtg gacagcaacc
     1201 aggagctggt ggccctgggc ctcagtaacc ttatcggagg catcttccag tgcttccccg
     1261 tgagttgctc tatgtctcgg agcctggtac aggagagcac cgggggcaac tcgcaggttg
     1321 ctggagccat ctcttccctt ttcatcctcc tcatcattgt caaacttggg gaactcttcc
     1381 atgacctgcc caaggcggtc ctggcagcca tcatcattgt gaacctgaag ggcatgctga
     1441 ggcagctcag cgacatgcgc tccctctgga aggccaatcg ggcggatctg cttatctggc
     1501 tggtgacctt cacggccacc atcttgctga acctggacct tggcttggtg gttgcggtca
     1561 tcttctccct gctgctcgtg gtggtccgga cacagatgcc ccactactct gtcctggggc
     1621 aggtgccaga cacggatatt tacagagatg tggcagagta ctcagaggcc aaggaagtcc
     1681 ggggggtgaa ggtcttccgc tcctcggcca ccgtgtactt tgccaatgct gagttctaca
     1741 gtgatgcgct gaagcagagg tgtggtgtgg atgtcgactt cctcatctcc cagaagaaga
     1801 aactgctcaa gaagcaggag cagctgaagc tgaagcaact gcagaaagag gagaagcttc
     1861 ggaaacaggc tgcctccccc aagggcgcct cagtttccat taatgtcaac accagccttg
     1921 aagacatgag gagcaacaac gttgaggact gcaagatgat gcaggtgagc tcaggagata
     1981 agatggaaga tgcaacagcc aatggtcaag aagactccaa ggccccagat gggtccacac
     2041 tgaaggccct gggcctgcct cagccagact tccacagcct catcctggac ctgggtgccc
     2101 tctcctttgt ggacactgtg tgcctcaaga gcctgaagaa tattttccat gacttccggg
     2161 agattgaggt ggaggtgtac atggcggcct gccacagccc tgtggtcagc cagcttgagg
     2221 ctgggcactt cttcgatgca tccatcacca agaagcatct ctttgcctct gtccatgatg
     2281 ctgtcacctt tgccctccaa cacccgaggc ctgtccccga cagccctgtt tcggtcacca
     2341 gactctgaac atgctacatc ctgcccaaga ctgcacctct ggaggtgcag ggcacccttg
     2401 agaagcccct cacccctagg ccgcctccag gtgctaccca ggagtcccct ccatgtacac
     2461 acacacaact cagggaagga ggtcctggga ctccaagttc agcgctccag gtctgggaca
     2521 gggcctgcat gcagtcaggc tggcagtggc gcggtacagg gagggaactg gtgcatattt
     2581 tagcctcagg aataaagatt tgtctgctca a
//
