LOCUS       NM_000111               2882 bp    mRNA    linear   PRI 09-JUL-2024
DEFINITION  Homo sapiens solute carrier family 26 member 3 (SLC26A3), mRNA.
ACCESSION   NM_000111
VERSION     NM_000111.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2882)
  AUTHORS   Li,Q., Wang,J., Zang,R., Yu,L., Yang,Z. and Sun,S.
  TITLE     Congenital chloride diarrhoea in a Chinese infant with a compound
            heterozygous SLC26A3 mutation
  JOURNAL   BMC Pediatr 24 (1), 305 (2024)
   PUBMED   38704545
  REMARK    GeneRIF: Congenital chloride diarrhoea in a Chinese infant with a
            compound heterozygous SLC26A3 mutation.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2882)
  AUTHORS   Sarker,R., Lin,R., Singh,V., Donowitz,M. and Tse,C.M.
  TITLE     SLC26A3 (DRA) is stimulated in a synergistic, intracellular
            Ca2+-dependent manner by cAMP and ATP in intestinal epithelial
            cells
  JOURNAL   Am J Physiol Cell Physiol 324 (6), C1263-C1273 (2023)
   PUBMED   37154494
  REMARK    GeneRIF: SLC26A3 (DRA) is stimulated in a synergistic,
            intracellular Ca[2+]-dependent manner by cAMP and ATP in intestinal
            epithelial cells.
REFERENCE   3  (bases 1 to 2882)
  AUTHORS   Krawczyk,M., Niewiadomska,O., Jankowska,I., Jankowski,K.,
            Swiderska,J., Lebensztejn,D., Wiecek,S., Gozdowska,J., Kulaga,Z.,
            Weber,S.N., Lammert,F. and Socha,P.
  TITLE     The rs12532734 Polymorphism Near the Solute Carrier 26A3 Gene Locus
            Is Associated With Gallstone Disease in Children
  JOURNAL   J Pediatr Gastroenterol Nutr 75 (6), 692-694 (2022)
   PUBMED   36084219
  REMARK    GeneRIF: The rs12532734 Polymorphism Near the Solute Carrier 26A3
            Gene Locus Is Associated With Gallstone Disease in Children.
REFERENCE   4  (bases 1 to 2882)
  AUTHORS   Kumar,A., Priyamvada,S., Ge,Y., Jayawardena,D., Singhal,M.,
            Anbazhagan,A.N., Chatterjee,I., Dayal,A., Patel,M., Zadeh,K.,
            Saksena,S., Alrefai,W.A., Gill,R.K., Zadeh,M., Zhao,N.,
            Mohamadzadeh,M. and Dudeja,P.K.
  TITLE     A Novel Role of SLC26A3 in the Maintenance of Intestinal Epithelial
            Barrier Integrity
  JOURNAL   Gastroenterology 160 (4), 1240-1255 (2021)
   PUBMED   33189700
  REMARK    GeneRIF: A Novel Role of SLC26A3 in the Maintenance of Intestinal
            Epithelial Barrier Integrity.
REFERENCE   5  (bases 1 to 2882)
  AUTHORS   Hayashi,H., Nagai,H., Ohba,K.I., Soleimani,M. and Suzuki,Y.
  TITLE     Segmental differences in Slc26a3-dependent Cl- absorption and HCO3-
            secretion in the mouse large intestine in vitro in Ussing chambers
  JOURNAL   J Physiol Sci 71 (1), 5 (2021)
   PUBMED   33514305
  REMARK    GeneRIF: Segmental differences in Slc26a3-dependent Cl(-)
            absorption and HCO3(-) secretion in the mouse large intestine in
            vitro in Ussing chambers.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2882)
  AUTHORS   Byeon,M.K., Frankel,A., Papas,T.S., Henderson,K.W. and
            Schweinfest,C.W.
  TITLE     Human DRA functions as a sulfate transporter in Sf9 insect cells
  JOURNAL   Protein Expr Purif 12 (1), 67-74 (1998)
   PUBMED   9473459
REFERENCE   7  (bases 1 to 2882)
  AUTHORS   Hoglund,P., Haila,S., Socha,J., Tomaszewski,L., Saarialho-Kere,U.,
            Karjalainen-Lindsberg,M.L., Airola,K., Holmberg,C., de la
            Chapelle,A. and Kere,J.
  TITLE     Mutations of the Down-regulated in adenoma (DRA) gene cause
            congenital chloride diarrhoea
  JOURNAL   Nat Genet 14 (3), 316-319 (1996)
   PUBMED   8896562
REFERENCE   8  (bases 1 to 2882)
  AUTHORS   Taguchi,T., Testa,J.R., Papas,T.S. and Schweinfest,C.
  TITLE     Localization of a candidate colon tumor-suppressor gene (DRA) to
            7q22-q31.1 by fluorescence in situ hybridization
  JOURNAL   Genomics 20 (1), 146-147 (1994)
   PUBMED   8020951
REFERENCE   9  (bases 1 to 2882)
  AUTHORS   Sandal,N.N. and Marcker,K.A.
  TITLE     Similarities between a soybean nodulin, Neurospora crassa sulphate
            permease II and a putative human tumour suppressor
  JOURNAL   Trends Biochem Sci 19 (1), 19 (1994)
   PUBMED   8140616
  REMARK    Review article
REFERENCE   10 (bases 1 to 2882)
  AUTHORS   Schweinfest,C.W., Henderson,K.W., Suster,S., Kondoh,N. and
            Papas,T.S.
  TITLE     Identification of a colon mucosa gene that is down-regulated in
            colon adenomas and adenocarcinomas
  JOURNAL   Proc Natl Acad Sci U S A 90 (9), 4166-4170 (1993)
   PUBMED   7683425
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BP262081.1, BC025671.1 and
            AC002467.1.
            
            On Aug 31, 2019 this sequence version replaced NM_000111.2.
            
            Summary: The protein encoded by this gene is a transmembrane
            glycoprotein that transports chloride ions across the cell membrane
            in exchange for bicarbonate ions. It is localized to the mucosa of
            the lower intestinal tract, particularly to the apical membrane of
            columnar epithelium and some goblet cells. The protein is essential
            for intestinal chloride absorption, and mutations in this gene have
            been associated with congenital chloride diarrhea. [provided by
            RefSeq, Oct 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: L02785.1, SRR11853560.26530.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000340010.10/ ENSP00000345873.5
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-16                BP262081.1         11-26
            17-2153             BC025671.1         1-2137
            2154-2154           AC002467.1         89527-89527         c
            2155-2879           BC025671.1         2139-2863
            2880-2882           AC002467.1         81022-81024         c
FEATURES             Location/Qualifiers
     source          1..2882
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q22.3-q31.1"
     gene            1..2882
                     /gene="SLC26A3"
                     /gene_synonym="CLD; DRA"
                     /note="solute carrier family 26 member 3"
                     /db_xref="GeneID:1811"
                     /db_xref="HGNC:HGNC:3018"
                     /db_xref="MIM:126650"
     exon            1..113
                     /gene="SLC26A3"
                     /gene_synonym="CLD; DRA"
                     /inference="alignment:Splign:2.1.0"
     exon            114..332
                     /gene="SLC26A3"
                     /gene_synonym="CLD; DRA"
                     /inference="alignment:Splign:2.1.0"
     CDS             202..2496
                     /gene="SLC26A3"
                     /gene_synonym="CLD; DRA"
                     /note="down-regulated in adenoma protein; solute carrier
                     family 26 (anion exchanger), member 3"
                     /codon_start=1
                     /product="chloride anion exchanger"
                     /protein_id="NP_000102.1"
                     /db_xref="CCDS:CCDS5748.1"
                     /db_xref="GeneID:1811"
                     /db_xref="HGNC:HGNC:3018"
                     /db_xref="MIM:126650"
                     /translation="MIEPFGNQYIVARPVYSTNAFEENHKKTGRHHKTFLDHLKVCCS
                     CSPQKAKRIVLSLFPIASWLPAYRLKEWLLSDIVSGISTGIVAVLQGLAFALLVDIPP
                     VYGLYASFFPAIIYLFFGTSRHISVGPFPILSMMVGLAVSGAVSKAVPDRNATTLGLP
                     NNSNNSSLLDDERVRVAAAASVTVLSGIIQLAFGILRIGFVVIYLSESLISGFTTAAA
                     VHVLVSQLKFIFQLTVPSHTDPVSIFKVLYSVFSQIEKTNIADLVTALIVLLVVSIVK
                     EINQRFKDKLPVPIPIEFIMTVIAAGVSYGCDFKNRFKVAVVGDMNPGFQPPITPDVE
                     TFQNTVGDCFGIAMVAFAVAFSVASVYSLKYDYPLDGNQELIALGLGNIVCGVFRGFA
                     GSTALSRSAVQESTGGKTQIAGLIGAIIVLIVVLAIGFLLAPLQKSVLAALALGNLKG
                     MLMQFAEIGRLWRKDKYDCLIWIMTFIFTIVLGLGLGLAASVAFQLLTIVFRTQFPKC
                     STLANIGRTNIYKNKKDYYDMYEPEGVKIFRCPSPIYFANIGFFRRKLIDAVGFSPLR
                     ILRKRNKALRKIRKLQKQGLLQVTPKGFICTVDTIKDSDEELDNNQIEVLDQPINTTD
                     LPFHIDWNDDLPLNIEVPKISLHSLILDFSAVSFLDVSSVRGLKSILQEFIRIKVDVY
                     IVGTDDDFIEKLNRYEFFDGEVKSSIFFLTIHDAVLHILMKKDYSTSKFNPSQEKDGK
                     IDFTINTNGGLRNRVYEVPVETKF"
     exon            333..472
                     /gene="SLC26A3"
                     /gene_synonym="CLD; DRA"
                     /inference="alignment:Splign:2.1.0"
     exon            473..583
                     /gene="SLC26A3"
                     /gene_synonym="CLD; DRA"
                     /inference="alignment:Splign:2.1.0"
     exon            584..771
                     /gene="SLC26A3"
                     /gene_synonym="CLD; DRA"
                     /inference="alignment:Splign:2.1.0"
     exon            772..936
                     /gene="SLC26A3"
                     /gene_synonym="CLD; DRA"
                     /inference="alignment:Splign:2.1.0"
     exon            937..1089
                     /gene="SLC26A3"
                     /gene_synonym="CLD; DRA"
                     /inference="alignment:Splign:2.1.0"
     exon            1090..1172
                     /gene="SLC26A3"
                     /gene_synonym="CLD; DRA"
                     /inference="alignment:Splign:2.1.0"
     exon            1173..1320
                     /gene="SLC26A3"
                     /gene_synonym="CLD; DRA"
                     /inference="alignment:Splign:2.1.0"
     exon            1321..1434
                     /gene="SLC26A3"
                     /gene_synonym="CLD; DRA"
                     /inference="alignment:Splign:2.1.0"
     exon            1435..1512
                     /gene="SLC26A3"
                     /gene_synonym="CLD; DRA"
                     /inference="alignment:Splign:2.1.0"
     exon            1513..1608
                     /gene="SLC26A3"
                     /gene_synonym="CLD; DRA"
                     /inference="alignment:Splign:2.1.0"
     exon            1609..1715
                     /gene="SLC26A3"
                     /gene_synonym="CLD; DRA"
                     /inference="alignment:Splign:2.1.0"
     exon            1716..1785
                     /gene="SLC26A3"
                     /gene_synonym="CLD; DRA"
                     /inference="alignment:Splign:2.1.0"
     exon            1786..1878
                     /gene="SLC26A3"
                     /gene_synonym="CLD; DRA"
                     /inference="alignment:Splign:2.1.0"
     exon            1879..1974
                     /gene="SLC26A3"
                     /gene_synonym="CLD; DRA"
                     /inference="alignment:Splign:2.1.0"
     exon            1975..2208
                     /gene="SLC26A3"
                     /gene_synonym="CLD; DRA"
                     /inference="alignment:Splign:2.1.0"
     exon            2209..2263
                     /gene="SLC26A3"
                     /gene_synonym="CLD; DRA"
                     /inference="alignment:Splign:2.1.0"
     exon            2264..2406
                     /gene="SLC26A3"
                     /gene_synonym="CLD; DRA"
                     /inference="alignment:Splign:2.1.0"
     exon            2407..2472
                     /gene="SLC26A3"
                     /gene_synonym="CLD; DRA"
                     /inference="alignment:Splign:2.1.0"
     exon            2473..2882
                     /gene="SLC26A3"
                     /gene_synonym="CLD; DRA"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2860..2865
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC26A3"
                     /gene_synonym="CLD; DRA"
                     /note="hexamer: ATTAAA"
     polyA_site      2882
                     /gene="SLC26A3"
                     /gene_synonym="CLD; DRA"
                     /note="major polyA site"
ORIGIN      
        1 acacagagcc tgtagacctg agtggatgga cactgcctct tagaactaga acttagaact
       61 ttatcttgaa aatgtaccac tgttgcagaa gctcctcaca gagtatgtgt caggcatttt
      121 taacctgcta aaggcaagaa gaagtgttca ccacatagtt gcaaaggtct tcaacttgcc
      181 acagccaaca gaaaaatcaa aatgattgaa ccctttggga atcagtatat tgtggccagg
      241 ccagtgtatt ctacaaatgc ttttgaggaa aatcataaaa agacaggaag acatcataag
      301 acatttctgg atcatctcaa agtgtgttgt agctgttccc cacaaaaggc caagagaatt
      361 gtcctctctt tgttccccat agcatcttgg ttgccagcat accggcttaa agaatggttg
      421 ctcagtgata ttgtttctgg tatcagcaca gggattgtgg ccgtactaca aggtttagca
      481 tttgctctgc tggtcgacat tcccccagtc tatgggttgt atgcatcctt tttcccagcc
      541 ataatctacc ttttcttcgg cacttccaga cacatatccg tgggtccgtt tccgattctg
      601 agtatgatgg tgggactagc agtttcagga gcagtttcaa aagcagtccc agatcgcaat
      661 gcaactactt tgggattgcc taacaactcg aataattctt cactactgga tgacgagagg
      721 gtgagggtgg cggcggcggc atcagtcaca gtgctttctg gaatcatcca gttggctttt
      781 gggattctgc ggattggatt tgtagtgata tacctgtctg agtccctcat cagtggcttc
      841 actactgctg ctgctgttca tgttttggtt tcccaactca aattcatttt tcagttgaca
      901 gtcccgtcac acactgatcc agtttcaatt ttcaaagtac tatactctgt attctcacaa
      961 atagagaaga ctaatattgc agacctggtg acagctctga ttgtcctttt ggttgtatcc
     1021 attgttaaag aaataaatca gcgcttcaaa gacaaacttc cagtgcccat tccaatcgaa
     1081 ttcattatga ccgtgattgc agcaggtgta tcctacggct gtgactttaa aaacaggttt
     1141 aaagtggctg tggttgggga catgaatcct ggatttcagc cccctattac acctgacgtg
     1201 gagactttcc aaaacaccgt aggagattgc ttcggcatcg caatggttgc atttgcagtg
     1261 gccttttcag ttgccagcgt ctattccctc aaatacgatt atccacttga tggcaatcag
     1321 gagttaatag ccttgggact gggtaacata gtctgtggag tattcagagg atttgctggg
     1381 agtactgccc tctccagatc agcagttcag gagagcacag gaggcaaaac acagattgct
     1441 gggcttattg gtgccatcat cgtgctgatt gtcgttctag ccattggatt tctcctggcg
     1501 cctctacaaa agtccgtcct ggcagcttta gcattgggaa acttaaaggg aatgctgatg
     1561 cagtttgctg aaataggcag attgtggcga aaggacaaat atgattgttt aatttggatc
     1621 atgaccttca tcttcaccat tgtcctggga ctcgggttag gcctggcagc tagtgtggca
     1681 tttcaactgc taaccatcgt gttcaggacc caatttccaa aatgcagcac gctggctaat
     1741 attggaagaa ccaacatcta taagaataaa aaagattatt atgatatgta tgagccagaa
     1801 ggagtgaaaa ttttcagatg tccatctcct atctactttg caaacattgg tttctttagg
     1861 cggaaactta tcgatgctgt tggctttagt ccacttcgaa ttctacgcaa gcgcaacaaa
     1921 gctttgagga aaatccgaaa actgcagaag caaggcttgc tacaagtgac accaaaagga
     1981 tttatatgta ctgttgacac cataaaagat tctgacgaag agctggacaa caatcagata
     2041 gaagtactgg accagccaat caataccaca gacctgcctt tccacattga ctggaatgat
     2101 gatcttcctc tcaacattga ggtccccaaa atcagcctcc acagcctcat tcttgacttt
     2161 tcagcagtgt cctttcttga tgtttcttca gtgaggggcc ttaaatcgat tttgcaagaa
     2221 tttatcagga tcaaggtaga tgtgtatatc gttggaactg atgatgactt cattgagaag
     2281 cttaaccggt atgaattttt tgatggtgaa gtgaaaagct caatattttt cttaacaatc
     2341 catgatgctg ttttgcatat tttgatgaag aaagattaca gtacttcaaa gtttaatccc
     2401 agtcaggaaa aagatggaaa aattgatttt accataaata caaatggagg attacgtaat
     2461 cgggtatatg aggtgccagt tgaaacaaaa ttctaatcaa catataattc agaaggatct
     2521 tcatctgact atgacataaa aacaacttta tacccagaaa gttattgata agttcataca
     2581 ttgtacgaag agtatttttg acagaatatg tttcaaactt tggaacaaga tggttctagc
     2641 atggcatatt tttcacatat ctagtatgaa attatataag tattctaaat tttatatctt
     2701 gtagctttat caaagggtga aaattatttt gttcatacat atttttgtag cactgacaga
     2761 tttccatcct agtcactacc ttcatgcata ggtttagcag tatagtggcg ccactgtttt
     2821 gaatctcata atttatacag gtcatattaa tatatttcca ttaaaaaatc agttgtacag
     2881 tg
//
