LOCUS       NM_000112               8054 bp    mRNA    linear   PRI 12-OCT-2024
DEFINITION  Homo sapiens solute carrier family 26 member 2 (SLC26A2), mRNA.
ACCESSION   NM_000112
VERSION     NM_000112.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8054)
  AUTHORS   Li,S., Sheng,Y., Wang,X., Wang,Y., Zhang,Y., Wu,C. and Jiang,X.
  TITLE     [Analysis of genetic variants and molecular pathogenesis in a
            Chinese pedigree affected with Multiple epiphyseal dysplasia]
  JOURNAL   Zhonghua Yi Xue Yi Chuan Xue Za Zhi 41 (7), 807-811 (2024)
   PUBMED   38946362
  REMARK    GeneRIF: [Analysis of genetic variants and molecular pathogenesis
            in a Chinese pedigree affected with Multiple epiphyseal dysplasia].
REFERENCE   2  (bases 1 to 8054)
  AUTHORS   Li,S., Sheng,Y., Wang,X., Wang,Q., Wang,Y., Zhang,Y., Wu,C. and
            Jiang,X.
  TITLE     Biallelic variants in SLC26A2 cause multiple epiphyseal dysplasia-4
            by disturbing chondrocyte homeostasis
  JOURNAL   Orphanet J Rare Dis 19 (1), 245 (2024)
   PUBMED   38956600
  REMARK    GeneRIF: Biallelic variants in SLC26A2 cause multiple epiphyseal
            dysplasia-4 by disturbing chondrocyte homeostasis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 8054)
  AUTHORS   Markova,T., Kenis,V., Melchenko,E., Alieva,A., Nagornova,T.,
            Orlova,A., Ogorodova,N., Shchagina,O., Polyakov,A., Dadali,E. and
            Kutsev,S.
  TITLE     Clinical and Genetic Characteristics of Multiple Epiphyseal
            Dysplasia Type 4
  JOURNAL   Genes (Basel) 13 (9), 1512 (2022)
   PUBMED   36140680
  REMARK    GeneRIF: Clinical and Genetic Characteristics of Multiple
            Epiphyseal Dysplasia Type 4.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 8054)
  AUTHORS   Superti-Furga,A., Hastbacka,J., Wilcox,W.R., Cohn,D.H., van der
            Harten,H.J., Rossi,A., Blau,N., Rimoin,D.L., Steinmann,B.,
            Lander,E.S. and Gitzelmann,R.
  TITLE     Achondrogenesis type IB is caused by mutations in the diastrophic
            dysplasia sulphate transporter gene
  JOURNAL   Nat Genet 12 (1), 100-102 (1996)
   PUBMED   8528239
REFERENCE   5  (bases 1 to 8054)
  AUTHORS   Hastbacka,J., de la Chapelle,A., Mahtani,M.M., Clines,G.,
            Reeve-Daly,M.P., Daly,M., Hamilton,B.A., Kusumi,K., Trivedi,B.,
            Weaver,A. et al.
  TITLE     The diastrophic dysplasia gene encodes a novel sulfate transporter:
            positional cloning by fine-structure linkage disequilibrium mapping
  JOURNAL   Cell 78 (6), 1073-1087 (1994)
   PUBMED   7923357
REFERENCE   6  (bases 1 to 8054)
  AUTHORS   Unger,S. and Superti-Furga,A.
  TITLE     Achondrogenesis Type 1B
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301689
REFERENCE   7  (bases 1 to 8054)
  AUTHORS   Unger,S. and Superti-Furga,A.
  TITLE     Diastrophic Dysplasia
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301524
REFERENCE   8  (bases 1 to 8054)
  AUTHORS   Superti-Furga,A. and Unger,S.
  TITLE     SLC26A2-Related Atelosteogenesis
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301493
REFERENCE   9  (bases 1 to 8054)
  AUTHORS   Unger,S. and Superti-Furga,A.
  TITLE     SLC26A2-Related Multiple Epiphyseal Dysplasia
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301483
REFERENCE   10 (bases 1 to 8054)
  AUTHORS   Hastbacka,J., Sistonen,P., Kaitila,I., Weiffenbach,B., Kidd,K.K.
            and de la Chapelle,A.
  TITLE     A linkage map spanning the locus for diastrophic dysplasia (DTD)
  JOURNAL   Genomics 11 (4), 968-973 (1991)
   PUBMED   1783404
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC008427.9, BC059390.1 and
            AW089339.1.
            
            On Aug 31, 2019 this sequence version replaced NM_000112.3.
            
            Summary: The diastrophic dysplasia sulfate transporter is a
            transmembrane glycoprotein implicated in the pathogenesis of
            several human chondrodysplasias. It apparently is critical in
            cartilage for sulfation of proteoglycans and matrix organization.
            [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038193.4533623.1,
                                           SRR14038196.951113.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000286298.5/ ENSP00000286298.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-125               AC008427.9         146025-146149
            126-1967            BC059390.1         1-1842
            1968-7644           AC008427.9         166581-172257
            7645-8054           AW089339.1         8-417               c
FEATURES             Location/Qualifiers
     source          1..8054
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q32"
     gene            1..8054
                     /gene="SLC26A2"
                     /gene_synonym="D5S1708; DTD; DTDST; EDM4; MST153; MSTP157"
                     /note="solute carrier family 26 member 2"
                     /db_xref="GeneID:1836"
                     /db_xref="HGNC:HGNC:10994"
                     /db_xref="MIM:606718"
     exon            1..222
                     /gene="SLC26A2"
                     /gene_synonym="D5S1708; DTD; DTDST; EDM4; MST153; MSTP157"
                     /inference="alignment:Splign:2.1.0"
     exon            223..946
                     /gene="SLC26A2"
                     /gene_synonym="D5S1708; DTD; DTDST; EDM4; MST153; MSTP157"
                     /inference="alignment:Splign:2.1.0"
     CDS             248..2467
                     /gene="SLC26A2"
                     /gene_synonym="D5S1708; DTD; DTDST; EDM4; MST153; MSTP157"
                     /note="sulfate anion transporter 1; diastrophic dysplasia
                     protein; solute carrier family 26 (sulfate transporter),
                     member 2; solute carrier family 26 (anion exchanger),
                     member 2"
                     /codon_start=1
                     /product="sulfate transporter"
                     /protein_id="NP_000103.2"
                     /db_xref="CCDS:CCDS4300.1"
                     /db_xref="GeneID:1836"
                     /db_xref="HGNC:HGNC:10994"
                     /db_xref="MIM:606718"
                     /translation="MSSESKEQHNVSPRDSAEGNDSYPSGIHLELQRESSTDFKQFET
                     NDQCRPYHRILIERQEKSDTNFKEFVIKKLQKNCQCSPAKAKNMILGFLPVLQWLPKY
                     DLKKNILGDVMSGLIVGILLVPQSIAYSLLAGQEPVYGLYTSFFASIIYFLLGTSRHI
                     SVGIFGVLCLMIGETVDRELQKAGYDNAHSAPSLGMVSNGSTLLNHTSDRICDKSCYA
                     IMVGSTVTFIAGVYQVAMGFFQVGFVSVYLSDALLSGFVTGASFTILTSQAKYLLGLN
                     LPRTNGVGSLITTWIHVFRNIHKTNLCDLITSLLCLLVLLPTKELNEHFKSKLKAPIP
                     IELVVVVAATLASHFGKLHENYNSSIAGHIPTGFMPPKVPEWNLIPSVAVDAIAISII
                     GFAITVSLSEMFAKKHGYTVKANQEMYAIGFCNIIPSFFHCFTTSAALAKTLVKESTG
                     CHTQLSGVVTALVLLLVLLVIAPLFYSLQKSVLGVITIVNLRGALRKFRDLPKMWSIS
                     RMDTVIWFVTMLSSALLSTEIGLLVGVCFSIFCVILRTQKPKSSLLGLVEESEVFESV
                     SAYKNLQIKPGIKIFRFVAPLYYINKECFKSALYKQTVNPILIKVAWKKAAKRKIKEK
                     VVTLGGIQDEMSVQLSHDPLELHTIVIDCSAIQFLDTAGIHTLKEVRRDYEAIGIQVL
                     LAQCNPTVRDSLTNGEYCKKEEENLLFYSVYEAMAFAEVSKNQKGVCVPNGLSLSSD"
     exon            947..8054
                     /gene="SLC26A2"
                     /gene_synonym="D5S1708; DTD; DTDST; EDM4; MST153; MSTP157"
                     /inference="alignment:Splign:2.1.0"
     regulatory      8032..8037
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC26A2"
                     /gene_synonym="D5S1708; DTD; DTDST; EDM4; MST153; MSTP157"
                     /note="hexamer: AATAAA"
     polyA_site      8054
                     /gene="SLC26A2"
                     /gene_synonym="D5S1708; DTD; DTDST; EDM4; MST153; MSTP157"
                     /note="major polyA site"
ORIGIN      
        1 gtttacactg gctctgcctc cggcatctct tcgccggtgc gtcctcgccg cgcccgtagg
       61 tcccggcagc cgggccccgc ctccttcgga gtccgagcga tgggcgggga aagggacagg
      121 caggtatagc tctgtcggcg ccgcggtgtc cacctcagtc aggccacggt ggaagacgcg
      181 tgccgcggcg cctggttgcc tgcagcggcc cggacccgag aggaagctga accatctatc
      241 tccagaaatg tcttcagaaa gtaaagagca acataacgtt tcacccagag actcagctga
      301 aggaaatgac agttatccat ctgggatcca tctggaactt caaagggaat caagtactga
      361 cttcaagcaa tttgagacca atgatcaatg cagaccttat cataggatcc ttattgagcg
      421 tcaagagaaa tcagatacaa acttcaagga gtttgttatt aaaaagctgc agaagaattg
      481 ccagtgcagt ccagccaaag ccaaaaatat gattttaggt ttccttcctg ttttgcagtg
      541 gctcccaaaa tacgacctaa agaaaaacat tttaggggat gtgatgtcag gcttgattgt
      601 gggcatatta ttggtgcccc agtccattgc ttattccctg ctggctggcc aagaacctgt
      661 ctatggtctg tacacatctt tttttgccag catcatttat tttctcttgg gtacctcccg
      721 tcacatctct gtgggcattt ttggagtact gtgccttatg attggtgaga cagttgaccg
      781 agaactacag aaagctggct atgacaatgc ccatagtgct ccttccttag gaatggtttc
      841 aaatgggagc acattattaa atcatacatc agacaggata tgtgacaaaa gttgctatgc
      901 aattatggtt ggcagcactg taacctttat agctggagtt tatcaggtag cgatgggctt
      961 ctttcaagtg ggttttgttt ctgtctacct ctcagatgcc ttgctgagtg gatttgtcac
     1021 tggtgcctcc ttcactattc ttacatctca ggccaagtat cttcttgggc tcaaccttcc
     1081 tcggactaat ggtgtgggct cactcatcac tacctggata catgtcttca gaaacatcca
     1141 taagaccaat ctctgtgatc ttatcaccag ccttttgtgc cttttggttc ttttgccaac
     1201 caaagaactc aatgaacact tcaaatccaa gcttaaggca ccgattccta ttgaacttgt
     1261 tgttgttgta gcagccacat tagcctctca ttttggaaaa ctacatgaaa attataattc
     1321 tagtattgct ggacatattc ccactgggtt tatgccaccc aaagtaccag aatggaacct
     1381 aattcctagt gtggctgtag atgcaatagc tatttccatc attggttttg ctatcactgt
     1441 atcactttct gagatgtttg ccaagaaaca tggttacaca gtcaaagcaa accaggaaat
     1501 gtatgccatt ggcttttgta atatcatccc ttccttcttc cactgtttta ctactagtgc
     1561 agctcttgca aagacattgg ttaaagaatc aacaggctgc catactcagc tttctggtgt
     1621 ggtaacagcc ctggttcttt tgttggtcct cctagtaata gctcctttgt tctattccct
     1681 tcaaaaaagt gtccttggtg tgatcacaat tgtaaatcta cggggagccc ttcgtaaatt
     1741 tagggatctt cccaaaatgt ggagtattag tagaatggat acagttatct ggtttgttac
     1801 tatgctgtcc tctgcactgc taagtactga aataggccta cttgttgggg tttgtttttc
     1861 tatattttgt gtcatcctcc gcactcagaa gccaaagagt tcactgcttg gcttggtgga
     1921 agagtctgag gtctttgaat ctgtgtctgc ttacaagaac cttcagatta agccaggcat
     1981 caagattttc cgctttgtag cccctctcta ctacataaac aaagaatgct ttaaatctgc
     2041 tttatacaaa caaactgtca acccaatctt aataaaggtg gcttggaaga aggcagcaaa
     2101 gagaaagatc aaagaaaaag tagtgactct tggtggaatc caggatgaaa tgtcagtgca
     2161 actttcccat gatcccttgg agctgcatac tatagtgatt gactgcagtg caattcaatt
     2221 tttagataca gcagggatcc acacactgaa agaagttcgc agagattatg aagccattgg
     2281 aatccaggtt ctgctggctc agtgcaatcc cactgtgagg gattccctaa ccaacggaga
     2341 atattgcaaa aaggaagaag aaaaccttct cttctatagt gtgtatgaag cgatggcttt
     2401 tgcagaagta tctaaaaatc agaaaggagt atgtgttccc aatggtctga gtcttagtag
     2461 tgattaattg agaaggtaga tagaagaatg tctagccaat aggttaaaat ttcaagtgtc
     2521 caacatttcc cagttccaca gtgggaaatt ttgcacactt gaaattttaa ccaagtggct
     2581 agatattatt cctcctttga agctaatggc atttgtatat acacactgca gcagagcttg
     2641 tagctggaca gagtcaaaaa gaagaaaata cggtttcagg ctttcttgca gatatgaagt
     2701 attcttggaa tgcaataagt atgtattgaa ctgtactgta aagtagctcc aaaacttaat
     2761 tactctcctg ttttaggggt tatacatttg gactgtgcat tctccaagag atgaagcggt
     2821 gaagttggga tttacattgg aagtgctgta gacttcttta tgtggctcag tggagagagg
     2881 gaaagaatgt tgcacctgct ctagtaccat aggtcaagag gcttctggat cacaaagtca
     2941 taactagaca ggtttgttct tgtagttttc tatccccagt ctttgctccc cagatggcag
     3001 tagtttttag taggaaagtg ccattcctgt ccttaaggca cagtctcatc agaagtctaa
     3061 tacctgggca ggtttataac atcctgagag ccagcctgac attagacaga ataccctttg
     3121 taatacattg gaaattttta ctcatgcctt tttgtttagg ataaataggt aagcacaaag
     3181 agctcttcaa aatcagaaaa aacaatagga gtccttcctt gtcttttctg tgatctctgt
     3241 ccttgtttct gagactttct ctaccattaa gctctatttt agctttcagt tattctagtt
     3301 tgtttcccat ggaatctgtc ctaaactggt gtttttgtca gtgacagtct tgccagtcag
     3361 caatttctaa cagcatttta aatgagtttg atgtacagta aatattgatg acaatgacag
     3421 cttttaactc ttcaagtcac ctaaagctat tatgcaggag gatttagaag tcacattcat
     3481 aaaacccaag tgctatgggt gtattattca tgatagctgg cccacaggtc atgaattgag
     3541 gaggaatttg ctttcaaaaa gcaagaatgt ccaacactga aagtttatag ttttatattt
     3601 ggaccttgaa aggtaagaaa aaaccaggtt ctccaaagtt aggaataggg aactaattta
     3661 tgaaacagcc atcttaaaaa aaaaaaaagt aaactgcaaa agtacaaaat catttttcaa
     3721 tctgttccca gtttctaaac aattttaaat atttatgaga agcaaaccct atgtgtaggg
     3781 catctgttgg agtgggatgc ttttagacat atattaagta tgtacatgtt taatatgtat
     3841 atttaaaatg catatatatt ttattatatc tatattatcc tatatagata tatgtaactt
     3901 agctttattg ttagctccat aagctgccag tgttgctttt ctgttggtag agctctccca
     3961 tttggtgaca tggaaaatac ctttccatta tcacaacaaa gcagttgctc agtagaaagt
     4021 ctagatttct gtcttatagg tgatttctgt cttataggtg attataatca agtgtaggct
     4081 tcctgaattt tgacatcctt ttagaacttg ggtctggaat tccagaaatg ttaattgctg
     4141 cttgtatttg ttcttgtttg ttttttagcc agtatttgcc ctttctatcc agccttatga
     4201 ataatagcag taaaatcaca gtatcttggt cagtctttat ttttttcctt ttttcttttt
     4261 taagagacag tcatccaggc cagagtgcag tttgatgata gcttactgaa gcttcccact
     4321 cctgggctca agttatcctt ccattttggc ctcctgagta gctagaccat aggtatgcat
     4381 caccacaccc tgctaatttt ttaaattttt ttctagagag agggtctcac tgtgttgccc
     4441 aggctggtct caaactccag gctcaagcaa tccttcagcc tcagcctccc agagtgttgg
     4501 gattacaggc gtgagccact gcacttggcc aagttattta tttttaatct ctcttgccct
     4561 tctcccaagg caggcttaag ttgagactat tataggtgtc taataacctg tgacagagta
     4621 atgagtacat gcttaagatg ttataattag ccaacaccaa cacagcaaaa aatataattc
     4681 cagccaaaga ttctggaaaa tccctcagaa ggagggataa caggatttga cctttaccag
     4741 cgatttctgt ccatatgtgg atgtaaacag ttctggaacg ttatgcatgc agttagcgaa
     4801 tccttgaatt atgttctggt ttgtacttgt cccatccatc caaacaagag attctgcttt
     4861 tggtagccat ctgtagaaac atttaagatg tcactagaat ttacatttca tcctctctac
     4921 ttgggttgag gttgcctata cttgcatatt gttaaaatgt tttggttgct gatattcaga
     4981 ggaatgaaac ctggaaccaa agcctaattt gccgataaaa aaactgtttt cggccaggtg
     5041 cagtggctca tgcctgtaat cccagcacgt tgggaggccg aggcgggtgg atcacctgaa
     5101 gtcaggagtt cgagaccatc ctggctaaca ctgtgaaacc ccgtctctac taaaaataca
     5161 aaaaattagc ggggcatggt ggcacgcgcc tgtagtccca gctactcagg aggctgaggc
     5221 aggagaatta cttgaacccg ggaggcggag gttgcagtaa gcagagattg tgccactgga
     5281 ctccagcctg ggtgacagag cgagactccg tctcaaacaa acaaacaaaa aactgttttc
     5341 atttgctctc ttgaccaaag gataggactt tagttcttta agcattattt taaacactat
     5401 attgatacaa aaatatcttg cttactctaa actttagagt ctaaatgaag ctttttctca
     5461 gtacaagatt ctgagtatca taaaatggtt atttaattga aacgtagtgt ggtatactct
     5521 tgatggttag aactcttaca gccttattta tttttaagtt tgttacagcc aaagggttgg
     5581 agtgtgccag tgcacaggta gactaaggaa aacattatag aggagtgaag agaacagacc
     5641 attgaaaaga ctattatctg accagcggag gcagaaaaga gaggaaccca gttgaatagg
     5701 atccaatccc tggttagcct ctacacaata atagggagac aaggattagg agccatacct
     5761 cccagagcaa ggtatctttc tagagcaaat ttctctttct agaaggggag ggtcacaggg
     5821 tcacagattc accaaagctg aaagggctga ggagctcatg gtagcctggg ctgacctact
     5881 ctggagcacg gtgtcttcct tctaaactga gtgactgtag tactatctgt gcctctgatg
     5941 gtaataaaac tgacaagatg tctaattttt ttttaagtag gaccaaagga aaacaagatt
     6001 tagatagtct gactttgctt ttgaacaaca gacattgcaa gtcaaaattg ttgtcaaatt
     6061 tacatatggt aaatgatgaa ctttaaaaat gtgtccaggt gttagatgag ttcattagac
     6121 tcttttaatg ctaatggcta gtacgtttaa acaaaacagc agttctctgc tgcaatattc
     6181 ccattgacca cttaaatgac cataagtggt catttaagaa catgttaggg ttagccctga
     6241 tctgaatata aaagtgagaa aagggctaca gtgcatttct tggtaactta aactgagtct
     6301 tgaagttata atgatccatt cgagttctgt gatccttatt gttcttaatt gtgtttctct
     6361 acgtattgtt acagatgagc catacgtttc tttgtatcaa tgtagacatg acttcagata
     6421 cctctgagga cctacccagc agtctaggac cctgggccaa gtgctgggac tatggtacta
     6481 aatccagtag atgggctgtg tagcaactct cccagggaac acactagggt acttagggag
     6541 gtgctttgtg gagcatgttg aagctttgag atctgagcag gaggcagtga tgtccctggt
     6601 ctattcaggg aaagatttca gtgtgaaatg gtaaacatcc aattgacagg atttagattt
     6661 tgcttagttt ttctgctttt taatgtttct atcccccatc tcagtgtttt ctttatccat
     6721 cccagtgatg ccttatttga aactgggctt aaactgcaaa aagaatgaag ttggatttag
     6781 gaagctgtta gatcattgag tggtgttgag agtgaagttt cactagcagg gaagtttcct
     6841 tgagcctaaa ataaaaagaa aaaattaaaa agaatcagtt tttttaatta aaaaaataga
     6901 aagctgttag gctcctaatt cgtggggttt ttttttgtaa aaacagttta gataatcctg
     6961 aatgcaatca ttaacttggt tgctaattac aagaatgaaa attataatgg aaaaggacaa
     7021 aataatatac cagctggttt gttattatag tccgtgtatt aaaatactat tgaaatacgt
     7081 taaaggtaaa tttttaaggt ttaaaaaaaa tttagtaact tacagggatg gagaatttag
     7141 atgtcagagg tggggagatt tatttttata aggtaatttt tatcctgata aggacttaaa
     7201 aaaaagtttt gcaactgaaa ttttaaagta aacatgttaa gtacagttaa aaagtaagca
     7261 ttgtagtaaa tagtggattc tctggtgtgt attttttatc tcagtgttga aaattggaaa
     7321 agaatggact gaagtctaaa aactggaata atgaaggaca ctaaatgcct ttattgtaga
     7381 tactatgttt gtaagtctat agctaagcaa cttaagccaa aaaggtcttt caactgaagc
     7441 tttaatcaac ttattttgga gatgttctct tcccttatct catgcgtcat ccctaaaata
     7501 ataagataca tgggatcaaa tagcccttgc cttttcaaca caaatcagtt ggaaaattat
     7561 ggtttgagtc ctgttgctgc catggcttct gtttctcaga aatgagtgtg tatgaacata
     7621 ccaatctatg taataggcta cctttttttg tcttctttgg aactttgtac acaaaccaag
     7681 acaatatcag ggtgacaggt gaatgaactt aaattctcag tcttgtctat tcaccaaaaa
     7741 agtatactgc ctgttttttc tttaattatt caaggttgat gacttttagg aacatgtttt
     7801 atactgtatt ttttaattaa agcaagtgcc ttgatgtaat tccatgtaaa tcattgctta
     7861 accctcttat gggatgagga tgagttatta atgtattgca gcctactgga aaggaggggg
     7921 agttggttaa tagcagatac ttttcttcta gaagcttatg ttttatgctg tttattatgt
     7981 aagatcctgt atgtgtgttg agatttagag gtttcatttg ttttgtctgc taataaattg
     8041 ttactctaat aata
//
