LOCUS       NM_001166347            2888 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens solute carrier family 26 member 11 (SLC26A11),
            transcript variant 1, mRNA.
ACCESSION   NM_001166347
VERSION     NM_001166347.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2888)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 2888)
  AUTHORS   Li,J., Xia,F. and Reithmeier,R.A.
  TITLE     N-glycosylation and topology of the human SLC26 family of anion
            transport membrane proteins
  JOURNAL   Am J Physiol Cell Physiol 306 (10), C943-C960 (2014)
   PUBMED   24647542
REFERENCE   3  (bases 1 to 2888)
  AUTHORS   Palmieri,M., Impey,S., Kang,H., di Ronza,A., Pelz,C., Sardiello,M.
            and Ballabio,A.
  TITLE     Characterization of the CLEAR network reveals an integrated control
            of cellular clearance pathways
  JOURNAL   Hum Mol Genet 20 (19), 3852-3866 (2011)
   PUBMED   21752829
  REMARK    GeneRIF: SLC26A11 protein localizes in lysosomes in HeLa cells
REFERENCE   4  (bases 1 to 2888)
  AUTHORS   Schroder,B.A., Wrocklage,C., Hasilik,A. and Saftig,P.
  TITLE     The proteome of lysosomes
  JOURNAL   Proteomics 10 (22), 4053-4076 (2010)
   PUBMED   20957757
  REMARK    Review article
REFERENCE   5  (bases 1 to 2888)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   6  (bases 1 to 2888)
  AUTHORS   Sindic,A., Chang,M.H., Mount,D.B. and Romero,M.F.
  TITLE     Renal physiology of SLC26 anion exchangers
  JOURNAL   Curr Opin Nephrol Hypertens 16 (5), 484-490 (2007)
   PUBMED   17693766
  REMARK    Review article
REFERENCE   7  (bases 1 to 2888)
  AUTHORS   Soleimani,M. and Xu,J.
  TITLE     SLC26 chloride/base exchangers in the kidney in health and disease
  JOURNAL   Semin Nephrol 26 (5), 375-385 (2006)
   PUBMED   17071331
  REMARK    Review article
REFERENCE   8  (bases 1 to 2888)
  AUTHORS   Vincourt,J.B., Jullien,D., Amalric,F. and Girard,J.P.
  TITLE     Molecular and functional characterization of SLC26A11, a
            sodium-independent sulfate transporter from high endothelial
            venules
  JOURNAL   FASEB J 17 (8), 890-892 (2003)
   PUBMED   12626430
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA290933.1, AK315132.1,
            BC035900.1, AK075248.1 and AI963799.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001166347.1.
            
            Summary: This gene encodes a member of the solute linked carrier 26
            family of anion exchangers. Members of this family of proteins are
            essential for numerous cellular functions including homeostasis and
            intracellular electrolyte balance. The encoded protein is a sodium
            independent sulfate transporter that is sensitive to the anion
            exchanger inhibitor 4,4'-diisothiocyanostilbene-2,2'-disulfonic
            acid. Alternate splicing results in multiple transcript
            variants.[provided by RefSeq, Oct 2009].
            
            Transcript Variant: This variant (1) represents the longest
            transcript. Variants 1, 2, 3 and 4 encode the same protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ544073.1, SRR1803612.45359.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000361193.8/ ENSP00000355384.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-32                DA290933.1         27-58
            33-696              AK315132.1         22-685
            697-2029            BC035900.1         662-1994
            2030-2886           AK075248.1         2016-2872
            2887-2888           AI963799.1         17-18               c
FEATURES             Location/Qualifiers
     source          1..2888
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q25.3"
     gene            1..2888
                     /gene="SLC26A11"
                     /note="solute carrier family 26 member 11"
                     /db_xref="GeneID:284129"
                     /db_xref="HGNC:HGNC:14471"
                     /db_xref="MIM:610117"
     exon            1..70
                     /gene="SLC26A11"
                     /inference="alignment:Splign:2.1.0"
     exon            71..270
                     /gene="SLC26A11"
                     /inference="alignment:Splign:2.1.0"
     exon            271..517
                     /gene="SLC26A11"
                     /inference="alignment:Splign:2.1.0"
     CDS             284..2104
                     /gene="SLC26A11"
                     /note="solute carrier family 26 (anion exchanger), member
                     11"
                     /codon_start=1
                     /product="sodium-independent sulfate anion transporter"
                     /protein_id="NP_001159819.1"
                     /db_xref="CCDS:CCDS11771.2"
                     /db_xref="GeneID:284129"
                     /db_xref="HGNC:HGNC:14471"
                     /db_xref="MIM:610117"
                     /translation="MPSSVTALGQARSSGPGMAPSACCCSPAALQRRLPILAWLPSYS
                     LQWLKMDFVAGLSVGLTAIPQALAYAEVAGLPPQYGLYSAFMGCFVYFFLGTSRDVTL
                     GPTAIMSLLVSFYTFHEPAYAVLLAFLSGCIQLAMGVLRLGFLLDFISYPVIKGFTSA
                     AAVTIGFGQIKNLLGLQNIPRPFFLQVYHTFLRIAETRVGDAVLGLVCMLLLLVLKLM
                     RDHVPPVHPEMPPGVRLSRGLVWAATTARNALVVSFAALVAYSFEVTGYQPFILTGET
                     AEGLPPVRIPPFSVTTANGTISFTEMVQDMGAGLAVVPLMGLLESIAVAKAFASQNNY
                     RIDANQELLAIGLTNMLGSLVSSYPVTGSFGRTAVNAQSGVCTPAGGLVTGVLVLLSL
                     DYLTSLFYYIPKSALAAVIIMAVAPLFDTKIFRTLWRVKRLDLLPLCVTFLLCFWEVQ
                     YGILAGALVSLLMLLHSAARPETKVSEGPVLVLQPASGLSFPAMEALREEILSRALEV
                     SPPRCLVLECTHVCSIDYTVVLGLGELLQDFQKQGVALAFVGLQVPVLRVLLSADLKG
                     FQYFSTLEEAEKHLRQEPGTQPYNIREDSILDQKVALLKA"
     exon            518..710
                     /gene="SLC26A11"
                     /inference="alignment:Splign:2.1.0"
     exon            711..796
                     /gene="SLC26A11"
                     /inference="alignment:Splign:2.1.0"
     exon            797..876
                     /gene="SLC26A11"
                     /inference="alignment:Splign:2.1.0"
     exon            877..1019
                     /gene="SLC26A11"
                     /inference="alignment:Splign:2.1.0"
     exon            1020..1195
                     /gene="SLC26A11"
                     /inference="alignment:Splign:2.1.0"
     exon            1196..1268
                     /gene="SLC26A11"
                     /inference="alignment:Splign:2.1.0"
     exon            1269..1319
                     /gene="SLC26A11"
                     /inference="alignment:Splign:2.1.0"
     exon            1320..1380
                     /gene="SLC26A11"
                     /inference="alignment:Splign:2.1.0"
     exon            1381..1436
                     /gene="SLC26A11"
                     /inference="alignment:Splign:2.1.0"
     exon            1437..1577
                     /gene="SLC26A11"
                     /inference="alignment:Splign:2.1.0"
     exon            1578..1705
                     /gene="SLC26A11"
                     /inference="alignment:Splign:2.1.0"
     exon            1706..1805
                     /gene="SLC26A11"
                     /inference="alignment:Splign:2.1.0"
     exon            1806..1939
                     /gene="SLC26A11"
                     /inference="alignment:Splign:2.1.0"
     exon            1940..2012
                     /gene="SLC26A11"
                     /inference="alignment:Splign:2.1.0"
     exon            2013..2888
                     /gene="SLC26A11"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2867..2872
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC26A11"
                     /note="hexamer: AATAAA"
     polyA_site      2888
                     /gene="SLC26A11"
                     /note="major polyA site"
ORIGIN      
        1 ctgtccccgg cgattcctgc ggacccagct gcggcgacgc caggagaccc caagctgcat
       61 cgccgagtgg aagcaactag aactccaggg ctgtgaaagc cacaggtggg ggctgagcga
      121 ggcgtggcct caggagcgga ggaccccccc actctccctc gagcgccgca gtccaccgta
      181 gcgggtggag cccgccttgg tgcgcagttg gaaaacctcg gagccccgct ggatctcctg
      241 gctgccaccc gcaccccccg ccagcctacg ccccaccgta gagatgcctt cttcggtgac
      301 ggcgctgggt caggccaggt cctctggccc cgggatggcc ccgagcgcct gctgctgctc
      361 ccctgcggcc ctgcagagga ggctgcccat cctggcgtgg ctgcccagct actccctgca
      421 gtggctgaag atggatttcg tcgccggcct ctcagttggc ctcactgcca ttccccaggc
      481 gctggcctat gctgaagtgg ctggactccc gccccagtat ggcctctact ctgccttcat
      541 gggctgcttc gtgtatttct tcctgggcac ctcccgggat gtgactctgg gccccaccgc
      601 cattatgtcc ctcctggtct ccttctacac cttccatgag cccgcctacg ctgtgctgct
      661 ggccttcctg tccggctgca tccagctggc catgggggtc ctgcgtttgg ggttcctgct
      721 ggacttcatt tcctaccccg tcattaaagg cttcacctct gctgctgccg tcaccatcgg
      781 ctttggacag atcaagaacc tgctgggact acagaacatc cccaggccgt tcttcctgca
      841 ggtgtaccac accttcctca ggattgcaga gaccagggta ggtgacgccg tcctggggct
      901 ggtctgcatg ctgctgctgc tggtgctgaa gctgatgcgg gaccacgtgc ctcccgtcca
      961 ccccgagatg ccccctggtg tgcggctcag ccgtgggctg gtctgggctg ccacgacagc
     1021 tcgcaacgcc ctggtggtct ccttcgcagc cctggttgcg tactccttcg aggtgactgg
     1081 ataccagcct ttcatcctaa caggggagac agctgagggg ctccctccag tccggatccc
     1141 gcccttctca gtgaccacag ccaacgggac gatctccttc accgagatgg tgcaggacat
     1201 gggagccggg ctggccgtgg tgcccctgat gggcctcctg gagagcattg cggtggccaa
     1261 agccttcgca tctcagaata attaccgcat cgatgccaac caggagctgc tggccatcgg
     1321 tctcaccaac atgttgggct ccctcgtctc ctcctacccg gtcacaggca gctttggacg
     1381 gacagccgtg aacgctcagt cgggggtgtg caccccggcg gggggcctgg tgacgggagt
     1441 gctggtgctg ctgtctctgg actacctgac ctcactgttc tactacatcc ccaagtctgc
     1501 cctggctgcc gtcatcatca tggccgtggc cccgctgttc gacaccaaga tcttcaggac
     1561 gctctggcgt gttaagaggc tggacctgct gcccctgtgc gtgaccttcc tgctgtgctt
     1621 ctgggaggtg cagtacggca tcctggccgg ggccctggtg tctctgctca tgctcctgca
     1681 ctctgcagcc aggcctgaga ccaaggtgtc agaggggccg gttctggtcc tgcagccggc
     1741 cagcggcctg tccttccctg ccatggaggc tctgcgggag gagatcctaa gccgggccct
     1801 ggaagtgtcc ccgccacgct gcctggtcct ggagtgcacc catgtctgca gcatcgacta
     1861 cactgtggtg ctgggactcg gcgagctcct ccaggacttc cagaagcagg gcgtcgccct
     1921 ggcctttgtg ggcctgcagg tccccgttct ccgtgtcctg ctgtccgctg acctgaaggg
     1981 gttccagtac ttctctaccc tggaagaagc agagaagcac ctgaggcagg agccagggac
     2041 ccagccctac aacatcagag aagactccat tctggaccaa aaggttgccc tgctcaaggc
     2101 ataatggggc cacccgtggg catccacagt ttgcagggtg ttccggaagg ttcttgtcac
     2161 tgtgattgga tgctggatgc cgcctgatag acatgctggc ctggctgaga aacccctgag
     2221 caggtaaccc agggaagaga aggaagccag gcctggaggt ccacggcagt gggagtgggg
     2281 ctcactggct tcctgtggga tgactggaaa atgacctcgc tgctgttccc tggcatgacc
     2341 ctctttggaa gagtggtttg gagagagcct tctagaatga cagactgtgc gaggaagcag
     2401 gggcaggggt ttccagcccg ggctgtgcga ggcatcctgg ggctggcagc accttcccgg
     2461 ctcaccagtg ccacctgcgg gggagggacg gggcaggcag gagtctggga ggcgggtccg
     2521 ctcctcttgt ctgcggcatc tgtgctctcc gagagaaaac caaggtgtgt caaatgacgt
     2581 caagtctcta tttaaaaata attttgtgtt ttctaaatgg aaaaagtgat agctttggtg
     2641 attttgtaaa agtcataaat gcttattgta aaaaatacag gaaaccaccc ctcaccctgt
     2701 ccacttgggt gatcattcca gacccctccc caaacatgca tatgtacctg tccgtcagtg
     2761 tgtggatgta tgtttacagt tctacataaa tgggatcatt ttatacatgg tgctctggaa
     2821 cccacatttt tcatgcagtc atttgcagtg aattatttat tgtgataata aatagcatta
     2881 gaatacaa
//
