LOCUS       NM_001012755            6207 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens solute carrier family 25 member 53 (SLC25A53), mRNA.
ACCESSION   NM_001012755 XM_377034
VERSION     NM_001012755.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6207)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 6207)
  AUTHORS   Palmieri,F.
  TITLE     The mitochondrial transporter family SLC25: identification,
            properties and physiopathology
  JOURNAL   Mol Aspects Med 34 (2-3), 465-484 (2013)
   PUBMED   23266187
  REMARK    GeneRIF: Compares and contrasts all the known human SLC25A* genes
            and includes functional information.
            Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL833609.1, BC140814.1 and AC234783.5.
            
            On Nov 22, 2018 this sequence version replaced NM_001012755.4.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AL833609.1, SRR14372079.2165595.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142680 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            MANE Ensembl match                 :: ENST00000594199.3/
                                                  ENSP00000468980.1
            RefSeq Select criteria             :: based on conservation,
                                                  longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-628               AL833609.1         20-647
            629-1874            BC140814.1         507-1752
            1875-1875           AC234783.5         31945-31945
            1876-4425           BC140814.1         1754-4303
            4426-5111           AC234783.5         34496-35181
            5112-6207           AL833609.1         5131-6226
FEATURES             Location/Qualifiers
     source          1..6207
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq22.2"
     gene            1..6207
                     /gene="SLC25A53"
                     /gene_synonym="MCART6"
                     /note="solute carrier family 25 member 53"
                     /db_xref="GeneID:401612"
                     /db_xref="HGNC:HGNC:31894"
                     /db_xref="MIM:300941"
     exon            1..132
                     /gene="SLC25A53"
                     /gene_synonym="MCART6"
                     /inference="alignment:Splign:2.1.0"
     exon            133..6207
                     /gene="SLC25A53"
                     /gene_synonym="MCART6"
                     /inference="alignment:Splign:2.1.0"
     CDS             164..1087
                     /gene="SLC25A53"
                     /gene_synonym="MCART6"
                     /note="mitochondrial carrier triple repeat protein 6"
                     /codon_start=1
                     /product="solute carrier family 25 member 53"
                     /protein_id="NP_001012773.2"
                     /db_xref="CCDS:CCDS35363.1"
                     /db_xref="GeneID:401612"
                     /db_xref="HGNC:HGNC:31894"
                     /db_xref="MIM:300941"
                     /translation="MGEQNHSPGKELQHRTRAEAPGKKSWHSQAYALGAVSNFMSTFL
                     TFPIYKVVFRQQIHAMAVSEAVRQLWHEGPQYFYRGIYPPLLSKTLQGTLLFGTYDSL
                     LCFLSPVGPHTLGHRWAAGLMSGVVEAVALSPFERVQNVLQDGRKQARFPSTFSILKE
                     FNSYGLWGRLSLGYYRGFWPVLARNSLGSALYFSFKDPIQDGLAEQGLPHWVPALVSG
                     SVNGTITCLVLYPLIVLVANMQSHIGWQNMPSLWASAQDVWNTRGRKLLLIYRGGSLV
                     ILRSSVTWGLTTAIHDFLQRKSHSRKELKTD"
     regulatory      2950..2955
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC25A53"
                     /gene_synonym="MCART6"
                     /note="hexamer: AATAAA"
     polyA_site      2973
                     /gene="SLC25A53"
                     /gene_synonym="MCART6"
                     /note="major polyA site"
     regulatory      3811..3816
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC25A53"
                     /gene_synonym="MCART6"
                     /note="hexamer: AATGAA"
     polyA_site      3827
                     /gene="SLC25A53"
                     /gene_synonym="MCART6"
     regulatory      6186..6191
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC25A53"
                     /gene_synonym="MCART6"
                     /note="hexamer: AATAAA"
     polyA_site      6207
                     /gene="SLC25A53"
                     /gene_synonym="MCART6"
ORIGIN      
        1 gggagctccg ttgtgcgtcg cttaagtgag ggcggcggat gggcgaaggt ccggtgactg
       61 cgactgtcgc tgctttctga ggccacagga aaggggccgt cggtcgccgc catgacagcg
      121 agcgaggcgg agtttcttcc atctgcaccc agttgtcttc agcatggggg agcagaacca
      181 ctctcccggg aaggagcttc agcacaggac gcgagcagag gctccaggaa agaaaagctg
      241 gcattcccag gcctatgccc ttggggccgt ttccaacttt atgtctactt ttctgacctt
      301 tcctatctat aaggttgtgt tccggcaaca gatccatgcc atggcagtgt cagaggctgt
      361 gagacagctt tggcatgaag gtcctcaata cttctaccgg ggaatctacc ctcctcttct
      421 ctccaagacg ttgcaaggga ctcttctgtt tgggacttat gatagcctgc tgtgctttct
      481 ctctcctgtt gggccacaca ccctgggaca ccgctgggct gccgggctca tgtctggcgt
      541 ggtggaggcc gtggcactca gcccctttga aagggtgcaa aatgtgctcc aggatggtcg
      601 caagcaagct cgcttcccca gcaccttcag cattctcaag gaattcaatt cttatgggct
      661 ttgggggcgg ctgtcactgg gctactatcg tggtttctgg cctgtcctgg ccaggaacag
      721 cctggggagt gctctatatt tttctttcaa ggaccccatc caggatggcc tggcagagca
      781 aggcctgccc cactgggttc ctgccttggt gtctggtagt gtcaatggaa caatcacctg
      841 cctagttctg tatcctctga ttgtgctggt tgctaatatg cagtcccata ttggatggca
      901 gaacatgcca agcctgtggg cctctgccca ggatgtatgg aacactcggg gccgaaagct
      961 gctcctgatc taccgtggag gctccctagt catcctaagg tccagtgtga catggggcct
     1021 cactacggca atccatgact tcctgcagag gaagtcgcac tccaggaaag agctgaagac
     1081 tgactagctg cagaaagtgt ggcatggcag ctttgttatt ctaaatcttc cctggttggt
     1141 tctatatagc ttacttcttt ggctaggttg cctaatacag ccatccttta gcatctataa
     1201 actcattgca tgggagaagt tcccaactac caacctgttg agcaaggaca aagcccaaaa
     1261 gtattcctta gtcaaaaaga aacgttcacc ccagtctctc cacagtttca gtagcctcag
     1321 agccaggagg cctttaaata acatgtaacc cagattaagt gtcattcctt taaggaattc
     1381 cttggcaata aacagaaact taaaaagatg accttactta ggcactctga gctctgggac
     1441 ccctctaggt gtcctccaga ccaaactgag tggaactcca atttcaaaga actatgcttg
     1501 actcttagga tgggaattcc ataaaacttc tcagatggct acattttcat gatattgttc
     1561 actgcctcta ccaccacctc tcacttctca aggctgtggg tcctactttc agggtagcag
     1621 ctgtggctgg aaatcctaaa ttaggcttgc atgaactcgt caggtgccac aagaactagt
     1681 ggggctggag atgggagtga gaagaggcgt ggcccatgga tggaaagaat aaaaactttg
     1741 aaagaaaaga tttaattaca tgcaaaatag aaacatttgc tatagtctgc ttggtgttat
     1801 ctgctaggac atttctgaga gcaaggtgat aacattgcct agaaaccgtt tgagtttccc
     1861 taagaaacct ggaagtgaag tgaccatatc tcttcacaga aaattgcata ttttgttgat
     1921 gtggttaaat gtagttacta tgacataaag atcagaaatc ttagcctgtc attcagagcc
     1981 attcaaaata tggtcatcat ataactttca acatattgtc actccactta cataaacccc
     2041 aaacactagc cataatgaac tattgttctc tccccagaca ttccatgaac tttcccatgg
     2101 ccatactctg gcccacacta ttctttccac ctgcagtgct ccttcttcac atgccagtct
     2161 accaaaatcc ttccagttcc ttgaagccca gctcagaggt caccttctct atggagttct
     2221 tgattttccc caactgaatg tgacattagt ctctgtgatg cccctttctt tttttttttt
     2281 ttgagacgga gtttcgctct tgttgcccag gctggagtgc caatggtgtg atctcagctc
     2341 actgcaacct ccacctcccg gattcaagtg attctcctgc ctcagcctcc cgagtagctg
     2401 gaattacagg cgcccaccac catgcctggc taattttgta tttttagtag agatggggtc
     2461 tctccatgtt ggtcaggctg gtctcgaact cccaacctca tcaggtgatc cacccacctc
     2521 ggtctcccaa agtgctggga ttacaggcgt gagccaccgc gcccagcctc tgtgatgccc
     2581 ctttctaaca gcacttcata cagggtactg attccattat gtcactaatc tcatgtgacc
     2641 ctttgttctt gtattcttca atacctccta ctagactgta aaactcattg aaagcaggga
     2701 tttttgtatg cattttaaaa tcttccattg tgcctaggtg ctcaataacg ttggtcaaat
     2761 tactgagttg attatcaagc tgtgatatgg tatatcctca gggtgctgtc ccttgtacat
     2821 gacgataaag ttattgactc actgtcagca agacacgtgc ctttgggctg tgtttttgct
     2881 ttcttttaat aattgattta gttttgtgct aatgataatg atgctgctac tgataataat
     2941 aataacaata ataaaaatta ctttcaactg gcacatttga tgagtttata ttactgatgg
     3001 catgtttgct attagcacca gttcaggaac tgaaatttca caaacagaat cacactgtac
     3061 aactgtacca tttgtttcaa ctctggaatt ttgaggattt ccaagatgac atgtgttata
     3121 gtttccccct acagatatct tagtaatgcc ctcctcttgc atctccttac tgaaccaaat
     3181 ttgtcctgta tttgtcttac ttggttgtag atttagcagt gagaacttct cactgaatgc
     3241 cacagaaatt aaagacatgg ttgttggagg tatgatgtca gagagcattt gccaccaagg
     3301 ttggcagaaa atggctggtc caggagagct gaagatgagc ttccacatct gcagatcggg
     3361 atgtgttggg acagtactca acttgtggat tcaaggaagt atgaacacag agtctgcata
     3421 aggaaaggaa aaagatgcat tcatctccca agtacactgg tgatttccac ttatgtcatt
     3481 ctgtccatcc atgtcccttt cttcatttta acttcttatt taaaaataat ttcaaacatt
     3541 taaaaatgtt gcaagcataa ataaagctta aagaacaccc atgtcccctt taccctaatt
     3601 cccctattat taatgtttct ccccatttgc tttattattt aagtgtgcac tctgtctata
     3661 cacacacagg atattttttc cctgaactat ctgagagttg catacatcag ttttcaatat
     3721 tcctagattc aatgtttgta gatccaaatt attttttaag agaccgtgtt ttatctctga
     3781 caatgggaca gttattacag aatataataa aatgaaaact cacacaatat atgtgatatt
     3841 gtgaaatata tacttggtct ttgatcctgt ttcttggcat acaactccta aaatccttag
     3901 aatttccaaa gtgatatctt tttgtatgct aataattgac tgatggctgg cagcctctgg
     3961 ttgcttcagg atgggaacta gtcaccagga agaccaaggc accattagag ggttgggact
     4021 taacagcctc attcccgacc tccagggagg ggagagggat ggaaggttaa gttgatcacc
     4081 agtggccaat gatttaatca atcatgccta cgcaatgaag cttccataaa aaccccaaag
     4141 cactgggttt ggagagcttc cagatagctg aacatgtgga ggttcctgga gggtggtgac
     4201 ccagggaggg cacagaagct ctgagcccct tccgcagtac ctcaccctat gcatctcttc
     4261 atctctatcc tttgatatat cctttataat aaagtggtaa acgttaagta tttccccaag
     4321 ttctgtgacc ctttctggca aattaaaccc aaagaagggg tcatgtgaac tcaaacttga
     4381 agcccatctg tcagaagttc tggaggcttg gatttgcgac tggtgtctga agggcctggg
     4441 aacagtcttg tgaaacctag tcctcagctt gtgggatatg acgctatctc caggtagatt
     4501 gtgtcagaat ggaattggag tacacccagc tggtgttcgc tgcagaactg attgctcact
     4561 tagtgtgtgg gaaaactcca cacatctgga catggaaata ttctgtgctg attgccgtgg
     4621 tgtaagagca atgcaaaaag tttgggtatt ttcccctcgg agtatatttt aaagctaaat
     4681 tgctaataat tgcttaaatt tactatattt gcctttataa aaactttatg tatgttgaag
     4741 cttgaagcta tgcaattata atataaacat ggatttacaa ctaaagcatg ttataattta
     4801 aataattgag tttttcaaat cggttcatat gaaatcctag gcaatattgt aaaattatac
     4861 agacctgtca actttttcca cttaaaagtt gtgagcaaaa tttaagggca tagtcgtttt
     4921 caagtaattt taaatgtcaa tgttaatatt tagtttagtg atgttaatgg agctatgttt
     4981 tctgatatta aaaatgagtt ttaggagttg agaccaataa aataaggagg taataaatat
     5041 ctatatctgt ttaaacacat aaaatataca atttaacact aaaattactt ggtataaaaa
     5101 gtcaaaaaaa agaataaaaa gccatcatac aacacaatat atgcgtgata tatatttttc
     5161 tctaaatata aactacatca gcttttataa agctcaagtt gaaataataa cgttttatga
     5221 caaatcatta tatggtatat tctgacttaa ttttgcattt acaatttatt tttaaacact
     5281 aaatagcatt ataattttac tgggataact atatatagtg tagtatatta aagttaataa
     5341 aatgacgttg catatgagag aaaaagcata ataaatcaga aacaatataa aaagctttca
     5401 gaaaagataa aaatattgta tttctctagt ctgttcactc tccagtgtct ctggttcttt
     5461 catatcatct tcctttcctc aaatctttta atactccctc cctcatcatt tccaactagt
     5521 gaccctactt tctatttcat taagaaaaca gatacattca gaagagaact gccagtttaa
     5581 agaacattta caaagccatc acccatgtaa taaccagcca gagcaagaaa tagagccctt
     5641 taataaccta ctcttctccc cccaccactg atgacaccgc tccctccatc ttaggtgtag
     5701 cccccatgct gacttttgta ataataattt ctttgctttt gtttataagt tttcttcctt
     5761 ataagcatct ctaaacaaca gttttgtttt acagatgttc aaacattaaa tgctttttag
     5821 acttggaatt gtgactatct tgtttcactc cacattgctt gtgagactca ttgatattgc
     5881 agatagctgt agttgatcca tttttattgt tgtacagttt accattgtat aaatatacca
     5941 tgatttattc atgataactt tgaggaacat tctggttgtt tgcaggtttt atttttacag
     6001 ttcattagtt ttattgatgt ataataattg tatatgttta tggggtatat gtgatatttt
     6061 gatacatgtg tacaatgtgt aatgattaaa tcaaggtaat tgggatatcc atcagctcaa
     6121 acatttatca tttctttgca ttgggaacat tccaaatctt ctcttctagc tattttgaaa
     6181 tacacaataa attgaatact gtggtca
//
