LOCUS       NM_033412               1171 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens solute carrier family 25 member 51 (SLC25A51),
            transcript variant 1, mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_033412
VERSION     NM_033412.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1171)
  AUTHORS   Lu,M.J., Busquets,J., Impedovo,V., Wilson,C.N., Chan,H.R.,
            Chang,Y.T., Matsui,W., Tiziani,S. and Cambronne,X.A.
  TITLE     SLC25A51 decouples the mitochondrial NAD+/NADH ratio to control
            proliferation of AML cells
  JOURNAL   Cell Metab 36 (4), 808-821 (2024)
   PUBMED   38354740
  REMARK    GeneRIF: SLC25A51 decouples the mitochondrial NAD[+]/NADH ratio to
            control proliferation of AML cells.
REFERENCE   2  (bases 1 to 1171)
  AUTHORS   Goyal,S. and Cambronne,X.A.
  TITLE     Layered mechanisms regulating the human mitochondrial NAD+
            transporter SLC25A51
  JOURNAL   Biochem Soc Trans 51 (6), 1989-2004 (2023)
   PUBMED   38108469
  REMARK    GeneRIF: Layered mechanisms regulating the human mitochondrial NAD+
            transporter SLC25A51.
            Review article
REFERENCE   3  (bases 1 to 1171)
  AUTHORS   Goyal,S., Paspureddi,A., Lu,M.J., Chan,H.R., Lyons,S.N.,
            Wilson,C.N., Niere,M., Ziegler,M. and Cambronne,X.A.
  TITLE     Dynamics of SLC25A51 reveal preference for oxidized NAD+ and
            substrate led transport
  JOURNAL   EMBO Rep 24 (10), e56596 (2023)
   PUBMED   37575034
  REMARK    GeneRIF: Dynamics of SLC25A51 reveal preference for oxidized NAD[+]
            and substrate led transport.
REFERENCE   4  (bases 1 to 1171)
  AUTHORS   Guldenpfennig,A., Hopp,A.K., Muskalla,L., Manetsch,P., Raith,F.,
            Hellweg,L., Dordelmann,C., Leslie Pedrioli,D.M., Johnsson,K.,
            Superti-Furga,G. and Hottiger,M.O.
  TITLE     Absence of mitochondrial SLC25A51 enhances PARP1-dependent DNA
            repair by increasing nuclear NAD+ levels
  JOURNAL   Nucleic Acids Res 51 (17), 9248-9265 (2023)
   PUBMED   37587695
  REMARK    GeneRIF: Absence of mitochondrial SLC25A51 enhances PARP1-dependent
            DNA repair by increasing nuclear NAD+ levels.
REFERENCE   5  (bases 1 to 1171)
  AUTHORS   Li,Y., Bie,J., Zhao,L., Song,C., Zhang,T., Li,M., Yang,C. and
            Luo,J.
  TITLE     SLC25A51 promotes tumor growth through sustaining mitochondria
            acetylation homeostasis and proline biogenesis
  JOURNAL   Cell Death Differ 30 (8), 1916-1930 (2023)
   PUBMED   37419986
  REMARK    GeneRIF: SLC25A51 promotes tumor growth through sustaining
            mitochondria acetylation homeostasis and proline biogenesis.
REFERENCE   6  (bases 1 to 1171)
  AUTHORS   Girardi,E., Agrimi,G., Goldmann,U., Fiume,G., Lindinger,S.,
            Sedlyarov,V., Srndic,I., Gurtl,B., Agerer,B., Kartnig,F.,
            Scarcia,P., Di Noia,M.A., Lineiro,E., Rebsamen,M., Wiedmer,T.,
            Bergthaler,A., Palmieri,L. and Superti-Furga,G.
  TITLE     Epistasis-driven identification of SLC25A51 as a regulator of human
            mitochondrial NAD import
  JOURNAL   Nat Commun 11 (1), 6145 (2020)
   PUBMED   33262325
  REMARK    GeneRIF: Epistasis-driven identification of SLC25A51 as a regulator
            of human mitochondrial NAD import.
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 1171)
  AUTHORS   Luongo,T.S., Eller,J.M., Lu,M.J., Niere,M., Raith,F., Perry,C.,
            Bornstein,M.R., Oliphint,P., Wang,L., McReynolds,M.R., Migaud,M.E.,
            Rabinowitz,J.D., Johnson,F.B., Johnsson,K., Ziegler,M.,
            Cambronne,X.A. and Baur,J.A.
  TITLE     SLC25A51 is a mammalian mitochondrial NAD+ transporter
  JOURNAL   Nature 588 (7836), 174-179 (2020)
   PUBMED   32906142
  REMARK    GeneRIF: SLC25A51 is a mammalian mitochondrial NAD(+) transporter.
REFERENCE   8  (bases 1 to 1171)
  AUTHORS   Kory,N., Uit de Bos,J., van der Rijt,S., Jankovic,N., Gura,M.,
            Arp,N., Pena,I.A., Prakash,G., Chan,S.H., Kunchok,T., Lewis,C.A.
            and Sabatini,D.M.
  TITLE     MCART1/SLC25A51 is required for mitochondrial NAD transport
  JOURNAL   Sci Adv 6 (43) (2020)
   PUBMED   33087354
  REMARK    Publication Status: Online-Only
REFERENCE   9  (bases 1 to 1171)
  AUTHORS   Palmieri,F.
  TITLE     The mitochondrial transporter family SLC25: identification,
            properties and physiopathology
  JOURNAL   Mol Aspects Med 34 (2-3), 465-484 (2013)
   PUBMED   23266187
  REMARK    GeneRIF: Compares and contrasts all the known human SLC25A* genes
            and includes functional information.
            Review article
REFERENCE   10 (bases 1 to 1171)
  AUTHORS   Hendrickson,S.L., Lautenberger,J.A., Chinn,L.W., Malasky,M.,
            Sezgin,E., Kingsley,L.A., Goedert,J.J., Kirk,G.D., Gomperts,E.D.,
            Buchbinder,S.P., Troyer,J.L. and O'Brien,S.J.
  TITLE     Genetic variants in nuclear-encoded mitochondrial genes influence
            AIDS progression
  JOURNAL   PLoS One 5 (9), e12862 (2010)
   PUBMED   20877624
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
            Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL138752.5 and BG953457.1.
            
            On Nov 22, 2018 this sequence version replaced NM_033412.3.
            
            Transcript Variant: This variant (1) represents the shortest
            transcript and encodes the functional protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163657.553178.1,
                                           SRR1803617.261653.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            MANE Ensembl match                 :: ENST00000242275.7/
                                                  ENSP00000242275.6
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-60                AL138752.5         41062-41121
            61-182              AL138752.5         45239-45360
            183-1124            AL138752.5         56597-57538
            1125-1171           BG953457.1         312-358
FEATURES             Location/Qualifiers
     source          1..1171
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9p13.2-p13.1"
     gene            1..1171
                     /gene="SLC25A51"
                     /gene_synonym="CG7943; MCART1"
                     /note="solute carrier family 25 member 51"
                     /db_xref="GeneID:92014"
                     /db_xref="HGNC:HGNC:23323"
                     /db_xref="MIM:619153"
     exon            1..60
                     /gene="SLC25A51"
                     /gene_synonym="CG7943; MCART1"
                     /inference="alignment:Splign:2.1.0"
     exon            61..182
                     /gene="SLC25A51"
                     /gene_synonym="CG7943; MCART1"
                     /inference="alignment:Splign:2.1.0"
     exon            183..1171
                     /gene="SLC25A51"
                     /gene_synonym="CG7943; MCART1"
                     /inference="alignment:Splign:2.1.0"
     CDS             225..1118
                     /gene="SLC25A51"
                     /gene_synonym="CG7943; MCART1"
                     /note="mitochondrial carrier triple repeat protein 1;
                     mitochondrial carrier triple repeat 1; mitochondrial NAD+
                     transporter; mitochondrial NAD(+) transporter SLC25A51"
                     /codon_start=1
                     /product="mitochondrial nicotinamide adenine dinucleotide
                     transporter SLC25A51"
                     /protein_id="NP_219480.1"
                     /db_xref="CCDS:CCDS6614.1"
                     /db_xref="GeneID:92014"
                     /db_xref="HGNC:HGNC:23323"
                     /db_xref="MIM:619153"
                     /translation="MMDSEAHEKRPPILTSSKQDISPHITNVGEMKHYLCGCCAAFNN
                     VAITFPIQKVLFRQQLYGIKTRDAILQLRRDGFRNLYRGILPPLMQKTTTLALMFGLY
                     EDLSCLLHKHVSAPEFATSGVAAVLAGTTEAIFTPLERVQTLLQDHKHHDKFTNTYQA
                     FKALKCHGIGEYYRGLVPILFRNGLSNVLFFGLRGPIKEHLPTATTHSAHLVNDFICG
                     GLLGAMLGFLFFPINVVKTRIQSQIGGEFQSFPKVFQKIWLERDRKLINLFRGAHLNY
                     HRSLISWGIINATYEFLLKVI"
     regulatory      1152..1157
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC25A51"
                     /gene_synonym="CG7943; MCART1"
                     /note="hexamer: AATAGA"
     polyA_site      1171
                     /gene="SLC25A51"
                     /gene_synonym="CG7943; MCART1"
                     /note="major polyA site"
ORIGIN      
        1 agtctgcgcc tgcgcgggcc ccggctcgct agccgtcctg cgggacgccg gcgctgatgg
       61 gaaatccagt tatcaaaatt gactcaagaa gagagaacct aacagaacaa taacaatgga
      121 agaaattggg aacattatca caaagctatc atcctgccaa actccaggct cagatgtcac
      181 aggttaaaaa aagtccttca tgaaaaagaa agatcttaag cagcatgatg gattcagaag
      241 ctcatgaaaa gaggccacca atactaacat cttcaaaaca agatatatca cctcatatta
      301 caaatgttgg tgagatgaag cattacttgt gtggctgctg tgcagccttc aacaatgtcg
      361 caatcacatt tcccattcag aaggtcctct ttcgacaaca gctgtatggc atcaaaaccc
      421 gggatgcaat acttcagttg agaagggatg gatttcgaaa tttgtatcgt ggaatccttc
      481 ccccattgat gcagaagaca actacgcttg cacttatgtt tggtctgtat gaggatttat
      541 cctgccttct ccacaagcat gtcagtgctc cagagtttgc aaccagtggc gtggcggcag
      601 tgcttgcagg gacaacagaa gcaattttca ctccactgga aagagttcag acattgcttc
      661 aagaccacaa gcatcatgac aaatttacca acacttacca ggctttcaag gcactgaaat
      721 gtcatggaat tggagagtat tatcgaggct tggtgcccat tcttttccgg aatggactca
      781 gcaatgtctt gtttttcggc cttcgaggtc ccattaagga gcatctgcct accgcaacga
      841 ctcacagtgc tcatctggtc aatgatttta tctgtggagg tctattgggt gccatgttgg
      901 gattcttgtt ttttccaatt aatgttgtaa aaactcgcat acagtctcag attggtgggg
      961 aatttcagtc tttccccaag gttttccaaa aaatctggct ggaacgggac agaaaactga
     1021 taaatctttt cagaggtgcc catctgaatt accatcggtc cctcatctct tggggcataa
     1081 tcaatgcaac ttatgagttc ttgttaaagg ttatatgaaa aaaccatcag ttaagtgcca
     1141 tttatcaact gaatagacct tctaagaaga a
//
