LOCUS       NM_001152               1307 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens solute carrier family 25 member 5 (SLC25A5), mRNA.
ACCESSION   NM_001152
VERSION     NM_001152.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1307)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 1307)
  AUTHORS   Moon,J.S., da Cunha,F.F., Huh,J.Y., Andreyev,A.Y., Lee,J.,
            Mahata,S.K., Reis,F.C., Nasamran,C.A. and Lee,Y.S.
  TITLE     ANT2 drives proinflammatory macrophage activation in obesity
  JOURNAL   JCI Insight 6 (20), e147033 (2021)
   PUBMED   34676827
  REMARK    GeneRIF: ANT2 drives proinflammatory macrophage activation in
            obesity.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1307)
  AUTHORS   Trisolini,L., Laera,L., Favia,M., Muscella,A., Castegna,A.,
            Pesce,V., Guerra,L., De Grassi,A., Volpicella,M. and Pierri,C.L.
  TITLE     Differential Expression of ADP/ATP Carriers as a Biomarker of
            Metabolic Remodeling and Survival in Kidney Cancers
  JOURNAL   Biomolecules 11 (1), 38 (2020)
   PUBMED   33396658
  REMARK    GeneRIF: Differential Expression of ADP/ATP Carriers as a Biomarker
            of Metabolic Remodeling and Survival in Kidney Cancers.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1307)
  AUTHORS   Namba,T., Doczi,J., Pinson,A., Xing,L., Kalebic,N.,
            Wilsch-Brauninger,M., Long,K.R., Vaid,S., Lauer,J., Bogdanova,A.,
            Borgonovo,B., Shevchenko,A., Keller,P., Drechsel,D., Kurzchalia,T.,
            Wimberger,P., Chinopoulos,C. and Huttner,W.B.
  TITLE     Human-Specific ARHGAP11B Acts in Mitochondria to Expand Neocortical
            Progenitors by Glutaminolysis
  JOURNAL   Neuron 105 (5), 867-881 (2020)
   PUBMED   31883789
REFERENCE   5  (bases 1 to 1307)
  AUTHORS   Lee,C.H., Kim,M.J., Lee,H.H., Paeng,J.C., Park,Y.J., Oh,S.W.,
            Chai,Y.J., Kim,Y.A., Cheon,G.J., Kang,K.W., Youn,H. and Chung,J.K.
  TITLE     Adenine Nucleotide Translocase 2 as an Enzyme Related to [18F] FDG
            Accumulation in Various Cancers
  JOURNAL   Mol Imaging Biol 21 (4), 722-730 (2019)
   PUBMED   30225759
  REMARK    GeneRIF: ANT2 can be used as a marker of dedifferentiated pathology
            and aggressiveness of cancer.
REFERENCE   6  (bases 1 to 1307)
  AUTHORS   Schiebel,K., Mertz,A., Winkelmann,M., Nagaraja,R. and Rappold,G.
  TITLE     Localization of the adenine nucleotide translocase gene ANT2 to
            chromosome Xq24-q25 with tight linkage to DXS425
  JOURNAL   Genomics 24 (3), 605-606 (1994)
   PUBMED   7713517
REFERENCE   7  (bases 1 to 1307)
  AUTHORS   Ku,D.H., Kagan,J., Chen,S.T., Chang,C.D., Baserga,R. and Wurzel,J.
  TITLE     The human fibroblast adenine nucleotide translocator gene.
            Molecular cloning and sequence
  JOURNAL   J Biol Chem 265 (27), 16060-16063 (1990)
   PUBMED   2168878
REFERENCE   8  (bases 1 to 1307)
  AUTHORS   Chen,S.T., Chang,C.D., Huebner,K., Ku,D.H., McFarland,M.,
            DeRiel,J.K., Baserga,R. and Wurzel,J.
  TITLE     A human ADP/ATP translocase gene has seven pseudogenes and
            localizes to chromosome X
  JOURNAL   Somat Cell Mol Genet 16 (2), 143-149 (1990)
   PUBMED   2157297
REFERENCE   9  (bases 1 to 1307)
  AUTHORS   Houldsworth,J. and Attardi,G.
  TITLE     Two distinct genes for ADP/ATP translocase are expressed at the
            mRNA level in adult human liver
  JOURNAL   Proc Natl Acad Sci U S A 85 (2), 377-381 (1988)
   PUBMED   2829183
REFERENCE   10 (bases 1 to 1307)
  AUTHORS   Battini,R., Ferrari,S., Kaczmarek,L., Calabretta,B., Chen,S.T. and
            Baserga,R.
  TITLE     Molecular cloning of a cDNA for a human ADP/ATP carrier which is
            growth-regulated
  JOURNAL   J Biol Chem 262 (9), 4355-4359 (1987)
   PUBMED   3031073
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DR759917.1, BC068199.1,
            BC056160.1 and BQ223988.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_001152.4.
            
            Summary: This gene is a member of the mitochondrial carrier
            subfamily of solute carrier protein genes. The product of this gene
            functions as a gated pore that translocates ADP from the cytoplasm
            into the mitochondrial matrix and ATP from the mitochondrial matrix
            into the cytoplasm. The protein forms a homodimer embedded in the
            inner mitochondria membrane. Suppressed expression of this gene has
            been shown to induce apoptosis and inhibit tumor growth. The human
            genome contains several non-transcribed pseudogenes of this
            gene.[provided by RefSeq, Jun 2013].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BX325584.2, SRR5189667.224480.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            MANE Ensembl match                 :: ENST00000317881.9/
                                                  ENSP00000360671.4
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1                 DR759917.1         45-45
            2-844               BC068199.1         5-847
            845-1230            BC056160.1         840-1225
            1231-1307           BQ223988.1         453-529
FEATURES             Location/Qualifiers
     source          1..1307
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq24"
     gene            1..1307
                     /gene="SLC25A5"
                     /gene_synonym="2F1; AAC2; ANT2; T2; T3"
                     /note="solute carrier family 25 member 5"
                     /db_xref="GeneID:292"
                     /db_xref="HGNC:HGNC:10991"
                     /db_xref="MIM:300150"
     exon            1..183
                     /gene="SLC25A5"
                     /gene_synonym="2F1; AAC2; ANT2; T2; T3"
                     /inference="alignment:Splign:2.1.0"
     CDS             73..969
                     /gene="SLC25A5"
                     /gene_synonym="2F1; AAC2; ANT2; T2; T3"
                     /note="adenine nucleotide translocator 2 (fibroblast);
                     solute carrier family 25 (mitochondrial carrier; adenine
                     nucleotide translocator), member 5"
                     /codon_start=1
                     /product="ADP/ATP translocase 2"
                     /protein_id="NP_001143.2"
                     /db_xref="CCDS:CCDS14578.1"
                     /db_xref="GeneID:292"
                     /db_xref="HGNC:HGNC:10991"
                     /db_xref="MIM:300150"
                     /translation="MTDAAVSFAKDFLAGGVAAAISKTAVAPIERVKLLLQVQHASKQ
                     ITADKQYKGIIDCVVRIPKEQGVLSFWRGNLANVIRYFPTQALNFAFKDKYKQIFLGG
                     VDKRTQFWLYFAGNLASGGAAGATSLCFVYPLDFARTRLAADVGKAGAEREFRGLGDC
                     LVKIYKSDGIKGLYQGFNVSVQGIIIYRAAYFGIYDTAKGMLPDPKNTHIVISWMIAQ
                     TVTAVAGLTSYPFDTVRRRMMMQSGRKGTDIMYTGTLDCWRKIARDEGGKAFFKGAWS
                     NVLRGMGGAFVLVLYDEIKKYT"
     exon            184..670
                     /gene="SLC25A5"
                     /gene_synonym="2F1; AAC2; ANT2; T2; T3"
                     /inference="alignment:Splign:2.1.0"
     exon            671..811
                     /gene="SLC25A5"
                     /gene_synonym="2F1; AAC2; ANT2; T2; T3"
                     /inference="alignment:Splign:2.1.0"
     exon            812..1307
                     /gene="SLC25A5"
                     /gene_synonym="2F1; AAC2; ANT2; T2; T3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1210..1215
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC25A5"
                     /gene_synonym="2F1; AAC2; ANT2; T2; T3"
                     /note="hexamer: AATAAA"
     polyA_site      1230
                     /gene="SLC25A5"
                     /gene_synonym="2F1; AAC2; ANT2; T2; T3"
                     /note="major polyA site"
ORIGIN      
        1 ccccgcagcg ccggagtcaa agccggttcc cggcccagtc ccgtcctgca gcagtctgcc
       61 tcctctttca acatgacaga tgccgctgtg tccttcgcca aggacttcct ggcaggtgga
      121 gtggccgcag ccatctccaa gacggcggta gcgcccatcg agcgggtcaa gctgctgctg
      181 caggtgcagc atgccagcaa gcagatcact gcagataagc aatacaaagg cattatagac
      241 tgcgtggtcc gtattcccaa ggagcaggga gttctgtcct tctggcgcgg taacctggcc
      301 aatgtcatca gatacttccc cacccaggct cttaacttcg ccttcaaaga taaatacaag
      361 cagatcttcc tgggtggtgt ggacaagaga acccagtttt ggctctactt tgcagggaat
      421 ctggcatcgg gtggtgccgc aggggccaca tccctgtgtt ttgtgtaccc tcttgatttt
      481 gcccgtaccc gtctagcagc tgatgtgggt aaagctggag ctgaaaggga attccgaggc
      541 ctcggtgact gcctggttaa gatctacaaa tctgatggga ttaagggcct gtaccaaggc
      601 tttaacgtgt ctgtgcaggg tattatcatc taccgagccg cctacttcgg tatctatgac
      661 actgcaaagg gaatgcttcc ggatcccaag aacactcaca tcgtcatcag ctggatgatc
      721 gcacagactg tcactgctgt tgccgggttg acttcctatc catttgacac tgttcgccgc
      781 cgcatgatga tgcagtcagg gcgcaaagga actgacatca tgtacacagg cacgcttgac
      841 tgctggcgga agattgctcg tgatgaagga ggcaaagctt ttttcaaggg tgcatggtcc
      901 aatgttctca gaggcatggg tggtgctttt gtgcttgtct tgtatgatga aatcaagaag
      961 tacacataag ttatttccta ggatttttcc ccctgtgaac aggcatgttg tattatataa
     1021 catatcttga gcattcttga cagactcctg gctgtcagtt tctcagtggc aactatttac
     1081 tggttgaaaa tgggaagcaa taatattcat ctgaccagtt ttctcttaaa gccatttcca
     1141 tgatgatgat gatgggactc aattgtattt tttatttcag tcactcctga taaataacaa
     1201 atttggagaa ataaaaatat ctaaaataaa ttttgtctgc agtatatttt catataaaaa
     1261 tgcatatttg agtgctacat tcgaataaat actacctttt tagtgaa
//
