LOCUS       NM_182556               2261 bp    mRNA    linear   PRI 19-JAN-2024
DEFINITION  Homo sapiens solute carrier family 25 member 45 (SLC25A45),
            transcript variant 1, mRNA.
ACCESSION   NM_182556
VERSION     NM_182556.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2261)
  AUTHORS   Seppala,I., Kleber,M.E., Lyytikainen,L.P., Hernesniemi,J.A.,
            Makela,K.M., Oksala,N., Laaksonen,R., Pilz,S., Tomaschitz,A.,
            Silbernagel,G., Boehm,B.O., Grammer,T.B., Koskinen,T., Juonala,M.,
            Hutri-Kahonen,N., Alfthan,G., Viikari,J.S., Kahonen,M.,
            Raitakari,O.T., Marz,W., Meinitzer,A. and Lehtimaki,T.
  CONSRTM   AtheroRemo Consortium
  TITLE     Genome-wide association study on dimethylarginines reveals novel
            AGXT2 variants associated with heart rate variability but not with
            overall mortality
  JOURNAL   Eur Heart J 35 (8), 524-531 (2014)
   PUBMED   24159190
REFERENCE   2  (bases 1 to 2261)
  AUTHORS   Palmieri,F.
  TITLE     The mitochondrial transporter family SLC25: identification,
            properties and physiopathology
  JOURNAL   Mol Aspects Med 34 (2-3), 465-484 (2013)
   PUBMED   23266187
  REMARK    GeneRIF: Compares and contrasts all the known human SLC25A* genes
            and includes functional information.
            Review article
REFERENCE   3  (bases 1 to 2261)
  AUTHORS   Haitina,T., Lindblom,J., Renstrom,T. and Fredriksson,R.
  TITLE     Fourteen novel human members of mitochondrial solute carrier family
            25 (SLC25) widely expressed in the central nervous system
  JOURNAL   Genomics 88 (6), 779-790 (2006)
   PUBMED   16949250
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AP000944.4.
            
            On Aug 13, 2020 this sequence version replaced NM_182556.3.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (a). Variants 1 and 6 both encode the same isoform (a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR18074968.2914661.1,
                                           SRR14038193.1145820.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2144333, SAMEA2144835
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000398802.6/ ENSP00000381782.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-161               AP000944.4         123334-123494       c
            162-216             AP000944.4         122763-122817       c
            217-260             AP000944.4         120980-121023       c
            261-332             AP000944.4         120715-120786       c
            333-518             AP000944.4         120224-120409       c
            519-777             AP000944.4         117666-117924       c
            778-2261            AP000944.4         116040-117523       c
FEATURES             Location/Qualifiers
     source          1..2261
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q13.1"
     gene            1..2261
                     /gene="SLC25A45"
                     /note="solute carrier family 25 member 45"
                     /db_xref="GeneID:283130"
                     /db_xref="HGNC:HGNC:27442"
                     /db_xref="MIM:610825"
     exon            1..161
                     /gene="SLC25A45"
                     /inference="alignment:Splign:2.1.0"
     exon            162..216
                     /gene="SLC25A45"
                     /inference="alignment:Splign:2.1.0"
     CDS             180..1046
                     /gene="SLC25A45"
                     /note="isoform a is encoded by transcript variant 1"
                     /codon_start=1
                     /product="solute carrier family 25 member 45 isoform a"
                     /protein_id="NP_872362.4"
                     /db_xref="CCDS:CCDS41670.1"
                     /db_xref="GeneID:283130"
                     /db_xref="HGNC:HGNC:27442"
                     /db_xref="MIM:610825"
                     /translation="MPVEEFVAGWISGALGLVLGHPFDTVKVRLQTQTTYRGIVDCMV
                     KIYRHESLLGFFKGMSFPIASIAVVNSVLFGVYSNTLLVLTATSHQERRAQPPSYMHI
                     FLAGCTGGFLQAYCLAPFDLIKVRLQNQTEPRAQPGSPPPRYQGPVHCAASIFREEGP
                     RGLFRGAWALTLRDTPTVGIYFITYEGLCRQYTPEGQNPSSATVLVAGGFAGIASWVA
                     ATPLDMIKSRMQMDGLRRRVYQGMLDCMVSSIRQEGLGVFFRGVTINSARAFPVNAVT
                     FLSYEYLLRWWG"
     exon            217..260
                     /gene="SLC25A45"
                     /inference="alignment:Splign:2.1.0"
     exon            261..332
                     /gene="SLC25A45"
                     /inference="alignment:Splign:2.1.0"
     exon            333..518
                     /gene="SLC25A45"
                     /inference="alignment:Splign:2.1.0"
     exon            519..777
                     /gene="SLC25A45"
                     /inference="alignment:Splign:2.1.0"
     exon            778..2261
                     /gene="SLC25A45"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2240..2245
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC25A45"
                     /note="hexamer: AATAAA"
     polyA_site      2261
                     /gene="SLC25A45"
                     /note="major polyA site"
ORIGIN      
        1 gactgagcag aatggtgcca ttgcagatca acacgcactt taaataatca aaacccctat
       61 ctttcccctg ggaaggagga agccgaggaa ggctgtgttt ctgactcaca cgggggagtc
      121 gggggagtcg taaacaaccc tgaagagaac agccaggcct gttcccgcaa gcccagacaa
      181 tgccggtgga ggaatttgtg gctggctgga tctctggcgc tctgggcttg gtcctgggac
      241 acccgtttga cactgtaaag gtgaggctgc agacccagac cacctaccgg ggcatcgttg
      301 attgcatggt caagatttac cgccatgagt ccctcctggg cttcttcaag ggaatgagct
      361 tccccattgc cagcatagct gtggtcaact ctgtcctgtt tggggtctat agcaacaccc
      421 tgctggtgct cacggccacc tcccaccagg agcggcgggc ccagccgccc agctacatgc
      481 acatcttcct agcgggctgc accggggggt tcctgcaggc ctactgtctg gctccttttg
      541 acctcatcaa agtccggcta caaaaccaga cagagccaag ggcccagcca gggagccccc
      601 caccccggta ccaggggccc gtgcactgtg cagcctccat cttccgggag gaggggcccc
      661 gggggctgtt ccgaggagcc tgggccctga cgctgaggga cacccccacg gtggggatct
      721 acttcatcac ctatgaaggg ctctgtcgcc agtacacacc agaaggccag aatcccagct
      781 cagccacggt gctggtggca gggggctttg caggcattgc ttcctgggtg gcagccacgc
      841 ccttagacat gatcaagtcc cggatgcaga tggatggact gagacgcaga gtgtaccagg
      901 ggatgctgga ctgcatggtg agcagcatcc ggcaggaagg actgggagtc ttcttccggg
      961 gggtcaccat caacagtgcc cgcgcctttc ccgtcaatgc tgtcaccttc ctcagctacg
     1021 aatatctcct ccgctggtgg ggatgagccc tgcggcaatg ccagcagctc cccatcaggc
     1081 ccacggcctg gaggccagtt tgagattgga ggccaggttg aaagcttgca aatcagtgca
     1141 agaggctcag cccttcctaa ccaaggtgcc tcccacccgc gcagatctgg gctgggcaga
     1201 cacctgtggg agccggaagc cagggggcct gtgcagcctc cctgtgtagc tggccttgac
     1261 tcctttgcct cccacatctg tgaaacaggg agcatgaggc acaagtgagc tggcaagtgg
     1321 tgctggtgac atcccagctc ctgtcctgtg ccttcacctc tttttttttt tttttttttt
     1381 tttgagatgg agtctttctc tgtcacccag gctggaatgc agtggcgtga tctcggctca
     1441 ctgcaacctc cgcctttcca ccttccgggt tcaagcaact ctcctgcctc agcctcccaa
     1501 gtagctggga ctataggcgc ccgccaccac acccagctaa atttttgtat ttttagtaga
     1561 gacagggttt caccatgtca gccaggatgg tcttgatctc ctgactttgt gatccgcccg
     1621 cgtcggcctc tcaaagtgct gggattacag gcgtgagcca ccgcgcccgg ctgccttcac
     1681 ctcttaagga gctctgagac tccacttctg agagtccctg cggcctccca cctccctgcc
     1741 tttcaaagct ctctccccca tgacccagga taaccctatg tctcctcccc cagaatcctt
     1801 cagtggctct catcaccttc aggaaaagcc caaactcctt ccaccctcca ggttcctccc
     1861 tccccacgag gctttgttct cctggggttg cttcctggac cctgaacaag ttgtgctctc
     1921 attggccggg cctggccagc agtgcacagt gcctggcagg ttgactctac catccccggg
     1981 gctggccccg ctctcctccg agacccaggc tgagcccagt cccctcaccc ttccttgact
     2041 tacctcccca cctgaggctg actttggggt tcccagacac cctacccaca cacatgcctt
     2101 gatcatagca cttgcctgcg cttcttcaga gtcattaatt tgcttctcgg cttccccact
     2161 ggactgtgag ctgcctgagg tcagggattg cgctttggat ggtttccagc ctgagcctgg
     2221 tgcttgaaca gacgtgtgca ataaatgctc gttaaatgat g
//
