LOCUS       NM_145305               2507 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens solute carrier family 25 member 43 (SLC25A43), mRNA.
ACCESSION   NM_145305
VERSION     NM_145305.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2507)
  AUTHORS   Gabrielson,M., Reizer,E., Stal,O. and Tina,E.
  TITLE     Mitochondrial regulation of cell cycle progression through SLC25A43
  JOURNAL   Biochem Biophys Res Commun 469 (4), 1090-1096 (2016)
   PUBMED   26721434
  REMARK    GeneRIF: In line with our previous results, we show a role for
            SLC25A43 as a regulator of cell cycle progression and proliferation
            through a putative mitochondrial checkpoint.
REFERENCE   2  (bases 1 to 2507)
  AUTHORS   Gabrielson,M. and Tina,E.
  TITLE     The mitochondrial transport protein SLC25A43 affects drug efficacy
            and drug-induced cell cycle arrest in breast cancer cell lines
  JOURNAL   Oncol Rep 29 (4), 1268-1274 (2013)
   PUBMED   23354756
  REMARK    GeneRIF: Our findings demonstrate that the mitochondrial protein
            SLC25A43 affects drug efficacy and cell cycle regulation following
            drug exposure in breast cancer cell lines.
REFERENCE   3  (bases 1 to 2507)
  AUTHORS   Palmieri,F.
  TITLE     The mitochondrial transporter family SLC25: identification,
            properties and physiopathology
  JOURNAL   Mol Aspects Med 34 (2-3), 465-484 (2013)
   PUBMED   23266187
  REMARK    GeneRIF: Compares and contrasts all the known human SLC25A* genes
            and includes functional information.
            Review article
REFERENCE   4  (bases 1 to 2507)
  AUTHORS   Tina,E., Lindqvist,B.M., Gabrielson,M., Lubovac,Z., Wegman,P. and
            Wingren,S.
  TITLE     The mitochondrial transporter SLC25A43 is frequently deleted and
            may influence cell proliferation in HER2-positive breast tumors
  JOURNAL   BMC Cancer 12, 350 (2012)
   PUBMED   22883974
  REMARK    GeneRIF: Our results indicate a possible role of SLC25A43 in
            HER2-positive breast cancer and support the hypothesis of altered
            mitochondrial function in cancer.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2507)
  AUTHORS   Lindqvist,B.M., Farkas,S.A., Wingren,S. and Nilsson,T.K.
  TITLE     DNA methylation pattern of the SLC25A43 gene in breast cancer
  JOURNAL   Epigenetics 7 (3), 300-306 (2012)
   PUBMED   22430806
  REMARK    GeneRIF: associations between site-specific methylation and
            clinicopathological parameters suggest that epigenetic changes in
            SLC25A43 gene could be of importance in breast carcinogenesis.
REFERENCE   6  (bases 1 to 2507)
  AUTHORS   Albagha,O.M., Wani,S.E., Visconti,M.R., Alonso,N., Goodman,K.,
            Brandi,M.L., Cundy,T., Chung,P.Y., Dargie,R., Devogelaer,J.P.,
            Falchetti,A., Fraser,W.D., Gennari,L., Gianfrancesco,F.,
            Hooper,M.J., Van Hul,W., Isaia,G., Nicholson,G.C., Nuti,R.,
            Papapoulos,S., Montes Jdel,P., Ratajczak,T., Rea,S.L., Rendina,D.,
            Gonzalez-Sarmiento,R., Di Stefano,M., Ward,L.C., Walsh,J.P. and
            Ralston,S.H.
  CONSRTM   Genetic Determinants of Paget's Disease (GDPD) Consortium
  TITLE     Genome-wide association identifies three new susceptibility loci
            for Paget's disease of bone
  JOURNAL   Nat Genet 43 (7), 685-689 (2011)
   PUBMED   21623375
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 2507)
  AUTHORS   Haitina,T., Lindblom,J., Renstrom,T. and Fredriksson,R.
  TITLE     Fourteen novel human members of mitochondrial solute carrier family
            25 (SLC25) widely expressed in the central nervous system
  JOURNAL   Genomics 88 (6), 779-790 (2006)
   PUBMED   16949250
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC004973.1, BC071871.1,
            AC004000.1 and BM907537.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_145305.2.
            
            Summary: This gene encodes a member of the mitochondrial carrier
            family of proteins.[provided by RefSeq, Dec 2009].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC019584.1, SRR1163657.385473.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            MANE Ensembl match                 :: ENST00000217909.8/
                                                  ENSP00000217909.7
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-68                AC004973.1         75291-75358
            69-1068             BC071871.1         72-1071
            1069-2483           AC004000.1         32158-33572
            2484-2507           BM907537.1         10-33               c
FEATURES             Location/Qualifiers
     source          1..2507
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq24"
     gene            1..2507
                     /gene="SLC25A43"
                     /note="solute carrier family 25 member 43"
                     /db_xref="GeneID:203427"
                     /db_xref="HGNC:HGNC:30557"
                     /db_xref="MIM:300641"
     exon            1..343
                     /gene="SLC25A43"
                     /inference="alignment:Splign:2.1.0"
     CDS             69..1094
                     /gene="SLC25A43"
                     /codon_start=1
                     /product="solute carrier family 25 member 43"
                     /protein_id="NP_660348.2"
                     /db_xref="CCDS:CCDS14577.1"
                     /db_xref="GeneID:203427"
                     /db_xref="HGNC:HGNC:30557"
                     /db_xref="MIM:300641"
                     /translation="MATWRRDGRLTGGQRLLCAGLAGTLSLSLTAPLELATVLAQVGV
                     VRGHARGPWATGHRVWRAEGLRALWKGNAVACLRLFPCSAVQLAAYRKFVVLFTDDLG
                     HISQWSSIMAGSLAGMVSTIVTYPTDLIKTRLIMQNILEPSYRGLLHAFSTIYQQEGF
                     LALYRGVSLTVVGALPFSAGSLLVYMNLEKIWNGPRDQFSLPQNFANVCLAAAVTQTL
                     SFPFETVKRKMQAQSPYLPHSGGVDVHFSGAVDCFRQIVKAQGVLGLWNGLTANLLKI
                     VPYFGIMFSTFEFCKRICLYQNGYILSPLSYKLTPGVDQSLQPQELRELKKFFKTRKP
                     KPKKPTL"
     exon            344..585
                     /gene="SLC25A43"
                     /inference="alignment:Splign:2.1.0"
     exon            586..758
                     /gene="SLC25A43"
                     /inference="alignment:Splign:2.1.0"
     exon            759..893
                     /gene="SLC25A43"
                     /inference="alignment:Splign:2.1.0"
     exon            894..2507
                     /gene="SLC25A43"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2482..2487
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC25A43"
                     /note="hexamer: ATTAAA"
     polyA_site      2507
                     /gene="SLC25A43"
                     /note="major polyA site"
ORIGIN      
        1 acctccgccc gtggccggag agccccaggc ccgagccacg cggtcttccg ggcccgggtc
       61 ggggctcgat ggctacgtgg aggcgggacg gccgactgac aggcggccaa aggctgctgt
      121 gcgctgggct ggcggggacg ctcagcctca gcctcaccgc gcccctggag ctcgccaccg
      181 tgctggccca ggttggcgtc gtgcgaggcc acgcccgggg accgtgggcc acagggcacc
      241 gggtgtggcg ggcagagggg ctccgggccc tgtggaaggg gaacgcggtg gcgtgcctgc
      301 gcctcttccc ctgcagcgcc gtgcagctcg ccgcctaccg caaatttgtt gtgctgttca
      361 cagatgacct gggccacatt tcccagtgga gctccatcat ggctgggagt ctcgcaggca
      421 tggtttccac cattgtaaca tatcctacag acctcatcaa aacccggttg atcatgcaga
      481 acatactgga accatcgtac agggggctcc tccatgcttt ttctactatt taccaacagg
      541 aagggttcct tgccctttat cgaggggttt ccctcactgt tgtaggtgct ctcccgttct
      601 ctgctggctc ccttcttgtt tacatgaacc tggagaaaat ctggaacgga ccccgagatc
      661 agttctctct cccacagaac tttgctaatg tctgtctggc tgctgcagtg acccagaccc
      721 tctcctttcc ctttgagacc gtgaagagaa agatgcaggc tcagagcccc tacctcccac
      781 acagtggagg agtagatgtc catttctcag gagcagtgga ctgcttccgg cagatagtga
      841 aggcccaggg ggtcctgggg ctctggaatg gattgacagc caatttactg aagatagttc
      901 catattttgg aattatgttt agcacctttg agttctgcaa gagaatctgt ctttatcaaa
      961 atggttacat tctgtctcca ctgagctata aattgacccc aggagtcgat cagagtttgc
     1021 agccccagga attacgagaa ttaaagaagt tcttcaaaac gagaaaaccg aagcctaaaa
     1081 aaccaactct ataaaatgga atggaactag aagtgcactg actgacagca tgttgcaatc
     1141 acagataaat gtagcctcat aactgtgcac ctgaggaggg atgagaagct actgctatct
     1201 gctgctctgg gaaatgagat ggtttggcca tgcaccacct cagatctcca aactgatgtc
     1261 cctgtgaaca cctgcactat gagaaggttt cccaacaaga gtgtatcatg atggcattcc
     1321 acgagatttt ataaccagag tctagcagtg ataaaatgta caatttacgc tctgaataga
     1381 aacatgacac caaagaaagg gcattgccat gacatctcaa agcaacaggt aattgaagtg
     1441 gctgagtgga taccacgttg tgaggtcagc cactgggtca cttgtagtca atgcaaagct
     1501 tgcacaaacc aacgtcagcc tagtttcact cagtttgacc tgagactttc caatacaatc
     1561 tgttgttttg ttttgttttt agagacaggg tcttgctctg tcacccagac tggagtacaa
     1621 tgacacaatc atagctcact gcagccttta actactgggc tcaagacatc ctcctgcttc
     1681 agcctccaga gagttgggac cataggtgca caccaccaca cctagctaat tttttgggga
     1741 ggtcttgcta tgttgcccag gctggtcttg aactcctggg ctcatgcaat cctcctgcct
     1801 tggcctccca aagcgctagg attagaggtg tgagccgctg caccctgccc cagtacaatc
     1861 ttttttgaac tcaaattttt gctgacatct gagtgcacac accacagtgt aaattatgcc
     1921 ttatcagaat ctaaatgaaa atagcgaaca tttaaaagct atcaccattg tagtagaatc
     1981 atccttcttt tttgaaattt gaagcatccc aggcttaaaa tcttgtgttt cagaaagaca
     2041 gtttatacca tgactgctta attatccccc caaagacctt ctgattgaag tcatgtacag
     2101 ttcagtggcc taaattctct gcctttttaa cttgctttgc aagcctactc tgaaaataag
     2161 ttatttagtc aagttattct caaagatgtc ccagttgcct agaaaggatc aaatggaaca
     2221 tttgacacac atactcaaaa aaatgtaact gactataaac actttaacct aatcatctgt
     2281 atcaaacttt ctaaaaatca aatctcagga ttgttccact ttagagattc tatgtaaagt
     2341 ttatataact atacttgtca aatagcacct atctatgcat ttaaaaatgc attaatatct
     2401 aacataaaat tgttaattta tacacacaca tacactcata catagagaga gattttcggt
     2461 atgttgcaag tattttttcc gattaaattt attttccaaa gaaaaaa
//
