LOCUS       NM_178526               3267 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens solute carrier family 25 member 42 (SLC25A42),
            transcript variant 1, mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_178526 XM_209204
VERSION     NM_178526.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3267)
  AUTHORS   Taga,K. and Takeuchi,H.
  TITLE     Novel role of host protein SLC25A42 in the HIV-1 reactivation of
            latent HIV-1 provirus
  JOURNAL   Microbiol Immunol 68 (3), 90-99 (2024)
   PUBMED   38244193
  REMARK    GeneRIF: Novel role of host protein SLC25A42 in the HIV-1
            reactivation of latent HIV-1 provirus.
REFERENCE   2  (bases 1 to 3267)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   3  (bases 1 to 3267)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 3267)
  AUTHORS   Almannai,M., Alasmari,A., Alqasmi,A., Faqeih,E., Al Mutairi,F.,
            Alotaibi,M., Samman,M.M., Eyaid,W., Aljadhai,Y.I., Shamseldin,H.E.,
            Craigen,W. and Alkuraya,F.S.
  TITLE     Expanding the phenotype of SLC25A42-associated mitochondrial
            encephalomyopathy
  JOURNAL   Clin Genet 93 (5), 1097-1102 (2018)
   PUBMED   29327420
  REMARK    GeneRIF: our report confirms the link between SLC25A42 and
            mitochondrial disease in humans, and suggests that pathogenic
            variants in SLC25A42 should be interpreted with the understanding
            that the associated phenotype may be highly variable.
REFERENCE   5  (bases 1 to 3267)
  AUTHORS   Palmieri,F.
  TITLE     The mitochondrial transporter family SLC25: identification,
            properties and physiopathology
  JOURNAL   Mol Aspects Med 34 (2-3), 465-484 (2013)
   PUBMED   23266187
  REMARK    GeneRIF: Compares and contrasts all the known human SLC25A* genes
            and includes functional information.
            Review article
REFERENCE   6  (bases 1 to 3267)
  AUTHORS   de Mateo,S., Castillo,J., Estanyol,J.M., Ballesca,J.L. and Oliva,R.
  TITLE     Proteomic characterization of the human sperm nucleus
  JOURNAL   Proteomics 11 (13), 2714-2726 (2011)
   PUBMED   21630459
REFERENCE   7  (bases 1 to 3267)
  AUTHORS   Fiermonte,G., Paradies,E., Todisco,S., Marobbio,C.M. and
            Palmieri,F.
  TITLE     A novel member of solute carrier family 25 (SLC25A42) is a
            transporter of coenzyme A and adenosine 3',5'-diphosphate in human
            mitochondria
  JOURNAL   J Biol Chem 284 (27), 18152-18159 (2009)
   PUBMED   19429682
  REMARK    GeneRIF: The main physiological role of SLC25A42 is to import CoA
            into mitochondria in exchange for intramitochondrial (deoxy)adenine
            nucleotides and adenosine 3',5'-diphosphate
REFERENCE   8  (bases 1 to 3267)
  AUTHORS   Haitina,T., Lindblom,J., Renstrom,T. and Fredriksson,R.
  TITLE     Fourteen novel human members of mitochondrial solute carrier family
            25 (SLC25) widely expressed in the central nervous system
  JOURNAL   Genomics 88 (6), 779-790 (2006)
   PUBMED   16949250
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC003038.1, FN356975.1,
            AF521885.1 and AI057363.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_178526.4.
            
            Summary: This gene encodes a solute carrier family 25 protein.
            Solute carrier family 25 proteins are localized to mitochondria and
            play critical roles in the transport of molecules across the inner
            mitochondrial membrane. The encoded protein is a mitochondrial
            transporter for coenzyme A (CoA) and adenosine 3',5'-diphosphate.
            [provided by RefSeq, Feb 2012].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FN356975.1, BC045598.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            MANE Ensembl match                 :: ENST00000318596.8/
                                                  ENSP00000326693.6
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-48                AC003038.1         31105-31152
            49-1089             FN356975.1         24-1064
            1090-3086           AF521885.1         279-2275
            3087-3267           AI057363.1         13-193              c
FEATURES             Location/Qualifiers
     source          1..3267
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.11"
     gene            1..3267
                     /gene="SLC25A42"
                     /gene_synonym="MECREN"
                     /note="solute carrier family 25 member 42"
                     /db_xref="GeneID:284439"
                     /db_xref="HGNC:HGNC:28380"
                     /db_xref="MIM:610823"
     exon            1..122
                     /gene="SLC25A42"
                     /gene_synonym="MECREN"
                     /inference="alignment:Splign:2.1.0"
     exon            123..237
                     /gene="SLC25A42"
                     /gene_synonym="MECREN"
                     /inference="alignment:Splign:2.1.0"
     CDS             157..1113
                     /gene="SLC25A42"
                     /gene_synonym="MECREN"
                     /codon_start=1
                     /product="mitochondrial coenzyme A transporter SLC25A42"
                     /protein_id="NP_848621.2"
                     /db_xref="CCDS:CCDS32966.1"
                     /db_xref="GeneID:284439"
                     /db_xref="HGNC:HGNC:28380"
                     /db_xref="MIM:610823"
                     /translation="MGNGVKEGPVRLHEDAEAVLSSSVSSKRDHRQVLSSLLSGALAG
                     ALAKTAVAPLDRTKIIFQVSSKRFSAKEAFRVLYYTYLNEGFLSLWRGNSATMVRVVP
                     YAAIQFSAHEEYKRILGSYYGFRGEALPPWPRLFAGALAGTTAASLTYPLDLVRARMA
                     VTPKEMYSNIFHVFIRISREEGLKTLYHGFMPTVLGVIPYAGLSFFTYETLKSLHREY
                     SGRRQPYPFERMIFGACAGLIGQSASYPLDVVRRRMQTAGVTGYPRASIARTLRTIVR
                     EEGAVRGLYKGLSMNWVKGPIAVGISFTTFDLMQILLRHLQS"
     exon            238..343
                     /gene="SLC25A42"
                     /gene_synonym="MECREN"
                     /inference="alignment:Splign:2.1.0"
     exon            344..369
                     /gene="SLC25A42"
                     /gene_synonym="MECREN"
                     /inference="alignment:Splign:2.1.0"
     exon            370..536
                     /gene="SLC25A42"
                     /gene_synonym="MECREN"
                     /inference="alignment:Splign:2.1.0"
     exon            537..653
                     /gene="SLC25A42"
                     /gene_synonym="MECREN"
                     /inference="alignment:Splign:2.1.0"
     exon            654..805
                     /gene="SLC25A42"
                     /gene_synonym="MECREN"
                     /inference="alignment:Splign:2.1.0"
     exon            806..3267
                     /gene="SLC25A42"
                     /gene_synonym="MECREN"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3104..3109
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC25A42"
                     /gene_synonym="MECREN"
                     /note="hexamer: AATAAA"
     polyA_site      3132
                     /gene="SLC25A42"
                     /gene_synonym="MECREN"
                     /note="major polyA site"
     regulatory      3245..3250
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC25A42"
                     /gene_synonym="MECREN"
                     /note="hexamer: AATAAA"
     polyA_site      3267
                     /gene="SLC25A42"
                     /gene_synonym="MECREN"
                     /note="major polyA site"
ORIGIN      
        1 gaggcggggc cgtggcggct ggaggtagcg gcggcggcga cgcgtccggg ccggtgaggg
       61 ggcgcggggg gcgccggggg ggcccaagcg tcagcggccc gcgcctgtcg ggctgaactg
      121 aggaccgagt ctcctgccat tccgagcagg cctggtatgg gtaatggtgt gaaggaaggc
      181 ccggtgcgat tgcatgagga tgctgaggct gtcctgtcct cgtccgtctc atcaaagcgt
      241 gaccacaggc aagtgctcag ctccctgctg tctggggccc tggctggtgc ccttgccaaa
      301 acagcggtag ctcccctgga ccgaaccaaa atcatcttcc aagtgtcttc aaaaagattt
      361 tctgccaagg aggccttccg ggtcctctac tacacctacc tcaacgaggg atttctcagc
      421 ttgtggcgcg ggaactcggc caccatggtg cgcgtggtgc cctacgccgc catccagttc
      481 agcgcacacg aggagtacaa gcgcatcctg ggcagctact atggcttccg tggagaagcc
      541 ctgccccctt ggcctcgcct cttcgccggc gcactggctg gaacgacagc cgcttcactg
      601 acctaccccc tggacctggt cagagcgcgg atggccgtaa ccccgaagga aatgtacagc
      661 aacatctttc atgtcttcat ccgcatctcg agagaagagg ggctgaagac tctctaccat
      721 ggatttatgc ccaccgtgct gggggtcatt ccctacgctg gcctgagctt cttcacctat
      781 gagacgctca agagcttgca cagagagtac agcggccgcc ggcagcccta ccccttcgag
      841 cgcatgatct tcggcgcctg cgctggcctc atcgggcagt cggcctcgta cccgctggat
      901 gtggtgcggc ggcgcatgca gacggccggc gtcacgggct acccgcgcgc ctccatcgcc
      961 cgcacgctgc gcaccatcgt gcgggaggag ggcgccgtgc gcggcctcta caaaggcttg
     1021 agcatgaact gggtcaaggg tcccatcgcc gtgggcatca gcttcaccac cttcgacctc
     1081 atgcagatcc tgctgcggca cctgcagagc taggggaccc tgagctgctc tcaggacggt
     1141 ggaccggtga cccctttgta ttctgggccc atggaacggt gggggggtgc gcttgattct
     1201 acttcaggag gcacatgggg cgctttatgg aacgagcagg tgggcctgag gggcctgggc
     1261 tcagagtcca cgtccaaacg caaagctggc agccctggaa gtgcagtgtt ggggcgatgg
     1321 tgtggggggt cccgcagctc ccctcttcct tcctctgcag acgctggcgc tgtctgccgg
     1381 aggtgttgcc caaaaggccc tagtggggcg tggtcagctc cacctcctga tcctgtgtgt
     1441 cctccgacat gctgctgatt ctagtgaccc ctgtccccac caggctcaga gccagaccgc
     1501 gcctggacct tcttgttctg actccacgtg cctgcccggc ctccagggtg cgggggcgcc
     1561 tttcttgcag gcggaccctg cccaggatgg ggccagcctc gtgctcagct ttggccacaa
     1621 atgcagcccc tggcccaccc caccctgccg gccctgcctt ctccagtatt tcccacatgg
     1681 ccacgactcc tcagtcacta gagcctcctg ctgggaacag tgtcccccag agcctcatgt
     1741 ctatcctaga ccctgcaagc agctgggtcc ccaagagtgc atctccccct agagttgcct
     1801 gcccatgccc acctgctttg taaccttccc aggagattca tgcttgctct gcacagcagg
     1861 gctcgaggcc caggccatga cacggaactg cctcaggttt gggtcagacc tgcatcctgg
     1921 ggcatctgct gaaatgtgag cacacaaacc acctcctttg gcccagaagc cccccaggcc
     1981 tagcatctca gtgccccaac cctctgccca gctgtggtat ccagcaggtc cttgggtccc
     2041 cacttgagca ggcacttggc tgggatatgg agcaatttaa agcccacagg ggttgttcag
     2101 tttctatgaa atggagcatg gggtgcctgc tagcctcaat cccccgaagt gggagcctca
     2161 tgatagagta tagcttgggg gtgggaggtg aggaaaatct gaggtaccca ggggaacccc
     2221 cagctaactg gtctctcaga ggagtccccc agggcccgcc agctatcaca gggactcaga
     2281 aacacccatt tcctaatgac atggtgagtt tcttgatttc ttttttttgt ttgttttgtt
     2341 ttggttttca acttggctga ccccgggtct atgatctatt cacatcgaac ccctgactgg
     2401 tctgcctggt gccagggtga gcgtgaccgt gagtgttgct ttcgacagct ggctcagcac
     2461 acgctgtgtg aagggatctg agcttgttca tctccagtcg tgacttcatt tcccttcctt
     2521 ctgtcctcct cctgttcttg ccttggacct gcaggtgtgc agaccgctct ctctgccttc
     2581 cttgcatgtg gccaccagcc atccctgatc ttgtccccag aggcccaggc agcctgtgat
     2641 ggctgtgagg ggctgtccca ctgtgtgggt atcccttacc cagcacttaa acttggcagg
     2701 agaggcaggg caaccctcac agggagatgg gagggcaccc aactcccaca agcatgcaac
     2761 agcagtagga attgggggtc tgccccaggt gggtgagacc aaatgagtgg atttggggcc
     2821 acaggctagg caggagagac aaggggtagg tgggagggtc ccccagtccc tgctgacccc
     2881 agtgtgtctc cccggagatg gctcctagct gagtgggacc cggcaggagt tggggacagt
     2941 gctgtccccc acccctgcac acagccaggc cctcaggctc tgcggtcact cgcctccctg
     3001 ctggtcactg gtcttggtct ggagttatat tttgatgcca tgaagacact gtttatatct
     3061 aatgtttata tattttaaag atttgtgcca agagagtata tttaataaaa acttaaatga
     3121 cttcttctcc tgctcctggc tcttctttgg ctctgaccgc ccccccatct tcccccatga
     3181 acccccaaac agggttgaag tgcttttgac acatttgtga taaaagttct gaataaaagt
     3241 cttgaataaa gaagttttta aatgcaa
//
