LOCUS       NM_173637               1535 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens solute carrier family 25 member 41 (SLC25A41),
            transcript variant 1, mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_173637
VERSION     NM_173637.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1535)
  AUTHORS   Eifler,K., Cuijpers,S.A.G., Willemstein,E., Raaijmakers,J.A., El
            Atmioui,D., Ovaa,H., Medema,R.H. and Vertegaal,A.C.O.
  TITLE     SUMO targets the APC/C to regulate transition from metaphase to
            anaphase
  JOURNAL   Nat Commun 9 (1), 1119 (2018)
   PUBMED   29549242
  REMARK    GeneRIF: The APC4 subunit is the major SUMO target in the
            anaphase-promoting complex/cyclosome, containing SUMO acceptor
            lysines at positions 772 and 798.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1535)
  AUTHORS   Palmieri,F.
  TITLE     The mitochondrial transporter family SLC25: identification,
            properties and physiopathology
  JOURNAL   Mol Aspects Med 34 (2-3), 465-484 (2013)
   PUBMED   23266187
  REMARK    GeneRIF: Compares and contrasts all the known human SLC25A* genes
            and includes functional information.
            Review article
REFERENCE   3  (bases 1 to 1535)
  AUTHORS   Haitina,T., Lindblom,J., Renstrom,T. and Fredriksson,R.
  TITLE     Fourteen novel human members of mitochondrial solute carrier family
            25 (SLC25) widely expressed in the central nervous system
  JOURNAL   Genomics 88 (6), 779-790 (2006)
   PUBMED   16949250
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC031671.1, AK097761.1 and AC011539.7.
            
            On May 17, 2019 this sequence version replaced NM_173637.3.
            
            Summary: SLC25A41 belongs to the SLC25 family of mitochondrial
            carrier proteins (Haitina et al., 2006 [PubMed 16949250]).[supplied
            by OMIM, Mar 2008].
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA1968968,
                              SAMEA2148093 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            MANE Ensembl match                 :: ENST00000321510.7/
                                                  ENSP00000322649.5
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1270              BC031671.1         17-1286
            1271-1305           AK097761.1         1369-1403
            1306-1311           AC011539.7         11802-11807         c
            1312-1533           AK097761.1         1404-1625
            1534-1535           BC031671.1         1404-1405
FEATURES             Location/Qualifiers
     source          1..1535
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.3"
     gene            1..1535
                     /gene="SLC25A41"
                     /gene_synonym="APC4; SCaMC-3L"
                     /note="solute carrier family 25 member 41"
                     /db_xref="GeneID:284427"
                     /db_xref="HGNC:HGNC:28533"
                     /db_xref="MIM:610822"
     exon            1..277
                     /gene="SLC25A41"
                     /gene_synonym="APC4; SCaMC-3L"
                     /inference="alignment:Splign:2.1.0"
     CDS             71..1183
                     /gene="SLC25A41"
                     /gene_synonym="APC4; SCaMC-3L"
                     /note="isoform a is encoded by transcript variant 1;
                     SCaMC-3-like; mitochondrial ATP-Mg/Pi carrier protein
                     SLC25A41; small calcium-binding mitochondrial carrier
                     protein 3-like; mitochondrial carrier protein SCaMC-3L"
                     /codon_start=1
                     /product="mitochondrial carrier protein SCaMC-3L isoform
                     a"
                     /protein_id="NP_775908.2"
                     /db_xref="CCDS:CCDS45937.1"
                     /db_xref="GeneID:284427"
                     /db_xref="HGNC:HGNC:28533"
                     /db_xref="MIM:610822"
                     /translation="MGAQPGEPQNTCSRIQTLFRRVKTLLIKAPPPPQPPPPPPSWNP
                     GCTHVYGYAFGHMHDNNLEHLPSQQVLDTGEQLMVPVEVLEVDNKEALWKFLLSGAMA
                     GAVSRTGTAPLDRAKVYMQVYSSKTNFTNLLGGLQSMVQEGGFRSLWRGNGINVLKIA
                     PEYAIKFSVFEQCKNYFCGIQGSPPFQERLLAGSLAVAISQTLINPMEVLKTRLTLRR
                     TGQYKGLLDCARQILQREGTRALYRGYLPNMLGIIPYACTDLAVYEMLQCFWVKSGRD
                     MGDPSGLVSLSSVTLSTTCGQMASYPLTLVRTRMQAQDTVEGSNPTMRGVLQRILAQQ
                     GWLGLYRGMTPTLLKVLPAGGISYVVYEAMKKTLGI"
     exon            278..433
                     /gene="SLC25A41"
                     /gene_synonym="APC4; SCaMC-3L"
                     /inference="alignment:Splign:2.1.0"
     exon            434..586
                     /gene="SLC25A41"
                     /gene_synonym="APC4; SCaMC-3L"
                     /inference="alignment:Splign:2.1.0"
     exon            587..694
                     /gene="SLC25A41"
                     /gene_synonym="APC4; SCaMC-3L"
                     /inference="alignment:Splign:2.1.0"
     exon            695..862
                     /gene="SLC25A41"
                     /gene_synonym="APC4; SCaMC-3L"
                     /inference="alignment:Splign:2.1.0"
     exon            863..1010
                     /gene="SLC25A41"
                     /gene_synonym="APC4; SCaMC-3L"
                     /inference="alignment:Splign:2.1.0"
     exon            1011..1535
                     /gene="SLC25A41"
                     /gene_synonym="APC4; SCaMC-3L"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1512..1517
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC25A41"
                     /gene_synonym="APC4; SCaMC-3L"
                     /note="hexamer: AATAAA"
     polyA_site      1535
                     /gene="SLC25A41"
                     /gene_synonym="APC4; SCaMC-3L"
                     /note="major polyA site"
ORIGIN      
        1 actcccgcat ggtagctgga gcagcaaaca actgcttagg gatttgaagc caggtgtcct
       61 aacttcctcc atgggcgctc agcctgggga acctcagaac acttgctcta ggatccagac
      121 actgtttagg agggtcaaga ccttactcat caaagccccg cctccccccc aacctccgcc
      181 tccaccccca tcctggaacc ctggctgtac acacgtgtat gggtacgcgt ttggccacat
      241 gcatgacaac aaccttgaac atctcccgtc acagcaggta ctggacacag gagagcagct
      301 gatggtcccc gtggaagtcc tggaagtgga taacaaggag gccttgtgga agtttctact
      361 ctcaggagct atggccgggg cggtgtctcg cacgggcacg gcacctctgg acagagccaa
      421 ggtgtacatg caggtctact cctccaagac gaacttcacc aacctgctgg gggggctaca
      481 gagcatggtc caggagggcg gcttccgctc cctgtggcgg ggcaacggca tcaacgtgct
      541 caagattgct cctgagtatg ccatcaagtt ctccgtattc gagcagtgca agaattactt
      601 ctgtggaata caagggtccc cgcccttcca ggagcgtctc cttgctggct ccctggctgt
      661 ggccatctcc cagaccctca tcaaccccat ggaggtgctg aagacgcggt tgaccttgcg
      721 tcggacgggc cagtacaagg ggctgctgga ctgcgccagg cagatcttgc agcgagaggg
      781 cacccgcgcc ctttaccgcg gctacctgcc caatatgctc ggcatcatcc cctatgcctg
      841 caccgacctg gctgtctatg agatgctcca gtgcttctgg gtgaagtcag gcagggatat
      901 gggggacccc agtggcctgg tcagtctgtc gtctgtgacg ctatccacga cctgtggcca
      961 gatggccagc tacccactga ctctggtgcg caccaggatg caggcccaag ataccgtgga
     1021 gggctcaaat cccaccatgc gcggagtcct ccagcggatc ctggcccagc agggctggct
     1081 agggctgtac cgaggcatga cccccacgct actgaaggtc ttaccagcag gtggcatcag
     1141 ctatgtggtg tacgaagcca tgaagaaaac cctgggcata taggctgtga gctggacgac
     1201 acagcctagg cagaaatggg acaggaggac ctgatgaccc ctggccccaa agagccctcg
     1261 aggcctcaag gttcaggccc tggggcagtt tttggtggca aaagcaggct gggggtgggg
     1321 gtggggctct gggtcagaag attcctgaag ctggggttgg tggtgggtgg aggggggcag
     1381 tgctgggtca gaaaactcct gggactccct ccccagggtg cagcctgaga caagaaacgt
     1441 ggactccagt ctggcccctt gtgggtcgtc ctggctccag ggcgaaatgg tgaacatgtc
     1501 acacaacaag gaataaagag atggtttttg ctgaa
//
