LOCUS       NM_001143780            1581 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens solute carrier family 25 member 39 (SLC25A39),
            transcript variant 1, mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_001143780
VERSION     NM_001143780.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1581)
  AUTHORS   Chen,X. and Gan,B.
  TITLE     SLC25A39 links mitochondrial GSH sensing with iron metabolism
  JOURNAL   Mol Cell 84 (4), 616-618 (2024)
   PUBMED   38364779
  REMARK    GeneRIF: SLC25A39 links mitochondrial GSH sensing with iron
            metabolism.
            Review article
REFERENCE   2  (bases 1 to 1581)
  AUTHORS   Shi,X., DeCiucis,M., Grabinska,K.A., Kanyo,J., Liu,A., Lam,T.T. and
            Shen,H.
  TITLE     Dual regulation of SLC25A39 by AFG3L2 and iron controls
            mitochondrial glutathione homeostasis
  JOURNAL   Mol Cell 84 (4), 802-810 (2024)
   PUBMED   38157846
  REMARK    GeneRIF: Dual regulation of SLC25A39 by AFG3L2 and iron controls
            mitochondrial glutathione homeostasis.
REFERENCE   3  (bases 1 to 1581)
  AUTHORS   Liu,Y., Liu,S., Tomar,A., Yen,F.S., Unlu,G., Ropek,N., Weber,R.A.,
            Wang,Y., Khan,A., Gad,M., Peng,J., Terzi,E., Alwaseem,H.,
            Pagano,A.E., Heissel,S., Molina,H., Allwein,B., Kenny,T.C.,
            Possemato,R.L., Zhao,L., Hite,R.K., Vinogradova,E.V., Mansy,S.S.
            and Birsoy,K.
  TITLE     Autoregulatory control of mitochondrial glutathione homeostasis
  JOURNAL   Science 382 (6672), 820-828 (2023)
   PUBMED   37917749
  REMARK    GeneRIF: Autoregulatory control of mitochondrial glutathione
            homeostasis.
REFERENCE   4  (bases 1 to 1581)
  AUTHORS   Shi,X., Reinstadler,B., Shah,H., To,T.L., Byrne,K., Summer,L.,
            Calvo,S.E., Goldberger,O., Doench,J.G., Mootha,V.K. and Shen,H.
  TITLE     Combinatorial GxGxE CRISPR screen identifies SLC25A39 in
            mitochondrial glutathione transport linking iron homeostasis to
            OXPHOS
  JOURNAL   Nat Commun 13 (1), 2483 (2022)
   PUBMED   35513392
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1581)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   6  (bases 1 to 1581)
  AUTHORS   Beddok,A., Perot,G., Le Guellec,S., Thebault,N., Coutte,A.,
            Sevestre,H., Chauffert,B. and Chibon,F.
  TITLE     Germinal GLT8D1, GATAD2A and SLC25A39 mutations in a patient with a
            glomangiopericytal tumor and five different sarcomas over a 10-year
            period
  JOURNAL   Sci Rep 11 (1), 9765 (2021)
   PUBMED   33963205
  REMARK    GeneRIF: Germinal GLT8D1, GATAD2A and SLC25A39 mutations in a
            patient with a glomangiopericytal tumor and five different sarcomas
            over a 10-year period.
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 1581)
  AUTHORS   Palmieri,F.
  TITLE     The mitochondrial transporter family SLC25: identification,
            properties and physiopathology
  JOURNAL   Mol Aspects Med 34 (2-3), 465-484 (2013)
   PUBMED   23266187
  REMARK    GeneRIF: Compares and contrasts all the known human SLC25A* genes
            and includes functional information.
            Review article
REFERENCE   8  (bases 1 to 1581)
  AUTHORS   Nilsson,R., Schultz,I.J., Pierce,E.L., Soltis,K.A.,
            Naranuntarat,A., Ward,D.M., Baughman,J.M., Paradkar,P.N.,
            Kingsley,P.D., Culotta,V.C., Kaplan,J., Palis,J., Paw,B.H. and
            Mootha,V.K.
  TITLE     Discovery of genes essential for heme biosynthesis through
            large-scale gene expression analysis
  JOURNAL   Cell Metab 10 (2), 119-130 (2009)
   PUBMED   19656490
  REMARK    GeneRIF: Required for functional heme biosynthesis in erythroid
            cells. Possibly regulate ALAS2 through iron-sulfur cluster
            biogenesis.
REFERENCE   9  (bases 1 to 1581)
  AUTHORS   Haitina,T., Lindblom,J., Renstrom,T. and Fredriksson,R.
  TITLE     Fourteen novel human members of mitochondrial solute carrier family
            25 (SLC25) widely expressed in the central nervous system
  JOURNAL   Genomics 88 (6), 779-790 (2006)
   PUBMED   16949250
REFERENCE   10 (bases 1 to 1581)
  AUTHORS   Yu,X.X., Lewin,D.A., Zhong,A., Brush,J., Schow,P.W., Sherwood,S.W.,
            Pan,G. and Adams,S.H.
  TITLE     Overexpression of the human 2-oxoglutarate carrier lowers
            mitochondrial membrane potential in HEK-293 cells: contrast with
            the unique cold-induced mitochondrial carrier CGI-69
  JOURNAL   Biochem J 353 (Pt 2), 369-375 (2001)
   PUBMED   11139402
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK289357.1 and BC096819.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001143780.2.
            
            Summary: This gene encodes a member of the SLC25 transporter or
            mitochondrial carrier family of proteins. Members of this family
            are encoded by the nuclear genome while their protein products are
            usually embedded in the inner mitochondrial membrane and exhibit
            wide-ranging substrate specificity. Although the encoded protein is
            currently considered an orphan transporter, this protein is related
            to other carriers known to transport amino acids. This protein may
            play a role in iron homeostasis. [provided by RefSeq, Mar 2016].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.1140769.1,
                                           SRR5189667.222450.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000377095.10/ ENSP00000366299.4
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1225              AK289357.1         9-1233
            1226-1581           BC096819.1         1176-1531
FEATURES             Location/Qualifiers
     source          1..1581
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q21.31"
     gene            1..1581
                     /gene="SLC25A39"
                     /gene_synonym="CGI-69; CGI69"
                     /note="solute carrier family 25 member 39"
                     /db_xref="GeneID:51629"
                     /db_xref="HGNC:HGNC:24279"
                     /db_xref="MIM:610820"
     exon            1..113
                     /gene="SLC25A39"
                     /gene_synonym="CGI-69; CGI69"
                     /inference="alignment:Splign:2.1.0"
     exon            114..213
                     /gene="SLC25A39"
                     /gene_synonym="CGI-69; CGI69"
                     /inference="alignment:Splign:2.1.0"
     CDS             129..1208
                     /gene="SLC25A39"
                     /gene_synonym="CGI-69; CGI69"
                     /note="isoform a is encoded by transcript variant 1;
                     probable mitochondrial glutathione transporter SLC25A39"
                     /codon_start=1
                     /product="mitochondrial glutathione transporter SLC25A39
                     isoform a"
                     /protein_id="NP_001137252.1"
                     /db_xref="CCDS:CCDS45700.1"
                     /db_xref="GeneID:51629"
                     /db_xref="HGNC:HGNC:24279"
                     /db_xref="MIM:610820"
                     /translation="MADQDPAGISPLQQMVASGTGAVVTSLFMTPLDVVKVRLQSQRP
                     SMASELMPSSRLWSLSYTKLPSSLQSTGKCLLYCNGVLEPLYLCPNGARCATWFQDPT
                     RFTGTMDAFVKIVRHEGTRTLWSGLPATLVMTVPATAIYFTAYDQLKAFLCGRALTSD
                     LYAPMVAGALARLGTVTVISPLELMRTKLQAQHVSYRELGACVRTAVAQGGWRSLWLG
                     WGPTALRDVPFSALYWFNYELVKSWLNGFRPKDQTSVGMSFVAGGISGTVAAVLTLPF
                     DVVKTQRQVALGAMEAVRVNPLHVDSTWLLLRRIRAESGTKGLFAGFLPRIIKAAPSC
                     AIMISTYEFGKSFFQRLNQDRLLGG"
     exon            214..273
                     /gene="SLC25A39"
                     /gene_synonym="CGI-69; CGI69"
                     /inference="alignment:Splign:2.1.0"
     exon            274..318
                     /gene="SLC25A39"
                     /gene_synonym="CGI-69; CGI69"
                     /inference="alignment:Splign:2.1.0"
     exon            319..452
                     /gene="SLC25A39"
                     /gene_synonym="CGI-69; CGI69"
                     /inference="alignment:Splign:2.1.0"
     exon            453..520
                     /gene="SLC25A39"
                     /gene_synonym="CGI-69; CGI69"
                     /inference="alignment:Splign:2.1.0"
     exon            521..645
                     /gene="SLC25A39"
                     /gene_synonym="CGI-69; CGI69"
                     /inference="alignment:Splign:2.1.0"
     exon            646..819
                     /gene="SLC25A39"
                     /gene_synonym="CGI-69; CGI69"
                     /inference="alignment:Splign:2.1.0"
     exon            820..929
                     /gene="SLC25A39"
                     /gene_synonym="CGI-69; CGI69"
                     /inference="alignment:Splign:2.1.0"
     exon            930..1011
                     /gene="SLC25A39"
                     /gene_synonym="CGI-69; CGI69"
                     /inference="alignment:Splign:2.1.0"
     exon            1012..1092
                     /gene="SLC25A39"
                     /gene_synonym="CGI-69; CGI69"
                     /inference="alignment:Splign:2.1.0"
     exon            1093..1581
                     /gene="SLC25A39"
                     /gene_synonym="CGI-69; CGI69"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      1581
                     /gene="SLC25A39"
                     /gene_synonym="CGI-69; CGI69"
                     /note="major polyA site"
ORIGIN      
        1 ggcgtcggcc taggtgcgct gcgagcgcgc gcggaccgcg cacaggcggc ggagccggta
       61 tgggcccgcc tgaccctggg cgccgcgccg cacgagcacc agcctagagc caggactgaa
      121 gcttcaagat ggctgaccag gaccctgcgg gcatcagccc cctccagcaa atggtggcct
      181 caggcaccgg ggctgtggtt acctctctct tcatgacacc cctggacgtg gtgaaggttc
      241 gcctgcagtc tcagcggccc tccatggcca gcgagctgat gccttcctcc agactgtgga
      301 gcctctccta taccaaattg ccctcctctc tccaatccac agggaagtgc ctcctgtatt
      361 gcaatggtgt cctggagcct ctgtacctgt gcccaaatgg tgcccgctgt gccacctggt
      421 ttcaagaccc tacccgcttc actggcacca tggatgcctt cgtgaagatc gtgaggcacg
      481 agggcaccag gaccctctgg agcggcctcc ccgccaccct ggtgatgact gtgccagcta
      541 ccgccatcta cttcactgcc tatgaccaac tgaaggcctt cctgtgtggt cgagccctga
      601 cctctgacct ctacgcaccc atggtggctg gcgcgctggc ccgcctgggc accgtgactg
      661 tgatcagccc cctggagctt atgcggacaa agctgcaggc tcagcatgtg tcgtaccggg
      721 agctgggtgc ctgtgttcga actgcagtgg ctcagggtgg ctggcgctca ctgtggctgg
      781 gctggggccc cactgccctt cgagatgtgc ccttctcagc cctgtactgg ttcaactatg
      841 agctggtgaa gagctggctc aatgggttca ggccgaagga ccagacttct gtgggcatga
      901 gctttgtggc tggtggcatc tcagggacgg tggctgcagt gctgactcta ccctttgacg
      961 tggtaaagac ccaacgccag gtcgctctgg gagcgatgga ggctgtgaga gtgaaccccc
     1021 tgcatgtgga ctccacctgg ctgctgctgc ggaggatccg ggccgagtcg ggcaccaagg
     1081 gactctttgc aggcttcctt cctcggatca tcaaggctgc cccctcctgt gccatcatga
     1141 tcagcaccta tgagttcggc aaaagcttct tccagaggct gaaccaggac cggcttctgg
     1201 gcggctgaaa ggggcaagga ggcaaggacc ccgtctctcc cacggatggg gagagggcag
     1261 gaggagaccc agccaagtgc cttttcctca gcactgaggg agggggcttg tttcccttcc
     1321 ctcccggcga caagctccag ggcagggctg tccctctggg cggcccagca cttcctcaga
     1381 cacaacttct tcctgctgct ccagtcgtgg ggatcatcac ttacccaccc cccaagttca
     1441 agaccaaatc ttccagctgc ccccttcgtg tttccctgtg tttgctgtag ctgggcatgt
     1501 ctccaggaac caagaagccc tcagcctggt gtagtctccc tgacccttgt taattcctta
     1561 agtctaaaga tgatgaactt c
//
