LOCUS       NM_016612               4672 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens solute carrier family 25 member 37 (SLC25A37),
            transcript variant 1, mRNA.
ACCESSION   NM_016612 XM_001128238 XM_001128248 XM_001128255 XM_001128269
VERSION     NM_016612.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4672)
  AUTHORS   Shi,X., Reinstadler,B., Shah,H., To,T.L., Byrne,K., Summer,L.,
            Calvo,S.E., Goldberger,O., Doench,J.G., Mootha,V.K. and Shen,H.
  TITLE     Combinatorial GxGxE CRISPR screen identifies SLC25A39 in
            mitochondrial glutathione transport linking iron homeostasis to
            OXPHOS
  JOURNAL   Nat Commun 13 (1), 2483 (2022)
   PUBMED   35513392
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4672)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   3  (bases 1 to 4672)
  AUTHORS   Yang,Y. and Xu,X.
  TITLE     Identification of key genes in coronary artery disease: an
            integrative approach based on weighted gene co-expression network
            analysis and their correlation with immune infiltration
  JOURNAL   Aging (Albany NY) 13 (6), 8306-8319 (2021)
   PUBMED   33686958
  REMARK    GeneRIF: Identification of key genes in coronary artery disease: an
            integrative approach based on weighted gene co-expression network
            analysis and their correlation with immune infiltration.
REFERENCE   4  (bases 1 to 4672)
  AUTHORS   Yang,L., Kong,D., He,M., Gong,J., Nie,Y., Tai,S. and Teng,C.B.
  TITLE     MiR-7 mediates mitochondrial impairment to trigger apoptosis and
            necroptosis in Rhabdomyosarcoma
  JOURNAL   Biochim Biophys Acta Mol Cell Res 1867 (12), 118826 (2020)
   PUBMED   32810522
  REMARK    GeneRIF: MiR-7 mediates mitochondrial impairment to trigger
            apoptosis and necroptosis in Rhabdomyosarcoma.
REFERENCE   5  (bases 1 to 4672)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 4672)
  AUTHORS   Haitina,T., Lindblom,J., Renstrom,T. and Fredriksson,R.
  TITLE     Fourteen novel human members of mitochondrial solute carrier family
            25 (SLC25) widely expressed in the central nervous system
  JOURNAL   Genomics 88 (6), 779-790 (2006)
   PUBMED   16949250
REFERENCE   7  (bases 1 to 4672)
  AUTHORS   Shaw,G.C., Cope,J.J., Li,L., Corson,K., Hersey,C., Ackermann,G.E.,
            Gwynn,B., Lambert,A.J., Wingert,R.A., Traver,D., Trede,N.S.,
            Barut,B.A., Zhou,Y., Minet,E., Donovan,A., Brownlie,A., Balzan,R.,
            Weiss,M.J., Peters,L.L., Kaplan,J., Zon,L.I. and Paw,B.H.
  TITLE     Mitoferrin is essential for erythroid iron assimilation
  JOURNAL   Nature 440 (7080), 96-100 (2006)
   PUBMED   16511496
REFERENCE   8  (bases 1 to 4672)
  AUTHORS   Li,Q.Z., Eckenrode,S., Ruan,Q.G., Wang,C.Y., Shi,J.D., McIndoe,R.A.
            and She,J.X.
  TITLE     Rapid decrease of RNA level of a novel mouse mitochondria solute
            carrier protein (Mscp) gene at 4-5 weeks of age
  JOURNAL   Mamm Genome 12 (11), 830-836 (2001)
   PUBMED   11845285
REFERENCE   9  (bases 1 to 4672)
  AUTHORS   Hu,R.M., Han,Z.G., Song,H.D., Peng,Y.D., Huang,Q.H., Ren,S.X.,
            Gu,Y.J., Huang,C.H., Li,Y.B., Jiang,C.L., Fu,G., Zhang,Q.H.,
            Gu,B.W., Dai,M., Mao,Y.F., Gao,G.F., Rong,R., Ye,M., Zhou,J.,
            Xu,S.H., Gu,J., Shi,J.X., Jin,W.R., Zhang,C.K., Wu,T.M.,
            Huang,G.Y., Chen,Z., Chen,M.D. and Chen,J.L.
  TITLE     Gene expression profiling in the human
            hypothalamus-pituitary-adrenal axis and full-length cDNA cloning
  JOURNAL   Proc Natl Acad Sci U S A 97 (17), 9543-9548 (2000)
   PUBMED   10931946
REFERENCE   10 (bases 1 to 4672)
  AUTHORS   Liu,P., Perryman,M.B., Liao,W. and Siciliano,M.J.
  TITLE     Efficiency and limitations of the hn-cDNA library approach for the
            isolation of human transcribed genes from hybrid cells
  JOURNAL   Somat Cell Mol Genet 18 (1), 7-18 (1992)
   PUBMED   1372133
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC051642.5.
            
            On Nov 23, 2018 this sequence version replaced NM_016612.3.
            
            Summary: SLC25A37 is a solute carrier localized in the
            mitochondrial inner membrane. It functions as an essential iron
            importer for the synthesis of mitochondrial heme and iron-sulfur
            clusters (summary by Chen et al., 2009 [PubMed 19805291]).[supplied
            by OMIM, Jan 2011].
            
            Transcript Variant: This variant (1) represents the shortest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.242489.1,
                                           SRR3476690.1097362.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            MANE Ensembl match                 :: ENST00000519973.6/
                                                  ENSP00000429200.1
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-257               AC051642.5         152500-152756       c
            258-486             AC051642.5         115376-115604       c
            487-543             AC051642.5         113334-113390       c
            544-4672            AC051642.5         106249-110377       c
FEATURES             Location/Qualifiers
     source          1..4672
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8p21.2"
     gene            1..4672
                     /gene="SLC25A37"
                     /gene_synonym="HT015; MFRN; MFRN1; MSC; MSCP; PRO1278;
                     PRO1584; PRO2217"
                     /note="solute carrier family 25 member 37"
                     /db_xref="GeneID:51312"
                     /db_xref="HGNC:HGNC:29786"
                     /db_xref="MIM:610387"
     exon            1..257
                     /gene="SLC25A37"
                     /gene_synonym="HT015; MFRN; MFRN1; MSC; MSCP; PRO1278;
                     PRO1584; PRO2217"
                     /inference="alignment:Splign:2.1.0"
     CDS             48..1064
                     /gene="SLC25A37"
                     /gene_synonym="HT015; MFRN; MFRN1; MSC; MSCP; PRO1278;
                     PRO1584; PRO2217"
                     /note="isoform 1 is encoded by transcript variant 1;
                     mitoferrin; mitoferrin-1; mitochondrial solute carrier
                     protein; predicted protein of HQ2217; mitochondrial iron
                     transporter 1; solute carrier family 25 (mitochondrial
                     iron transporter), member 37"
                     /codon_start=1
                     /product="mitoferrin-1 isoform 1"
                     /protein_id="NP_057696.2"
                     /db_xref="CCDS:CCDS47828.1"
                     /db_xref="GeneID:51312"
                     /db_xref="HGNC:HGNC:29786"
                     /db_xref="MIM:610387"
                     /translation="MELRSGSVGSQAVARRMDGDSRDGGGGKDATGSEDYENLPTSAS
                     VSTHMTAGAMAGILEHSVMYPVDSVKTRMQSLSPDPKAQYTSIYGALKKIMRTEGFWR
                     PLRGVNVMIMGAGPAHAMYFACYENMKRTLNDVFHHQGNSHLANGIAGSMATLLHDAV
                     MNPAEVVKQRLQMYNSQHRSAISCIRTVWRTEGLGAFYRSYTTQLTMNIPFQSIHFIT
                     YEFLQEQVNPHRTYNPQSHIISGGLAGALAAAATTPLDVCKTLLNTQENVALSLANIS
                     GRLSGMANAFRTVYQLNGLAGYFKGIQARVIYQMPSTAISWSVYEFFKYFLTKRQLEN
                     RAPY"
     exon            258..486
                     /gene="SLC25A37"
                     /gene_synonym="HT015; MFRN; MFRN1; MSC; MSCP; PRO1278;
                     PRO1584; PRO2217"
                     /inference="alignment:Splign:2.1.0"
     exon            487..543
                     /gene="SLC25A37"
                     /gene_synonym="HT015; MFRN; MFRN1; MSC; MSCP; PRO1278;
                     PRO1584; PRO2217"
                     /inference="alignment:Splign:2.1.0"
     exon            544..4672
                     /gene="SLC25A37"
                     /gene_synonym="HT015; MFRN; MFRN1; MSC; MSCP; PRO1278;
                     PRO1584; PRO2217"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1740..1745
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC25A37"
                     /gene_synonym="HT015; MFRN; MFRN1; MSC; MSCP; PRO1278;
                     PRO1584; PRO2217"
                     /note="hexamer: AATAAA"
     polyA_site      1759
                     /gene="SLC25A37"
                     /gene_synonym="HT015; MFRN; MFRN1; MSC; MSCP; PRO1278;
                     PRO1584; PRO2217"
     regulatory      4652..4657
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC25A37"
                     /gene_synonym="HT015; MFRN; MFRN1; MSC; MSCP; PRO1278;
                     PRO1584; PRO2217"
                     /note="hexamer: AATAAA"
     polyA_site      4672
                     /gene="SLC25A37"
                     /gene_synonym="HT015; MFRN; MFRN1; MSC; MSCP; PRO1278;
                     PRO1584; PRO2217"
                     /note="major polyA site"
ORIGIN      
        1 ctccctgccc acctcctgca gcctcctgcg ccccgccgag ctggcggatg gagctgcgca
       61 gcgggagcgt gggcagccag gcggtggcgc ggaggatgga tggggacagc cgagatggcg
      121 gcggcggcaa ggacgccacc gggtcggagg actacgagaa cctgccgact agcgcctccg
      181 tgtccaccca catgacagca ggagcgatgg ccgggatcct ggagcactcg gtcatgtacc
      241 cggtggactc ggtgaagaca cgaatgcaga gtttgagtcc agatcccaaa gcccagtaca
      301 caagtatcta cggagccctc aagaaaatca tgcggaccga aggcttctgg aggcccttgc
      361 gaggcgtcaa cgtcatgatc atgggtgcag ggccggccca tgccatgtat tttgcctgct
      421 atgaaaacat gaaaaggact ttaaatgacg ttttccacca ccaaggaaac agccacctag
      481 ccaacgggat agctgggagt atggccaccc tgctccacga tgcggtaatg aatccagcag
      541 aagtggtgaa gcagcgcttg cagatgtaca actcgcagca ccggtcagca atcagctgca
      601 tccggacggt gtggaggacc gaggggttgg gggccttcta ccggagctac accacgcagc
      661 tgaccatgaa catccccttc cagtccatcc acttcatcac ctatgagttc ctgcaggagc
      721 aggtcaaccc ccaccggacc tacaacccgc agtcccacat catctcaggc gggctggccg
      781 gggccctcgc cgcggccgcc acgacccccc tggacgtctg taagaccctt ctgaacactc
      841 aggagaacgt ggccctctcg ctggccaaca tcagcggccg gctgtcgggt atggccaatg
      901 ccttccggac ggtgtaccag ctcaacggcc tggccggcta cttcaaaggc atccaggcgc
      961 gtgtcatcta ccagatgccc tccaccgcca tttcttggtc tgtctatgag ttcttcaagt
     1021 actttctcac caagcgccag ctggaaaatc gagctccata ctaaaggaag ggatcataga
     1081 atcttttctt aaagtcattc tctgcctgca tccagcccct tgccctctcc tcacacgtag
     1141 atcatttttt ttttgcaggg tgctgcctat gggccctctg ctccccaatg ccttagagag
     1201 aggaggggac ggcacggccg ctcaccggaa ggctgtgtgc ggggacatcc gaggtggtgg
     1261 tggacaggaa ggacttggga aggggagcga gaaattgctt tttctcttcc tccctgggca
     1321 gaatgtagct tttctgcttc actgtggcag cctcctccct ggatccttag atcccagagg
     1381 agggaagaaa atttgcagtg actgaaaaca gtaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     1441 aaaaaaaaaa aaaaaaattt atgtatataa aagttgcatt acacagtaca aaatagatgg
     1501 ataatgttta tcctttattt ttctatgtag aagtttttga atttgtgtgt gtgcttgtgc
     1561 gtgtctacac ctagtattac ggctgggact ctccagctgt ttttgttgtt gttatgtttt
     1621 taagagggtt gaattcttcc atcaggtgaa cgaaaaaggc aacaaagtaa taaatcagtg
     1681 aatgtggccg gcagctgtgt ttagcccctc cagatggaag tttcacttga atgtaaaata
     1741 ataaagttta tattttgaat ttctcttttc atgggggaaa aaaggtacgt taaaaaaatc
     1801 aaaataatga tatgtcactt gcagctacct ttttttttct tttaaattca atcagccacc
     1861 ttcatgtgcc tttttccttt gtctttcccc aaaattccag gaccagagat ctggccctgg
     1921 cctattttct cttgctgtgt acacacacgc acacatgctg ggtggcagga tctcgcccgc
     1981 tggagggtgg tggagcccag tagaattggg gtgactgggc ataaacctgc tgagactgct
     2041 tccttccctg gttgtgagtg atgtgaatgc ctgccttccc cggtcagcac ttagaagccc
     2101 ttgataggca gcatttggcg acttgtgggg caggtgtttg ggataaatcc taccttcatc
     2161 ctaggactta tttctgcatc agccttttaa ctcaggcact tcaggtaacg tgatctatgt
     2221 gtgttttgac tgaatctcat ctcctgtgtt tccctgtgca gtctagggaa gcatgtctcc
     2281 agtctttgtc cctgtcttgt cccaaccatt aattctcatg tcacagcttc tcactgcatg
     2341 tgacaagagc caggcctatc tgctagggcc ctgcggctga ggtctgacct ggaccctcat
     2401 gcccgagtcg gaagacccct ctccagaagc cattctgcat ccttgtctgc tctgcgtcac
     2461 ccgagaacac aggcttcgca gcctcgcttt ctgaaatggt gtgtgccgag tcagattgcc
     2521 gctcagagaa aatacaagcc cgttttccct agctgtgcca tttggtgctc tgccaggctg
     2581 ccgtgcaagg gaataccgac gagacgagct gcactgtctc tgatttggag ccctcaccgg
     2641 agcttgtctt taaaaatgag caggaagctc atgtatgttt gcatttcagt gagccgggtc
     2701 ctgacctgcc gccacccatc acggtcagcg tggtgcatct taccgaggag gcgcaggcct
     2761 ggattctttt gagtggtgct actgcctagg aagtaacacg tggagaattt ccatcttggg
     2821 accatgcaca cagtgccttg gggagtagat tttgccctaa tagcgatgaa gaattttatc
     2881 agtcagtgga gttccttttt cagatcaggg atgggaaaga gccaaactgg gtacctccca
     2941 cgtgtgcccc gtgaacagcc ctttgcagct gggctgtggg gcttggctgc tgccctgtcc
     3001 catctggcag ttaacgcctt ctccctgctc tgccccccac tccccaaaac cagttgcagc
     3061 ctcaacccac atggggatgt agaaagccgt aaagtccacg ctactgttga aaatgtttac
     3121 atctccgctc tcaacctgcc ttgggttcgt gttaaatggt gttaaattct gcaaatggag
     3181 gggaaaaaaa tcaaattcta aatttcaaag tagaatttaa agcaaatttg taaaaaaatt
     3241 atcctaccac cccttttggt ccacttaaga tatgccacgc tgaagcaagg tatttcctac
     3301 tggattttgc tttcactggt gtttagaaaa taaacttgat ttctctagga gcactccttt
     3361 ggttagaggg atgcaagaag gagaggtgaa ggtggcgtgt ggtggctcat gcctgtaatc
     3421 ccagcacttt ggggaggccg aggcaggcgg atcacttgag gccagcagtt tgagaccagc
     3481 ctggccaaca tgatgaaacc ccatctctac taaaaataca aaaaattagc tgggcatggt
     3541 ggcaggcacc tgtaatccca gttacttggg aggctgaggc aggagaattg cttgaaccca
     3601 ggaggtggag gttgcagtga gctgagattg tgccactgca cttcagcctg ggcgacagag
     3661 tgactctgtc aaaaaggaaa ggcaaaaacc ggaccctgga gctctgtggg ccctgattgc
     3721 aggcccctcc ctgtgtgatg agggatgagt cagcttgggg agccacttgg ccagcctgca
     3781 tgcctggtca tcaggaggtt gagaaaagcc ttgaaagttg tgaagcactg agcagataca
     3841 agtgtttgtt aattttgtag aaattaactt tcccatctgg cctttatctc caaagttggt
     3901 attgttgctc cacgcagact gcagtccggt ttcttattgt gactttgaca atgcaaagtg
     3961 caaaatagga agaggcctcc ccaccccact atcccaccct ggtgaccaat tcagtgtaac
     4021 ctttgcacgt actcagtcat tggtgtcttt ggagtgacat ctgcagccag ttagtgccac
     4081 ctgagtacag cactcgtact tttacatgat gtgtgtgtga gtagctcttc tgtccaaacc
     4141 atgatttgag gttcaactac ctgtagatca aagctttatt ttagaacgat aaactgattt
     4201 tttccaaatg ggtgaaatct tctccccatg actatgtttt cttaactttg cattgaatct
     4261 atttactggg ttacattcta tgtgtagttt gctttcttca tttttttttc ttttaaaatg
     4321 ctcatgtctt attccaagca ccttcctcca aagtccccat aaagctgcat ctccaacaca
     4381 ttgttatgcc aataaggttt tatttaactt tatttaagga tgattgtgtc tttgaatgac
     4441 aaatgtactg ctgcttccta cctgcaagac gaacaatgta tgtttcaagg gtgagcaagt
     4501 gttatttctt aaatttctca aatgcctgta gtaactattg tttctgcctc tcaattgttg
     4561 ccagctcttt gaagaagggg agaattgtgt gtttttgtgt ggggatgttt ctgatatgct
     4621 gctacagttg caaaacactg gagctagaga aaataaagta ctgatcttcg aa
//
