LOCUS       NM_001320870            1940 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens solute carrier family 25 member 35 (SLC25A35),
            transcript variant 1, mRNA.
ACCESSION   NM_001320870 XM_005256637
VERSION     NM_001320870.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1940)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 1940)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 1940)
  AUTHORS   Palmieri,F.
  TITLE     The mitochondrial transporter family SLC25: identification,
            properties and physiopathology
  JOURNAL   Mol Aspects Med 34 (2-3), 465-484 (2013)
   PUBMED   23266187
  REMARK    GeneRIF: Compares and contrasts all the known human SLC25A* genes
            and includes functional information.
            Review article
REFERENCE   4  (bases 1 to 1940)
  AUTHORS   Hendrickson,S.L., Lautenberger,J.A., Chinn,L.W., Malasky,M.,
            Sezgin,E., Kingsley,L.A., Goedert,J.J., Kirk,G.D., Gomperts,E.D.,
            Buchbinder,S.P., Troyer,J.L. and O'Brien,S.J.
  TITLE     Genetic variants in nuclear-encoded mitochondrial genes influence
            AIDS progression
  JOURNAL   PLoS One 5 (9), e12862 (2010)
   PUBMED   20877624
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1940)
  AUTHORS   Haitina,T., Lindblom,J., Renstrom,T. and Fredriksson,R.
  TITLE     Fourteen novel human members of mitochondrial solute carrier family
            25 (SLC25) widely expressed in the central nervous system
  JOURNAL   Genomics 88 (6), 779-790 (2006)
   PUBMED   16949250
REFERENCE   6  (bases 1 to 1940)
  AUTHORS   Girard,A., Sachidanandam,R., Hannon,G.J. and Carmell,M.A.
  TITLE     A germline-specific class of small RNAs binds mammalian Piwi
            proteins
  JOURNAL   Nature 442 (7099), 199-202 (2006)
   PUBMED   16751776
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC135178.13, BC041597.1, BC105995.1 and BM987725.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001320870.1.
            
            Summary: SLC25A35 belongs to the SLC25 family of mitochondrial
            carrier proteins (Haitina et al., 2006 [PubMed 16949250]).[supplied
            by OMIM, Mar 2008].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163657.484957.1,
                                           SRR1803611.96932.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000577745.2/ ENSP00000464231.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-57                AC135178.13        89183-89239
            58-82               BC041597.1         1-25
            83-1845             BC105995.1         1-1763
            1846-1940           BM987725.1         17-111              c
FEATURES             Location/Qualifiers
     source          1..1940
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17p13.1"
     gene            1..1940
                     /gene="SLC25A35"
                     /note="solute carrier family 25 member 35"
                     /db_xref="GeneID:399512"
                     /db_xref="HGNC:HGNC:31921"
                     /db_xref="MIM:610818"
     exon            1..968
                     /gene="SLC25A35"
                     /inference="alignment:Splign:2.1.0"
     CDS             594..1496
                     /gene="SLC25A35"
                     /note="isoform a is encoded by transcript variant 1"
                     /codon_start=1
                     /product="solute carrier family 25 member 35 isoform a"
                     /protein_id="NP_001307799.1"
                     /db_xref="CCDS:CCDS82067.1"
                     /db_xref="GeneID:399512"
                     /db_xref="HGNC:HGNC:31921"
                     /db_xref="MIM:610818"
                     /translation="MDFLMSGLAACGACVFTNPLEVVKTRMQLQGELQAPGTYQRHYR
                     NVFHAFITIGKVDGLAALQKGLAPALLYQFLMNGIRLGTYGLAEAGGYLHTAEGTHSP
                     ARSAAAGAMAGVMGAYLGSPIYMVKTHLQAQAASEIAVGHQYKHQGMFQALTEIGQKH
                     GLVGLWRGALGGLPRVIVGSSTQLCTFSSTKDLLSQWEIFPPQSWKLALVAAMMSGIA
                     VVLAMAPFDVACTRLYNQPTDAQGKGLMYRGILDALLQTARTEGIFGMYKGIGASYFR
                     LGPHTILSLFFWDQLRSLYYTDTK"
     exon            969..1034
                     /gene="SLC25A35"
                     /inference="alignment:Splign:2.1.0"
     exon            1035..1187
                     /gene="SLC25A35"
                     /inference="alignment:Splign:2.1.0"
     exon            1188..1322
                     /gene="SLC25A35"
                     /inference="alignment:Splign:2.1.0"
     exon            1323..1940
                     /gene="SLC25A35"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1919..1924
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC25A35"
                     /note="hexamer: TATAAA"
     polyA_site      1940
                     /gene="SLC25A35"
                     /note="major polyA site"
ORIGIN      
        1 agtggcagga gtgtggcggc ccggcctccg caggctaccc ggggttgaag ctactgcgag
       61 ctccggtggc tgcctgggga cgctcaggga cgctcattcc tggccagagt cctgacttct
      121 ttctcggatc gagatctcgt tgctggctcg aggaaatcac cggctcttct cccggatcct
      181 tttcttctct cacttgctgg ctttcttctt cctgcctccc tggcttccat ctcccaaccc
      241 cgcgattccc tcctctactc ccgtgctccc gtcgcccgcc atcctgagcc atcccacctg
      301 caaccttctg tcttttgccc ctccttgacc tcagagggtc ctgccttaag cttctcacca
      361 gaatctccta gatttctatc tcttccctgc ttgccagctc ttgactccca aattccagct
      421 gacgtttgac cacttgacat ttgaccctga cacccttgac tgcaaatcta aattcttatc
      481 ttctgcaacc tgtactgctg aaacaggcct tccccctgtc ttccaacccc gctttctgac
      541 acccattttt actttcttac tcttgggtca gttcctgcta cagctatccc accatggact
      601 tcttgatgag tggcctggca gcctgcgggg cctgtgtatt caccaatccc ctggaggtgg
      661 tgaagaccag gatgcagttg caaggagaac tgcaggcccc tggcacatac cagcggcact
      721 accgaaatgt cttccatgcc ttcatcacca tcggcaaggt ggatggcctt gctgccctgc
      781 agaaaggcct ggcccccgcc ctcttgtacc agttcctgat gaatggcatc cgactgggca
      841 cctatgggct ggctgaggct gggggctacc tgcacacagc cgaaggcacc cacagtcctg
      901 cccgcagcgc agcagctggg gccatggctg gggtcatggg agcctacttg gggagcccca
      961 tctacatggt gaagacacac ctgcaggcac aggcagcctc agaaattgct gtagggcacc
     1021 agtataagca tcagggcatg tttcaggcgc taaccgagat tggccagaaa catggtctgg
     1081 tggggttatg gcgtggggct ctgggcggcc tgccccgagt tatcgtcggt tcctccaccc
     1141 agctgtgcac cttctcatcc accaaggacc tcctgagcca gtgggagatc tttcctcccc
     1201 agagctggaa gttggcgctg gtggctgcca tgatgagtgg cattgcagtt gtcttggcca
     1261 tggcaccctt tgatgtggcc tgcacaaggc tctacaacca gcccacagat gcacagggca
     1321 agggcctcat gtaccggggg atactggacg ctctgctgca gacagctcgg accgagggca
     1381 tttttggcat gtacaagggt ataggtgcct cctacttccg cctcggcccc cacaccatcc
     1441 tctccctctt cttctgggac cagctgcgct ccctctacta cacagacact aaataacagc
     1501 cgctttccca gtctccacca aatgagcact ccttggccac ttgtgcctcc accactatgt
     1561 cctggtgact actgattagg tgacctttca tccatccatg ggggacagcc aaccccactc
     1621 cccatctgtt ctcagggttg aatcactaca agagatgagt ttcccttctt tccttgggtg
     1681 ttgctttaaa ccttccctac ccattccctg ggtaactcac acccctctct cagggctgaa
     1741 cgagtcatcc caaagtgtat ttcctcccac tcaccactgc cacccttgag tccctcctgc
     1801 tcccatgcac agttttaaac tcctccctcc aaaaccaaag ggaatcgaga gacccaattc
     1861 ccaggcgtct gggacccagg tgtcctgtta gattcaaagg cacagagatt atattgatta
     1921 taaagcaagt ttattctgaa
//
