LOCUS       NM_207348               3129 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens solute carrier family 25 member 34 (SLC25A34), mRNA.
ACCESSION   NM_207348
VERSION     NM_207348.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3129)
  AUTHORS   Lawlor,N., George,J., Bolisetty,M., Kursawe,R., Sun,L.,
            Sivakamasundari,V., Kycia,I., Robson,P. and Stitzel,M.L.
  TITLE     Single-cell transcriptomes identify human islet cell signatures and
            reveal cell-type-specific expression changes in type 2 diabetes
  JOURNAL   Genome Res 27 (2), 208-222 (2017)
   PUBMED   27864352
  REMARK    GeneRIF: The SLC25A34 transcript, based on single cell
            transcriptomics, is specific to the beta cells in the human islet.
REFERENCE   2  (bases 1 to 3129)
  AUTHORS   Palmieri,F.
  TITLE     The mitochondrial transporter family SLC25: identification,
            properties and physiopathology
  JOURNAL   Mol Aspects Med 34 (2-3), 465-484 (2013)
   PUBMED   23266187
  REMARK    GeneRIF: Compares and contrasts all the known human SLC25A* genes
            and includes functional information.
            Review article
REFERENCE   3  (bases 1 to 3129)
  AUTHORS   Hendrickson,S.L., Lautenberger,J.A., Chinn,L.W., Malasky,M.,
            Sezgin,E., Kingsley,L.A., Goedert,J.J., Kirk,G.D., Gomperts,E.D.,
            Buchbinder,S.P., Troyer,J.L. and O'Brien,S.J.
  TITLE     Genetic variants in nuclear-encoded mitochondrial genes influence
            AIDS progression
  JOURNAL   PLoS One 5 (9), e12862 (2010)
   PUBMED   20877624
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3129)
  AUTHORS   Haitina,T., Lindblom,J., Renstrom,T. and Fredriksson,R.
  TITLE     Fourteen novel human members of mitochondrial solute carrier family
            25 (SLC25) widely expressed in the central nervous system
  JOURNAL   Genomics 88 (6), 779-790 (2006)
   PUBMED   16949250
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL450998.19, BC027998.1 and AW291716.1.
            
            On Nov 22, 2018 this sequence version replaced NM_207348.2.
            
            Summary: SLC25A34 belongs to the SLC25 family of mitochondrial
            carrier proteins (Haitina et al., 2006 [PubMed 16949250]).[supplied
            by OMIM, Mar 2008].
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC027998.1, BI550141.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968832
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000294454.6/ ENSP00000294454.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-56                AL450998.19        13494-13549
            57-2883             BC027998.1         1-2827
            2884-3129           AW291716.1         16-261              c
FEATURES             Location/Qualifiers
     source          1..3129
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p36.21"
     gene            1..3129
                     /gene="SLC25A34"
                     /note="solute carrier family 25 member 34"
                     /db_xref="GeneID:284723"
                     /db_xref="HGNC:HGNC:27653"
                     /db_xref="MIM:610817"
     exon            1..606
                     /gene="SLC25A34"
                     /inference="alignment:Splign:2.1.0"
     CDS             229..1143
                     /gene="SLC25A34"
                     /codon_start=1
                     /product="solute carrier family 25 member 34"
                     /protein_id="NP_997231.1"
                     /db_xref="CCDS:CCDS162.1"
                     /db_xref="GeneID:284723"
                     /db_xref="HGNC:HGNC:27653"
                     /db_xref="MIM:610817"
                     /translation="METVPPAVDLVLGASACCLACVFTNPLEVVKTRLQLQGELQARG
                     TYPRPYHGFIASVAAVARADGLWGLQKGLAAGLLYQGLMNGVRFYCYSLACQAGLTQQ
                     PGGTVVAGAVAGALGAFVGSPAYLIKTQLQAQTVAAVAVGHQHNHQTVLGALETIWRQ
                     QGLLGLWQGVGGAVPRVMVGSAAQLATFASAKAWVQKQQWLPEDSWLVALAGGMISSI
                     AVVVVMTPFDVVSTRLYNQPVDTAGRGQLYGGLTDCMVKIWRQEGPLALYKGLGPAYL
                     RLGPHTILSMLFWDELRKLAGRAQHKGT"
     exon            607..672
                     /gene="SLC25A34"
                     /inference="alignment:Splign:2.1.0"
     exon            673..825
                     /gene="SLC25A34"
                     /inference="alignment:Splign:2.1.0"
     exon            826..960
                     /gene="SLC25A34"
                     /inference="alignment:Splign:2.1.0"
     exon            961..3129
                     /gene="SLC25A34"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3101..3106
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC25A34"
                     /note="hexamer: AATAAA"
     polyA_site      3129
                     /gene="SLC25A34"
                     /note="major polyA site"
ORIGIN      
        1 agaccgctgg aacagctgag cagagcaggt ggactgctga gatagaccag ggacaccagg
       61 cagccacagg cctgtcagac caggaccctt accctctaga catggcctcg gtcccctgca
      121 aaccccagcc ccgtagccct gcgaggttac agacagccta aacgccacca ccacagggcc
      181 tgtgccgtgc ccctgacccg ggcacagaag gccactggcc cggaggccat ggagacggtg
      241 cccccagcag tggacctggt gctgggtgct tctgcctgct gcctggcctg tgtcttcacc
      301 aaccccctgg aggtggtgaa gacgcggctg cagctgcagg gggagctgca ggcccggggc
      361 acctacccac ggccctacca tggcttcata gcctctgtcg ctgctgtggc ccgagcagac
      421 gggctgtggg gcctgcagaa ggggctggct gccggccttc tgtaccaagg cctcatgaat
      481 ggcgttcgtt tctactgcta cagcctggcg tgccaggctg gcctcacgca gcaaccaggt
      541 ggcaccgtgg ttgcgggagc cgtggcgggg gcactgggag ccttcgtggg gagccctgct
      601 tacctgatca aaacgcagct gcaagctcag acagtggccg cagtggccgt gggacaccag
      661 cacaatcacc agactgtcct gggtgccttg gagaccatct ggcggcagca agggctcttg
      721 gggctgtggc agggcgttgg tggggctgtg ccccgagtca tggtgggctc agctgcccag
      781 ctggccacct tcgcctctgc caaggcctgg gtacagaagc aacagtggct ccctgaggac
      841 agctggctgg tggccctggc tgggggcatg atcagcagca tagccgtggt tgtcgtcatg
      901 actcccttcg atgtggtcag cacgcggcta tacaatcagc cggtggacac agctggcagg
      961 ggccagctct atgggggcct caccgactgc atggtgaaga tctggcggca ggagggcccc
     1021 ctggcactct acaagggcct gggccccgcc tacctgcgcc tgggccccca caccatcctc
     1081 agcatgctct tctgggacga gcttcggaaa ctggctgggc gggcccagca caagggcacc
     1141 tagacgacgg ccctcacccc cacgtcctga cacggccggc acttggccgg aagtgagagc
     1201 ctgctccagg acaactggct gtcccggggc gggccatggg cccaggccct gccagaggtc
     1261 ccgggagagt gtggacagct ctggtccatc cagccccttg gcccacccag gtccagagca
     1321 tccacttcaa gttaccaccc attctgtctt ccagacagtt ctcttccttc tctgtactgc
     1381 gtactgggtc accacatccc agagccttgc tcagttatag caactgctgc gggcgtgcac
     1441 atggcatagg cccagtaact tacatacatc ggctcactta ggcctcagac agcagcacga
     1501 ggcaggcact tttacttctt ttaccattag aaagccaagg cctagagtgg tgggctttga
     1561 ccacagccac acaattttga agtggcagag ccaggactgg agcttagccc tgctcaccct
     1621 agacctatgc gcttgacaag tgcgtgactg tgacaggccc atgggcccgg actgcccata
     1681 ggggtcactg taccatggca aaggctgagg tgcaccagga ggctgtggcg tcgtcacctg
     1741 ccttatttgc tggagaagct gtagcaaaga accacagact gggcgactta gacaatagaa
     1801 atgtattttc tcacagttct ggaggctgga tgctggagac caaggtgtca gtgggctggt
     1861 ttcttctgag gcctctgtcc atggcttgca gatgctgctt tctctctgtg tctgcacatg
     1921 gtggtccctc gatgtgcgtc tgggtcctga tctcctcctc ttataaggac acaaatcatg
     1981 ttggcttagg gcccaccctc atgaccccac tttaattttt tttttttttt ttgagatgaa
     2041 gtctcactct gccacccaag ctggagtgca gtggcacgat ctcggttcac tgcaaccttg
     2101 gcctcctagg ttcaagcaat tctcctgccc cagcctcctg agtagctggg attacaggtg
     2161 tgtgccacca cacccggcca atttttgtat ctttagtaga gatggggttt tgccatgttg
     2221 gccagactgg tctcgaactc ctgacctcaa gtgatccact ggccttggcc tcccaaagtg
     2281 ctgggattac aggcatgagc cacctcactt ggcccaattt taacttaatt atctctgtca
     2341 agagcctatc tccatataca gtcacatcct gagctactag ggggtaggac ttcaacatgc
     2401 acttctgcag gggccgcagt tcagccaaca tcatcttttt ttttgagatg gagtctcgct
     2461 ttgttgccca ggctggagtg cggtggtgca atctcggctc accacaacct ccacctccca
     2521 ggttcaagtg attctcctgc ctcagcctcc cgagttgctg ggactatagg tgtgcgccac
     2581 catgcccagc taattttgta tttttagtag agacaggctt tcgctgtgtt ggccaggctg
     2641 gtcttgaatg cctgaccttg ccgcccgcct cggcctccca aaatgctggg attacaggcg
     2701 tgagccaccg cgcctggcct cagccaacat catctaaggg ctctcacgga gggcctccca
     2761 gctgcccgcc ctgtgggcat ttgcacatat cctgacaagc ctgaaagaag ctccgggtgc
     2821 ccattgttca gtccaggtgc ccattgttcc cgggactgag gcccgggaaa gggaagcgac
     2881 gtggcagggc cagcagcaga ccctgggcct ttctctagac tgagcaccat tccccgtggg
     2941 tgtgctctca gcgccgcacc gaccttcaca ctgcagagat ggatgccaac tccctggcag
     3001 gggcaggact gctgccgagc agccccacct gccctcccag ccacacccca agtctgtaag
     3061 ggccgctccc aggaacacct gctactgcac actccaaacc aataaagttt tatattttgt
     3121 ttacttcaa
//
