LOCUS       NM_032315               3865 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens solute carrier family 25 member 33 (SLC25A33), mRNA.
ACCESSION   NM_032315
VERSION     NM_032315.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3865)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 3865)
  AUTHORS   Di Noia,M.A., Todisco,S., Cirigliano,A., Rinaldi,T., Agrimi,G.,
            Iacobazzi,V. and Palmieri,F.
  TITLE     The human SLC25A33 and SLC25A36 genes of solute carrier family 25
            encode two mitochondrial pyrimidine nucleotide transporters
  JOURNAL   J Biol Chem 289 (48), 33137-33148 (2014)
   PUBMED   25320081
  REMARK    GeneRIF: The main physiological role of SLC25A33 and SLC25A36 is to
            import/export pyrimidine nucleotides into and from mitochondria
REFERENCE   3  (bases 1 to 3865)
  AUTHORS   Palmieri,F.
  TITLE     The mitochondrial transporter family SLC25: identification,
            properties and physiopathology
  JOURNAL   Mol Aspects Med 34 (2-3), 465-484 (2013)
   PUBMED   23266187
  REMARK    GeneRIF: Compares and contrasts all the known human SLC25A* genes
            and includes functional information.
            Review article
REFERENCE   4  (bases 1 to 3865)
  AUTHORS   Hendrickson,S.L., Lautenberger,J.A., Chinn,L.W., Malasky,M.,
            Sezgin,E., Kingsley,L.A., Goedert,J.J., Kirk,G.D., Gomperts,E.D.,
            Buchbinder,S.P., Troyer,J.L. and O'Brien,S.J.
  TITLE     Genetic variants in nuclear-encoded mitochondrial genes influence
            AIDS progression
  JOURNAL   PLoS One 5 (9), e12862 (2010)
   PUBMED   20877624
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3865)
  AUTHORS   Favre,C., Zhdanov,A., Leahy,M., Papkovsky,D. and O'Connor,R.
  TITLE     Mitochondrial pyrimidine nucleotide carrier (PNC1) regulates
            mitochondrial biogenesis and the invasive phenotype of cancer cells
  JOURNAL   Oncogene 29 (27), 3964-3976 (2010)
   PUBMED   20453889
  REMARK    GeneRIF: PNC1 is essential for mitochondria maintenance.
REFERENCE   6  (bases 1 to 3865)
  AUTHORS   Floyd,S., Favre,C., Lasorsa,F.M., Leahy,M., Trigiante,G.,
            Stroebel,P., Marx,A., Loughran,G., O'Callaghan,K., Marobbio,C.M.,
            Slotboom,D.J., Kunji,E.R., Palmieri,F. and O'Connor,R.
  TITLE     The insulin-like growth factor-I-mTOR signaling pathway induces the
            mitochondrial pyrimidine nucleotide carrier to promote cell growth
  JOURNAL   Mol Biol Cell 18 (9), 3545-3555 (2007)
   PUBMED   17596519
REFERENCE   7  (bases 1 to 3865)
  AUTHORS   Haitina,T., Lindblom,J., Renstrom,T. and Fredriksson,R.
  TITLE     Fourteen novel human members of mitochondrial solute carrier family
            25 (SLC25) widely expressed in the central nervous system
  JOURNAL   Genomics 88 (6), 779-790 (2006)
   PUBMED   16949250
REFERENCE   8  (bases 1 to 3865)
  AUTHORS   Wang,B., Li,N., Sui,L., Wu,Y., Wang,X., Wang,Q., Xia,D., Wan,T. and
            Cao,X.
  TITLE     HuBMSC-MCP, a novel member of mitochondrial carrier superfamily,
            enhances dendritic cell endocytosis
  JOURNAL   Biochem Biophys Res Commun 314 (1), 292-300 (2004)
   PUBMED   14715278
  REMARK    GeneRIF: BMSC-MCP is a phylogenetically conserved and widely
            expressed mitochondrial carrier protein which perhaps associates
            with mitochondrial oxidative phosphorylation
REFERENCE   9  (bases 1 to 3865)
  AUTHORS   Hildyard,J.C. and Halestrap,A.P.
  TITLE     Identification of the mitochondrial pyruvate carrier in
            Saccharomyces cerevisiae
  JOURNAL   Biochem J 374 (Pt 3), 607-611 (2003)
   PUBMED   12887330
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL928921.21, BC004991.1, BC073135.1 and AL954705.14.
            
            On Nov 22, 2018 this sequence version replaced NM_032315.2.
            
            Summary: SLC25A33 belongs to the SLC25 family of mitochondrial
            carrier proteins (Haitina et al., 2006 [PubMed 16949250]).[supplied
            by OMIM, Mar 2008].
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163658.168099.1,
                                           SRR1163658.441097.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            MANE Ensembl match                 :: ENST00000302692.7/
                                                  ENSP00000306328.5
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-34                AL928921.21        111458-111491
            35-1401             BC004991.1         1-1367
            1402-1465           BC073135.1         1384-1447
            1466-3865           AL954705.14        13850-16249
FEATURES             Location/Qualifiers
     source          1..3865
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p36.22"
     gene            1..3865
                     /gene="SLC25A33"
                     /gene_synonym="BMSC-MCP; PNC1"
                     /note="solute carrier family 25 member 33"
                     /db_xref="GeneID:84275"
                     /db_xref="HGNC:HGNC:29681"
                     /db_xref="MIM:610816"
     exon            1..283
                     /gene="SLC25A33"
                     /gene_synonym="BMSC-MCP; PNC1"
                     /inference="alignment:Splign:2.1.0"
     CDS             228..1193
                     /gene="SLC25A33"
                     /gene_synonym="BMSC-MCP; PNC1"
                     /note="mitochondrial carrier protein; novel mitochondrial
                     carrier protein; huBMSC-MCP; bone marrow stromal cell
                     mitochondrial carrier protein; solute carrier family 25
                     (pyrimidine nucleotide carrier), member 33"
                     /codon_start=1
                     /product="solute carrier family 25 member 33"
                     /protein_id="NP_115691.1"
                     /db_xref="CCDS:CCDS103.1"
                     /db_xref="GeneID:84275"
                     /db_xref="HGNC:HGNC:29681"
                     /db_xref="MIM:610816"
                     /translation="MATGGQQKENTLLHLFAGGCGGTVGAIFTCPLEVIKTRLQSSRL
                     ALRTVYYPQVHLGTISGAGMVRPTSVTPGLFQVLKSILEKEGPKSLFRGLGPNLVGVA
                     PSRAVYFACYSKAKEQFNGIFVPNSNIVHIFSAGSAAFITNSLMNPIWMVKTRMQLEQ
                     KVRGSKQMNTLQCARYVYQTEGIRGFYRGLTASYAGISETIICFAIYESLKKYLKEAP
                     LASSANGTEKNSTSFFGLMAAAALSKGCASCIAYPHEVIRTRLREEGTKYKSFVQTAR
                     LVFREEGYLAFYRGLFAQLIRQIPNTAIVLSTYELIVYLLEDRTQ"
     exon            284..463
                     /gene="SLC25A33"
                     /gene_synonym="BMSC-MCP; PNC1"
                     /inference="alignment:Splign:2.1.0"
     exon            464..541
                     /gene="SLC25A33"
                     /gene_synonym="BMSC-MCP; PNC1"
                     /inference="alignment:Splign:2.1.0"
     exon            542..642
                     /gene="SLC25A33"
                     /gene_synonym="BMSC-MCP; PNC1"
                     /inference="alignment:Splign:2.1.0"
     exon            643..709
                     /gene="SLC25A33"
                     /gene_synonym="BMSC-MCP; PNC1"
                     /inference="alignment:Splign:2.1.0"
     exon            710..990
                     /gene="SLC25A33"
                     /gene_synonym="BMSC-MCP; PNC1"
                     /inference="alignment:Splign:2.1.0"
     exon            991..3865
                     /gene="SLC25A33"
                     /gene_synonym="BMSC-MCP; PNC1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1437..1442
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC25A33"
                     /gene_synonym="BMSC-MCP; PNC1"
                     /note="hexamer: ATTAAA"
     polyA_site      1465
                     /gene="SLC25A33"
                     /gene_synonym="BMSC-MCP; PNC1"
                     /note="major polyA site"
     regulatory      3845..3850
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC25A33"
                     /gene_synonym="BMSC-MCP; PNC1"
                     /note="hexamer: AATAAA"
     polyA_site      3865
                     /gene="SLC25A33"
                     /gene_synonym="BMSC-MCP; PNC1"
ORIGIN      
        1 agctccccgc cgggctcgcg ccgcagaggc cggtgaggcg ccggcggcca cgccgcggaa
       61 ggcgcgggcc gagcagagcc gggcgttgga gcccgcgcgc gcatggaggc gttgccggca
      121 gccccctgag ggcagcgggg agacaagacc cggcgacctc gcgcatccct cgagccgcca
      181 cgcgctctcg ccaccgggcg gcgacgggcc gcggagccgg cgcggccatg gcgacgggcg
      241 gccagcagaa ggagaacacg ctgcttcacc tcttcgccgg cgggtgtgga ggcacagttg
      301 gtgctatttt cacttgtcca ctagaagtca ttaagacacg gttgcagtct tcaagattag
      361 ctctccggac agtctactat cctcaggttc atctggggac cattagtgga gctggaatgg
      421 tgagaccaac atccgtgaca cctggactct ttcaggttct gaagtcgatc ttggagaaag
      481 agggaccaaa gtcacttttt agaggcttgg gtccaaattt ggttggagtt gcaccatcaa
      541 gggctgtata ctttgcatgt tactccaaag ccaaagagca atttaatggc attttcgtgc
      601 ctaacagcaa tattgtgcat attttctcag ctggctctgc agcttttatc acaaattcct
      661 taatgaatcc tatatggatg gttaaaaccc gaatgcagct agaacagaaa gtgaggggct
      721 ctaagcagat gaatacactc cagtgtgctc gttacgttta ccagaccgaa ggcattcgtg
      781 gcttctatag aggattaact gcctcgtatg ctggaatttc cgaaactata atctgctttg
      841 ctatttatga aagtttaaag aagtatctga aagaagctcc attagcctct tctgcaaatg
      901 ggactgagaa aaattccaca agtttttttg gacttatggc agctgctgct ctttctaagg
      961 gctgtgcctc ctgcattgct tatccacacg aagtcataag gacgaggctc cgggaagagg
     1021 gcaccaagta caagtctttt gtccagacgg cgcgcctggt gttccgggaa gaaggctacc
     1081 ttgcctttta tagaggactg tttgcccagc ttatccggca gatcccaaat actgccattg
     1141 tgttgtctac ttatgagtta attgtgtacc tgttagaaga ccgtactcag taacaggccg
     1201 gaaaattgtg ctctagaaga ataaaactga aaaactctag agaatttttt ttccccattg
     1261 atgtttagaa agtttgagac tgaaacagga aaggccataa aatatctggt tcatatcacc
     1321 tgttggacat ttccttttgg attcatgctt tctggaaggt ttaaattcat taacgttaat
     1381 agttaattat aacttttttt ttaacttaag aggattcagg gttaagcacc aactaaatta
     1441 aatcatgcta tttaatttaa gtatacattt ggcttgtgtc ctcttttatg ctcactatac
     1501 tatgaaggac ttaagtaatt cagataaacc tgccctagaa ctgcagagaa aaatgataaa
     1561 gtgagaatac aacttgtttt ataatctgac tttaagatct tgcactgcta gacagggaag
     1621 aagtgtcgca ttttggctgg gcactgtggc tcacgcccgt aatcccagca ctttgggagg
     1681 ccgaggcaga tggatcacgt gaagtcagga gttccagacc agcctggcca acatggcgaa
     1741 accctgtctc tactaaaaat acaaaaatta gccggacgtg tgcctgtaat cccagctact
     1801 tgggaggctg aggcaggaga atcacttgaa acccaggggg cagaggttgc agcgagctga
     1861 gatcacgtca cttcactcca gcctggtcga cagagtgaga ctccatctca aaaaaaaaaa
     1921 aattgtgtca cattttggtg gtggtgtgtg gaccaggaca aacttcccag caatttttct
     1981 tctttgtaca tttccaatta cttgcagatt gatcatctaa gcgttcagac tgctgagatg
     2041 aatatatata actttctgag actcaatatt ttaagctata aaaaacttcc tgaagttatc
     2101 cttttctccc tactttgaac caaaggcaag aatttttaaa gaactgtttt atcaatggcc
     2161 tggctcctgg atatagttcc ggaagttaag accagttgcc ttgttaagtg tgttgacagc
     2221 acagctaccc tgtttggctg tgaatccaga atgtgatgaa gaacagtcat tcccactgag
     2281 gtctttagcc ctgttcttgg acctctgctc ttgcagaaaa ggagcacaac gtaggactat
     2341 ggctcacccg tcagagagct cacattctga tagaaagcac tgggattgtt taaatatcct
     2401 agttcaacat taaaaaaaaa aaaaatttaa tcccagcact ttgggaggcc aaggcgggca
     2461 gatcacgagg tcaggagatc gagaccatcc tggctaacac ggtgaaaccc cgtctctact
     2521 aaaaaaatac aaaaaaattg gccatgcgtg gtggcgggca cccatagtcc cagctactcg
     2581 ggaggctgag gcaggagaat ggcgtgaacc tgggaggcgg agcttgcagt gagctgagat
     2641 ggcgccactg cactccagcc tgggccacag agtgcgactc catctcaaaa aaaaaaaaaa
     2701 aaccaggatg ttaccccctt ggttttaaag caaatttaat aagggaacaa aaagatgata
     2761 ctaagaagaa ggcaagtaaa acccctagtc ttccattagc tctttcactg gaatttgagt
     2821 atattgtaca tgaaggttgg ttttcaattt gaacgtctag aaagatactc atttctaata
     2881 cctatgcact gtagtttcag gtttacttgc agacaccctg gtagggttaa gaggaggata
     2941 tttccaagtt attttaaatt gagtttactt ttaactgggg ttcttgactc tagtgtaatt
     3001 gctccaacaa ctacgtagaa gtcaaaatga gtgactttag tgaagcttct gtactttaca
     3061 atacatgaca gtaatgctat tccagaagtt ttgttttgtt ttgttttgag atggagtctc
     3121 gctctgtctc tcccaggctg gagtgcagtg gcacaatctc ggctcactac agcctccacc
     3181 tcccggtttc aagcaattct cctgtcttag cctcctgagt agctgggact acaggcatgc
     3241 gccaccacac ctggctaatt ttgtattttt agtagagatg gggtttcacc atgttggcca
     3301 ggctggtctc aaactcttga cctcaggtga tctacccgcc tcggcctccc aaagtactgg
     3361 gattacagga gggagccacc atacctggcc cgcgccgccc cttcctttgt tgttattgtt
     3421 gttttgagac aaggtatcac tcgatcactg aagctggata cagtggcaag atcatagctc
     3481 actgtaacct caaactcctg ggcacaaggg atcctcgcat ctcagcctcc caagtagctt
     3541 ggaccacagg aaagtaccac catgcccagc taatgttttt tcattttttg tgcagacgag
     3601 gttttgctat gttgtccagg ctggtctcag actactggcc agaagcgatc ttacctcctc
     3661 agcctcccaa agcactggaa ttacagagta acatctaatt ttaatattca cattcctatt
     3721 ttaatattca tattcgatga tggcacttag caacatcctc ctatatccat attaaaacct
     3781 gttttccaag attgtgtcta atatgaaggt gtaaaattgc tttgttttca ctccttcttg
     3841 aatgaataaa tttgatagta accaa
//
